JP2008526876A5 - - Google Patents

Download PDF

Info

Publication number
JP2008526876A5
JP2008526876A5 JP2007550488A JP2007550488A JP2008526876A5 JP 2008526876 A5 JP2008526876 A5 JP 2008526876A5 JP 2007550488 A JP2007550488 A JP 2007550488A JP 2007550488 A JP2007550488 A JP 2007550488A JP 2008526876 A5 JP2008526876 A5 JP 2008526876A5
Authority
JP
Japan
Prior art keywords
composition
irna agent
antisense strand
nucleotides
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007550488A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008526876A (ja
JP5081630B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/000425 external-priority patent/WO2006074346A2/en
Publication of JP2008526876A publication Critical patent/JP2008526876A/ja
Publication of JP2008526876A5 publication Critical patent/JP2008526876A5/ja
Application granted granted Critical
Publication of JP5081630B2 publication Critical patent/JP5081630B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2007550488A 2005-01-07 2006-01-06 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 Expired - Fee Related JP5081630B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64236405P 2005-01-07 2005-01-07
US60/642,364 2005-01-07
US65982805P 2005-03-09 2005-03-09
US60/659,828 2005-03-09
PCT/US2006/000425 WO2006074346A2 (en) 2005-01-07 2006-01-06 RNAi MODULATION OF RSV AND THERAPEUTIC USES THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011220918A Division JP5814728B2 (ja) 2005-01-07 2011-10-05 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法

Publications (3)

Publication Number Publication Date
JP2008526876A JP2008526876A (ja) 2008-07-24
JP2008526876A5 true JP2008526876A5 (enExample) 2009-02-19
JP5081630B2 JP5081630B2 (ja) 2012-11-28

Family

ID=36648197

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007550488A Expired - Fee Related JP5081630B2 (ja) 2005-01-07 2006-01-06 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法
JP2011220918A Expired - Fee Related JP5814728B2 (ja) 2005-01-07 2011-10-05 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法
JP2014113800A Pending JP2014156491A (ja) 2005-01-07 2014-06-02 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011220918A Expired - Fee Related JP5814728B2 (ja) 2005-01-07 2011-10-05 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法
JP2014113800A Pending JP2014156491A (ja) 2005-01-07 2014-06-02 ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法

Country Status (14)

