JP2006515866A5 - - Google Patents
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- Publication number
- JP2006515866A5 JP2006515866A5 JP2005512876A JP2005512876A JP2006515866A5 JP 2006515866 A5 JP2006515866 A5 JP 2006515866A5 JP 2005512876 A JP2005512876 A JP 2005512876A JP 2005512876 A JP2005512876 A JP 2005512876A JP 2006515866 A5 JP2006515866 A5 JP 2006515866A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- hydrogen
- acyl
- compound according
- above formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 72
- 125000002252 acyl group Chemical group 0.000 claims 43
- 229910052739 hydrogen Inorganic materials 0.000 claims 38
- 239000001257 hydrogen Substances 0.000 claims 38
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 23
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000547 substituted alkyl group Chemical group 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 12
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- -1 imino, substituted imino Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000013522 chelant Substances 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- WYMDDFRYORANCC-UHFFFAOYSA-N 2-[[3-[bis(carboxymethyl)amino]-2-hydroxypropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)CN(CC(O)=O)CC(O)=O WYMDDFRYORANCC-UHFFFAOYSA-N 0.000 claims 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229950003776 protoporphyrin Drugs 0.000 claims 1
- 0 CCCC(*)N*(C)CC Chemical compound CCCC(*)N*(C)CC 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42917402P | 2002-11-25 | 2002-11-25 | |
| US47553903P | 2003-06-02 | 2003-06-02 | |
| PCT/US2003/037895 WO2004063213A2 (en) | 2002-11-25 | 2003-11-25 | Peptides which target tumor and endothelial cells, compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006515866A JP2006515866A (ja) | 2006-06-08 |
| JP2006515866A5 true JP2006515866A5 (enExample) | 2007-01-18 |
Family
ID=32397181
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005510345A Pending JP2006514116A (ja) | 2002-11-25 | 2003-11-25 | 血管形生、細胞移動、細胞侵入及び細胞増殖を阻害するペプチド、組成物及びそれらの使用 |
| JP2005512876A Pending JP2006515866A (ja) | 2002-11-25 | 2003-11-25 | 腫瘍および内皮細胞を標的とするペプチド、その組成物および使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005510345A Pending JP2006514116A (ja) | 2002-11-25 | 2003-11-25 | 血管形生、細胞移動、細胞侵入及び細胞増殖を阻害するペプチド、組成物及びそれらの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7517855B2 (enExample) |
| EP (2) | EP1569678A4 (enExample) |
| JP (2) | JP2006514116A (enExample) |
| KR (2) | KR20050096917A (enExample) |
| AU (2) | AU2003298726A1 (enExample) |
| BR (2) | BR0316523A (enExample) |
| CA (2) | CA2507045A1 (enExample) |
| EA (2) | EA200500871A1 (enExample) |
| HR (2) | HRP20050584A2 (enExample) |
| MX (2) | MXPA05005469A (enExample) |
| NO (2) | NO20053111L (enExample) |
| NZ (2) | NZ540363A (enExample) |
| PL (2) | PL377763A1 (enExample) |
| WO (2) | WO2004047771A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004047771A2 (en) * | 2002-11-25 | 2004-06-10 | Attenuon, Llc. | Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof |
| EP1766405A1 (en) * | 2004-05-21 | 2007-03-28 | MDS Inc. doing Business Through Its MDS Pharma Services Division | Method of quantifying the cell-binding properties of a medical device |
| US20060078535A1 (en) * | 2004-10-13 | 2006-04-13 | The Regents Of The University Of Michigan | Anticancer compounds and methods |
| JP2008528635A (ja) | 2005-02-01 | 2008-07-31 | アテニュオン，エルエルシー | Ａｃ−ＰＨＳＣＮ−ＮＨ２の酸付加塩 |
| KR20070100832A (ko) * | 2005-02-01 | 2007-10-11 | 아테뉴온, 엘엘씨 | 항혈관신생 ｐｈｓｃｎ 펩티드를 함유하는 조성물 |
| CA2668500C (en) * | 2006-11-08 | 2018-07-31 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| AU2016213759B2 (en) * | 2006-11-08 | 2018-03-29 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| EP4067370A1 (en) | 2009-05-08 | 2022-10-05 | Chongxi Yu | High penetration prodrug compositions of peptides and peptide related compounds |
| KR101228668B1 (ko) | 2010-09-17 | 2013-01-31 | 가톨릭대학교 산학협력단 | 혈관신생 억제 활성을 갖는 펩타이드 및 이의 용도 |
| GB2510488B (en) | 2011-06-23 | 2020-04-08 | Univ Texas | Identifying peptides at the single molecule level |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| CN102417540A (zh) * | 2011-11-21 | 2012-04-18 | 中国药科大学 | 一种聚乙二醇修饰的整合素阻断剂hm-3及其应用 |
| EP2846847B1 (en) * | 2012-05-11 | 2020-03-25 | C.P. Medical Corporation | Biocompatible hydrogel treatments for retinal detachment |
| CA2875369C (en) | 2012-06-04 | 2017-11-21 | Suncor Energy Inc. | Formulations containing paraffinic oil and anti-settling agent |
| EP2967056B1 (en) | 2013-03-15 | 2018-02-21 | Suncor Energy Inc. | Herbicidal compositions |
| JP5970439B2 (ja) * | 2013-09-20 | 2016-08-17 | チョンシー ユー | ペプチド及び関連化合物の経皮送達システム |
| EP3543703A1 (en) * | 2014-09-15 | 2019-09-25 | Board of Regents, The University of Texas System | Improved single molecule peptide sequencing |
| EP3821010A4 (en) | 2018-07-12 | 2022-04-20 | Board of Regents, The University of Texas System | Molecular neighborhood detection by oligonucleotides |
| JP7588289B2 (ja) | 2019-02-15 | 2024-11-22 | ニュートリエン・エージー・ソリューションズ・（カナダ）・インコーポレイテッド | 植物の健康を増進するプロトポルフィリンｉｘ誘導体及びその使用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| EP0051682B1 (en) * | 1980-05-13 | 1984-09-05 | Mitsubishi Kasei Corporation | Cysteine derivatives and process for their preparation |
| US4440788A (en) * | 1980-05-13 | 1984-04-03 | Mitsubishi Chemical Industries, Limited | Cysteine derivatives |
| US4394519A (en) * | 1982-01-19 | 1983-07-19 | Research Corporation | Amino acid blocking agents |
| GB8504253D0 (en) * | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| DE3815221C2 (de) * | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5091176A (en) * | 1988-11-02 | 1992-02-25 | W. R. Grace & Co.-Conn. | Polymer-modified peptide drugs having enhanced biological and pharmacological activities |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5229366A (en) * | 1990-10-23 | 1993-07-20 | Fuji Photo Film Co., Ltd. | Peptide-containing polyethylene glycol derivatives and application thereof |
| US5149801A (en) * | 1990-11-21 | 1992-09-22 | The Regents Of The University Of California | Boronated porphyrin compounds |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5698155A (en) * | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US5608110A (en) * | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| US5639725A (en) * | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| ZA962077B (en) * | 1995-03-14 | 1997-03-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
| JP3142577B2 (ja) * | 1995-03-14 | 2001-03-07 | シーメンス アクチエンゲゼルシヤフト | 着脱自在な精密計量供給ユニット |
| US5618513A (en) * | 1995-06-07 | 1997-04-08 | Mallinckrodt Medical, Inc. | Method for preparing radiolabeled peptides |
| MY147327A (en) * | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
| EP0927045B1 (en) * | 1996-09-10 | 2005-12-14 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
| US6331409B1 (en) * | 1996-11-21 | 2001-12-18 | The Regents Of The University Of Michigan | Methods and compositions for wound healing |
| US6001965A (en) * | 1996-11-21 | 1999-12-14 | The Regents Of The University Of Michigan | Anticancer compounds and methods |
| US6025150A (en) * | 1996-11-21 | 2000-02-15 | The Regents Of The University Of Michigan | Methods and compositions for wound healing |
| WO1998030538A1 (en) * | 1997-01-14 | 1998-07-16 | Kaneka Corporation | Process for producing cysteine derivatives |
| US5994309A (en) * | 1997-07-25 | 1999-11-30 | Angstrom Pharmaceuticals, Inc. | Anti-invasive and anti-angiogenic compositions and methods |
| DE69839844D1 (de) * | 1997-09-10 | 2008-09-18 | Burnham Inst | Verfahren zur auffindung von zielsuchenden verbindungen spezifisch für angiogenese vaskulatur |
| US5954047A (en) * | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
| WO2000009537A2 (en) * | 1998-08-14 | 2000-02-24 | Administrators Of The Tulane Educational Fund | Compounds having growth hormone releasing activity |
| DE60221115T2 (de) | 2001-01-18 | 2008-03-13 | The Regents Of The University Of Michigan, Ann Arbor | Zusammensetzungen und verfahren zur verwendung von fibronektin-fragmenten bei krebsdiagnose |
| WO2004047771A2 (en) * | 2002-11-25 | 2004-06-10 | Attenuon, Llc. | Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof |
-
2003
- 2003-11-25 WO PCT/US2003/038175 patent/WO2004047771A2/en not_active Ceased
- 2003-11-25 NZ NZ540363A patent/NZ540363A/en unknown
- 2003-11-25 US US10/723,144 patent/US7517855B2/en not_active Expired - Fee Related
- 2003-11-25 HR HR20050584A patent/HRP20050584A2/hr not_active Application Discontinuation
- 2003-11-25 MX MXPA05005469A patent/MXPA05005469A/es not_active Application Discontinuation
- 2003-11-25 AU AU2003298726A patent/AU2003298726A1/en not_active Abandoned
- 2003-11-25 MX MXPA05005545A patent/MXPA05005545A/es unknown
- 2003-11-25 EA EA200500871A patent/EA200500871A1/ru unknown
- 2003-11-25 EP EP03796483A patent/EP1569678A4/en not_active Withdrawn
- 2003-11-25 NZ NZ540889A patent/NZ540889A/en not_active IP Right Cessation
- 2003-11-25 PL PL377763A patent/PL377763A1/pl not_active Application Discontinuation
- 2003-11-25 US US10/722,843 patent/US20050020810A1/en not_active Abandoned
- 2003-11-25 BR BR0316523-0A patent/BR0316523A/pt not_active IP Right Cessation
- 2003-11-25 JP JP2005510345A patent/JP2006514116A/ja active Pending
- 2003-11-25 CA CA002507045A patent/CA2507045A1/en not_active Abandoned
- 2003-11-25 KR KR1020057009356A patent/KR20050096917A/ko not_active Withdrawn
- 2003-11-25 HR HR20050585A patent/HRP20050585A2/xx not_active Application Discontinuation
- 2003-11-25 AU AU2003297609A patent/AU2003297609A1/en not_active Abandoned
- 2003-11-25 BR BR0316550-7A patent/BR0316550A/pt not_active IP Right Cessation
- 2003-11-25 KR KR1020057009447A patent/KR20050097494A/ko not_active Withdrawn
- 2003-11-25 EA EA200500870A patent/EA200500870A1/ru unknown
- 2003-11-25 PL PL377701A patent/PL377701A1/pl not_active Application Discontinuation
- 2003-11-25 CA CA002506813A patent/CA2506813A1/en not_active Abandoned
- 2003-11-25 WO PCT/US2003/037895 patent/WO2004063213A2/en not_active Ceased
- 2003-11-25 JP JP2005512876A patent/JP2006515866A/ja active Pending
- 2003-11-25 EP EP03812058A patent/EP1594521A4/en not_active Withdrawn
-
2005
- 2005-06-24 NO NO20053111A patent/NO20053111L/no not_active Application Discontinuation
- 2005-06-24 NO NO20053112A patent/NO20053112L/no not_active Application Discontinuation
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