JP2008517977A5 - - Google Patents

Info

Publication number

JP2008517977A5

JP2008517977A5 JP2007538414A JP2007538414A JP2008517977A5 JP 2008517977 A5 JP2008517977 A5 JP 2008517977A5 JP 2007538414 A JP2007538414 A JP 2007538414A JP 2007538414 A JP2007538414 A JP 2007538414A JP 2008517977 A5 JP2008517977 A5 JP 2008517977A5

Authority

JP

Japan

Prior art keywords

cyclo

dap

trp

phe

leu

Prior art date

2005-10-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 206010021746 Infantile colic Diseases 0.000 claims description 3
• 238000009472 formulation Methods 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 239000002462 tachykinin receptor antagonist Substances 0.000 claims 6
• 239000005557 antagonist Substances 0.000 claims 5
• 235000013305 food Nutrition 0.000 claims 3
• 108010092101 MEN 11420 Proteins 0.000 claims 2
• 102000003141 Tachykinin Human genes 0.000 claims 2
• WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 claims 2
• 125000001488 beta-D-galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 2
• NGCNKEZHGRXHNL-WVWQGFTISA-N n-[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-2-[(1s,4s,7s,10s,13s,16s)-13-benzyl-16-(1h-indol-3-ylmethyl)-7-(2-methylpropyl)-3,6,9,12,15,18,20-heptaoxo-2,5,8,11,14,17,21-heptazabicyclo[8.8.4]docosan-4-yl]acetamide Chemical compound C([C@H]1C(=O)N[C@H]2CC(=O)NC[C@H](NC(=O)[C@H](CC=3C=CC=CC=3)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC2=O)C(=O)N[C@H](C(N1)=O)CC(C)C)C(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O NGCNKEZHGRXHNL-WVWQGFTISA-N 0.000 claims 2
• 229950000640 nepadutant Drugs 0.000 claims 2
• 239000006188 syrup Substances 0.000 claims 2
• 235000020357 syrup Nutrition 0.000 claims 2
• 108060008037 tachykinin Proteins 0.000 claims 2
• 208000002881 Colic Diseases 0.000 claims 1
• 239000008267 milk Substances 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 239000002746 neurokinin 2 receptor antagonist Substances 0.000 claims 1
• 239000008203 oral pharmaceutical composition Substances 0.000 claims 1
• 241000700159 Rattus Species 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1