JP2008500363A5 - - Google Patents

Info

Publication number

JP2008500363A5

JP2008500363A5 JP2007515318A JP2007515318A JP2008500363A5 JP 2008500363 A5 JP2008500363 A5 JP 2008500363A5 JP 2007515318 A JP2007515318 A JP 2007515318A JP 2007515318 A JP2007515318 A JP 2007515318A JP 2008500363 A5 JP2008500363 A5 JP 2008500363A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutical composition

alkyl

alkylaryl

arylalkyl

Prior art date

2005-05-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims description 13
• 125000000217 alkyl group Chemical group 0.000 claims description 9
• 125000003342 alkenyl group Chemical group 0.000 claims description 8
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
• 125000003118 aryl group Chemical group 0.000 claims description 8
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 5
• 125000005843 halogen group Chemical group 0.000 claims description 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 2
• 239000008024 pharmaceutical diluent Substances 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
• 101150073133 Cpt1a gene Proteins 0.000 claims 1
• 102000015303 Fatty Acid Synthases Human genes 0.000 claims 1
• 108010039731 Fatty Acid Synthases Proteins 0.000 claims 1
• 101710151321 Melanostatin Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102400000064 Neuropeptide Y Human genes 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000005907 cancer growth Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1
• 0 CC(C)(C1=*(C2)C2C1(CC=*C)S1)C1=O Chemical compound CC(C)(C1=*(C2)C2C1(CC=*C)S1)C1=O 0.000 description 3