JP2008517917A - 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド - Google Patents
癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド Download PDFInfo
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- 238000006467 substitution reaction Methods 0.000 description 1
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- 238000004809 thin layer chromatography Methods 0.000 description 1
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- 230000004614 tumor growth Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62079404P | 2004-10-21 | 2004-10-21 | |
| PCT/US2005/037739 WO2006047214A2 (en) | 2004-10-21 | 2005-10-21 | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517917A true JP2008517917A (ja) | 2008-05-29 |
| JP2008517917A5 JP2008517917A5 (https=) | 2008-12-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538030A Pending JP2008517917A (ja) | 2004-10-21 | 2005-10-21 | 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8017102B2 (https=) |
| EP (1) | EP1812082B1 (https=) |
| JP (1) | JP2008517917A (https=) |
| CA (1) | CA2582552A1 (https=) |
| WO (1) | WO2006047214A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017519753A (ja) * | 2014-06-13 | 2017-07-20 | トラスティーズ オブ タフツ カレッジ | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US10709722B2 (en) | 2014-06-13 | 2020-07-14 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047214A2 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
| US7749966B2 (en) * | 2006-12-21 | 2010-07-06 | Boston Biomedical Research Institute | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity |
| CA2930681C (en) | 2007-04-09 | 2019-10-15 | The Board Of Trustees Of The University Of Arkansas | Fusion protein of collagen-binding domain and parathyroid hormone |
| JP5264725B2 (ja) | 2007-06-29 | 2013-08-14 | 第一三共株式会社 | ペプチド性薬物の粘膜吸収促進剤を含有する粘膜投与用組成物、及びその投与方法 |
| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン類似体 |
| EP2376099A4 (en) * | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| EP2571992B1 (en) | 2010-05-21 | 2018-04-25 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
| JP5969469B2 (ja) | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| EP2585102B1 (en) | 2010-06-24 | 2015-05-06 | Indiana University Research and Technology Corporation | Amide-based insulin prodrugs |
| US9579273B2 (en) | 2011-12-14 | 2017-02-28 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| BR112014015156A2 (pt) | 2011-12-20 | 2020-10-27 | Indiana University Research And Technology Corporation | análogos de insulina à base de ctp, seus métodos de produção e uso no tratamento de hiperglicemia, bem como sequência de ácido nucleico e célula hospedeira |
| EP3395358B1 (en) | 2012-09-26 | 2019-11-06 | Indiana University Research and Technology Corporation | Insulin analog dimers |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン‐インクレチン複合物 |
| CA2936675C (en) | 2014-01-12 | 2023-06-27 | Igf Oncology, Llc | Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses thereof |
| CN108271356A (zh) | 2014-09-24 | 2018-07-10 | 印第安纳大学研究及科技有限公司 | 肠降血糖素-胰岛素缀合物 |
| JP6701208B2 (ja) | 2014-09-24 | 2020-05-27 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 脂質化アミド系インスリンプロドラッグ |
| CN108367048B (zh) | 2015-10-02 | 2022-08-12 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| EP3595699A4 (en) * | 2017-03-16 | 2020-12-23 | Blaze Bioscience, Inc. | PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE |
| CN117442747A (zh) | 2017-05-21 | 2024-01-26 | Igf肿瘤公司 | 胰岛素样生长因子——用于治疗骨髓增生异常综合症的化学治疗缀合物 |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| US20030092631A1 (en) * | 2001-03-14 | 2003-05-15 | Genentech, Inc. | IGF antagonist peptides |
| JP2004520808A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988008715A1 (en) | 1987-05-11 | 1988-11-17 | Procyte Corporation | Method of tumor inhibition in warm-blooded animals |
| IL106992A (en) * | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| DE59101382D1 (de) * | 1990-12-31 | 1994-05-19 | Fatzer Ag Romanshorn | Vorrichtung zur Stossdämpfung für ein auf Zug beanspruchtes Seil für Steinschlag- und Schneeverbauungen. |
| ATE124742T1 (de) * | 1992-02-18 | 1995-07-15 | Fatzer Ag | Spiraldrahtseilanker, insbesondere zur verankerung von steinschlag- und lawinenschutzsystemen. |
| WO1993021939A1 (en) | 1992-04-27 | 1993-11-11 | New England Deaconess Hospital Corporation | Method of treating cancer |
| US5395105A (en) * | 1993-11-05 | 1995-03-07 | Thommen, Jr.; Robert A. | Safety net system |
| CA2145829C (en) * | 1994-04-08 | 2003-03-18 | Bernhard Eicher | Method and apparatus for producing a retaining net |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US5961099A (en) * | 1998-01-23 | 1999-10-05 | Brugg Cable Products, Inc. | Safety net system for debris and mud slides |
| CH692921A5 (de) * | 1998-02-25 | 2002-12-13 | Fatzer Ag | Drahtgeflecht vorzugsweise als Steinschlagschutz oder für die Sicherung einer Erdoberflächenschicht. |
| US7173005B2 (en) * | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| US6050038A (en) * | 1998-09-11 | 2000-04-18 | Fey; James M. | Foundation system for supporting a superstructure |
| JP4751556B2 (ja) * | 2000-02-28 | 2011-08-17 | ジーンシーグス， インコーポレイテッド | ナノカプセルカプセル化システムおよび方法 |
| EP1383793B1 (en) * | 2000-03-29 | 2011-10-19 | DGI BioTechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
| IL153288A0 (en) | 2000-06-07 | 2003-07-06 | Applied Research Systems | Use of growth hormone or a derivative thereof in the preparation of a medicament for hematopoiesis |
| CH695104A5 (de) * | 2000-11-13 | 2005-12-15 | Fatzer Ag | Auffangnetz insbesondere für Steinschlagverbauungen |
| US7771727B2 (en) | 2002-03-01 | 2010-08-10 | The Administrators Of The Tulane Educational Fund | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US20040142381A1 (en) * | 2002-07-31 | 2004-07-22 | Hubbard Stevan R. | Methods for designing IGF1 receptor modulators for therapeutics |
| US20060246036A1 (en) | 2002-09-06 | 2006-11-02 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
| US20030138430A1 (en) * | 2002-09-20 | 2003-07-24 | Stimmel Julie Beth | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| CA2542834C (en) * | 2003-10-21 | 2012-04-24 | Igf Oncology, Llc | Conjugates or co-administration of igf-1 receptor ligands with anti-cancer chemotherapeutic agents |
| WO2006047214A2 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
-
2005
- 2005-10-21 WO PCT/US2005/037739 patent/WO2006047214A2/en not_active Ceased
- 2005-10-21 JP JP2007538030A patent/JP2008517917A/ja active Pending
- 2005-10-21 CA CA002582552A patent/CA2582552A1/en not_active Abandoned
- 2005-10-21 EP EP05809814.6A patent/EP1812082B1/en not_active Expired - Lifetime
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2007
- 2007-04-20 US US11/788,627 patent/US8017102B2/en active Active
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2011
- 2011-08-15 US US13/210,359 patent/US8920777B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| JP2004520808A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| US20030092631A1 (en) * | 2001-03-14 | 2003-05-15 | Genentech, Inc. | IGF antagonist peptides |
Non-Patent Citations (1)
| Title |
|---|
| JPN6011034051; Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ， １９９１， Ｖｏｌ．５１， ｐｐ．１７４-１８０ * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017519753A (ja) * | 2014-06-13 | 2017-07-20 | トラスティーズ オブ タフツ カレッジ | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US10709722B2 (en) | 2014-06-13 | 2020-07-14 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP2020183448A (ja) * | 2014-06-13 | 2020-11-12 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US11033525B2 (en) | 2014-06-13 | 2021-06-15 | Bach Biosciences, Llc | Fap-activated therapeutic agents, and uses related thereto |
| US11266669B2 (en) | 2014-06-13 | 2022-03-08 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP7093912B2 (ja) | 2014-06-13 | 2022-07-01 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| JP2022116203A (ja) * | 2014-06-13 | 2022-08-09 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US11925655B2 (en) | 2014-06-13 | 2024-03-12 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| US12023316B2 (en) | 2014-06-13 | 2024-07-02 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| US12053450B2 (en) | 2014-06-13 | 2024-08-06 | Bach Biosciences, Llc | FAP-activated therapeutic agents, and uses related thereto |
| JP7530111B2 (ja) | 2014-06-13 | 2024-08-07 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US12121505B2 (en) | 2014-06-13 | 2024-10-22 | Bach Biosciences, Llc | Fap-activated therapeutic agents, and uses related thereto |
| JP2024150608A (ja) * | 2014-06-13 | 2024-10-23 | バック バイオサイエンシーズ，エルエルシー | Ｆａｐ活性化治療剤及びそれに関連する使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110301340A1 (en) | 2011-12-08 |
| US8017102B2 (en) | 2011-09-13 |
| CA2582552A1 (en) | 2006-05-04 |
| WO2006047214A3 (en) | 2006-06-15 |
| EP1812082B1 (en) | 2013-08-14 |
| US8920777B2 (en) | 2014-12-30 |
| WO2006047214A2 (en) | 2006-05-04 |
| EP1812082A4 (en) | 2010-06-02 |
| US20070224119A1 (en) | 2007-09-27 |
| EP1812082A2 (en) | 2007-08-01 |
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