JP2008531018A - 免疫刺激性オリゴヌクレオチド - Google Patents

免疫刺激性オリゴヌクレオチド Download PDF

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JP2008531018A
JP2008531018A JP2007557215A JP2007557215A JP2008531018A JP 2008531018 A JP2008531018 A JP 2008531018A JP 2007557215 A JP2007557215 A JP 2007557215A JP 2007557215 A JP2007557215 A JP 2007557215A JP 2008531018 A JP2008531018 A JP 2008531018A
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oligonucleotide
seq
phosphodiester
guanine
nucleotide
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JP2008531018A5 (fr
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アーサー エム． クリーグ，
ウルリケ サミュロウィッツ，
イョルク フォルメル，
Original Assignee
コーリー ファーマシューティカル グループ，インコーポレイテッド
コーリー ファーマシューティカル ゲーエムベーハー
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/33—Chemical structure of the base
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007557215A 2005-02-24 2006-02-24 免疫刺激性オリゴヌクレオチド Pending JP2008531018A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65593105P 2005-02-24 2005-02-24
PCT/US2006/006778 WO2006091915A2 (fr) 2005-02-24 2006-02-24 Oligonucleotides immunostimulateurs

Publications (2)

Publication Number Publication Date
JP2008531018A true JP2008531018A (ja) 2008-08-14
JP2008531018A5 JP2008531018A5 (fr) 2009-04-09

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JP2007557215A Pending JP2008531018A (ja) 2005-02-24 2006-02-24 免疫刺激性オリゴヌクレオチド

Country Status (7)

Country Link
US (1) US20080009455A9 (fr)
EP (1) EP1851314A2 (fr)
JP (1) JP2008531018A (fr)
CN (1) CN101160401A (fr)
AU (1) AU2006216493A1 (fr)
CA (1) CA2598992A1 (fr)
WO (1) WO2006091915A2 (fr)

Cited By (2)

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WO2014010718A1 (fr) * 2012-07-13 2014-01-16 株式会社新日本科学 Adjuvant d'acide nucléique chiral
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries

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US20030109469A1 (en) * 1993-08-26 2003-06-12 Carson Dennis A. Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US7935675B1 (en) * 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
EP1872786A1 (fr) * 1997-09-05 2008-01-02 The Regents of the University of California Utilisation d'oligonucléotides immunostimulatrices pour la prévention ou la réduction de l'inflammation liées aux granulocytes, stimulée par les antigènes
CA2328406A1 (fr) * 1998-05-14 1999-11-18 Hermann Wagner Procedes de regulation de l'hematopoiese au moyen d'oligonucleotides a cpg
NZ508927A (en) 1998-05-22 2003-12-19 Ottawa Health Research Inst Methods and products for inducing mucosal immunity
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
JP5084984B2 (ja) 1999-02-17 2012-11-28 シーエスエル、リミテッド 免疫原複合体およびそれに関する方法
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
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KR100917101B1 (ko) * 2000-08-04 2009-09-15 도요 보세키 가부시키가이샤 플렉시블 금속적층체 및 그 제조방법
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JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
US10286065B2 (en) 2014-09-19 2019-05-14 Board Of Regents, The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
CN111447949A (zh) * 2017-12-15 2020-07-24 拜耳动物保健有限责任公司 免疫刺激寡核苷酸

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AU2006216493A9 (en) 2008-04-03
US20080009455A9 (en) 2008-01-10
US20060211644A1 (en) 2006-09-21
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