JP2008530225A5 - - Google Patents
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- Publication number
- JP2008530225A5 JP2008530225A5 JP2007556275A JP2007556275A JP2008530225A5 JP 2008530225 A5 JP2008530225 A5 JP 2008530225A5 JP 2007556275 A JP2007556275 A JP 2007556275A JP 2007556275 A JP2007556275 A JP 2007556275A JP 2008530225 A5 JP2008530225 A5 JP 2008530225A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- powder
- ray diffraction
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 26
- -1 4-acetylpiperazin-1-yl Chemical group 0.000 claims 9
- 238000000634 powder X-ray diffraction Methods 0.000 claims 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- FHUPHXAYPNYFIU-UHFFFAOYSA-N 1-propan-2-ylindazole-3-carboxylic acid Chemical compound C1=CC=C2N(C(C)C)N=C(C(O)=O)C2=C1 FHUPHXAYPNYFIU-UHFFFAOYSA-N 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 206010010774 Constipation Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- CXNHEHQDYWNAFN-OKILXGFUSA-N (1s,5r)-8-[2-(4-acetylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]octan-3-one Chemical compound N1([C@]2([H])CC[C@]1(CC(=O)C2)[H])CCN1CCN(C(C)=O)CC1 CXNHEHQDYWNAFN-OKILXGFUSA-N 0.000 claims 1
- 206010052105 Gastrointestinal hypomotility Diseases 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000007542 Paresis Diseases 0.000 claims 1
- 206010054048 Postoperative ileus Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000007822 coupling agent Substances 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 230000003483 hypokinetic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65367705P | 2005-02-17 | 2005-02-17 | |
| PCT/US2006/005399 WO2006088988A1 (en) | 2005-02-17 | 2006-02-16 | Crystalline form of an indazole-carboxamide compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008530225A JP2008530225A (ja) | 2008-08-07 |
| JP2008530225A5 true JP2008530225A5 (enExample) | 2009-03-26 |
Family
ID=36424659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556275A Pending JP2008530225A (ja) | 2005-02-17 | 2006-02-16 | インダゾール−カルボキサミド化合物の結晶型 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060183901A1 (enExample) |
| EP (1) | EP1848716A1 (enExample) |
| JP (1) | JP2008530225A (enExample) |
| TW (1) | TW200640921A (enExample) |
| WO (1) | WO2006088988A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI377206B (en) | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| ATE509021T1 (de) * | 2006-02-16 | 2011-05-15 | Theravance Inc | Verfahren zur herstellung von zwischenverbindungen zu 5-ht4-rezeptoragonist- verbindungen |
| WO2010022052A1 (en) * | 2008-08-19 | 2010-02-25 | Scinopharm Taiwan, Ltd. | Polymorphic form of granisetron hydrochloride and methods of making the same |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937247A (en) * | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
| IT1226389B (it) * | 1988-07-12 | 1991-01-15 | Angeli Inst Spa | Nuovi derivati ammidinici e guanidinici |
| JP3829879B2 (ja) * | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| US5654320A (en) * | 1995-03-16 | 1997-08-05 | Eli Lilly And Company | Indazolecarboxamides |
| IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| WO2006069125A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
-
2006
- 2006-02-16 JP JP2007556275A patent/JP2008530225A/ja active Pending
- 2006-02-16 EP EP06735182A patent/EP1848716A1/en not_active Withdrawn
- 2006-02-16 WO PCT/US2006/005399 patent/WO2006088988A1/en not_active Ceased
- 2006-02-16 TW TW095105173A patent/TW200640921A/zh unknown
- 2006-02-16 US US11/355,323 patent/US20060183901A1/en not_active Abandoned
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