JP2008517917A5 - - Google Patents
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- Publication number
- JP2008517917A5 JP2008517917A5 JP2007538030A JP2007538030A JP2008517917A5 JP 2008517917 A5 JP2008517917 A5 JP 2008517917A5 JP 2007538030 A JP2007538030 A JP 2007538030A JP 2007538030 A JP2007538030 A JP 2007538030A JP 2008517917 A5 JP2008517917 A5 JP 2008517917A5
- Authority
- JP
- Japan
- Prior art keywords
- igf
- receptor
- receptor ligand
- ligand
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003446 ligand Substances 0.000 claims 24
- 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 23
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 23
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 14
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 14
- 239000002246 antineoplastic agent Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 102000003746 Insulin Receptor Human genes 0.000 claims 2
- 108010001127 Insulin Receptor Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000000018 receptor agonist Substances 0.000 claims 2
- 229940044601 receptor agonist Drugs 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical group [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 101710146739 Enterotoxin Proteins 0.000 claims 1
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims 1
- 108010039491 Ricin Proteins 0.000 claims 1
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000000147 enterotoxin Substances 0.000 claims 1
- 231100000655 enterotoxin Toxicity 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 1
- 229940055742 indium-111 Drugs 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- OHSVLFRHMCKCQY-NJFSPNSNSA-N lutetium-177 Chemical compound [177Lu] OHSVLFRHMCKCQY-NJFSPNSNSA-N 0.000 claims 1
- WUAPFZMCVAUBPE-IGMARMGPSA-N rhenium-186 Chemical compound [186Re] WUAPFZMCVAUBPE-IGMARMGPSA-N 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62079404P | 2004-10-21 | 2004-10-21 | |
| PCT/US2005/037739 WO2006047214A2 (en) | 2004-10-21 | 2005-10-21 | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517917A JP2008517917A (ja) | 2008-05-29 |
| JP2008517917A5 true JP2008517917A5 (https=) | 2008-12-11 |
Family
ID=36228252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538030A Pending JP2008517917A (ja) | 2004-10-21 | 2005-10-21 | 癌を治療するための毒素および放射性核種結合ｉｇｆ−１受容体リガンド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8017102B2 (https=) |
| EP (1) | EP1812082B1 (https=) |
| JP (1) | JP2008517917A (https=) |
| CA (1) | CA2582552A1 (https=) |
| WO (1) | WO2006047214A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2582552A1 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
| WO2008079324A1 (en) * | 2006-12-21 | 2008-07-03 | Boston Biomedical Research Institute | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity |
| WO2008124166A2 (en) | 2007-04-09 | 2008-10-16 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
| JP5264725B2 (ja) * | 2007-06-29 | 2013-08-14 | 第一三共株式会社 | ペプチド性薬物の粘膜吸収促進剤を含有する粘膜投与用組成物、及びその投与方法 |
| AU2009210570B2 (en) | 2008-01-30 | 2014-11-20 | Indiana University Research And Technology Corporation | Ester-based insulin prodrugs |
| WO2010080606A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| CN102307584A (zh) * | 2008-12-19 | 2012-01-04 | 印第安纳大学研究及科技有限公司 | 表现出对胰岛素受体的高活性的基于yl的胰岛素-样生长因子 |
| BR112012029611A2 (pt) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | proteína de fusão biespecífica, composição farmacêutica, método de tratamento de dano ao tecido em um indivíduo, método de promoção da regeração ou sobrevivência do tecido em um indivíduo e molécula de ácido nucleico |
| EP2582719B1 (en) | 2010-06-16 | 2016-08-10 | Indiana University Research and Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
| JP5912112B2 (ja) | 2010-06-24 | 2016-04-27 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | アミド系インスリンプロドラッグ |
| ES2695161T3 (es) | 2011-12-14 | 2019-01-02 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| AU2013323669B2 (en) | 2012-09-26 | 2018-03-01 | Indiana University Research And Technology Corporation | Insulin analog dimers |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| JP6835590B2 (ja) * | 2014-01-12 | 2021-02-24 | アイジーエフ オンコロジー、 エルエルシー | インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用 |
| JP6744826B2 (ja) * | 2014-06-13 | 2020-08-19 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Ｆａｐ活性化治療剤及びそれに関連する使用 |
| US9737556B2 (en) | 2014-06-13 | 2017-08-22 | Trustees Of Tufts College | FAP-activated therapeutic agents, and uses related thereto |
| WO2016049174A1 (en) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Lipidated amide-based insulin prodrugs |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| CN115960249A (zh) | 2015-10-02 | 2023-04-14 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| EP3595699A4 (en) * | 2017-03-16 | 2020-12-23 | Blaze Bioscience, Inc. | PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE |
| WO2018217669A1 (en) | 2017-05-21 | 2018-11-29 | Igf Oncology, Llc | An insulin-like growth factor-chemotherapeputic conjugate for treating myelodysplastic syndrome |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0316408A1 (en) | 1987-05-11 | 1989-05-24 | Procyte Corporation | Method of tumor inhibition in warm-blooded animals |
| US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
| IL106992A (en) * | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| EP0494046B1 (de) * | 1990-12-31 | 1994-04-13 | Fatzer Ag | Vorrichtung zur Stossdämpfung für ein auf Zug beanspruchtes Seil für Steinschlag- und Schneeverbauungen |
| ATE124742T1 (de) * | 1992-02-18 | 1995-07-15 | Fatzer Ag | Spiraldrahtseilanker, insbesondere zur verankerung von steinschlag- und lawinenschutzsystemen. |
| AU3973793A (en) | 1992-04-27 | 1993-11-29 | New England Deaconess Hospital Corporation | Method of treating cancer |
| US5395105A (en) * | 1993-11-05 | 1995-03-07 | Thommen, Jr.; Robert A. | Safety net system |
| CA2145829C (en) * | 1994-04-08 | 2003-03-18 | Bernhard Eicher | Method and apparatus for producing a retaining net |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US5961099A (en) * | 1998-01-23 | 1999-10-05 | Brugg Cable Products, Inc. | Safety net system for debris and mud slides |
| CH692921A5 (de) * | 1998-02-25 | 2002-12-13 | Fatzer Ag | Drahtgeflecht vorzugsweise als Steinschlagschutz oder für die Sicherung einer Erdoberflächenschicht. |
| US7173005B2 (en) * | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| US6050038A (en) * | 1998-09-11 | 2000-04-18 | Fey; James M. | Foundation system for supporting a superstructure |
| JP4751556B2 (ja) * | 2000-02-28 | 2011-08-17 | ジーンシーグス， インコーポレイテッド | ナノカプセルカプセル化システムおよび方法 |
| WO2001072771A2 (en) * | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
| JP2003535144A (ja) | 2000-06-07 | 2003-11-25 | アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ | 多能性造血幹細胞の流動を刺激するヒト成長ホルモン |
| JP2004520808A (ja) * | 2000-08-24 | 2004-07-15 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| CH695104A5 (de) * | 2000-11-13 | 2005-12-15 | Fatzer Ag | Auffangnetz insbesondere für Steinschlagverbauungen |
| US7071300B2 (en) * | 2001-03-14 | 2006-07-04 | Genentech, Inc. | IGF antagonist peptides |
| EP1487493B1 (en) | 2002-03-01 | 2010-01-20 | The Administrators of The Tulane Educational Fund | Conjugates of cytotoxic agents and biologically active peptides |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US20040142381A1 (en) * | 2002-07-31 | 2004-07-22 | Hubbard Stevan R. | Methods for designing IGF1 receptor modulators for therapeutics |
| US20060246036A1 (en) | 2002-09-06 | 2006-11-02 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
| US20030138430A1 (en) * | 2002-09-20 | 2003-07-24 | Stimmel Julie Beth | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| EP1680073B1 (en) * | 2003-10-21 | 2013-01-02 | IGF Oncology, LLC | Compounds and method for treating cancer |
| CA2582552A1 (en) * | 2004-10-21 | 2006-05-04 | Igf Oncology, Llc | Toxins and radionuclides coupled to igf-1 receptor ligands for treatment of cancer |
-
2005
- 2005-10-21 CA CA002582552A patent/CA2582552A1/en not_active Abandoned
- 2005-10-21 JP JP2007538030A patent/JP2008517917A/ja active Pending
- 2005-10-21 WO PCT/US2005/037739 patent/WO2006047214A2/en not_active Ceased
- 2005-10-21 EP EP05809814.6A patent/EP1812082B1/en not_active Expired - Lifetime
-
2007
- 2007-04-20 US US11/788,627 patent/US8017102B2/en active Active
-
2011
- 2011-08-15 US US13/210,359 patent/US8920777B2/en not_active Expired - Lifetime
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