KR20070098882A - 5-ｈｔ7 수용체 안타고니스트 - Google Patents
5-ｈｔ7 수용체 안타고니스트 Download PDFInfo
- Publication number
- KR20070098882A KR20070098882A KR1020077017188A KR20077017188A KR20070098882A KR 20070098882 A KR20070098882 A KR 20070098882A KR 1020077017188 A KR1020077017188 A KR 1020077017188A KR 20077017188 A KR20077017188 A KR 20077017188A KR 20070098882 A KR20070098882 A KR 20070098882A
- Authority
- KR
- South Korea
- Prior art keywords
- substituted
- unsubstituted
- formula
- compounds
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *C(C(*)NC1C(*)(*)C2(*)*)c3c1c2c(*)c(*)c3* Chemical compound *C(C(*)NC1C(*)(*)C2(*)*)c3c1c2c(*)c(*)c3* 0.000 description 5
- HHABXEIJFIXBSD-UHFFFAOYSA-N Cc1cc(NCCCN2C(CC3)c4c3cccc4CC2)ccc1 Chemical compound Cc1cc(NCCCN2C(CC3)c4c3cccc4CC2)ccc1 HHABXEIJFIXBSD-UHFFFAOYSA-N 0.000 description 1
- JJYPMNFTHPTTDI-UHFFFAOYSA-N Cc1cccc(N)c1 Chemical compound Cc1cccc(N)c1 JJYPMNFTHPTTDI-UHFFFAOYSA-N 0.000 description 1
- NUVVJGQWDACNDV-UHFFFAOYSA-N ClCCCN(CC1)C2c3c1cccc3CC2 Chemical compound ClCCCN(CC1)C2c3c1cccc3CC2 NUVVJGQWDACNDV-UHFFFAOYSA-N 0.000 description 1
- CQWOTKCLUYJOPP-UHFFFAOYSA-N O=C(C1)c2cccc3c2C1NCC3 Chemical compound O=C(C1)c2cccc3c2C1NCC3 CQWOTKCLUYJOPP-UHFFFAOYSA-N 0.000 description 1
- BUAVPRGEIAVFBF-UHFFFAOYSA-N OC(CC1NCCc2ccccc12)=O Chemical compound OC(CC1NCCc2ccccc12)=O BUAVPRGEIAVFBF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04380280.0 | 2004-12-28 | ||
| EP04380280A EP1676840A1 (en) | 2004-12-28 | 2004-12-28 | 5-HT7 Receptor antagonists |
| US11/048,991 | 2005-02-02 | ||
| US11/048,991 US20060142321A1 (en) | 2004-12-28 | 2005-02-02 | 5-HT7 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070098882A true KR20070098882A (ko) | 2007-10-05 |
Family
ID=34931895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077017188A Withdrawn KR20070098882A (ko) | 2004-12-28 | 2005-12-27 | 5-ｈｔ7 수용체 안타고니스트 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20060142321A1 (https=) |
| EP (2) | EP1676840A1 (https=) |
| JP (1) | JP2008525512A (https=) |
| KR (1) | KR20070098882A (https=) |
| CN (1) | CN101389608A (https=) |
| AT (1) | ATE518836T1 (https=) |
| AU (1) | AU2005321462A1 (https=) |
| BR (1) | BRPI0519788A2 (https=) |
| CA (1) | CA2591201A1 (https=) |
| ES (1) | ES2370877T3 (https=) |
| MX (1) | MX2007007893A (https=) |
| RU (1) | RU2007128964A (https=) |
| WO (1) | WO2006069775A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1875899A1 (en) * | 2006-06-29 | 2008-01-09 | Laboratorios Del Dr. Esteve, S.A. | Use of 5HT7 receptor agonists for the treatment of pain |
| US20130287705A1 (en) * | 2010-11-03 | 2013-10-31 | Mcmaster University | Method of treating mucosal inflammation |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| AU2020321955A1 (en) | 2019-07-30 | 2022-03-17 | Eikonizo Therapapeutics, Inc. | HDAC6 inhibitors and uses thereof |
| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ193654A (en) | 1979-05-16 | 1984-08-24 | Wuelfing Johann A | Naphthalene sulphonamido-alkyl-piperidines,pyrrolidines or piperazines and pharmaceutical compositions |
| EP0076072B1 (en) | 1981-09-24 | 1987-05-13 | BEECHAM - WUELFING GmbH & Co. KG | Sulphonamides |
