JP2008517917A - 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド - Google Patents
癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62079404P | 2004-10-21 | 2004-10-21 | |
| PCT/US2005/037739 WO2006047214A2 (en) | 2004-10-21 | 2005-10-21 | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517917A true JP2008517917A (ja) | 2008-05-29 |
| JP2008517917A5 JP2008517917A5 (https=) | 2008-12-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538030A Pending JP2008517917A (ja) | 2004-10-21 | 2005-10-21 | 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド |
Country Status (5)
| Country | Link |
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| US (2) | US8017102B2 (https=) |
| EP (1) | EP1812082B1 (https=) |
| JP (1) | JP2008517917A (https=) |
| CA (1) | CA2582552A1 (https=) |
| WO (1) | WO2006047214A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017519753A (ja) * | 2014-06-13 | 2017-07-20 | トラスティーズ オブ タフツ カレッジ | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US10709722B2 (en) | 2014-06-13 | 2020-07-14 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2582552A1 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
| WO2008079324A1 (en) * | 2006-12-21 | 2008-07-03 | Boston Biomedical Research Institute | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity |
| WO2008124166A2 (en) | 2007-04-09 | 2008-10-16 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
| JP5264725B2 (ja) * | 2007-06-29 | 2013-08-14 | 第一三共株式会社 | ペプチド性薬物の粘膜吸収促進剤を含有する粘膜投与用組成物、及びその投与方法 |
| AU2009210570B2 (en) | 2008-01-30 | 2014-11-20 | Indiana University Research And Technology Corporation | Ester-based insulin prodrugs |
| WO2010080606A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| CN102307584A (zh) * | 2008-12-19 | 2012-01-04 | 印第安纳大学研究及科技有限公司 | 表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子 |
| BR112012029611A2 (pt) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | proteína de fusão biespecífica, composição farmacêutica, método de tratamento de dano ao tecido em um indivíduo, método de promoção da regeração ou sobrevivência do tecido em um indivíduo e molécula de ácido nucleico |
| EP2582719B1 (en) | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| JP5912112B2 (ja) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | アミド系インスリンプロドラッグ |
| ES2695161T3 (es) | 2011-12-14 | 2019-01-02 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| AU2013323669B2 (en) | 2012-09-26 | 2018-03-01 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| JP6835590B2 (ja) * | 2014-01-12 | 2021-02-24 | アイジーエフ オンコロジー、 エルエルシー | インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用 |
| WO2016049174A1 (en) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Lipidated amide-based insulin prodrugs |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| CN115960249A (zh) | 2015-10-02 | 2023-04-14 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| EP3595699A4 (en) * | 2017-03-16 | 2020-12-23 | Blaze Bioscience, Inc. | PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE |
| WO2018217669A1 (en) | 2017-05-21 | 2018-11-29 | Igf Oncology, Llc | An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
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| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| US20030092631A1 (en) * | 2001-03-14 | 2003-05-15 | Genentech, Inc. | IGF antagonist peptides |
| JP2004520808A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
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| EP0316408A1 (en) | 1987-05-11 | 1989-05-24 | Procyte Corporation | Method of tumor inhibition in warm-blooded animals |
| IL106992A (en) * | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| EP0494046B1 (de) * | 1990-12-31 | 1994-04-13 | Fatzer Ag | Vorrichtung zur Stossdämpfung für ein auf Zug beanspruchtes Seil für Steinschlag- und Schneeverbauungen |
| ATE124742T1 (de) * | 1992-02-18 | 1995-07-15 | Fatzer Ag | Spiraldrahtseilanker, insbesondere zur verankerung von steinschlag- und lawinenschutzsystemen. |
| AU3973793A (en) | 1992-04-27 | 1993-11-29 | New England Deaconess Hospital Corporation | Method of treating cancer |
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| CA2145829C (en) * | 1994-04-08 | 2003-03-18 | Bernhard Eicher | Method and apparatus for producing a retaining net |
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| CH692921A5 (de) * | 1998-02-25 | 2002-12-13 | Fatzer Ag | Drahtgeflecht vorzugsweise als Steinschlagschutz oder für die Sicherung einer Erdoberflächenschicht. |
| US7173005B2 (en) * | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| US6050038A (en) * | 1998-09-11 | 2000-04-18 | Fey; James M. | Foundation system for supporting a superstructure |
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| WO2001072771A2 (en) * | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
| JP2003535144A (ja) | 2000-06-07 | 2003-11-25 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | 多能性造血幹細胞の流動を刺激するヒト成長ホルモン |
| CH695104A5 (de) * | 2000-11-13 | 2005-12-15 | Fatzer Ag | Auffangnetz insbesondere für Steinschlagverbauungen |
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| EP1680073B1 (en) * | 2003-10-21 | 2013-01-02 | IGF Oncology, LLC | Compounds and method for treating cancer |
| CA2582552A1 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
-
2005
- 2005-10-21 CA CA002582552A patent/CA2582552A1/en not_active Abandoned
- 2005-10-21 JP JP2007538030A patent/JP2008517917A/ja active Pending
- 2005-10-21 WO PCT/US2005/037739 patent/WO2006047214A2/en not_active Ceased
- 2005-10-21 EP EP05809814.6A patent/EP1812082B1/en not_active Expired - Lifetime
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2007
- 2007-04-20 US US11/788,627 patent/US8017102B2/en active Active
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2011
- 2011-08-15 US US13/210,359 patent/US8920777B2/en not_active Expired - Lifetime
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| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| JP2004520808A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| US20030092631A1 (en) * | 2001-03-14 | 2003-05-15 | Genentech, Inc. | IGF antagonist peptides |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017519753A (ja) * | 2014-06-13 | 2017-07-20 | トラスティーズ オブ タフツ カレッジ | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US10709722B2 (en) | 2014-06-13 | 2020-07-14 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP2020183448A (ja) * | 2014-06-13 | 2020-11-12 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US11033525B2 (en) | 2014-06-13 | 2021-06-15 | Bach Biosciences, Llc | Fap-activated therapeutic agents, and uses related thereto |
| US11266669B2 (en) | 2014-06-13 | 2022-03-08 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP7093912B2 (ja) | 2014-06-13 | 2022-07-01 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| JP2022116203A (ja) * | 2014-06-13 | 2022-08-09 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US11925655B2 (en) | 2014-06-13 | 2024-03-12 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| US12023316B2 (en) | 2014-06-13 | 2024-07-02 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| US12053450B2 (en) | 2014-06-13 | 2024-08-06 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP7530111B2 (ja) | 2014-06-13 | 2024-08-07 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US12121505B2 (en) | 2014-06-13 | 2024-10-22 | Bach Biosciences, Llc | Fap-activated therapeutic agents, and uses related thereto |
| JP2024150608A (ja) * | 2014-06-13 | 2024-10-23 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812082B1 (en) | 2013-08-14 |
| US8920777B2 (en) | 2014-12-30 |
| US20070224119A1 (en) | 2007-09-27 |
| WO2006047214A2 (en) | 2006-05-04 |
| CA2582552A1 (en) | 2006-05-04 |
| WO2006047214A3 (en) | 2006-06-15 |
| EP1812082A2 (en) | 2007-08-01 |
| US8017102B2 (en) | 2011-09-13 |
| US20110301340A1 (en) | 2011-12-08 |
| EP1812082A4 (en) | 2010-06-02 |
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