JP2008524262A5 - - Google Patents
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- Publication number
- JP2008524262A5 JP2008524262A5 JP2007547060A JP2007547060A JP2008524262A5 JP 2008524262 A5 JP2008524262 A5 JP 2008524262A5 JP 2007547060 A JP2007547060 A JP 2007547060A JP 2007547060 A JP2007547060 A JP 2007547060A JP 2008524262 A5 JP2008524262 A5 JP 2008524262A5
- Authority
- JP
- Japan
- Prior art keywords
- hemihydrate
- disorder
- compound according
- disorders
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 230000003542 behavioural effect Effects 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 3
- 238000000113 differential scanning calorimetry Methods 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 206010001488 Aggression Diseases 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000032841 Bulimia Diseases 0.000 claims 2
- 206010006550 Bulimia nervosa Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 208000027626 Neurocognitive disease Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims 2
- 206010041250 Social phobia Diseases 0.000 claims 2
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims 2
- 208000025748 atypical depressive disease Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 201000010064 diabetes insipidus Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 201000009941 intracranial hypertension Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 2
- 208000022821 personality disease Diseases 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 201000000484 premenstrual tension Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 230000036186 satiety Effects 0.000 claims 2
- 235000019627 satiety Nutrition 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims 2
- 201000002859 sleep apnea Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 238000001179 sorption measurement Methods 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000004584 weight gain Effects 0.000 claims 2
- 235000019786 weight gain Nutrition 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 239000010871 livestock manure Substances 0.000 claims 1
- WRZCAWKMTLRWPR-VSODYHHCSA-N lorcaserin hydrochloride hemihydrate Chemical compound O.Cl.Cl.C[C@H]1CNCCC2=CC=C(Cl)C=C12.C[C@H]1CNCCC2=CC=C(Cl)C=C12 WRZCAWKMTLRWPR-VSODYHHCSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002411 thermogravimetry Methods 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63822104P | 2004-12-21 | 2004-12-21 | |
| US60/638,221 | 2004-12-21 | ||
| PCT/US2005/046983 WO2006069363A2 (en) | 2004-12-21 | 2005-12-20 | Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012114460A Division JP5781008B2 (ja) | 2004-12-21 | 2012-05-18 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008524262A JP2008524262A (ja) | 2008-07-10 |
| JP2008524262A5 true JP2008524262A5 (OSRAM) | 2009-02-05 |
| JP5270167B2 JP5270167B2 (ja) | 2013-08-21 |
Family
ID=36602366
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547060A Expired - Lifetime JP5270167B2 (ja) | 2004-12-21 | 2005-12-20 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
| JP2012114460A Expired - Lifetime JP5781008B2 (ja) | 2004-12-21 | 2012-05-18 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
| JP2014113743A Pending JP2014156490A (ja) | 2004-12-21 | 2014-06-02 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012114460A Expired - Lifetime JP5781008B2 (ja) | 2004-12-21 | 2012-05-18 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
| JP2014113743A Pending JP2014156490A (ja) | 2004-12-21 | 2014-06-02 | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US8168624B2 (OSRAM) |
| EP (3) | EP2327698B1 (OSRAM) |
| JP (3) | JP5270167B2 (OSRAM) |
| KR (1) | KR101281919B1 (OSRAM) |
| CN (2) | CN101084193B (OSRAM) |
| AT (1) | ATE442359T1 (OSRAM) |
| AU (1) | AU2005318959B2 (OSRAM) |
| BR (1) | BRPI0519726B8 (OSRAM) |
| CA (1) | CA2589988C (OSRAM) |
| CU (1) | CU20070138A7 (OSRAM) |
| CY (1) | CY1109599T1 (OSRAM) |
| DE (1) | DE602005016603D1 (OSRAM) |
| DK (1) | DK1838677T3 (OSRAM) |
| EA (2) | EA201200954A1 (OSRAM) |
| ES (1) | ES2332009T3 (OSRAM) |
| HR (1) | HRP20090640T1 (OSRAM) |
| IL (1) | IL183844A (OSRAM) |
| MA (1) | MA29147B1 (OSRAM) |
| ME (1) | ME01090B (OSRAM) |
| NI (1) | NI200700160A (OSRAM) |
| NZ (2) | NZ555981A (OSRAM) |
| PL (1) | PL1838677T3 (OSRAM) |
