JP2008520687A5 - - Google Patents
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- Publication number
- JP2008520687A5 JP2008520687A5 JP2007543219A JP2007543219A JP2008520687A5 JP 2008520687 A5 JP2008520687 A5 JP 2008520687A5 JP 2007543219 A JP2007543219 A JP 2007543219A JP 2007543219 A JP2007543219 A JP 2007543219A JP 2008520687 A5 JP2008520687 A5 JP 2008520687A5
- Authority
- JP
- Japan
- Prior art keywords
- neural stem
- neurons
- population
- stem cell
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 230000021164 cell adhesion Effects 0.000 claims description 2
- 210000001178 neural stem cell Anatomy 0.000 claims 9
- 210000002569 neuron Anatomy 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 4
- 239000003102 growth factor Substances 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 210000000278 spinal cord Anatomy 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 claims 1
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62922004P | 2004-11-17 | 2004-11-17 | |
| US60/629,220 | 2004-11-17 | ||
| PCT/US2005/041631 WO2006055685A2 (en) | 2004-11-17 | 2005-11-17 | Transplantation of human neural cells for treatment of neurodegenerative conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012020641A Division JP5805551B2 (ja) | 2004-11-17 | 2012-02-02 | 神経変性状態を治療するためのヒト神経細胞の移植 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520687A JP2008520687A (ja) | 2008-06-19 |
| JP2008520687A5 true JP2008520687A5 (https=) | 2012-03-22 |
| JP5424559B2 JP5424559B2 (ja) | 2014-02-26 |
Family
ID=36407743
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543219A Expired - Fee Related JP5424559B2 (ja) | 2004-11-17 | 2005-11-17 | 神経変性状態を治療するためのヒト神経細胞の移植 |
| JP2012020641A Expired - Fee Related JP5805551B2 (ja) | 2004-11-17 | 2012-02-02 | 神経変性状態を治療するためのヒト神経細胞の移植 |
| JP2014262195A Expired - Fee Related JP5981526B2 (ja) | 2004-11-17 | 2014-12-25 | 神経変性状態を治療するためのヒト神経細胞の移植 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012020641A Expired - Fee Related JP5805551B2 (ja) | 2004-11-17 | 2012-02-02 | 神経変性状態を治療するためのヒト神経細胞の移植 |
| JP2014262195A Expired - Fee Related JP5981526B2 (ja) | 2004-11-17 | 2014-12-25 | 神経変性状態を治療するためのヒト神経細胞の移植 |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US7691629B2 (https=) |
| EP (2) | EP1814979B1 (https=) |
| JP (3) | JP5424559B2 (https=) |
| KR (2) | KR101429284B1 (https=) |
| CN (2) | CN101084303A (https=) |
| ES (1) | ES2537004T3 (https=) |
| HK (1) | HK1202238A1 (https=) |
| IL (2) | IL183092A (https=) |
| IN (1) | IN2014CN03629A (https=) |
| NO (1) | NO340914B1 (https=) |
| PH (1) | PH12015501195B1 (https=) |
| RU (2) | RU2434636C2 (https=) |
| WO (1) | WO2006055685A2 (https=) |
Families Citing this family (50)
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| US7838292B1 (en) * | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| EP1814979B1 (en) | 2004-11-17 | 2015-04-08 | Neuralstem, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
| AU2006220696B2 (en) | 2005-03-07 | 2010-08-19 | Sanbio, Inc. | Use of neuronal precursor cells for treatment of central nervous system lesions |
| GB0822246D0 (en) | 2008-12-05 | 2009-01-14 | Reneuron Ltd | Composition |
| CN102387807A (zh) | 2008-12-19 | 2012-03-21 | 先进科技及再生医学有限责任公司 | 肺部疾病和病症的治疗 |
| BRPI0923177A2 (pt) * | 2008-12-19 | 2020-08-25 | Advanced Technologies And Regenerative Medicine, Llc | usos de composições para tratar dor neuropática e espacidade, as referidas composições, e kit |
| GB0902034D0 (en) | 2009-02-06 | 2009-03-11 | Reneuron Ltd | Method |
| US10386360B2 (en) | 2009-03-13 | 2019-08-20 | University Of Central Florida Research Foundation, Inc. | Bio-microelectromechanical system transducer and associated methods |
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| US8835168B2 (en) | 2009-04-23 | 2014-09-16 | University Of Central Florida Research Foundation, Inc. | Synthetic mammalian neuromuscular junction and method of making |
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| US10357517B1 (en) | 2012-10-01 | 2019-07-23 | University Of South Florida | Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592 |
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| US10694747B2 (en) | 2012-11-21 | 2020-06-30 | S. C. Johnson & Son, Inc. | Dispenser comprising only one single hinge |
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| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| CN104278008B (zh) | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| KR101675123B1 (ko) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물 |
| EP3584312A1 (en) * | 2014-06-27 | 2019-12-25 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus e4orf1, and methods of making and using the same |
| US10935541B2 (en) | 2014-08-07 | 2021-03-02 | University Of Central Florida Research Foundation, Inc. | Devices and methods comprising neuromuscular junctions |
| WO2016064737A1 (en) | 2014-10-20 | 2016-04-28 | Neuralstem, Inc. | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
| US10286009B2 (en) * | 2015-05-16 | 2019-05-14 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
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| EP3412296B1 (en) * | 2016-02-05 | 2025-11-12 | Kyungpook National University Industry-Academic Cooperation Foundation | Pharmaceutical composition containing stem cell in which vascular endothelial growth factor is overexpressed as effective ingredient for preventing or treating neurodegenerative disease |
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| FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
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| KR20260020476A (ko) | 2019-01-23 | 2026-02-11 | 아스테리아스 바이오세라퓨틱스, 인크. | 인간 만능 줄기 세포로부터의 배측-유래된 희소돌기아교세포 전구 세포 |
| CN111494422B (zh) * | 2019-01-29 | 2022-04-29 | 中国科学院遗传与发育生物学研究所 | 治疗脊髓损伤的产品及其应用 |
| WO2021132600A1 (ja) | 2019-12-27 | 2021-07-01 | 株式会社Ｒａｉｎｂｏｗ | 頭蓋内に安全に細胞を投与するための総合システム |
| CN115166260B (zh) * | 2022-07-11 | 2023-06-13 | 东南大学 | 血浆脑细胞来源外泌体中维生素d结合蛋白在诊断抑郁症中的应用 |
| CN118064356A (zh) | 2022-11-22 | 2024-05-24 | 浙江霍德生物工程有限公司 | 前脑神经前体细胞在治疗与前脑神经细胞的死亡和/或功能不全相关的疾病中的应用 |
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-
2005
- 2005-11-17 EP EP05851748.3A patent/EP1814979B1/en not_active Expired - Lifetime
- 2005-11-17 KR KR1020077012097A patent/KR101429284B1/ko not_active Expired - Fee Related
- 2005-11-17 IN IN3629CHN2014 patent/IN2014CN03629A/en unknown
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- 2005-11-17 KR KR1020137020263A patent/KR101505347B1/ko not_active Expired - Fee Related
- 2005-11-17 CN CNA2005800394500A patent/CN101084303A/zh active Pending
- 2005-11-17 RU RU2007122507/14A patent/RU2434636C2/ru not_active IP Right Cessation
- 2005-11-17 WO PCT/US2005/041631 patent/WO2006055685A2/en not_active Ceased
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- 2005-11-17 CN CN201410240718.8A patent/CN104042629A/zh active Pending
- 2005-11-17 ES ES05851748.3T patent/ES2537004T3/es not_active Expired - Lifetime
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2007
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2009
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2010
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2011
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2012
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2013
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2014
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2015
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2017
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