| WO1997029097A1 (en) | 1996-02-09 | 1997-08-14 | Smithkline Beecham Plc | Sulfonamide derivatives as 5ht7 receptor antagonists |
| GB9612884D0 (en) | 1996-06-20 | 1996-08-21 | Smithkline Beecham Plc | Novel compounds |
| JP2000512646A (ja) * | 1996-06-25 | 2000-09-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５ｈｔ７受容体アンタゴニストとしてのスルホンアミド誘導体 |
| ES2243999T3 (es) | 1996-06-28 | 2005-12-01 | Meiji Seika Kaisha Ltd. | Compuestos de tetrahidrobencindol. |
| WO1999024022A2 (en) | 1997-11-10 | 1999-05-20 | F. Hoffmann-La Roche Ag | Isoquinoline derivatives for treating disorders associated with 5ht7 receptors |
| WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
| GB0128885D0 (en) | 2001-12-03 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
-
2004
- 2004-12-28 EP EP04380280A patent/EP1676840A1/en not_active Withdrawn
-
2005
- 2005-02-02 US US11/048,991 patent/US20060142321A1/en not_active Abandoned
- 2005-12-27 MX MX2007007893A patent/MX2007007893A/es not_active Application Discontinuation
- 2005-12-27 BR BRPI0519788-0A patent/BRPI0519788A2/pt not_active IP Right Cessation
- 2005-12-27 ES ES05820659T patent/ES2370877T3/es not_active Expired - Lifetime
- 2005-12-27 AT AT05820659T patent/ATE518836T1/de not_active IP Right Cessation
- 2005-12-27 JP JP2007548746A patent/JP2008525512A/ja active Pending
- 2005-12-27 CA CA002591201A patent/CA2591201A1/en not_active Abandoned
- 2005-12-27 WO PCT/EP2005/014044 patent/WO2006069775A1/en not_active Ceased
- 2005-12-27 AU AU2005321462A patent/AU2005321462A1/en not_active Abandoned
- 2005-12-27 CN CNA2005800452313A patent/CN101389608A/zh active Pending
- 2005-12-27 KR KR1020077017188A patent/KR20070098882A/ko not_active Withdrawn
- 2005-12-27 RU RU2007128964/04A patent/RU2007128964A/ru not_active Application Discontinuation
- 2005-12-27 EP EP05820659A patent/EP1836172B1/en not_active Expired - Lifetime
-
2009
- 2009-05-22 US US12/471,128 patent/US7662862B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0519788A2 (pt) | 2009-03-17 |
| WO2006069775A1 (en) | 2006-07-06 |
| ATE518836T1 (de) | 2011-08-15 |
| US20090264458A1 (en) | 2009-10-22 |
| EP1676840A1 (en) | 2006-07-05 |
| EP1836172A1 (en) | 2007-09-26 |
| CN101389608A (zh) | 2009-03-18 |
| RU2007128964A (ru) | 2009-02-10 |
| ES2370877T3 (es) | 2011-12-23 |
| EP1836172B1 (en) | 2011-08-03 |
| AU2005321462A1 (en) | 2006-07-06 |
| US20060142321A1 (en) | 2006-06-29 |
| JP2008525512A (ja) | 2008-07-17 |
| MX2007007893A (es) | 2007-10-03 |
| CA2591201A1 (en) | 2006-07-06 |
| US7662862B2 (en) | 2010-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6593322B1 (en) | Compounds and methods for modulation of estrogen receptors | |
| WO2000055137A1 (en) | Compounds and methods for modulation of estrogen receptors | |
| KR20070091040A (ko) | 5-ｈｔ7 수용체 안타고니스트 | |
| US7662862B2 (en) | 5-HT7 receptor antagonists | |
| KR20070046879A (ko) | 5-ｈｔ7 수용체 안타고니스트 | |
| KR20070046878A (ko) | 5-ｈｔ7 수용체 안타고니스트 | |
| CN101010301A (zh) | 5－ht7受体拮抗剂 | |
| US7211584B2 (en) | 5-HT7 receptor ligands | |
| US7553965B2 (en) | 5-HT7 receptor antagonists | |
| ES2257167B1 (es) | Inhibidores del receptor 5-ht7. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20070725 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |