JP2008518035A5 - - Google Patents
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- Publication number
- JP2008518035A5 JP2008518035A5 JP2007539189A JP2007539189A JP2008518035A5 JP 2008518035 A5 JP2008518035 A5 JP 2008518035A5 JP 2007539189 A JP2007539189 A JP 2007539189A JP 2007539189 A JP2007539189 A JP 2007539189A JP 2008518035 A5 JP2008518035 A5 JP 2008518035A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- hydrogen
- alkynyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 Tetracycline compounds Chemical class 0.000 claims 46
- 229910052739 hydrogen Inorganic materials 0.000 claims 44
- 239000001257 hydrogen Substances 0.000 claims 44
- 125000000217 alkyl group Chemical group 0.000 claims 34
- 150000002431 hydrogen Chemical class 0.000 claims 26
- 125000003342 alkenyl group Chemical group 0.000 claims 24
- 239000004098 Tetracycline Substances 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 22
- 229960002180 tetracycline Drugs 0.000 claims 22
- 229930101283 tetracycline Natural products 0.000 claims 22
- 235000019364 tetracycline Nutrition 0.000 claims 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 21
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims 19
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 18
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 18
- 125000004414 alkyl thio group Chemical group 0.000 claims 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 16
- 150000002148 esters Chemical class 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 15
- 239000000651 prodrug Substances 0.000 claims 15
- 229940002612 prodrug Drugs 0.000 claims 15
- 125000003282 alkyl amino group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 10
- 125000002252 acyl group Chemical class 0.000 claims 9
- 125000004103 aminoalkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 7
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 7
- 125000005018 aryl alkenyl group Chemical group 0.000 claims 6
- 125000005015 aryl alkynyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 4
- 150000007942 carboxylates Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical class *C#N 0.000 claims 4
- 150000003522 tetracyclines Chemical class 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000005084 alkoxyalkylaminoalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 claims 2
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 claims 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 2
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000003435 aroyl group Chemical group 0.000 claims 2
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000495778 Escherichia faecalis Species 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000004946 alkenylalkyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 150000001349 alkyl fluorides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229940072172 tetracycline antibiotic Drugs 0.000 claims 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 C[C@](C([C@](C(C1C(C(C(*)=O)=C2O)=[N-])[C@@]2N(C)C)O)C2=C1O)c(ccc(CNCc1ccccc1)c1O)c1C2=O Chemical compound C[C@](C([C@](C(C1C(C(C(*)=O)=C2O)=[N-])[C@@]2N(C)C)O)C2=C1O)c(ccc(CNCc1ccccc1)c1O)c1C2=O 0.000 description 6
- CQYRZWXZTMADFF-LFINXQGZSA-N C[C@H]([C@@H]([C@@H](C(C1C(C(C(N)=O)=C2O)=O)[C@@H]2N(C)C)O)C2=C1O)c1ccc(CCC(NC(C)(C)C)=O)c(O)c1C2=O Chemical compound C[C@H]([C@@H]([C@@H](C(C1C(C(C(N)=O)=C2O)=O)[C@@H]2N(C)C)O)C2=C1O)c1ccc(CCC(NC(C)(C)C)=O)c(O)c1C2=O CQYRZWXZTMADFF-LFINXQGZSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62202704P | 2004-10-25 | 2004-10-25 | |
| US62274904P | 2004-10-27 | 2004-10-27 | |
| PCT/US2005/039014 WO2006047756A2 (en) | 2004-10-25 | 2005-10-25 | Substituted tetracycline compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012014078A Division JP2012111770A (ja) | 2004-10-25 | 2012-01-26 | 置換テトラサイクリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518035A JP2008518035A (ja) | 2008-05-29 |
| JP2008518035A5 true JP2008518035A5 (enExample) | 2008-12-18 |
Family
ID=35842579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539189A Pending JP2008518035A (ja) | 2004-10-25 | 2005-10-25 | 置換テトラサイクリン化合物 |
| JP2012014078A Pending JP2012111770A (ja) | 2004-10-25 | 2012-01-26 | 置換テトラサイクリン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012014078A Pending JP2012111770A (ja) | 2004-10-25 | 2012-01-26 | 置換テトラサイクリン化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8466132B2 (enExample) |
| EP (18) | EP2284152A3 (enExample) |
| JP (2) | JP2008518035A (enExample) |
| AU (1) | AU2005299569B2 (enExample) |
| CA (1) | CA2585248A1 (enExample) |
| IL (2) | IL182728A (enExample) |
| WO (1) | WO2006047756A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| JP2002501026A (ja) * | 1998-01-23 | 2002-01-15 | トルスティーズ オブ トゥフツ カレッジ | 薬学的に活性の化合物及びその利用法 |
| PT1240133E (pt) * | 1999-09-14 | 2006-07-31 | Tufts College | Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| KR100997596B1 (ko) * | 2000-07-07 | 2010-11-30 | 파라테크 파마슈티컬스, 인크. | 7-치환 테트라사이클린 화합물 |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| MXPA03000055A (es) | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de monociclina sustituidos en posicion 9.. |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP2311797A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| EA012136B1 (ru) * | 2002-07-12 | 2009-08-28 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
| EP1648859B1 (en) * | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2284152A3 (en) | 2004-10-25 | 2011-10-05 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1848685A1 (en) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| AU2006272698B2 (en) * | 2005-07-21 | 2012-11-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| CA2652347A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| ES2548261T3 (es) * | 2006-12-21 | 2015-10-15 | Paratek Pharmaceuticals, Inc. | Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
| AU2007338681B2 (en) * | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| JP5395052B2 (ja) * | 2007-03-23 | 2014-01-22 | モレキュラー リサーチ センター インコーポレイテッド | 炎症を処置するための組成物および方法 |
| US7935687B2 (en) | 2007-04-12 | 2011-05-03 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| WO2008134048A2 (en) * | 2007-04-27 | 2008-11-06 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing and purifying aminoalkyl tetracycline compounds |
| CN101784517A (zh) | 2007-07-06 | 2010-07-21 | 帕拉特克药品公司 | 合成取代的四环素化合物的方法 |
| WO2009111064A2 (en) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| CA2721399A1 (en) * | 2008-04-14 | 2009-10-22 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2730377C (en) | 2008-07-11 | 2017-09-19 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
| WO2010033939A1 (en) * | 2008-09-19 | 2010-03-25 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
| ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
| JP5944825B2 (ja) * | 2009-08-28 | 2016-07-05 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物 |
| BRPI1106121A2 (pt) * | 2011-11-25 | 2015-12-08 | Univ Minas Gerais | composições farmacêuticas contendo 11, 12-pirazolminociclina e uso para alívio de dor de origem neuropática |
| CN102603683B (zh) * | 2012-02-10 | 2014-04-09 | 山东大学 | 一种呋喃类化合物及其制备方法与应用 |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| ES2978198T3 (es) | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
| CN110087655A (zh) | 2016-11-01 | 2019-08-02 | 帕拉特克药品公司 | 9-氨基甲基米诺环素化合物及其在治疗社区获得性细菌性肺炎(cabp)中的用途 |
| US11807623B2 (en) | 2017-11-30 | 2023-11-07 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| WO2019241466A1 (en) | 2018-06-13 | 2019-12-19 | Texas Tech University System | Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes |
| KR20230009454A (ko) * | 2020-05-13 | 2023-01-17 | 루넬라 바이오테크 인코포레이티드 | 암 줄기 세포 표적화 및 전이 예방을 위한 9-아미노-독시사이클린의 미리스토일 유도체 |
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-
2005
- 2005-10-25 EP EP10182876A patent/EP2284152A3/en not_active Withdrawn
- 2005-10-25 EP EP10183111A patent/EP2305637A3/en not_active Withdrawn
- 2005-10-25 EP EP08017317A patent/EP2033950A1/en not_active Withdrawn
- 2005-10-25 EP EP10184179A patent/EP2284153A3/en not_active Withdrawn
- 2005-10-25 EP EP10182875A patent/EP2269978A3/en not_active Withdrawn
- 2005-10-25 EP EP15165987.7A patent/EP2949644A3/en not_active Withdrawn
- 2005-10-25 EP EP20100182880 patent/EP2269985A3/en not_active Withdrawn
- 2005-10-25 EP EP10184202A patent/EP2287150A3/en not_active Withdrawn
- 2005-10-25 JP JP2007539189A patent/JP2008518035A/ja active Pending
- 2005-10-25 EP EP10182871A patent/EP2284151A3/en not_active Withdrawn
- 2005-10-25 EP EP10184238A patent/EP2287148A3/en not_active Withdrawn
- 2005-10-25 EP EP10182869A patent/EP2284150A3/en not_active Withdrawn
- 2005-10-25 AU AU2005299569A patent/AU2005299569B2/en not_active Ceased
- 2005-10-25 EP EP10182873A patent/EP2284164A3/en not_active Withdrawn
- 2005-10-25 EP EP10182877A patent/EP2284156A3/en not_active Withdrawn
- 2005-10-25 WO PCT/US2005/039014 patent/WO2006047756A2/en not_active Ceased
- 2005-10-25 EP EP10182872A patent/EP2295419A3/en not_active Withdrawn
- 2005-10-25 EP EP10182867A patent/EP2269991A3/en not_active Withdrawn
- 2005-10-25 EP EP10184262A patent/EP2287140A3/en not_active Withdrawn
- 2005-10-25 CA CA002585248A patent/CA2585248A1/en not_active Abandoned
- 2005-10-25 EP EP10182879A patent/EP2284155A3/en not_active Withdrawn
- 2005-10-25 EP EP05824836A patent/EP1807387A2/en not_active Withdrawn
- 2005-10-25 US US11/258,622 patent/US8466132B2/en not_active Expired - Fee Related
-
2007
- 2007-04-22 IL IL182728A patent/IL182728A/en not_active IP Right Cessation
-
2011
- 2011-05-29 IL IL213209A patent/IL213209A0/en unknown
-
2012
- 2012-01-26 JP JP2012014078A patent/JP2012111770A/ja active Pending
-
2013
- 2013-06-14 US US13/918,197 patent/US20140155357A1/en not_active Abandoned
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