JP2008531484A5 - - Google Patents
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- JP2008531484A5 JP2008531484A5 JP2007555298A JP2007555298A JP2008531484A5 JP 2008531484 A5 JP2008531484 A5 JP 2008531484A5 JP 2007555298 A JP2007555298 A JP 2007555298A JP 2007555298 A JP2007555298 A JP 2007555298A JP 2008531484 A5 JP2008531484 A5 JP 2008531484A5
- Authority
- JP
- Japan
- Prior art keywords
- cell binding
- mixture
- binding agent
- drug
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 48
- 239000011230 binding agent Substances 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 25
- 229940079593 drug Drugs 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 20
- 239000011347 resin Substances 0.000 claims 8
- 229920005989 resin Polymers 0.000 claims 8
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
- 238000004587 chromatography analysis Methods 0.000 claims 5
- 239000012038 nucleophile Substances 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 102000000588 Interleukin-2 Human genes 0.000 claims 4
- 108010002350 Interleukin-2 Proteins 0.000 claims 4
- 102000000646 Interleukin-3 Human genes 0.000 claims 4
- 108010002386 Interleukin-3 Proteins 0.000 claims 4
- 102000004388 Interleukin-4 Human genes 0.000 claims 4
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 238000009295 crossflow filtration Methods 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 239000002254 cytotoxic agent Substances 0.000 claims 4
- 231100000599 cytotoxic agent Toxicity 0.000 claims 4
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 229940076264 interleukin-3 Drugs 0.000 claims 4
- 229940028885 interleukin-4 Drugs 0.000 claims 4
- 229940100601 interleukin-6 Drugs 0.000 claims 4
- 230000000269 nucleophilic effect Effects 0.000 claims 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 4
- BLFRQYKZFKYQLO-UHFFFAOYSA-N 4-aminobutan-1-ol Chemical compound NCCCCO BLFRQYKZFKYQLO-UHFFFAOYSA-N 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
- 108090000371 Esterases Proteins 0.000 claims 2
- 101150021185 FGF gene Proteins 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 108010008488 Glycylglycine Proteins 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 2
- 101710127797 Macrophage colony-stimulating factor 1 Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 108010039918 Polylysine Proteins 0.000 claims 2
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 2
- 239000012506 Sephacryl® Substances 0.000 claims 2
- 229920005654 Sephadex Polymers 0.000 claims 2
- 239000012507 Sephadex™ Substances 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 239000012505 Superdex™ Substances 0.000 claims 2
- 229940123237 Taxane Drugs 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000008351 acetate buffer Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000007979 citrate buffer Substances 0.000 claims 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 2
- 229940043237 diethanolamine Drugs 0.000 claims 2
- 229940043257 glycylglycine Drugs 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 229960003646 lysine Drugs 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- 229920000656 polylysine Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000008362 succinate buffer Substances 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 229960003080 taurine Drugs 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000012434 nucleophilic reagent Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 description 32
- 125000003342 alkenyl group Chemical group 0.000 description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 20
- 125000000217 alkyl group Chemical group 0.000 description 14
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 7
- 125000003107 substituted aryl group Chemical group 0.000 description 7
- 125000000392 cycloalkenyl group Chemical group 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65243405P | 2005-02-11 | 2005-02-11 | |
| US60/652,434 | 2005-02-11 | ||
| PCT/US2006/004937 WO2006086733A2 (en) | 2005-02-11 | 2006-02-10 | Process for preparing maytansinoid antibody conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531484A JP2008531484A (ja) | 2008-08-14 |
| JP2008531484A5 true JP2008531484A5 (enExample) | 2009-04-02 |
| JP5165387B2 JP5165387B2 (ja) | 2013-03-21 |
Family
ID=36605757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555298A Expired - Fee Related JP5165387B2 (ja) | 2005-02-11 | 2006-02-10 | 安定な薬物複合体を調製するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060182750A1 (enExample) |
| EP (2) | EP1853322B1 (enExample) |
| JP (1) | JP5165387B2 (enExample) |
| AU (1) | AU2006213662B2 (enExample) |
| CA (1) | CA2597407C (enExample) |
| ES (1) | ES2503719T3 (enExample) |
| WO (1) | WO2006086733A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PT1392359E (pt) | 2001-05-11 | 2010-01-27 | Ludwig Inst For Cancer Res Ltd | Proteínas de ligação específica e suas utilizações |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| AU2012227185B2 (en) * | 2005-08-24 | 2015-07-02 | Immunogen, Inc. | Process for preparing maytansinoid antibody conjugates |
| CA2893252C (en) | 2005-08-24 | 2018-05-29 | Immunogen, Inc. | Process for preparing antibody maytansinoid conjugates |
| WO2008091701A2 (en) | 2007-01-25 | 2008-07-31 | Dana-Farber Cancer Institute | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| MX2010001757A (es) | 2007-08-14 | 2010-09-14 | Ludwig Inst Cancer Res | Anticuerpo monoclonal 175 que activa el receptor egf y derivados y usos del mismo. |
| BRPI0911442A2 (pt) * | 2008-04-30 | 2019-03-12 | Immunogen, Inc. | conjugados potentes e ligantes hidrofílicos |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| UY32560A (es) * | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| ME03479B (me) | 2009-06-03 | 2020-01-20 | Immunogen Inc | Metodi konjugacije |
| US9173961B2 (en) | 2010-02-10 | 2015-11-03 | Immunogen, Inc. | CD20 antibodies and uses thereof |
| US9540438B2 (en) | 2011-01-14 | 2017-01-10 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof |
| IL279304B (en) | 2011-02-15 | 2022-07-01 | Immunogen Inc | Method for producing an indolinobenzodiazepine |
| ME03353B (me) * | 2011-03-29 | 2019-10-20 | Immunogen Inc | Priprema konjugata antitela i majtanzinoida jednostepenim postupkom |
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| CA2831562A1 (en) * | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Process for manufacturing conjugates of improved homogeneity |
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| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| EP3164420A4 (en) * | 2014-06-30 | 2018-05-23 | Tarveda Therapeutics, Inc. | Targeted conjugates and particles and formulations thereof |
| KR102062025B1 (ko) | 2014-06-30 | 2020-01-03 | 타베다 세라퓨틱스, 인코포레이티드 | 표적화된 콘주게이트 및 입자 및 그것의 제형 |
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| WO2017048728A1 (en) * | 2015-09-14 | 2017-03-23 | Rutgers, The State University Of New Jersey | Targeted conjugates |
| WO2017075495A1 (en) * | 2015-10-28 | 2017-05-04 | Tarveda Therapeutics, Inc. | Sstr-targeted conjugates and particles and formulations thereof |
| KR20180112060A (ko) | 2016-02-23 | 2018-10-11 | 타베다 세라퓨틱스, 인코포레이티드 | Hsp90 표적화된 접합체 및 이의 입자 및 제형 |
| JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール．ピー．シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
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| US11480502B2 (en) | 2016-08-29 | 2022-10-25 | United States of America, as represented by the Secretary, Department of Heatlth and Human Service | Method and composition for optical clearing of tissues |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
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| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| US20180346488A1 (en) | 2017-04-20 | 2018-12-06 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| TWI827575B (zh) | 2017-12-28 | 2024-01-01 | 美商伊繆諾金公司 | 苯二氮平衍生物 |
| TWI865337B (zh) | 2018-07-25 | 2024-12-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之有效的製造方法 |
| CN113661172A (zh) | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物 |
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-
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- 2006-02-10 US US11/352,121 patent/US20060182750A1/en not_active Abandoned
- 2006-02-10 JP JP2007555298A patent/JP5165387B2/ja not_active Expired - Fee Related
- 2006-02-10 EP EP06720665.6A patent/EP1853322B1/en not_active Not-in-force
- 2006-02-10 CA CA2597407A patent/CA2597407C/en not_active Expired - Fee Related
- 2006-02-10 ES ES06720665.6T patent/ES2503719T3/es active Active
- 2006-02-10 WO PCT/US2006/004937 patent/WO2006086733A2/en not_active Ceased
- 2006-02-10 EP EP12160182A patent/EP2468304A3/en not_active Withdrawn
- 2006-02-10 AU AU2006213662A patent/AU2006213662B2/en not_active Ceased
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