Country Link
US (8) US7507809B2 (enExample)
EP (4) EP2487243A3 (enExample)
JP (3) JP5081630B2 (enExample)
KR (1) KR101169668B1 (enExample)
CN (2) CN102600480B (enExample)
AT (1) ATE551421T1 (enExample)
AU (2) AU2006203934B2 (enExample)
CA (1) CA2594334A1 (enExample)
DK (1) DK2230304T3 (enExample)
EA (3) EA017847B1 (enExample)
ES (1) ES2385811T3 (enExample)
IL (2) IL184162A (enExample)
NZ (1) NZ556097A (enExample)
WO (1) WO2006074346A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
DE10100586C1 (de) * 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
EP1309726B2 (en) 2000-03-30 2018-10-03 Whitehead Institute For Biomedical Research Rna sequence-specific mediators of rna interference
RU2322500C2 (ru) * 2000-12-01 2008-04-20 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. Малые молекулы рнк, опосредующие интерференцию рнк
US7767802B2 (en) * 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7423142B2 (en) 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US7592322B2 (en) * 2004-10-22 2009-09-22 Alnylam Pharmaceuticals, Inc. RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
JP5081630B2 (ja) 2005-01-07 2012-11-28 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法
US20100196509A1 (en) 2005-02-28 2010-08-05 Jonathan Braun Methods for Diagnosis and Treatment of Endometrial Cancer
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
WO2006113526A2 (en) 2005-04-15 2006-10-26 The Regents Of The University Of California Prevention of chlamydia infection using a protective antibody
US8648052B2 (en) * 2005-04-15 2014-02-11 The Regents Of The University Of California Prevention of chlamydia infection using SIRNA
DK2308514T3 (da) 2007-03-23 2013-09-02 To Bbb Holding B V Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren
US20100215588A1 (en) * 2007-04-26 2010-08-26 Rami Skaliter Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system
WO2009004085A2 (en) 2007-07-05 2009-01-08 Novartis Ag Dsrna for treating viral infection
EP2211956A4 (en) * 2007-10-10 2014-07-09 Parion Sciences Inc DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA
WO2009055445A2 (en) * 2007-10-22 2009-04-30 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2229459B1 (en) * 2007-12-13 2014-08-27 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of RSV infection
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
WO2010048590A1 (en) * 2008-10-23 2010-04-29 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules
WO2010141511A2 (en) * 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
US20120220649A1 (en) * 2009-10-30 2012-08-30 Daiichi Sankyo Company, Limited Modified double-stranded polynucleotide
JP5911805B2 (ja) 2009-11-20 2016-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 上皮膜タンパク質−２（ｅｍｐ２）および増殖性硝子体網膜症（ｐｖｒ）
WO2011120053A1 (en) 2010-03-26 2011-09-29 Mersana Therapeutics, Inc. Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
JP6106085B2 (ja) * 2010-08-24 2017-03-29 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 内部非核酸スペーサーを含む一本鎖ＲＮＡｉ剤
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US8778383B2 (en) 2011-06-07 2014-07-15 Parion Sciences, Inc. Methods of treatment
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
DK2855435T3 (en) 2012-05-29 2018-07-16 Parion Sciences Inc DENDRIMER-LIKE AMINOAMIDES WITH SODIUM CHANNEL BLOCKING ACTIVITY FOR THE TREATMENT OF DRY EYES AND OTHER MILK DISEASES
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
KR20150137350A (ko) * 2014-05-29 2015-12-09 삼성전자주식회사 화상형성장치 및 화상형성장치의 스캔 방법
WO2017035278A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
CN105693557A (zh) * 2016-01-04 2016-06-22 湖北卓熙氟化股份有限公司 一种氟化氢尿素及其制备方法
JP2018012236A (ja) * 2016-07-20 2018-01-25 株式会社東芝 印刷システム
CN108689886B (zh) * 2018-06-22 2021-06-15 湖北卓熙氟化股份有限公司 一种氟化氢尿素的制备方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501729A (en) 1982-12-13 1985-02-26 Research Corporation Aerosolized amiloride treatment of retained pulmonary secretions
HU205839B (en) * 1987-11-18 1992-07-28 Chinoin Gyogyszer Es Vegyeszet Synergetic artropodicide composition containining pirethroides and phosphate-esters as active components
US5693532A (en) * 1994-11-04 1997-12-02 Ribozyme Pharmaceuticals, Inc. Respiratory syncytial virus ribozymes
WO1995023225A2 (en) * 1994-02-23 1995-08-31 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting the expression of disease related genes
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
WO1997014792A2 (en) * 1995-10-17 1997-04-24 Hybridon, Inc. Oligonucleotides with anti-respiratory syncytial virus activity
JP2000506384A (ja) * 1996-02-15 2000-05-30 ナショナル インスティチューツ オブ ヘルス ＲＮａｓｅ Ｌ アクチベーター及びＲＳＶ感染の治療に有効なアンチセンスオリゴヌクレオチド
US6214805B1 (en) * 1996-02-15 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services RNase L activators and antisense oligonucleotides effective to treat RSV infections
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
WO1998012312A1 (en) * 1996-09-18 1998-03-26 Vanderbilt University Antisense gene therapy for rna viruses
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
FR2798857B1 (fr) * 1999-09-23 2003-06-06 Pf Medicament Utilisation d'une proteine de membrane ompa d'enterobacterie associee a un peptide immunogene du vrs pour la preparation de vaccins administrables par voie nasale
US20070026394A1 (en) * 2000-02-11 2007-02-01 Lawrence Blatt Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
RU2322500C2 (ru) * 2000-12-01 2008-04-20 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. Малые молекулы рнк, опосредующие интерференцию рнк
US20060287267A1 (en) * 2001-05-18 2006-12-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
US20030170891A1 (en) * 2001-06-06 2003-09-11 Mcswiggen James A. RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2003008628A2 (en) * 2001-07-20 2003-01-30 Ribozyme Pharmacuticals, Inc. Enzymatic nucleic acid peptide conjugates
US6881835B2 (en) * 2002-01-04 2005-04-19 Dr. Chip Biotechnology Inc. Detection of respiratory viruses
US20030203356A1 (en) * 2002-01-22 2003-10-30 The Cleveland Clinic Foundation RNase L activator-antisense complexes
US20030203868A1 (en) * 2002-02-06 2003-10-30 Bushman Frederic D. Inhibition of pathogen replication by RNA interference
US20040204420A1 (en) * 2002-08-05 2004-10-14 Rana Tariq M. Compounds for modulating RNA interference
US7923547B2 (en) * 2002-09-05 2011-04-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US20040242518A1 (en) * 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
AU2003279004B2 (en) * 2002-09-28 2009-10-08 Massachusetts Institute Of Technology Influenza therapeutic
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
WO2004064737A2 (en) 2003-01-17 2004-08-05 Alnylam Pharmaceuticals Therapeutics compositions
EP3450559A1 (en) 2003-03-07 2019-03-06 Alnylam Pharmaceuticals, Inc. Therapeutic compositions
EP1608735A4 (en) * 2003-04-03 2008-11-05 Alnylam Pharmaceuticals RNAI CONJUGATES
CA2522349A1 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals, Inc. Protected monomers
ES2702942T3 (es) * 2003-04-17 2019-03-06 Alnylam Pharmaceuticals Inc Agentes de ARNi modificados
TW572579U (en) * 2003-05-12 2004-01-11 Enermax Technology Corp Power supply still capable of dissipating heat after powering off a computer
EP2371835A1 (en) 2003-07-03 2011-10-05 The Trustees Of The University Of Pennsylvania Inhibition of syk kinase expression
CN101044152A (zh) * 2004-02-05 2007-09-26 因特拉迪格姆公司 组合RNAi治疗的方法和组合物
CA2561741C (en) * 2004-04-05 2016-09-27 Alnylam Pharmaceuticals, Inc. Processes and reagents for oligonucleotide synthesis and purification
US7297786B2 (en) * 2004-07-09 2007-11-20 University Of Iowa Research Foundation RNA interference in respiratory epitheial cells
US7592322B2 (en) * 2004-10-22 2009-09-22 Alnylam Pharmaceuticals, Inc. RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof
WO2006121464A2 (en) * 2004-11-05 2006-11-16 Intradigm Corporation Compositions for treating respiratory viral infections and their use
JP5081630B2 (ja) 2005-01-07 2012-11-28 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法
US7427605B2 (en) * 2005-03-31 2008-09-23 Calando Pharmaceuticals, Inc. Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
WO2007115168A2 (en) * 2006-03-31 2007-10-11 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of eg5 gene
US8598333B2 (en) * 2006-05-26 2013-12-03 Alnylam Pharmaceuticals, Inc. SiRNA silencing of genes expressed in cancer
WO2009055445A2 (en) 2007-10-22 2009-04-30 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP2229459B1 (en) 2007-12-13 2014-08-27 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of RSV infection
WO2010048590A1 (en) 2008-10-23 2010-04-29 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of rsv infection using modified duplex rna molecules

Similar Documents

Publication Publication Date Title
JP2008526876A5 (enExample)
EA200900681A1 (ru) Композиция для лечения респираторных синцитиальных вирусов
TWI823866B (zh) 用於抑制類血管生成素蛋白-3(ANGPTL3)表現的RNAi藥劑及組合物及使用方法
JP7007304B2 (ja) Ｂ型肝炎感染症治療用のＰＡＰＤ５又はＰＡＰＤ７のｍＲＮＡ減少用核酸分子
EP2421970B1 (en) Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon
JP4718379B2 (ja) 修飾された低分子干渉ｒｎａ分子および使用方法
JP2008283975A5 (enExample)
JP2020094063A5 (enExample)
JP2007529224A5 (enExample)
JP2009514877A5 (enExample)
JP2008517940A5 (enExample)
EA200870528A1 (ru) Композиции и способы ингибирования экспрессии гена pcsk9
JP2011511636A5 (enExample)
JP2016513976A5 (enExample)
RU2010139908A (ru) Модуляция rsv, piv и других респираторных вирусов с помощью rnai и ее применение
WO2007127919A3 (en) Compositions and methods for inhibiting expression of a gene from the jc virus
CN111511914A (zh) 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染
CN114846140A (zh) 用于治疗hbv的靶向hbv的治疗性寡核苷酸和tlr7激动剂的药物组合
WO2007111998A3 (en) Dsrna compositions and methods for treating hpv infection
RU2014121304A (ru) Ингибирование экспрессии вирусных генов
JP2008500817A5 (ja) Ｄｎａウイルスのマイクロｒｎａ及びそれを阻害する医薬品
Bohle et al. Species specific inhibition of viral replication using dicer substrate siRNAs (DsiRNAs) targeting the viral nucleoprotein of the fish pathogenic rhabdovirus viral hemorrhagic septicemia virus (VHSV)
JP2004537030A5 (enExample)
US20050059617A1 (en) Novel anitsense oligonucleotide derivatives against to hepatitis c virus
EP1945270A4 (en) COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V LEIDEN GENE MUTATION