JP2008522875A5 - - Google Patents

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Publication number
JP2008522875A5
JP2008522875A5 JP2007545566A JP2007545566A JP2008522875A5 JP 2008522875 A5 JP2008522875 A5 JP 2008522875A5 JP 2007545566 A JP2007545566 A JP 2007545566A JP 2007545566 A JP2007545566 A JP 2007545566A JP 2008522875 A5 JP2008522875 A5 JP 2008522875A5
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JP
Japan
Prior art keywords
mold
mold apparatus
insert
compression core
mold insert
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2007545566A
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English (en)
Japanese (ja)
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JP2008522875A (ja
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Priority claimed from PCT/US2005/044121 external-priority patent/WO2006062974A2/en
Publication of JP2008522875A publication Critical patent/JP2008522875A/ja
Publication of JP2008522875A5 publication Critical patent/JP2008522875A5/ja
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JP2007545566A 2004-12-07 2005-12-07 マイクロニードルの成形方法 Withdrawn JP2008522875A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63431904P 2004-12-07 2004-12-07
PCT/US2005/044121 WO2006062974A2 (en) 2004-12-07 2005-12-07 Method of molding a microneedle

Publications (2)

Publication Number Publication Date
JP2008522875A JP2008522875A (ja) 2008-07-03
JP2008522875A5 true JP2008522875A5 (https=) 2009-01-29

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JP2007545566A Withdrawn JP2008522875A (ja) 2004-12-07 2005-12-07 マイクロニードルの成形方法

Country Status (11)

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US (3) US8088321B2 (https=)
EP (2) EP1824655B1 (https=)
JP (1) JP2008522875A (https=)
KR (1) KR20070098851A (https=)
CN (2) CN102358015A (https=)
AT (1) ATE468961T1 (https=)
AU (1) AU2005314151B2 (https=)
CA (1) CA2589733C (https=)
DE (1) DE602005021541D1 (https=)
IL (1) IL183556A (https=)
WO (1) WO2006062974A2 (https=)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130026511A (ko) * 2004-11-18 2013-03-13 쓰리엠 이노베이티브 프로퍼티즈 컴파니 로우-프로파일 미세 바늘 어레이 인가 장치
WO2006062974A2 (en) * 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127976A2 (en) * 2006-05-01 2007-11-08 Georgia Tech Research Corporation Particle based molding
WO2008157592A1 (en) 2007-06-20 2008-12-24 3M Innovative Properties Company Ultrasonic injection molding on a web
CN101340784A (zh) * 2007-07-04 2009-01-07 深圳富泰宏精密工业有限公司 电子装置机壳及其制造方法
WO2009142741A1 (en) * 2008-05-21 2009-11-26 Theraject, Inc. Method of manufacturing solid solution peforator patches and uses thereof
JP2012509106A (ja) 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
CN102458559B (zh) 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
USD638534S1 (en) 2010-01-08 2011-05-24 Ratio, Inc. Drug delivery device
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
USD619245S1 (en) 2010-01-08 2010-07-06 Ratio, Inc. Drug delivery device
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
EP2563454A4 (en) * 2010-04-28 2014-01-22 Kimberly Clark Co INJECTION MICRONADEL ARRAY AND METHOD FOR FORMING THE MICRONADEL ARRAY
CA2797204C (en) 2010-04-28 2018-06-12 Kimberly-Clark Worldwide, Inc. Device for delivery of rheumatoid arthritis medication
MX2012012317A (es) * 2010-04-28 2012-11-21 Kimberly Clark Co Arreglo de microagujas moldeado por inyeccion y metodo para formar el arreglo de microagujas.
EP2563455A4 (en) 2010-04-28 2014-02-19 Kimberly Clark Co METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER
JP5860033B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド ｓｉＲＮＡ送達用の医療デバイス
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
MX344881B (es) * 2010-12-02 2017-01-11 3M Innovative Properties Co Microagujas de polimero cristalino liquido.
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CN103442876B (zh) * 2011-03-15 2016-07-13 3M创新有限公司 精确成形的制品的超声辅助的模制以及方法
USD687550S1 (en) 2011-06-09 2013-08-06 3M Innovative Properties Company Handle for a micro-needle device
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR20140079429A (ko) 2011-10-27 2014-06-26 킴벌리-클라크 월드와이드, 인크. 생체활성 제제를 전달하기 위한 이식형 기구
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
US10155332B2 (en) * 2011-12-09 2018-12-18 National Taiwan University Of Science And Technology In-mold vibratile injection compression molding method and molding apparatus thereof
CN103301092B (zh) 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
EP4112112A1 (en) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US8663537B2 (en) 2012-05-18 2014-03-04 3M Innovative Properties Company Injection molding apparatus and method
KR102219636B1 (ko) 2012-12-27 2021-02-23 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공형 마이크로니들을 갖는 물품 및 제조 방법
SG11201509546PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising an inverted actuator
SG11201509722PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising a dual cover
US9872975B2 (en) 2013-05-31 2018-01-23 3M Innovative Properties Company Microneedle injection and infusion apparatus and method of using same
ES2871105T3 (es) 2013-07-16 2021-10-28 Kindeva Drug Delivery Lp Artículo que comprende una microaguja
WO2015009530A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle array article
JP6430501B2 (ja) 2013-07-16 2018-11-28 スリーエム イノベイティブ プロパティズ カンパニー 斜角開口部を有する中空マイクロニードル
EP3021930B1 (en) 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10632653B2 (en) * 2014-10-17 2020-04-28 Kao Corporation Fine hollow protrusion manufacturing method
SG10201809690VA (en) 2015-01-21 2018-12-28 3M Innovative Properties Co Microneedle array and method of use
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (ja) * 2016-01-27 2017-08-03 花王株式会社 微細中空突起具の製造方法
KR101747099B1 (ko) * 2016-02-11 2017-06-14 권영덕 생체적합성 고분자를 이용한 마이크로니들의 제조방법
JP6626403B2 (ja) * 2016-05-10 2019-12-25 富士フイルム株式会社 凹状パターンを有するモールドの作製方法、及びパターンシートの製造方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
WO2018211421A1 (en) * 2017-05-19 2018-11-22 Sabic Global Technologies B.V. Methods and systems of producing polymer microneedle arrays via ultrasonic embossing, and resulting microneedle arrays
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
EP3762199A1 (en) * 2018-03-05 2021-01-13 BAE SYSTEMS plc Pre-defined recess
WO2019188796A1 (ja) * 2018-03-27 2019-10-03 富士フイルム株式会社 凹状台座パターンを有するモールドの作製方法及びパターンシートの製造方法
WO2019220320A1 (en) 2018-05-16 2019-11-21 3M Innovative Properties Company Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
EP3698841A1 (en) * 2019-02-19 2020-08-26 L'oreal Injection device
CN113825612B (zh) * 2019-03-15 2025-07-08 国际人造丝公司 减少浇口白晕的方法和用于该方法的模具设计
JP6618647B1 (ja) * 2019-04-26 2019-12-11 三光化成株式会社 微細パターン転写用モールド及び微細パターン成形方法
CN113874065A (zh) 2019-05-16 2021-12-31 联邦高等教育系统匹兹堡大学 用于皮肤和非皮肤药物递送的具有底切特征的微针阵列
DE102019122648B4 (de) 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
BR112022022039A2 (pt) 2020-04-28 2022-12-13 Ticona Llc Conjunto de microagulhas
CN113797435B (zh) * 2020-06-16 2025-05-09 苏州悦肤达医疗科技有限公司 一种微针浇注系统及微针制备方法
CA3163460A1 (en) 2020-07-29 2022-02-03 Joshua Ray Windmiller Continuous analyte monitoring system with microneedle array
CN112454809A (zh) * 2020-09-27 2021-03-09 鹰潭荣嘉集团医疗器械实业有限公司 一种输液器注塑成型装置及方法
KR20220065661A (ko) * 2020-11-13 2022-05-20 주식회사 대웅테라퓨틱스 마이크로니들 어레이 및 이의 제조방법
US12582337B2 (en) 2020-12-03 2026-03-24 Biolinq Incorporated Solid-state substrate-integrated reference electrode and counter electrode
US11389632B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Intradermal drug delivery device
CN112720967B (zh) * 2021-01-18 2025-06-24 优微智点(北京)生物科技有限公司 微阵列透皮给药微针的制作装置及方法
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
SE545874C2 (en) 2021-05-08 2024-02-27 Biolinq Incorporated Fault detection for microneedle array based continuous analyte monitoring device
CA3226577A1 (en) 2021-07-07 2023-01-12 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
CN114260351B (zh) * 2021-12-23 2024-01-26 哈尔滨工业大学 一种大面积阵列微结构跨尺度模压成形装置和方法
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
TWI817854B (zh) * 2022-11-29 2023-10-01 淡江大學學校財團法人淡江大學 微針模具組及使用其製造微針貼片的方法
EP4658168A2 (en) 2023-02-02 2025-12-10 Biolinq, Inc. Method for improved sensor sensitivity of a microneedle-based continuous analyte monitoring system
US12318224B2 (en) 2023-02-23 2025-06-03 Aquilx Incorporated Wearable biosensor device
USD1083977S1 (en) 2023-02-28 2025-07-15 Biolinq Incorporated Display with graphical user interface for a wearable sensor
USD1035004S1 (en) 2023-02-28 2024-07-09 Biolinq Incorporated Wearable sensor
USD1068516S1 (en) 2023-02-28 2025-04-01 Biolinq Incorporated Wearable sensor
USD1083640S1 (en) 2023-05-16 2025-07-15 Biolinq Incorporated Wearable sensor

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US275400A (en) * 1883-04-10 Running-gear for vehicles
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4381963A (en) * 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
JPS6058010B2 (ja) 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4515543A (en) 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US4793954A (en) * 1987-08-17 1988-12-27 The B. F. Goodrich Company Shear processing thermoplastics in the presence of ultrasonic vibration
JPH01182016A (ja) * 1988-01-16 1989-07-19 Etsuhisa Abe プラスチック射出成形方法
JPH01218813A (ja) * 1988-02-29 1989-09-01 Komatsu Ltd プラスチックの成形方法
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
JP3131620B2 (ja) * 1990-11-12 2001-02-05 株式会社不二越 射出圧縮成形法
US5160823A (en) * 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
US5141677A (en) * 1991-01-22 1992-08-25 Minnesota Mining And Manufacturing Company Method of hot stamping intraocular lens bodies
US5152917B1 (en) 1991-02-06 1998-01-13 Minnesota Mining & Mfg Structured abrasive article
US5256360A (en) * 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
DE4222856C1 (https=) * 1992-07-11 1993-05-27 Buerkert Gmbh
US5376317A (en) 1992-12-08 1994-12-27 Galic Maus Ventures Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle
SG64333A1 (en) * 1993-09-13 1999-04-27 Minnesota Mining & Mfg Abrasive article method of manufacture of same method of using same for finishing and a production tool
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
CA2201315A1 (en) 1994-09-30 1996-04-11 Peter Ping Ling Direct introduction of foreign materials into cells
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5645977A (en) * 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
ATE231015T1 (de) * 1996-09-17 2003-02-15 Deka Products Lp System zur medikamentenabgabe durch transport
US6021559A (en) 1996-11-01 2000-02-08 3M Innovative Properties Company Methods of making a cube corner article master mold
US6248281B1 (en) 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
DE69839969D1 (de) * 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
AU3478200A (en) 1999-02-02 2000-08-25 Ortho-Mcneil Pharmaceutical, Inc. Method of manufacture for transdermal matrices
US6306331B1 (en) * 1999-03-24 2001-10-23 International Business Machines Corporation Ultra mold for encapsulating very thin packages
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6361733B1 (en) * 1999-09-22 2002-03-26 Delphi Technologies, Inc. Ultrasonic injection molding
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2573801A (en) * 1999-11-02 2001-05-14 University Of Hawaii Method for fabricating arrays of micro-needles
DE60022540T2 (de) 1999-11-15 2006-06-14 Velcro Ind Befestigungselement für die haut
US6511463B1 (en) * 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) * 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
ES2717656T3 (es) * 2000-11-30 2019-06-24 Valeritas Inc Dispositivo con microsonda amovible sustancialmente libre sobre el alojamiento
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
WO2002100466A2 (en) * 2001-06-08 2002-12-19 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
WO2003002069A2 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
CA2500453A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
CN100387318C (zh) * 2001-10-31 2008-05-14 中国科学院电工研究所 透过皮肤给药的微型针阵列片及其制造方法
EP1451584B1 (en) * 2001-11-09 2011-05-11 3dbiosurfaces Technologies, LLC High surface area substrates for microarrays and methods to make same
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US20030215816A1 (en) 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
KR20120087197A (ko) * 2002-07-19 2012-08-06 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
NL1021421C2 (nl) 2002-09-10 2004-03-11 Fountain Patents B V Inrichting en werkwijze voor het vervaardigen van producten uit een warm plastische massa.
JP2004114552A (ja) * 2002-09-27 2004-04-15 Mitsuboshi Belting Ltd 針状体の製造方法および針状体
DE10246942A1 (de) * 2002-10-08 2004-04-22 Battenfeld Gmbh Vorrichtung zum Erzeugen von Mikrostrukturen
KR100563330B1 (ko) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Ｌｉｇａ공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법
DE10325260A1 (de) * 2003-06-03 2004-12-30 Gauss, Ralph Kunststoffeinspritzeinheit durch Doppelnadel
WO2005000382A2 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
EP1643918A1 (en) * 2003-07-02 2006-04-12 Alza Corporation Microprojection array immunization patch and method
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1675539A4 (en) * 2003-10-24 2007-09-12 Alza Corp METHOD AND SYSTEM FOR PRETREATMENT FOR IMPROVING TRANSDERMAL DRUG DELIVERY
CN1905842A (zh) 2003-11-21 2007-01-31 阿尔扎公司 超声促进疫苗透皮释放的方法和系统
EP1718452A1 (en) * 2004-02-23 2006-11-08 3M Innovative Properties Company Method of molding for microneedle arrays
WO2006062974A2 (en) * 2004-12-07 2006-06-15 3M Innovative Properties Company Method of molding a microneedle
WO2007075806A2 (en) * 2005-12-23 2007-07-05 3M Innovative Properties Company Manufacturing microneedle arrays

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