JP2004518657A5 - - Google Patents
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- Publication number
- JP2004518657A5 JP2004518657A5 JP2002551525A JP2002551525A JP2004518657A5 JP 2004518657 A5 JP2004518657 A5 JP 2004518657A5 JP 2002551525 A JP2002551525 A JP 2002551525A JP 2002551525 A JP2002551525 A JP 2002551525A JP 2004518657 A5 JP2004518657 A5 JP 2004518657A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- alkyl
- alkoxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000005647 linker group Chemical group 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003368 amide group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- 125000003302 alkenyloxy group Chemical group 0.000 claims 3
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims 3
- 239000004305 biphenyl Substances 0.000 claims 3
- 235000010290 biphenyl Nutrition 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000005425 toluyl group Chemical group 0.000 claims 3
- 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000033 alkoxyamino group Chemical group 0.000 claims 2
- 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 1
- RLJUIKVXQJUBAN-UHFFFAOYSA-N 2-(1-benzyl-2-ethyl-3-oxamoylbenzo[f]indol-4-yl)oxyacetic acid Chemical compound CCC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C3=CC=CC=C3C=C2N1CC1=CC=CC=C1 RLJUIKVXQJUBAN-UHFFFAOYSA-N 0.000 claims 1
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- -1 amino, carbonyl Chemical group 0.000 claims 1
- ZKYVBSXZRJFJRC-UHFFFAOYSA-N benzyl 2-(1-benzyl-2-ethyl-3-oxamoylbenzo[f]indol-4-yl)oxyacetate Chemical compound C12=CC=CC=C2C=C2N(CC=3C=CC=CC=3)C(CC)=C(C(=O)C(N)=O)C2=C1OCC(=O)OCC1=CC=CC=C1 ZKYVBSXZRJFJRC-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- GQBNRKIHKLCHTG-UHFFFAOYSA-N ethyl 2-(1-benzyl-2-ethyl-3-oxamoylbenzo[f]indol-4-yl)oxyacetate Chemical compound C12=CC3=CC=CC=C3C(OCC(=O)OCC)=C2C(C(=O)C(N)=O)=C(CC)N1CC1=CC=CC=C1 GQBNRKIHKLCHTG-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25628100P | 2000-12-18 | 2000-12-18 | |
| PCT/US2001/043184 WO2002050028A2 (en) | 2000-12-18 | 2001-12-06 | Substituted benzoindoles as spla2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004518657A JP2004518657A (ja) | 2004-06-24 |
| JP2004518657A5 true JP2004518657A5 (https=) | 2005-12-22 |
Family
ID=22971644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002551525A Pending JP2004518657A (ja) | 2000-12-18 | 2001-12-06 | 新規なｓＰＬＡ２インヒビター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6930123B2 (https=) |
| EP (1) | EP1349832A2 (https=) |
| JP (1) | JP2004518657A (https=) |
| AU (1) | AU2002237655A1 (https=) |
| CA (1) | CA2431023A1 (https=) |
| WO (1) | WO2002050028A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8249010B2 (en) | 2008-11-05 | 2012-08-21 | Huawei Technologies Co., Ltd. | Method and apparatus for feeding back and receiving acknowledgement information of semi-persistent scheduling data packets |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| KR101213495B1 (ko) * | 2010-06-03 | 2013-01-14 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU163443B (https=) * | 1970-08-26 | 1973-08-28 | ||
| WO2000010568A1 (en) * | 1998-08-24 | 2000-03-02 | Draheim Susan E | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase a¿2? |
| JP2002532571A (ja) * | 1998-12-22 | 2002-10-02 | イーライ・リリー・アンド・カンパニー | 新規ｓＰＬＡ２インヒビター |
| JP2003505372A (ja) | 1999-07-19 | 2003-02-12 | イーライ・リリー・アンド・カンパニー | ｓＰＬＡ２インヒビター |
| DE60032254D1 (de) | 1999-09-20 | 2007-01-18 | Lilly Co Eli | Hydroxyfunktionelle amid-1h-indolderivate aktiv als spla2 inhibitoren |
-
2001
- 2001-12-06 JP JP2002551525A patent/JP2004518657A/ja active Pending
- 2001-12-06 AU AU2002237655A patent/AU2002237655A1/en not_active Abandoned
- 2001-12-06 EP EP01986459A patent/EP1349832A2/en not_active Withdrawn
- 2001-12-06 US US10/450,929 patent/US6930123B2/en not_active Expired - Fee Related
- 2001-12-06 WO PCT/US2001/043184 patent/WO2002050028A2/en not_active Ceased
- 2001-12-06 CA CA002431023A patent/CA2431023A1/en not_active Abandoned
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