JP2004518658A5 - - Google Patents
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- Publication number
- JP2004518658A5 JP2004518658A5 JP2002551527A JP2002551527A JP2004518658A5 JP 2004518658 A5 JP2004518658 A5 JP 2004518658A5 JP 2002551527 A JP2002551527 A JP 2002551527A JP 2002551527 A JP2002551527 A JP 2002551527A JP 2004518658 A5 JP2004518658 A5 JP 2004518658A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- amino
- hydrogen
- dioxoethyl
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000005647 linker group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000002877 alkyl aryl group Chemical group 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 3
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims 3
- -1 amino, carbonyl Chemical group 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 235000010290 biphenyl Nutrition 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000004702 methyl esters Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000005425 toluyl group Chemical group 0.000 claims 3
- 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- XFWYGPJGSADHTQ-UHFFFAOYSA-N 2-[(1-benzyl-2-ethyl-3-oxamoyl-6,7,8,9-tetrahydrobenzo[g]indol-4-yl)oxy]acetic acid Chemical compound CCC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCCC3=C2N1CC1=CC=CC=C1 XFWYGPJGSADHTQ-UHFFFAOYSA-N 0.000 claims 2
- PXKIHESMECOGFM-UHFFFAOYSA-N 2-[(1-benzyl-2-methyl-3-oxamoyl-6,7,8,9-tetrahydrobenzo[g]indol-4-yl)oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCCC3=C2N1CC1=CC=CC=C1 PXKIHESMECOGFM-UHFFFAOYSA-N 0.000 claims 2
- ZRGYYOLGPYAKHM-UHFFFAOYSA-N 2-[[1-[(2-bromophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC=C1Br ZRGYYOLGPYAKHM-UHFFFAOYSA-N 0.000 claims 2
- KKLIXGKAGOYMQS-UHFFFAOYSA-N 2-[[2-methyl-3-oxamoyl-1-[(2-phenylphenyl)methyl]-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC=C1C1=CC=CC=C1 KKLIXGKAGOYMQS-UHFFFAOYSA-N 0.000 claims 2
- 125000000033 alkoxyamino group Chemical group 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 150000002475 indoles Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 1
- VCUWZUBFYRWFSA-UHFFFAOYSA-N 2-[(1-benzyl-2-ethyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl)oxy]acetic acid Chemical compound CCC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC=C1 VCUWZUBFYRWFSA-UHFFFAOYSA-N 0.000 claims 1
- GPJLXZYUPFLUAV-UHFFFAOYSA-N 2-[(1-benzyl-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl)oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC=C1 GPJLXZYUPFLUAV-UHFFFAOYSA-N 0.000 claims 1
- SACJSCPRTMXKND-UHFFFAOYSA-N 2-[4-[2-(benzenesulfonamido)-2-oxoethoxy]-1-benzyl-2-methyl-7,8-dihydro-6h-cyclopenta[g]indol-3-yl]-2-oxoacetamide Chemical compound C1=C2CCCC2=C2N(CC=3C=CC=CC=3)C(C)=C(C(=O)C(N)=O)C2=C1OCC(=O)NS(=O)(=O)C1=CC=CC=C1 SACJSCPRTMXKND-UHFFFAOYSA-N 0.000 claims 1
- QDOYKUBOULWYOE-UHFFFAOYSA-N 2-[[1-[(2-fluorophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC=C1F QDOYKUBOULWYOE-UHFFFAOYSA-N 0.000 claims 1
- QPRDXUYNINPIJV-UHFFFAOYSA-N 2-[[1-[(3-fluorophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC(F)=C1 QPRDXUYNINPIJV-UHFFFAOYSA-N 0.000 claims 1
- NECXUEJKKBTQOR-UHFFFAOYSA-N 2-[[1-[(3-fluorophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid;hydrate Chemical compound O.CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=CC(F)=C1 NECXUEJKKBTQOR-UHFFFAOYSA-N 0.000 claims 1
- AQXWFEXRWZRPPX-UHFFFAOYSA-N 2-[[1-[(4-fluorophenyl)methyl]-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl]oxy]acetic acid Chemical compound CC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=C3CCCC3=C2N1CC1=CC=C(F)C=C1 AQXWFEXRWZRPPX-UHFFFAOYSA-N 0.000 claims 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- LBZKCAJYHMFIHZ-UHFFFAOYSA-N methyl 2-[(1-benzyl-2-ethyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl)oxy]acetate Chemical compound CCC1=C(C(=O)C(N)=O)C2=C(OCC(=O)OC)C=C3CCCC3=C2N1CC1=CC=CC=C1 LBZKCAJYHMFIHZ-UHFFFAOYSA-N 0.000 claims 1
- RNQBSGBIXRVGAB-UHFFFAOYSA-N methyl 2-[(1-benzyl-2-methyl-3-oxamoyl-7,8-dihydro-6h-cyclopenta[g]indol-4-yl)oxy]acetate Chemical compound CC1=C(C(=O)C(N)=O)C=2C(OCC(=O)OC)=CC=3CCCC=3C=2N1CC1=CC=CC=C1 RNQBSGBIXRVGAB-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25639700P | 2000-12-18 | 2000-12-18 | |
| PCT/US2001/043187 WO2002050030A2 (en) | 2000-12-18 | 2001-12-06 | Cycloalkylfused [g]-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004518658A JP2004518658A (ja) | 2004-06-24 |
| JP2004518658A5 true JP2004518658A5 (https=) | 2005-12-22 |
Family
ID=22972097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551527A Pending JP2004518658A (ja) | 2000-12-18 | 2001-12-06 | 新規なｓＰＬＡ２インヒビター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6974831B2 (https=) |
| EP (1) | EP1349834A2 (https=) |
| JP (1) | JP2004518658A (https=) |
| AU (1) | AU2002233928A1 (https=) |
| CA (1) | CA2430808A1 (https=) |
| WO (1) | WO2002050030A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005107767A2 (en) * | 2004-05-03 | 2005-11-17 | Ilypsa, Inc. | Modulation of lysophosphatidylcholine and treatment of diet-induced conditions |
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| US7666898B2 (en) * | 2005-11-03 | 2010-02-23 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors |
| MX2008005661A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Inhibidores de fosfolipasa, que incluyen inhibidores de fosfolipasa multivalente, y uso de los mismos, que incluyen como inhibidores de fosfolipasa localizadas en el lumen. |
| EP1948602A2 (en) * | 2005-11-03 | 2008-07-30 | Ilypsa, Inc. | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
| AU2006311851A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-A2 inhibitors |
| MX2008005664A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de indol que tienen sustituyentes c4-acidos y uso de los mismos como inhibidores de fosfolipasa a2. |
| AU2007339382B2 (en) | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| EP2081922B1 (en) | 2006-12-22 | 2012-02-01 | Schering Corporation | 5,6-Ring annulated indole derivatives and use thereof |
| JP5211068B2 (ja) * | 2006-12-22 | 2013-06-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体 |
| TW200924780A (en) * | 2007-08-29 | 2009-06-16 | Schering Corp | 2-carboxy substituted indole derivatives and methods of use thereof |
| WO2009032116A1 (en) * | 2007-08-29 | 2009-03-12 | Schering Corporation | 2, 3-substituted indole derivatives for treating viral infections |
| ATE541845T1 (de) * | 2007-08-29 | 2012-02-15 | Schering Corp | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
| MX2010005356A (es) * | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| CA2705587A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
| AR072088A1 (es) * | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN117120442A (zh) * | 2021-01-26 | 2023-11-24 | 薛定谔公司 | 用于治疗癌症、自身免疫性病症和炎性病症的三环化合物 |
| AR129979A1 (es) * | 2022-07-22 | 2024-10-16 | Schroedinger Inc | Compuestos cíclicos y métodos de uso de estos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU679053B2 (en) | 1993-03-25 | 1997-06-19 | Pharmacia & Upjohn Company | Indoletetralins having dopaminergic activity |
| IL109309A (en) | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| WO2000010568A1 (en) | 1998-08-24 | 2000-03-02 | Draheim Susan E | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2? |
| US6140327A (en) | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
| US6831095B1 (en) * | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
-
2001
- 2001-12-06 WO PCT/US2001/043187 patent/WO2002050030A2/en not_active Ceased
- 2001-12-06 EP EP01984924A patent/EP1349834A2/en not_active Withdrawn
- 2001-12-06 AU AU2002233928A patent/AU2002233928A1/en not_active Abandoned
- 2001-12-06 US US10/450,741 patent/US6974831B2/en not_active Expired - Fee Related
- 2001-12-06 JP JP2002551527A patent/JP2004518658A/ja active Pending
- 2001-12-06 CA CA002430808A patent/CA2430808A1/en not_active Abandoned
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