JP2008531665A5 - - Google Patents
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- Publication number
- JP2008531665A5 JP2008531665A5 JP2007557572A JP2007557572A JP2008531665A5 JP 2008531665 A5 JP2008531665 A5 JP 2008531665A5 JP 2007557572 A JP2007557572 A JP 2007557572A JP 2007557572 A JP2007557572 A JP 2007557572A JP 2008531665 A5 JP2008531665 A5 JP 2008531665A5
- Authority
- JP
- Japan
- Prior art keywords
- effective amount
- pharmaceutically acceptable
- pharmaceutically effective
- compound
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940125782 compound 2 Drugs 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 5
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 claims 4
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 4
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229960004502 levodopa Drugs 0.000 claims 4
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 3
- 229940123736 Decarboxylase inhibitor Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003954 decarboxylase inhibitor Substances 0.000 claims 2
- 229940099362 Catechol O methyltransferase inhibitor Drugs 0.000 claims 1
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- OUBCNLGXQFSTLU-UHFFFAOYSA-N nitisinone Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1C(=O)C1C(=O)CCCC1=O OUBCNLGXQFSTLU-UHFFFAOYSA-N 0.000 claims 1
- 239000012053 oil suspension Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0504103.3A GB0504103D0 (en) | 2005-02-28 | 2005-02-28 | Novel method |
| PCT/GB2006/000684 WO2006090177A1 (en) | 2005-02-28 | 2006-02-27 | USE OF 2-(2-NITRO-4-TRIFLUOROMETHYLBENZOYL)-l,3- CYCLOHEXANEDIONE IN THE TREATMENT OF PARKINSON'S DISEASE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531665A JP2008531665A (ja) | 2008-08-14 |
| JP2008531665A5 true JP2008531665A5 (enExample) | 2009-03-12 |
Family
ID=34430351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007557572A Pending JP2008531665A (ja) | 2005-02-28 | 2006-02-27 | パーキンソン病の治療における２−（２−ニトロ−４−トリフルオロメチルベンゾイル）−１，３−シクロヘキサンジオンの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20090326072A1 (enExample) |
| EP (1) | EP1853241B1 (enExample) |
| JP (1) | JP2008531665A (enExample) |
| CN (1) | CN101163466B (enExample) |
| AT (1) | ATE524171T1 (enExample) |
| AU (1) | AU2006217650B2 (enExample) |
| BR (1) | BRPI0609177A2 (enExample) |
| CA (1) | CA2598517A1 (enExample) |
| DK (1) | DK1853241T3 (enExample) |
| ES (1) | ES2374761T3 (enExample) |
| GB (1) | GB0504103D0 (enExample) |
| IL (1) | IL185410A0 (enExample) |
| MX (1) | MX2007010480A (enExample) |
| PT (1) | PT1853241E (enExample) |
| RU (1) | RU2420272C2 (enExample) |
| WO (1) | WO2006090177A1 (enExample) |
| ZA (1) | ZA200707486B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3311813B1 (en) | 2007-08-27 | 2019-08-07 | Dart Neuroscience (Cayman) Ltd | Therapeutic isoxazole compounds |
| JP2011507910A (ja) * | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
| US20100160295A1 (en) * | 2008-11-06 | 2010-06-24 | Synosia Therapeutics | Treatment of restless leg syndrome and sleep disorders |
| PL2723320T3 (pl) * | 2011-06-23 | 2016-06-30 | Swedish Orphan Biovitrum Int Ab | Ciekła kompozycja farmaceutyczna zawierająca nityzynon |
| CN103622942A (zh) * | 2013-11-04 | 2014-03-12 | 江苏大学 | 左旋多巴/卡比多巴复方缓释混悬剂及其制备方法 |
| MA42519A (fr) * | 2015-07-29 | 2018-06-06 | Takeda Gmbh | Inhibiteur de la pde4 pour le traitement de la néphropathie diabétique |
| ITUB20160650A1 (it) | 2016-02-11 | 2017-08-11 | Dipharma S A | Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione |
| US9783485B1 (en) | 2016-11-30 | 2017-10-10 | Dipharma S.A. | Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4780127A (en) * | 1982-03-25 | 1988-10-25 | Stauffer Chemical Company | Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides |
| US5092919A (en) * | 1991-01-15 | 1992-03-03 | Imperial Chemical Industries Plc | Certain 2-(2'-methyl-3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones |
| DK0591275T3 (da) * | 1991-06-24 | 1999-10-11 | Zeneca Ltd | Anvendelse af 2-(2-nitro-4-trifluormethylbenzoyl)-1,3-cyklohexandion til behandling af tyrosinæmi samt farmaceutiske sammen |
| FR2777781B1 (fr) * | 1998-04-24 | 2004-04-09 | Rhone Poulenc Rorer Sa | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
| US20050288187A1 (en) * | 2002-07-03 | 2005-12-29 | Hanauske-Abel Hartmut M | Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases |
| EP1646377A4 (en) * | 2003-07-11 | 2009-09-09 | Merck & Co Inc | TREATMENT OF MOVEMENT DISORDERS WITH METABOTROPIC GLUTAMATE 4 RECEPTOR POSITIVE ALLOSTERIC MODULATOR |
| AU2006347397A1 (en) * | 2006-08-18 | 2008-02-21 | Syngenta Limited | Use of HPPD inhibitors in the treatment of depression and/or withdrawal symptoms associated with addictive drugs |
| US20100160295A1 (en) * | 2008-11-06 | 2010-06-24 | Synosia Therapeutics | Treatment of restless leg syndrome and sleep disorders |
-
2005
- 2005-02-28 GB GBGB0504103.3A patent/GB0504103D0/en not_active Ceased
-
2006
- 2006-02-27 PT PT06709910T patent/PT1853241E/pt unknown
- 2006-02-27 ES ES06709910T patent/ES2374761T3/es active Active
- 2006-02-27 AU AU2006217650A patent/AU2006217650B2/en not_active Ceased
- 2006-02-27 ZA ZA200707486A patent/ZA200707486B/xx unknown
- 2006-02-27 CA CA002598517A patent/CA2598517A1/en not_active Abandoned
- 2006-02-27 MX MX2007010480A patent/MX2007010480A/es not_active Application Discontinuation
- 2006-02-27 RU RU2007131934/15A patent/RU2420272C2/ru not_active IP Right Cessation
- 2006-02-27 DK DK06709910.1T patent/DK1853241T3/da active
- 2006-02-27 US US12/090,645 patent/US20090326072A1/en not_active Abandoned
- 2006-02-27 WO PCT/GB2006/000684 patent/WO2006090177A1/en not_active Ceased
- 2006-02-27 EP EP06709910A patent/EP1853241B1/en active Active
- 2006-02-27 JP JP2007557572A patent/JP2008531665A/ja active Pending
- 2006-02-27 BR BRPI0609177-6A patent/BRPI0609177A2/pt not_active IP Right Cessation
- 2006-02-27 AT AT06709910T patent/ATE524171T1/de active
- 2006-02-27 CN CN2006800133878A patent/CN101163466B/zh not_active Expired - Fee Related
-
2007
- 2007-08-21 IL IL185410A patent/IL185410A0/en unknown
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