JP2008525512A5 - - Google Patents
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- Publication number
- JP2008525512A5 JP2008525512A5 JP2007548746A JP2007548746A JP2008525512A5 JP 2008525512 A5 JP2008525512 A5 JP 2008525512A5 JP 2007548746 A JP2007548746 A JP 2007548746A JP 2007548746 A JP2007548746 A JP 2007548746A JP 2008525512 A5 JP2008525512 A5 JP 2008525512A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- formula
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000002920 convulsive effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000012672 seasonal affective disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04380280A EP1676840A1 (en) | 2004-12-28 | 2004-12-28 | 5-HT7 Receptor antagonists |
| US11/048,991 US20060142321A1 (en) | 2004-12-28 | 2005-02-02 | 5-HT7 receptor antagonists |
| PCT/EP2005/014044 WO2006069775A1 (en) | 2004-12-28 | 2005-12-27 | 5-ht7 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525512A JP2008525512A (ja) | 2008-07-17 |
| JP2008525512A5 true JP2008525512A5 (https=) | 2009-02-05 |
Family
ID=34931895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548746A Pending JP2008525512A (ja) | 2004-12-28 | 2005-12-27 | ５−ｈｔ７受容体拮抗薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20060142321A1 (https=) |
| EP (2) | EP1676840A1 (https=) |
| JP (1) | JP2008525512A (https=) |
| KR (1) | KR20070098882A (https=) |
| CN (1) | CN101389608A (https=) |
| AT (1) | ATE518836T1 (https=) |
| AU (1) | AU2005321462A1 (https=) |
| BR (1) | BRPI0519788A2 (https=) |
| CA (1) | CA2591201A1 (https=) |
| ES (1) | ES2370877T3 (https=) |
| MX (1) | MX2007007893A (https=) |
| RU (1) | RU2007128964A (https=) |
| WO (1) | WO2006069775A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1875899A1 (en) * | 2006-06-29 | 2008-01-09 | Laboratorios Del Dr. Esteve, S.A. | Use of 5HT7 receptor agonists for the treatment of pain |
| US20130287705A1 (en) * | 2010-11-03 | 2013-10-31 | Mcmaster University | Method of treating mucosal inflammation |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| AU2020321955A1 (en) | 2019-07-30 | 2022-03-17 | Eikonizo Therapapeutics, Inc. | HDAC6 inhibitors and uses thereof |
| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ193654A (en) | 1979-05-16 | 1984-08-24 | Wuelfing Johann A | Naphthalene sulphonamido-alkyl-piperidines,pyrrolidines or piperazines and pharmaceutical compositions |
| EP0076072B1 (en) | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulphonamides |
| WO1997029097A1 (en) | 1996-02-09 | 1997-08-14 | Smithkline Beecham Plc | Sulfonamide derivatives as 5ht7 receptor antagonists |
| GB9612884D0 (en) | 1996-06-20 | 1996-08-21 | Smithkline Beecham Plc | Novel compounds |
| JP2000512646A (ja) * | 1996-06-25 | 2000-09-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ７受容体アンタゴニストとしてのスルホンアミド誘導体 |
| ES2243999T3 (es) | 1996-06-28 | 2005-12-01 | Meiji Seika Kaisha Ltd. | Compuestos de tetrahidrobencindol. |
| WO1999024022A2 (en) | 1997-11-10 | 1999-05-20 | F. Hoffmann-La Roche Ag | Isoquinoline derivatives for treating disorders associated with 5ht7 receptors |
| WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
| GB0128885D0 (en) | 2001-12-03 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
-
2004
- 2004-12-28 EP EP04380280A patent/EP1676840A1/en not_active Withdrawn
-
2005
- 2005-02-02 US US11/048,991 patent/US20060142321A1/en not_active Abandoned
- 2005-12-27 MX MX2007007893A patent/MX2007007893A/es not_active Application Discontinuation
- 2005-12-27 BR BRPI0519788-0A patent/BRPI0519788A2/pt not_active IP Right Cessation
- 2005-12-27 ES ES05820659T patent/ES2370877T3/es not_active Expired - Lifetime
- 2005-12-27 AT AT05820659T patent/ATE518836T1/de not_active IP Right Cessation
- 2005-12-27 JP JP2007548746A patent/JP2008525512A/ja active Pending
- 2005-12-27 CA CA002591201A patent/CA2591201A1/en not_active Abandoned
- 2005-12-27 WO PCT/EP2005/014044 patent/WO2006069775A1/en not_active Ceased
- 2005-12-27 AU AU2005321462A patent/AU2005321462A1/en not_active Abandoned
- 2005-12-27 CN CNA2005800452313A patent/CN101389608A/zh active Pending
- 2005-12-27 KR KR1020077017188A patent/KR20070098882A/ko not_active Withdrawn
- 2005-12-27 RU RU2007128964/04A patent/RU2007128964A/ru not_active Application Discontinuation
- 2005-12-27 EP EP05820659A patent/EP1836172B1/en not_active Expired - Lifetime
-
2009
- 2009-05-22 US US12/471,128 patent/US7662862B2/en not_active Expired - Fee Related
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