HRP20100681T1 - Derivati hinaholina korisni za tretman periferne arterijske bolesti i kao inhibitori fosfodiesteraze - Google Patents

Derivati hinaholina korisni za tretman periferne arterijske bolesti i kao inhibitori fosfodiesteraze Download PDF

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Publication number
HRP20100681T1
HRP20100681T1 HR20100681T HRP20100681T HRP20100681T1 HR P20100681 T1 HRP20100681 T1 HR P20100681T1 HR 20100681 T HR20100681 T HR 20100681T HR P20100681 T HRP20100681 T HR P20100681T HR P20100681 T1 HRP20100681 T1 HR P20100681T1
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Croatia
Prior art keywords
compound
treatment
peripheral arterial
image
use according
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HR20100681T
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English (en)
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Franklin Richard
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Shire Biopharmaceuticals Holdings Ireland Limited
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Publication of HRP20100681T1 publication Critical patent/HRP20100681T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Spoj formulenjegov uravnotezeni oblik, neka farmaceutski prihvatljiva sol ovog spoja ili njegovog uravnotezenog oblika, gdje, R1 predstavlja H, C1-6 alkil, C2-6 alkenil, C2-8 alkinil, C1-6 alkoksi, ili C6-10 aril; R2 predstavlja R3 predstavlja OH, halogen, SH, O-C1-6 alkil ili NH2; iX i Y svaki neovisno, predstavlja H ili halogen, za uporabu kod povisenih sadrzaja lipoproteina visoke gustoce i apolipoproteina u plazmi, ili za upotrebu u tretmanu periferne arterijske bolesti, ateroskleroze, povremenog sepanja, kongestivne srcane smetnje, neke bolesti povezane s povisenom agregacijom plocica, tromboze, mozdanog udara ili seksualne disfunkcije. Patent sadrzi jos 15 patentnih zahtjeva.

Claims (16)

1. Spoj formule [image] njegov uravnoteženi oblik, neka farmaceutski prihvatljiva sol ovog spoja ili njegovog uravnoteženog oblika, gdje, R1 predstavlja H, C1-6 alkil, C2-6 alkenil, C2-8 alkinil, C1-6 alkoksi, ili C6-10 aril; R2 predstavlja [image] R3 predstavlja OH, halogen, SH, O-C1-6 alkil ili NH2; i X i Y svaki neovisno, predstavlja H ili halogen, za uporebu kod povišenih sadržaja lipoproteina visoke gustoće i apolipoproteina u plazmi, ili za upotrebu u tretmanu periferne arterijske bolesti, ateroskleroze, povremenog šepanja, kongestivne srčane smetnje, neke bolesti povezane s povišenom agregacijom pločica, tromboze, moždanog udara ili seksualne disfunkcije.
2. Spoj za upotrebu prema Zahtjevu 1, pri čemu taj spoj ima formulu [image]
3. Spoj za upotrebu prema Zahtjevu 1, pri čemu R2 predstavlja [image]
4. Spoj za upotrebu prema Zahtjevu 1, pri čemu R1 predstavlja H ili C1-6 alkil.
5. Spoj za upotrebu prema Zahtjevu 1, pri čemu R1 predstavlja H.
6. Spoj za upotrebu prema Zahtjevu 1, pri čemu X predstavlja H ili halogen.
7. Spoj za upotrebu prema Zahtjevu 1, pri čemu Y predstavlja H ili Cl.
8. Spoj za upotrebu prema Zahtjevu 1, pri čemu X predstavlja Cl.
9. Spoj za upotrebu prema Zahtjevu 1, pri čemu Y predstavlja Cl.
10. Spoj za upotrebu prema Zahtjevu 1, pri čemu taj spoj predstavlja [image]
11. Spoj prema Zahtjevu 1, za upotrebu u tretmanu periferne arterijske bolesti.
12. Spoj prema Zahtjevu 1, za upotrebu u tretmanu ateroskleroze.
13. Spoj prema Zahtjevu 1, za upotrebu u tretmanu povremenog šepanja.
14. Spoj prema Zahtjevu 1, za upotrebu u tretmanu kongestivne srčane smetnje.
15. Spoj prema Zahtjevu 1, za upotrebu u tretmanu moždanog udara.
16. Spoj prema Zahtjevu 1, za upotrebu u tretmanu seksualne disfunkcije.
HR20100681T 2004-08-04 2010-12-08 Derivati hinaholina korisni za tretman periferne arterijske bolesti i kao inhibitori fosfodiesteraze HRP20100681T1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59843204P 2004-08-04 2004-08-04

Publications (1)

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HRP20100681T1 true HRP20100681T1 (hr) 2011-01-31

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HR20100681T HRP20100681T1 (hr) 2004-08-04 2010-12-08 Derivati hinaholina korisni za tretman periferne arterijske bolesti i kao inhibitori fosfodiesteraze

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Country Link
US (1) US20060030574A1 (hr)
EP (2) EP1949893B1 (hr)
JP (1) JP4758993B2 (hr)
CN (1) CN101014344A (hr)
AT (1) ATE484278T1 (hr)
AU (1) AU2005271275A1 (hr)
BR (1) BRPI0513943A (hr)
CA (1) CA2575512C (hr)
CY (1) CY1110881T1 (hr)
DE (1) DE602005024192D1 (hr)
DK (1) DK1949893T3 (hr)
EA (1) EA200700406A1 (hr)
ES (1) ES2353848T3 (hr)
HR (1) HRP20100681T1 (hr)
MX (1) MX2007001513A (hr)
NO (1) NO20071098L (hr)
PL (1) PL1949893T3 (hr)
PT (1) PT1949893E (hr)
RS (1) RS51519B (hr)
SI (1) SI1949893T1 (hr)
WO (1) WO2006017823A2 (hr)
ZA (1) ZA200701850B (hr)

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Also Published As

Publication number Publication date
DK1949893T3 (da) 2011-01-31
ZA200701850B (en) 2008-08-27
SI1949893T1 (sl) 2011-02-28
ES2353848T3 (es) 2011-03-07
CA2575512C (en) 2010-12-14
CY1110881T1 (el) 2015-06-10
CA2575512A1 (en) 2006-02-16
CN101014344A (zh) 2007-08-08
BRPI0513943A (pt) 2008-05-20
JP2008509163A (ja) 2008-03-27
PT1949893E (pt) 2011-01-04
EP1949893A2 (en) 2008-07-30
US20060030574A1 (en) 2006-02-09
EA200700406A1 (ru) 2007-08-31
WO2006017823A3 (en) 2006-05-04
AU2005271275A1 (en) 2006-02-16
RS51519B (en) 2011-06-30
EP1949893A3 (en) 2008-08-20
MX2007001513A (es) 2007-03-27
WO2006017823A2 (en) 2006-02-16
DE602005024192D1 (de) 2010-11-25
ATE484278T1 (de) 2010-10-15
EP1778235A2 (en) 2007-05-02
PL1949893T3 (pl) 2011-04-29
EP1949893B1 (en) 2010-10-13
EP1778235A4 (en) 2008-08-20
NO20071098L (no) 2007-05-03
JP4758993B2 (ja) 2011-08-31

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