| PT (1) | PT1838677E (OSRAM) |
| RS (1) | RS50996B (OSRAM) |
| SI (1) | SI1838677T1 (OSRAM) |
| TN (1) | TNSN07235A1 (OSRAM) |
| WO (1) | WO2006069363A2 (OSRAM) |
| ZA (1) | ZA200705125B (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| ES2571220T3 (es) | 2003-06-17 | 2016-05-24 | Arena Pharm Inc | Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina |
| EP2332920A3 (en) | 2003-06-17 | 2011-12-21 | Arena Pharmaceuticals, Inc. | Processes for preparing 3-benzazepines |
| JP5270167B2 (ja) | 2004-12-21 | 2013-08-21 | アリーナ ファーマシューティカルズ， インコーポレイテッド | （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形 |
| DE602005016601D1 (de) | 2004-12-23 | 2009-10-22 | Arena Pharm Inc | 5ht2c-rezeptor-modulator-zusammensetzungen und anwendungsverfahren |
| EP1926712B1 (en) | 2005-09-01 | 2009-07-29 | Eli Lilly And Company | 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
| EP1924560B1 (en) | 2005-09-01 | 2009-08-05 | Eli Lilly And Company | 6-substituted- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
| EP1924561B1 (en) | 2005-09-01 | 2012-11-14 | Eli Lilly & Company | 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists |
| ES2440483T3 (es) | 2005-09-01 | 2014-01-29 | Eli Lilly And Company | 2,3,4,5-Tetrahidro-1H-benzo[d]azepinas sustituidas con heterociclo enlazado en 6-N como agonistas del receptor 5-HT2C |
| US8168782B2 (en) * | 2006-04-03 | 2012-05-01 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates related thereto |
| WO2007140213A1 (en) | 2006-05-26 | 2007-12-06 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| CN101547892B (zh) * | 2006-12-05 | 2014-08-20 | 艾尼纳制药公司 | 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体 |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
| WO2012030951A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Fast-dissolve dosage forms of 5-ht2c agonists |
| KR101913442B1 (ko) | 2010-09-01 | 2018-10-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태 |
| SG188361A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
| WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| SG10201506870PA (en) * | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
| BR112013004707A2 (pt) | 2010-09-01 | 2016-05-10 | Arena Pharm Inc | administração de um composto antiobesidade a indivíduos com comprometimento renal |
| AU2015268758B2 (en) * | 2010-09-01 | 2017-08-24 | Arena Pharmaceuticals, Inc. | Modified-release dosage forms of 5-HT2c agonists useful for weight management |
| US20150297610A1 (en) * | 2012-10-09 | 2015-10-22 | Arena Pharmaceuticals, Inc. | Method of weight management |
| EP2868656A1 (en) | 2013-11-05 | 2015-05-06 | LEK Pharmaceuticals d.d. | Stabilized amorphous lorcaserin hydrochloride |
| WO2015102017A1 (en) * | 2013-11-13 | 2015-07-09 | Cadila Healthcare Limited | Processes for the preparation of lorcaserin |
| WO2015096119A1 (zh) * | 2013-12-27 | 2015-07-02 | 杭州普晒医药科技有限公司 | 氯卡色林盐及其晶体、其制备方法和用途 |
| EP2924024A3 (en) | 2014-03-21 | 2016-01-20 | Medichem, S.A. | Solid forms of lorcaserin hydrochloride |
| US9981912B2 (en) | 2014-04-21 | 2018-05-29 | Hangzhou Pushai Pharmaceutical Technology Co., Ltd. | Cocrystal of lorcaserin, preparation methods, pharmaceutical compositions and uses thereof |
| WO2015170346A1 (en) | 2014-05-09 | 2015-11-12 | Council Of Scientific & Industrial Research | A process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine its enantiomers |
| WO2016069875A1 (en) | 2014-10-30 | 2016-05-06 | Arena Pharmaceuticals, Inc. | Compositions and methods for ceasing tobacco smoking |
| CN104829532A (zh) * | 2015-05-15 | 2015-08-12 | 浙江理工大学 | 一种制备绿卡色林盐酸盐单晶的方法 |
| CN104844512B (zh) * | 2015-05-15 | 2017-03-29 | 东北制药集团股份有限公司 | 一种绿卡色林盐酸盐半水合物晶型的制备方法 |
| HK1245079A1 (zh) | 2015-06-30 | 2018-08-24 | 纽拉德有限公司 | 新颖呼吸控制调节化合物以及其制备和使用方法 |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN120289468A (zh) | 2015-10-16 | 2025-07-11 | 艾伯维公司 | 制备咪唑并[1,2-a]吡咯并[2,3-e]吡嗪类化合物及其固态形式的方法 |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| EP3210975A1 (en) | 2016-02-24 | 2017-08-30 | Enantia, S.L. | Cocrystals of lorcaserin |
| CN106478506B (zh) * | 2016-09-30 | 2019-03-15 | 山东科兴生物制品有限公司 | 半水绿卡色林盐酸盐的制备方法 |
| CN112704670B (zh) * | 2021-01-08 | 2022-07-15 | 安徽中医药大学 | 一种盐酸氯卡色林渗透泵控释制剂及其制备方法 |
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