BRPI0607695A2 - composto ou um sal, éster, solvato, estereoisÈmero, tautÈmero ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento de um mamìfero, e para preparar um composto - Google Patents
composto ou um sal, éster, solvato, estereoisÈmero, tautÈmero ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento de um mamìfero, e para preparar um compostoInfo
- Publication number
- BRPI0607695A2 BRPI0607695A2 BRPI0607695-5A BRPI0607695A BRPI0607695A2 BR PI0607695 A2 BRPI0607695 A2 BR PI0607695A2 BR PI0607695 A BRPI0607695 A BR PI0607695A BR PI0607695 A2 BRPI0607695 A2 BR PI0607695A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- methods
- certain
- ester
- treating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- NUAQIRUAZSJTAI-TYIWBIPUSA-N chembl2374194 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@H](N)CC(C)C)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 NUAQIRUAZSJTAI-TYIWBIPUSA-N 0.000 abstract 2
- 108700023456 demethylvancomycin Proteins 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65727405P | 2005-02-28 | 2005-02-28 | |
| PCT/US2006/007337 WO2006094082A2 (en) | 2005-02-28 | 2006-02-27 | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0607695A2 true BRPI0607695A2 (pt) | 2009-11-03 |
Family
ID=36941795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607695-5A BRPI0607695A2 (pt) | 2005-02-28 | 2006-02-27 | composto ou um sal, éster, solvato, estereoisÈmero, tautÈmero ou pró-droga farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento de um mamìfero, e para preparar um composto |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20070185015A1 (enExample) |
| EP (1) | EP1868630A2 (enExample) |
| JP (2) | JP2008531713A (enExample) |
| AU (1) | AU2006218533A1 (enExample) |
| BR (1) | BRPI0607695A2 (enExample) |
| CA (1) | CA2599297A1 (enExample) |
| MX (1) | MX2007010500A (enExample) |
| WO (1) | WO2006094082A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1818340A4 (en) | 2004-11-29 | 2009-02-25 | Univ Nagoya Nat Univ Corp | ANTIBIOTIC MONOMERS GLYCOPEPTIDE DERIVATIVES |
| US7632918B2 (en) * | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| TW200808818A (en) | 2006-05-26 | 2008-02-16 | Shionogi & Co | Glycopeptide antibiotic derivatives |
| KR20100109936A (ko) * | 2007-12-26 | 2010-10-11 | 리드 테라퓨틱스, 인크. | 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드 |
| WO2010048340A2 (en) * | 2008-10-24 | 2010-04-29 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
| WO2011140009A1 (en) * | 2010-05-04 | 2011-11-10 | Biomarin Pharmaceutical Inc. | Methods of using semi-synthetic glycopeptides as antibacterial agents |
| IL270686B (en) * | 2017-05-22 | 2022-09-01 | Insmed Inc | Derivatives of glycopeptides and their uses |
| CN107987131B (zh) * | 2017-11-16 | 2021-03-09 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的化合物、其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| GB8522574D0 (en) * | 1985-09-12 | 1985-10-16 | Lepetit Spa | Amides of teicoplanin compounds |
| US5500410A (en) * | 1989-03-29 | 1996-03-19 | Gruppo Lepetit S.P.A. | Substituted alkylamide derivatives of teicoplanin |
| US5840684A (en) * | 1994-01-28 | 1998-11-24 | Eli Lilly And Company | Glycopeptide antibiotic derivatives |
| US5488131A (en) * | 1994-03-23 | 1996-01-30 | California Institute Of Technology | Synthesis of compounds with predetermined chirality |
| JP3031202B2 (ja) * | 1994-08-08 | 2000-04-10 | 株式会社デンソー | 携帯無線局 |
