CA2506813A1 - Peptides which target tumor and endothelial cells, compositions and uses thereof - Google Patents

Peptides which target tumor and endothelial cells, compositions and uses thereof Download PDF

Info

Publication number
CA2506813A1
CA2506813A1 CA002506813A CA2506813A CA2506813A1 CA 2506813 A1 CA2506813 A1 CA 2506813A1 CA 002506813 A CA002506813 A CA 002506813A CA 2506813 A CA2506813 A CA 2506813A CA 2506813 A1 CA2506813 A1 CA 2506813A1
Authority
CA
Canada
Prior art keywords
compound
hydrogen
substituted
acyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002506813A
Other languages
English (en)
French (fr)
Inventor
Amy L. Allan
Won Hyung Yoon
Patricia L. Gladstone
Robert J. Ternansky
Graham Parry
Fernando Donate
Andrew Mazar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tactic Pharma LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2506813A1 publication Critical patent/CA2506813A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CA002506813A 2002-11-25 2003-11-25 Peptides which target tumor and endothelial cells, compositions and uses thereof Abandoned CA2506813A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42917402P 2002-11-25 2002-11-25
US60/429,174 2002-11-25
US47553903P 2003-06-02 2003-06-02
US60/475,539 2003-06-02
PCT/US2003/037895 WO2004063213A2 (en) 2002-11-25 2003-11-25 Peptides which target tumor and endothelial cells, compositions and uses thereof

Publications (1)

Publication Number Publication Date
CA2506813A1 true CA2506813A1 (en) 2004-07-29

Family

ID=32397181

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002506813A Abandoned CA2506813A1 (en) 2002-11-25 2003-11-25 Peptides which target tumor and endothelial cells, compositions and uses thereof
CA002507045A Abandoned CA2507045A1 (en) 2002-11-25 2003-11-25 Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002507045A Abandoned CA2507045A1 (en) 2002-11-25 2003-11-25 Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof

Country Status (14)

Country Link
US (2) US7517855B2 (enExample)
EP (2) EP1594521A4 (enExample)
JP (2) JP2006514116A (enExample)
KR (2) KR20050096917A (enExample)
AU (2) AU2003297609A1 (enExample)
BR (2) BR0316523A (enExample)
CA (2) CA2506813A1 (enExample)
EA (2) EA200500871A1 (enExample)
HR (2) HRP20050585A2 (enExample)
MX (2) MXPA05005469A (enExample)
NO (2) NO20053112L (enExample)
NZ (2) NZ540889A (enExample)
PL (2) PL377701A1 (enExample)
WO (2) WO2004047771A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316523A (pt) * 2002-11-25 2005-10-18 Attenuon Llc Composto, composição farmacêutica e método para tratar ou prevenir câncer em um paciente
WO2005114194A1 (en) * 2004-05-21 2005-12-01 Mds Inc. Doing Business Through Its Mds Pharma Services Division Method of quantifying the cell-binding properties of a medical device
US20060078535A1 (en) * 2004-10-13 2006-04-13 The Regents Of The University Of Michigan Anticancer compounds and methods
US20080261892A1 (en) * 2005-02-01 2008-10-23 Ternansky Robert J Acid Addition Salts of Ac-Phscn-Nh2
KR20070100832A (ko) * 2005-02-01 2007-10-11 아테뉴온, 엘엘씨 항혈관신생 ｐｈｓｃｎ 펩티드를 함유하는 조성물
AU2016213759B2 (en) * 2006-11-08 2018-03-29 Chongxi Yu Transdermal delivery systems of peptides and related compounds
AU2006350707A1 (en) 2006-11-08 2008-05-15 Chongxi Yu Transdermal delivery systems of peptides and related compounds
KR20180110187A (ko) 2009-05-08 2018-10-08 테크필즈 바이오켐 코., 엘티디. 펩티드 및 펩티드­관련 화합물의 고침투성 전구약물 조성물
KR101228668B1 (ko) 2010-09-17 2013-01-31 가톨릭대학교 산학협력단 혈관신생 억제 활성을 갖는 펩타이드 및 이의 용도
US9625469B2 (en) 2011-06-23 2017-04-18 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CN102417540A (zh) * 2011-11-21 2012-04-18 中国药科大学 一种聚乙二醇修饰的整合素阻断剂hm-3及其应用
AU2013259166B2 (en) * 2012-05-11 2016-03-10 Theragenics Corporation Biocompatible hydrogel treatments for retinal detachment
US20150305329A1 (en) 2012-06-04 2015-10-29 Michael Fefer Formulations Containing Paraffinic Oil and Anti-Settling Agent
CA2877585C (en) 2013-03-15 2016-04-12 Suncor Energy Inc. Herbicidal compositions
JP5970439B2 (ja) * 2013-09-20 2016-08-17 チョンシー ユー ペプチド及び関連化合物の経皮送達システム
US10545153B2 (en) 2014-09-15 2020-01-28 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
AU2019301750A1 (en) 2018-07-12 2021-01-28 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
CA3117476A1 (en) 2018-10-05 2020-04-09 Board Of Regents, The University Of Texas System Solid-phase n-terminal peptide capture and release
JP7588289B2 (ja) 2019-02-15 2024-11-22 ニュートリエン・エージー・ソリューションズ・（カナダ）・インコーポレイテッド 植物の健康を増進するプロトポルフィリンｉｘ誘導体及びその使用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4440788A (en) * 1980-05-13 1984-04-03 Mitsubishi Chemical Industries, Limited Cysteine derivatives
WO1981003330A1 (fr) * 1980-05-13 1981-11-26 Mitsubishi Chem Ind Derives de la cysteine et leur production
US4394519A (en) * 1982-01-19 1983-07-19 Research Corporation Amino acid blocking agents
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3815221C2 (de) * 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5091176A (en) * 1988-11-02 1992-02-25 W. R. Grace & Co.-Conn. Polymer-modified peptide drugs having enhanced biological and pharmacological activities
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5229366A (en) * 1990-10-23 1993-07-20 Fuji Photo Film Co., Ltd. Peptide-containing polyethylene glycol derivatives and application thereof
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5561220A (en) 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5556609A (en) 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5608110A (en) 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5639725A (en) 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
ATE218381T1 (de) 1995-03-14 2002-06-15 Siemens Ag Ultraschall-zerstäuber mit abnehmbarer präzisionsdosiereinheit
US5950619A (en) * 1995-03-14 1999-09-14 Siemens Aktiengesellschaft Ultrasonic atomizer device with removable precision dosating unit
US5618513A (en) * 1995-06-07 1997-04-08 Mallinckrodt Medical, Inc. Method for preparing radiolabeled peptides
MY147327A (en) 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
JP2001501600A (ja) * 1996-09-10 2001-02-06 ザ バーナム インスティテュート 腫瘍ホーミング分子、それに由来する結合体、およびその使用方法
US6331409B1 (en) * 1996-11-21 2001-12-18 The Regents Of The University Of Michigan Methods and compositions for wound healing
US6001965A (en) * 1996-11-21 1999-12-14 The Regents Of The University Of Michigan Anticancer compounds and methods
US6025150A (en) * 1996-11-21 2000-02-15 The Regents Of The University Of Michigan Methods and compositions for wound healing
US6011170A (en) * 1997-01-14 2000-01-04 Kaneka Corporation Process for producing of cysteine derivatives
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
WO1999013329A1 (en) * 1997-09-10 1999-03-18 The Burnham Institute Methods of identifying molecules that home to angiogenic vasculature in tumors
NZ504021A (en) * 1997-10-17 2003-04-29 Systemic Pulmonary Delivery Lt Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication
EP1159292A2 (en) * 1998-08-14 2001-12-05 Administrators of The Tulane Educational Fund Compounds having growth hormone releasing activity
CA2435320C (en) 2001-01-18 2008-06-03 The Regents Of The University Of Michigan Compositions and methods for the use of fibronectin fragments in the diagnosis of cancer
BR0316523A (pt) * 2002-11-25 2005-10-18 Attenuon Llc Composto, composição farmacêutica e método para tratar ou prevenir câncer em um paciente

Also Published As

Publication number Publication date
BR0316550A (pt) 2005-10-04
EP1594521A2 (en) 2005-11-16
AU2003298726A1 (en) 2004-08-10
EP1569678A2 (en) 2005-09-07
EA200500871A1 (ru) 2006-04-28
NO20053112L (no) 2005-08-05
EA200500870A1 (ru) 2006-04-28
AU2003297609A1 (en) 2004-06-18
MXPA05005469A (es) 2005-09-08
JP2006514116A (ja) 2006-04-27
KR20050097494A (ko) 2005-10-07
NZ540363A (en) 2007-11-30
CA2507045A1 (en) 2004-06-10
JP2006515866A (ja) 2006-06-08
EP1594521A4 (en) 2008-01-09
NZ540889A (en) 2008-09-26
PL377701A1 (pl) 2006-02-06
NO20053111D0 (no) 2005-06-24
US7517855B2 (en) 2009-04-14
US20040162239A1 (en) 2004-08-19
WO2004063213A2 (en) 2004-07-29
MXPA05005545A (es) 2005-10-18
KR20050096917A (ko) 2005-10-06
WO2004063213A3 (en) 2005-03-03
HRP20050585A2 (en) 2006-02-28
PL377763A1 (pl) 2006-02-20
US20050020810A1 (en) 2005-01-27
NO20053111L (no) 2005-08-24
WO2004047771A2 (en) 2004-06-10
NO20053112D0 (no) 2005-06-24
BR0316523A (pt) 2005-10-18
WO2004047771A3 (en) 2005-09-15
EP1569678A4 (en) 2008-01-02
HRP20050584A2 (hr) 2006-04-30

Similar Documents

Publication Publication Date Title
CA2506813A1 (en) Peptides which target tumor and endothelial cells, compositions and uses thereof
EP1404371B1 (en) Peptide-based compounds for targeting intergin receptors
US8461119B2 (en) Agents that modulate Eph receptor activity
US11723944B2 (en) Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
KR20200105840A (ko) EphA2에 특이적인 바이사이클릭 펩티드 리간드
MXPA06001090A (es) Agentes de imagenologia de peptido biciclico.
NO331741B1 (no) Peptidbaserte forbindelser som har affinitet for integrinreseptorer, farmasoytiske sammensetninger omfattende slike og bruk av disse for fremstilling av et kontrastmiddel og et medikament.
KR20070118230A (ko) Ｅｐｈｂ 수용체-결합 펩티드
US20050232924A1 (en) Antibodies and/or conjugates thereof which bind to the amino terminal fragment of urokinase, compositions and uses thereof
EP4417618A1 (en) Epha2 bicyclic peptide ligand and conjugate thereof
ZA200504222B (en) Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof
EP1852441A2 (en) Agents that modulate EPH receptor activity
HK1088239A (en) Peptides which target tumor and endothelial cells, compositions and uses thereof
HK1109904A (en) Agents that modulate eph receptor activity

Legal Events

Date Code Title Description
FZDE Discontinued