JP2008524211A5 - - Google Patents
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- Publication number
- JP2008524211A5 JP2008524211A5 JP2007546610A JP2007546610A JP2008524211A5 JP 2008524211 A5 JP2008524211 A5 JP 2008524211A5 JP 2007546610 A JP2007546610 A JP 2007546610A JP 2007546610 A JP2007546610 A JP 2007546610A JP 2008524211 A5 JP2008524211 A5 JP 2008524211A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- methyl
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- RNKWPUZHQPNTNU-LJQANCHMSA-N (5s)-5-[[6-(4-chlorophenyl)-3,4-dihydro-1h-2,7-naphthyridin-2-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione Chemical compound C1CC2=CC(C=3C=CC(Cl)=CC=3)=NC=C2CN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O RNKWPUZHQPNTNU-LJQANCHMSA-N 0.000 claims 1
- ICQYHSNJHJJYCT-HXUWFJFHSA-N (5s)-5-[[6-(4-chlorophenyl)-3,4-dihydro-1h-isoquinolin-2-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione Chemical compound C1CC2=CC(C=3C=CC(Cl)=CC=3)=CC=C2CN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O ICQYHSNJHJJYCT-HXUWFJFHSA-N 0.000 claims 1
- BUQOYLRBXGPDSU-LJQANCHMSA-N (5s)-5-methyl-5-[(6-pyridin-3-yl-3,4-dihydro-1h-isoquinolin-2-yl)sulfonylmethyl]imidazolidine-2,4-dione Chemical compound C1CC2=CC(C=3C=NC=CC=3)=CC=C2CN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O BUQOYLRBXGPDSU-LJQANCHMSA-N 0.000 claims 1
- YOECDUXBAFEAQP-GOSISDBHSA-N (5s)-5-methyl-5-[[6-[2-(trifluoromethyl)pyrimidin-5-yl]-3,4-dihydro-1h-isoquinolin-2-yl]sulfonylmethyl]imidazolidine-2,4-dione Chemical compound C1CC2=CC(C=3C=NC(=NC=3)C(F)(F)F)=CC=C2CN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O YOECDUXBAFEAQP-GOSISDBHSA-N 0.000 claims 1
- DZUUXTVUBNSYHE-JOCHJYFZSA-N 2-[4-[2-[[(4s)-4-methyl-2,5-dioxoimidazolidin-4-yl]methylsulfonyl]-3,4-dihydro-1h-isoquinolin-6-yl]phenyl]acetonitrile Chemical compound C1CC2=CC(C=3C=CC(CC#N)=CC=3)=CC=C2CN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O DZUUXTVUBNSYHE-JOCHJYFZSA-N 0.000 claims 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 235000012501 ammonium carbonate Nutrition 0.000 claims 1
- 239000001099 ammonium carbonate Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 *C(CS(I)(=O)=O)(C(N1)=O)NC1=O Chemical compound *C(CS(I)(=O)=O)(C(N1)=O)NC1=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0403086A SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Compounds |
| PCT/SE2005/001918 WO2006065216A1 (en) | 2004-12-17 | 2005-12-14 | Novel hydantoin derivatives as metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008524211A JP2008524211A (ja) | 2008-07-10 |
| JP2008524211A5 true JP2008524211A5 (https=) | 2009-02-12 |
Family
ID=34075236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546610A Pending JP2008524211A (ja) | 2004-12-17 | 2005-12-14 | メタロプロテイナーゼ阻害剤としての新規ヒダントイン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7700604B2 (https=) |
| EP (1) | EP1831196A4 (https=) |
| JP (1) | JP2008524211A (https=) |
| KR (1) | KR20070090923A (https=) |
| CN (1) | CN101080403B (https=) |
| AR (1) | AR051796A1 (https=) |
| AU (1) | AU2005317287B2 (https=) |
| BR (1) | BRPI0517033A (https=) |
| CA (1) | CA2590843A1 (https=) |
| IL (1) | IL183667A0 (https=) |
| MX (1) | MX2007007025A (https=) |
| NO (1) | NO20073571L (https=) |
| NZ (1) | NZ555832A (https=) |
| RU (2) | RU2378269C2 (https=) |
| SA (1) | SA05260410B1 (https=) |
| SE (1) | SE0403086D0 (https=) |
| TW (1) | TW200635916A (https=) |
| UA (1) | UA89801C2 (https=) |
| WO (1) | WO2006065216A1 (https=) |
| ZA (1) | ZA200705076B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| US7648992B2 (en) * | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| EP1859356B1 (en) * | 2005-03-16 | 2019-07-10 | Sensus Metering Systems Inc. | Method, system, apparatus, and computer program product for determining a physical location of a sensor |
| TW200740769A (en) * | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| AU2009241365B2 (en) | 2008-04-28 | 2015-01-22 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
| AR080374A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida |
| JP6754360B2 (ja) * | 2015-07-09 | 2020-09-09 | 田辺三菱製薬株式会社 | 新規イミド誘導体およびその医薬としての用途 |
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| NL9000386A (nl) | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
| DK161690D0 (da) | 1990-07-05 | 1990-07-05 | Novo Nordisk As | Fremgangsmaade til fremstilling af enantiomere forbindelser |
| IL99957A0 (en) | 1990-11-13 | 1992-08-18 | Merck & Co Inc | Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them |
| PH31245A (en) | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
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| US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| NL9201230A (nl) | 1992-07-09 | 1994-02-01 | Dsm Nv | Werkwijze voor de bereiding van optisch aktief methionineamide. |
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| AU687953B2 (en) | 1993-11-16 | 1998-03-05 | Merck & Co., Inc. | Piperidinylcamphorsulfonyl oxytocin antagonists |
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| WO1997019075A1 (en) | 1995-11-22 | 1997-05-29 | Darwin Discovery Limited | Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (mmp) and/or tumour necrosis factor (tnf) |
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| ATE212619T1 (de) | 1996-10-22 | 2002-02-15 | Upjohn Co | Alpha-amino sulfonyl hydroxamsäure als matrix metalloproteinase inhibitoren |
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| DE59802394D1 (de) | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
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| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100903D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| US6890915B2 (en) | 2001-05-25 | 2005-05-10 | Bristol-Myers Squibb Pharma Company | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
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| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| JP4485941B2 (ja) | 2002-06-05 | 2010-06-23 | 株式会社カネカ | 光学活性α−メチルシステイン誘導体の製造方法 |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SE0202693D0 (sv) * | 2002-09-11 | 2002-09-11 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| AU2003282920A1 (en) * | 2002-10-04 | 2004-05-04 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| US7132432B2 (en) * | 2003-06-05 | 2006-11-07 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) |
| US20040266832A1 (en) | 2003-06-26 | 2004-12-30 | Li Zheng J. | Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine |
| TWI220073B (en) | 2003-07-24 | 2004-08-01 | Au Optronics Corp | Method for manufacturing polysilicon film |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401763D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
-
2004
- 2004-12-17 SE SE0403086A patent/SE0403086D0/sv unknown
-
2005
- 2005-12-14 WO PCT/SE2005/001918 patent/WO2006065216A1/en not_active Ceased
- 2005-12-14 KR KR1020077013484A patent/KR20070090923A/ko not_active Withdrawn
- 2005-12-14 CA CA002590843A patent/CA2590843A1/en not_active Abandoned
- 2005-12-14 MX MX2007007025A patent/MX2007007025A/es not_active Application Discontinuation
- 2005-12-14 UA UAA200706363A patent/UA89801C2/ru unknown
- 2005-12-14 EP EP05815746A patent/EP1831196A4/en not_active Withdrawn
- 2005-12-14 NZ NZ555832A patent/NZ555832A/en not_active IP Right Cessation
- 2005-12-14 JP JP2007546610A patent/JP2008524211A/ja active Pending
- 2005-12-14 RU RU2007126745/04A patent/RU2378269C2/ru not_active IP Right Cessation
- 2005-12-14 CN CN2005800434419A patent/CN101080403B/zh not_active Expired - Fee Related
- 2005-12-14 BR BRPI0517033-8A patent/BRPI0517033A/pt not_active IP Right Cessation
- 2005-12-14 US US11/721,590 patent/US7700604B2/en not_active Expired - Fee Related
- 2005-12-14 AU AU2005317287A patent/AU2005317287B2/en not_active Ceased
- 2005-12-15 AR ARP050105274A patent/AR051796A1/es unknown
- 2005-12-16 TW TW094144601A patent/TW200635916A/zh unknown
- 2005-12-17 SA SA05260410A patent/SA05260410B1/ar unknown
-
2007
- 2007-06-04 IL IL183667A patent/IL183667A0/en unknown
- 2007-06-12 ZA ZA200705076A patent/ZA200705076B/xx unknown
- 2007-07-10 NO NO20073571A patent/NO20073571L/no not_active Application Discontinuation
-
2009
- 2009-09-10 RU RU2009133846/04A patent/RU2009133846A/ru not_active Application Discontinuation
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