| US5919756A (en) * | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| US5974507A (en) * | 1997-04-14 | 1999-10-26 | International Business Machines Corporation | Optimizing a cache eviction mechanism by selectively introducing different levels of randomness into a replacement algorithm |
| US6026445A (en) * | 1997-11-17 | 2000-02-15 | International Business Machines Corporation | System and method for saving and reusing recently acquired name to address mappings |
| BRPI9914221B8 (pt) * | 1998-12-23 | 2021-05-25 | Advanced Medicine Inc | derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos |
| US6699836B2 (en) * | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| US6498238B1 (en) * | 1999-05-19 | 2002-12-24 | Princeton University | Glycopeptide antibacterial compounds, compositions containing same and methods of using same |
| US20030008812A1 (en) * | 2001-02-02 | 2003-01-09 | Christensen Burton G. | Glycopeptide derivatives |
| US7348309B2 (en) * | 2001-03-30 | 2008-03-25 | Wisconsin Alumni Research Foundation | Glycorandomization and production of novel vancomycin analogs |
| KR20060091049A (ko) * | 2002-08-30 | 2006-08-17 | 케이.유.루벤 리서치 앤드 디벨럽먼트 | 글리코펩티드 항생제 및 그것의 반합성 유도체 및 항바이러스제로서의 그것의 사용 |
| AU2003287605A1 (en) * | 2002-11-12 | 2004-06-03 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7521418B2 (en) * | 2003-05-27 | 2009-04-21 | Theravance, Inc. | Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent |
| US7368422B2 (en) * | 2005-02-28 | 2008-05-06 | Novartis Vaccines And Diagnostics Inc. | Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US7632918B2 (en) * | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| US7461206B2 (en) * | 2006-08-21 | 2008-12-02 | Amazon Technologies, Inc. | Probabilistic technique for consistency checking cache entries |
-
2006
- 2006-02-24 US US11/361,682 patent/US20070185015A1/en not_active Abandoned
- 2006-02-27 BR BRPI0607695-5A patent/BRPI0607695A2/pt not_active IP Right Cessation
- 2006-02-27 CA CA002599297A patent/CA2599297A1/en not_active Abandoned
- 2006-02-27 MX MX2007010500A patent/MX2007010500A/es not_active Application Discontinuation
- 2006-02-27 EP EP06721134A patent/EP1868630A2/en not_active Withdrawn
- 2006-02-27 AU AU2006218533A patent/AU2006218533A1/en not_active Abandoned
- 2006-02-27 JP JP2007558191A patent/JP2008531713A/ja active Pending
- 2006-02-27 WO PCT/US2006/007337 patent/WO2006094082A2/en not_active Ceased
-
2008
- 2008-11-10 US US12/268,364 patent/US20090131304A1/en not_active Abandoned
-
2009
- 2009-02-18 JP JP2009035926A patent/JP2009102448A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009102448A (ja) | 2009-05-14 |
| WO2006094082A2 (en) | 2006-09-08 |
| EP1868630A2 (en) | 2007-12-26 |
| JP2008531713A (ja) | 2008-08-14 |
| US20070185015A1 (en) | 2007-08-09 |
| CA2599297A1 (en) | 2006-09-08 |
| WO2006094082A3 (en) | 2007-01-18 |
| US20090131304A1 (en) | 2009-05-21 |
| AU2006218533A1 (en) | 2006-09-08 |
| MX2007010500A (es) | 2008-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: EM ADITAMENTO A EXIGENCIA PUBLICADA NA RPI 1940 DE 11/03/2008, APRESENTE NOVOS DOCUMENTOS COMPROBATORIOS DA CESSAO DE DIREITOS ENTRE "NORTH CHINA PHARMACEUTICAL GROUP CORPORATION" E "NOVARTIS VACCINES AND DIAGNOSTICS INC." COM DATA ANTERIOR A ENTRADA NA FASE NACIONAL (28/08/2008), OU APRESENTE PETICAO DE TRANSFERENCIA DEVIDAMENTE DOCUMENTADA PARA A DEVIDA REGULARIZACAO DO PEDIDO. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |