JP2008524157A5 - - Google Patents
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- Publication number
- JP2008524157A5 JP2008524157A5 JP2007546040A JP2007546040A JP2008524157A5 JP 2008524157 A5 JP2008524157 A5 JP 2008524157A5 JP 2007546040 A JP2007546040 A JP 2007546040A JP 2007546040 A JP2007546040 A JP 2007546040A JP 2008524157 A5 JP2008524157 A5 JP 2008524157A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- propionamide
- carbonyl
- furan
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 C 1 -C 6 - acylamino Chemical group 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229940080818 propionamide Drugs 0.000 claims 7
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 3
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 claims 2
- QMLKZFUXBWSYPQ-LLVKDONJSA-N (2r)-2-[3-(5-methylfuran-2-carbonyl)phenyl]-n-methylsulfonylpropanamide Chemical compound CS(=O)(=O)NC(=O)[C@H](C)C1=CC=CC(C(=O)C=2OC(C)=CC=2)=C1 QMLKZFUXBWSYPQ-LLVKDONJSA-N 0.000 claims 1
- ALVSFWLWMDNFCI-LLVKDONJSA-N (2r)-2-[3-(cyclopentanecarbonyl)phenyl]-n-methylsulfonylpropanamide Chemical compound CS(=O)(=O)NC(=O)[C@H](C)C1=CC=CC(C(=O)C2CCCC2)=C1 ALVSFWLWMDNFCI-LLVKDONJSA-N 0.000 claims 1
- UDQFAHZEZAPWAA-CQSZACIVSA-N (2r)-2-[3-(cyclopentanecarbonyl)phenyl]-n-pyridin-3-ylpropanamide Chemical compound O=C([C@H](C)C=1C=C(C=CC=1)C(=O)C1CCCC1)NC1=CC=CN=C1 UDQFAHZEZAPWAA-CQSZACIVSA-N 0.000 claims 1
- YCOSKCOPQMFEOM-SECBINFHSA-N (2r)-2-[3-(furan-2-carbonyl)phenyl]-n-hydroxypropanamide Chemical compound ONC(=O)[C@H](C)C1=CC=CC(C(=O)C=2OC=CC=2)=C1 YCOSKCOPQMFEOM-SECBINFHSA-N 0.000 claims 1
- WCJBYBPJIJMSLR-SNVBAGLBSA-N (2r)-2-[3-(furan-2-carbonyl)phenyl]-n-methylsulfonylpropanamide Chemical compound CS(=O)(=O)NC(=O)[C@H](C)C1=CC=CC(C(=O)C=2OC=CC=2)=C1 WCJBYBPJIJMSLR-SNVBAGLBSA-N 0.000 claims 1
- GNJWNKUYSZZYFV-CYBMUJFWSA-N (2r)-2-[3-(furan-2-carbonyl)phenyl]-n-pyridin-2-ylpropanamide Chemical compound O=C([C@H](C)C=1C=C(C=CC=1)C(=O)C=1OC=CC=1)NC1=CC=CC=N1 GNJWNKUYSZZYFV-CYBMUJFWSA-N 0.000 claims 1
- XVLQJHWGFDHHJJ-MRVPVSSYSA-N (2r)-n-hydroxy-2-[3-(1,3-thiazole-2-carbonyl)phenyl]propanamide Chemical compound ONC(=O)[C@H](C)C1=CC=CC(C(=O)C=2SC=CN=2)=C1 XVLQJHWGFDHHJJ-MRVPVSSYSA-N 0.000 claims 1
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- HQISNSLVINRTDG-SNVBAGLBSA-N 2-[[(2r)-2-[3-(furan-2-carbonyl)phenyl]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](C)C1=CC=CC(C(=O)C=2OC=CC=2)=C1 HQISNSLVINRTDG-SNVBAGLBSA-N 0.000 claims 1
- UOZMHOLOTKSDBC-NFJWQWPMSA-N 2-[[(2r)-2-[3-(furan-2-carbonyl)phenyl]propanoyl]amino]propanoic acid Chemical compound OC(=O)C(C)NC(=O)[C@H](C)C1=CC=CC(C(=O)C=2OC=CC=2)=C1 UOZMHOLOTKSDBC-NFJWQWPMSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010061876 Obstruction Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- DXZDEAJXVCLRLE-UHFFFAOYSA-N azepin-2-one Chemical compound O=C1C=CC=CC=N1 DXZDEAJXVCLRLE-UHFFFAOYSA-N 0.000 claims 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N benzofuran Natural products C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 230000035605 chemotaxis Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 0 C[C@](C(N*)=O)[Al] Chemical compound C[C@](C(N*)=O)[Al] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04029684 | 2004-12-15 | ||
| EP04029684.0 | 2004-12-15 | ||
| PCT/EP2005/056742 WO2006063999A1 (en) | 2004-12-15 | 2005-12-13 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008524157A JP2008524157A (ja) | 2008-07-10 |
| JP2008524157A5 true JP2008524157A5 (enExample) | 2009-02-05 |
| JP5100394B2 JP5100394B2 (ja) | 2012-12-19 |
Family
ID=36102640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546040A Expired - Fee Related JP5100394B2 (ja) | 2004-12-15 | 2005-12-13 | ２−アリールプロピオン酸誘導体及びそれを含有する医薬組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7939521B2 (enExample) |
| EP (1) | EP1856031B1 (enExample) |
| JP (1) | JP5100394B2 (enExample) |
| KR (1) | KR101291483B1 (enExample) |
| CN (1) | CN101184726B (enExample) |
| AT (1) | ATE423760T1 (enExample) |
| AU (1) | AU2005315591B2 (enExample) |
| BR (1) | BRPI0519326A2 (enExample) |
| CA (1) | CA2589495C (enExample) |
| CY (1) | CY1109091T1 (enExample) |
| DE (1) | DE602005013001D1 (enExample) |
| DK (1) | DK1856031T3 (enExample) |
| ES (1) | ES2322487T3 (enExample) |
| HR (1) | HRP20090279T1 (enExample) |
| IL (1) | IL183932A (enExample) |
| ME (1) | ME01868B (enExample) |
| MX (1) | MX2007007133A (enExample) |
| NO (1) | NO338627B1 (enExample) |
| NZ (1) | NZ555502A (enExample) |
| PL (1) | PL1856031T3 (enExample) |
| PT (1) | PT1856031E (enExample) |
| RS (1) | RS50962B (enExample) |
| RU (1) | RU2410372C2 (enExample) |
| SI (1) | SI1856031T1 (enExample) |
| WO (1) | WO2006063999A1 (enExample) |
| ZA (1) | ZA200704824B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007056341A1 (en) | 2005-11-08 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of atp-binding cassette transporters |
| AU2007253424B2 (en) * | 2006-05-18 | 2013-03-07 | Dompe' Farmaceutici S.P.A. | (2R)-2-[(4-sulfonyl)aminophenyl]propanamides and pharmaceutical compositions containing them |
| CN104447716A (zh) * | 2007-05-09 | 2015-03-25 | 沃泰克斯药物股份有限公司 | Cftr调节剂 |
| HUE031871T2 (en) | 2007-12-07 | 2017-08-28 | Vertex Pharma | Methods for the preparation of cycloalkylcarboxamide pyridine benzoic acids |
| EP3683218B1 (en) | 2007-12-07 | 2024-09-18 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
| NZ736561A (en) | 2008-02-28 | 2018-02-23 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
| GB0813403D0 (en) * | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| EP2316820A1 (en) * | 2009-10-28 | 2011-05-04 | Dompe S.p.A. | 2-aryl-propionamide derivatives useful as bradykinin receptor antagonists and pharmaceutical compositions containing them |
| GB2475359A (en) * | 2009-11-11 | 2011-05-18 | Biocopea Ltd | A compound for use in treating a fulminant respiratory disorder |
| EP3150198B1 (en) | 2010-04-07 | 2021-09-22 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
| CN103159652B (zh) * | 2011-12-19 | 2016-06-08 | 天津市国际生物医药联合研究院 | 亚磺酰胺类化合物的制备及其应用 |
| CA3128556A1 (en) | 2012-01-25 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
| HRP20210516T2 (hr) | 2013-11-12 | 2021-10-01 | Vertex Pharmaceuticals Incorporated | Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr |
| US9695114B2 (en) | 2013-12-18 | 2017-07-04 | Monsanto Technology Llc | Processes for the diazotization of 2,5-dichloroanilines |
| WO2016081556A1 (en) | 2014-11-18 | 2016-05-26 | Vertex Pharmaceuticals Incorporated | Process of conducting high throughput testing high performance liquid chromatography |
| CN109134281B (zh) * | 2018-08-27 | 2021-10-08 | 浙江山峪科技股份有限公司 | 间二烷胺基苯酚的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1435721A (en) * | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| JPS4981366A (enExample) * | 1972-12-15 | 1974-08-06 | ||
| GB2222588B (en) * | 1988-09-09 | 1991-03-06 | Erba Carlo Spa | Cycloalkyl-substituted 4-aminophenyl derivatives and process for their preparation |
| IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| GB0002029D0 (en) * | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
| IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
| ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
| ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| AU2003225971A1 (en) * | 2002-03-28 | 2003-10-13 | Yang Gao | Substituted biaryl amides as c5a receptor modulators |
-
2005
- 2005-12-13 PL PL05817430T patent/PL1856031T3/pl unknown
- 2005-12-13 CN CN2005800480262A patent/CN101184726B/zh not_active Expired - Fee Related
- 2005-12-13 US US11/721,971 patent/US7939521B2/en not_active Expired - Fee Related
- 2005-12-13 ME MEP-2009-242A patent/ME01868B/me unknown
- 2005-12-13 ZA ZA200704824A patent/ZA200704824B/xx unknown
- 2005-12-13 JP JP2007546040A patent/JP5100394B2/ja not_active Expired - Fee Related
- 2005-12-13 BR BRPI0519326-5A patent/BRPI0519326A2/pt not_active Application Discontinuation
- 2005-12-13 ES ES05817430T patent/ES2322487T3/es not_active Expired - Lifetime
- 2005-12-13 MX MX2007007133A patent/MX2007007133A/es active IP Right Grant
- 2005-12-13 DE DE602005013001T patent/DE602005013001D1/de not_active Expired - Lifetime
- 2005-12-13 WO PCT/EP2005/056742 patent/WO2006063999A1/en not_active Ceased
- 2005-12-13 KR KR1020077015497A patent/KR101291483B1/ko not_active Expired - Fee Related
- 2005-12-13 RS RSP-2009/0242A patent/RS50962B/sr unknown
- 2005-12-13 SI SI200530668T patent/SI1856031T1/sl unknown
- 2005-12-13 HR HR20090279T patent/HRP20090279T1/xx unknown
- 2005-12-13 PT PT05817430T patent/PT1856031E/pt unknown
- 2005-12-13 CA CA2589495A patent/CA2589495C/en not_active Expired - Fee Related
- 2005-12-13 RU RU2007126825/04A patent/RU2410372C2/ru not_active IP Right Cessation
- 2005-12-13 AU AU2005315591A patent/AU2005315591B2/en not_active Ceased
- 2005-12-13 EP EP05817430A patent/EP1856031B1/en not_active Expired - Lifetime
- 2005-12-13 AT AT05817430T patent/ATE423760T1/de active
- 2005-12-13 DK DK05817430T patent/DK1856031T3/da active
- 2005-12-13 NZ NZ555502A patent/NZ555502A/en not_active IP Right Cessation
-
2007
- 2007-06-14 IL IL183932A patent/IL183932A/en not_active IP Right Cessation
- 2007-07-13 NO NO20073622A patent/NO338627B1/no not_active IP Right Cessation
-
2009
- 2009-05-21 CY CY20091100538T patent/CY1109091T1/el unknown
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