JP2008531713A5 - - Google Patents

Info

Publication number

JP2008531713A5

JP2008531713A5 JP2007558191A JP2007558191A JP2008531713A5 JP 2008531713 A5 JP2008531713 A5 JP 2008531713A5 JP 2007558191 A JP2007558191 A JP 2007558191A JP 2007558191 A JP2007558191 A JP 2007558191A JP 2008531713 A5 JP2008531713 A5 JP 2008531713A5

Authority

JP

Japan

Prior art keywords

substituted

group

alkyl

amino

compound

Prior art date

2006-02-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• 125000001072 heteroaryl group Chemical group 0.000 claims 5
• 125000003118 aryl group Chemical group 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• NUAQIRUAZSJTAI-YRPZDAAMSA-N O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@H](N)CC(C)C)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@H](N)CC(C)C)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 NUAQIRUAZSJTAI-YRPZDAAMSA-N 0.000 claims 3
• 125000002877 alkyl aryl group Chemical group 0.000 claims 3
• 125000003710 aryl alkyl group Chemical group 0.000 claims 3
• 125000004429 atom Chemical group 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 125000003277 amino group Chemical group 0.000 claims 2
• 125000004104 aryloxy group Chemical group 0.000 claims 2
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 125000000547 substituted alkyl group Chemical group 0.000 claims 2
• 125000003107 substituted aryl group Chemical group 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 230000010933 acylation Effects 0.000 claims 1
• 238000005917 acylation reaction Methods 0.000 claims 1
• 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 230000000845 anti-microbial effect Effects 0.000 claims 1
• 235000010290 biphenyl Nutrition 0.000 claims 1
• 239000004305 biphenyl Substances 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• -1 carboxyl ester Chemical class 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
• 125000005309 thioalkoxy group Chemical group 0.000 claims 1
• 0 CC(C)CC(C(NC(C(c(cc1Cl)ccc1OC(C1OC(C(C2O)OC(CC3(C)*)OC(C)C3O)OC(CO)C2O)=CC(C(C(NC)=O)NC(C(CC(N)=O)N2)=O)=CC1Oc1ccc(C(C(C(*C(C(C)=O)c3c(-c(cc(C4)cc5)c5O)c(O)c(*)c(O)c3)=O)NC4=O)OC)cc1Cl)O)C2=O)=O)IN Chemical compound CC(C)CC(C(NC(C(c(cc1Cl)ccc1OC(C1OC(C(C2O)OC(CC3(C)*)OC(C)C3O)OC(CO)C2O)=CC(C(C(NC)=O)NC(C(CC(N)=O)N2)=O)=CC1Oc1ccc(C(C(C(*C(C(C)=O)c3c(-c(cc(C4)cc5)c5O)c(O)c(*)c(O)c3)=O)NC4=O)OC)cc1Cl)O)C2=O)=O)IN 0.000 description 1