JP2008516011A5 - - Google Patents
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- JP2008516011A5 JP2008516011A5 JP2007534633A JP2007534633A JP2008516011A5 JP 2008516011 A5 JP2008516011 A5 JP 2008516011A5 JP 2007534633 A JP2007534633 A JP 2007534633A JP 2007534633 A JP2007534633 A JP 2007534633A JP 2008516011 A5 JP2008516011 A5 JP 2008516011A5
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- JP
- Japan
- Prior art keywords
- polymer
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- group
- pharmaceutical composition
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000642 polymer Polymers 0.000 claims 43
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 229920002873 Polyethylenimine Polymers 0.000 claims 6
- 210000003527 eukaryotic cell Anatomy 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108020004491 Antisense DNA Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 claims 1
- 239000003816 antisense DNA Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000005019 carboxyalkenyl group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000000527 sonication Methods 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61576404P | 2004-10-04 | 2004-10-04 | |
| US60/615,764 | 2004-10-04 | ||
| US69835705P | 2005-07-11 | 2005-07-11 | |
| US60/698,357 | 2005-07-11 | ||
| PCT/US2005/033274 WO2006041617A1 (en) | 2004-10-04 | 2005-09-16 | Biodegradable cationic polymers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516011A JP2008516011A (ja) | 2008-05-15 |
| JP2008516011A5 true JP2008516011A5 (https=) | 2008-10-16 |
| JP5191233B2 JP5191233B2 (ja) | 2013-05-08 |
Family
ID=35759127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534633A Expired - Fee Related JP5191233B2 (ja) | 2004-10-04 | 2005-09-16 | 生分解性カチオン性ポリマー |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7358223B2 (https=) |
| EP (1) | EP1799748B1 (https=) |
| JP (1) | JP5191233B2 (https=) |
| KR (1) | KR20070059171A (https=) |
| CN (2) | CN101035835B (https=) |
| AT (1) | ATE458021T1 (https=) |
| AU (1) | AU2005294699B2 (https=) |
| CA (1) | CA2581632C (https=) |
| DE (1) | DE602005019439D1 (https=) |
| DK (1) | DK1799748T3 (https=) |
| MX (1) | MX2007003822A (https=) |
| RU (1) | RU2440380C2 (https=) |
| WO (1) | WO2006041617A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005032597A1 (en) * | 2003-09-29 | 2005-04-14 | Nitto Denko Corporation | Biodegradable polyacetals for in vivo polynucleotide delivery |
| US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| ES2900801T3 (es) | 2004-12-22 | 2022-03-18 | Nitto Denko Corp | Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
| JP4870941B2 (ja) * | 2005-05-09 | 2012-02-08 | 公立大学法人大阪府立大学 | 高分子化合物 |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
| JP5059312B2 (ja) * | 2005-09-16 | 2012-10-24 | Ｈｏｙａ株式会社 | 高分散性リン酸カルシウム系化合物ナノ粒子及びその製造方法 |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| CN100549044C (zh) * | 2006-11-16 | 2009-10-14 | 南京慧基生物技术有限公司 | 可生物降解的交联聚乙烯亚胺及其应用 |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | 日東電工股份有限公司 | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| CN107049965A (zh) * | 2007-08-06 | 2017-08-18 | Clsn实验室股份有限公司 | 核酸‑脂聚合物组合物 |
| KR20100065190A (ko) * | 2007-09-14 | 2010-06-15 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| WO2009091812A2 (en) * | 2008-01-14 | 2009-07-23 | Surmodics, Inc. | Devices and methods for elution of nucleic acid delivery complexes |
| CA2717370A1 (en) * | 2008-03-14 | 2009-09-17 | Egen, Inc. | Biodegradable cross-linked branched poly (alkylene imines) |
| KR101100770B1 (ko) | 2009-04-14 | 2011-12-29 | 전북대학교산학협력단 | 유가금속의 회수방법 |
| WO2009148292A2 (ko) * | 2008-05-30 | 2009-12-10 | 전북대학교 산학협력단 | 표면개질된 바이오매스, 그의 제조방법 및 그를 이용하는 유가금속의 회수 방법 |
| KR100894585B1 (ko) * | 2008-05-30 | 2009-04-24 | 전북대학교산학협력단 | 표면개질된 바이오매스, 그의 제조방법 및 그를 이용하는 생체흡착제 |
| DE102008002254A1 (de) * | 2008-06-06 | 2010-01-21 | Evonik Röhm Gmbh | Monomermischungen, Polymere sowie Beschichtungszusammensetzungen |
| KR101050383B1 (ko) * | 2009-03-11 | 2011-07-19 | 전북대학교산학협력단 | 표면개질된 대장균 바이오매스의 제조방법 및 이에 의한 생체흡착제 |
| US8827884B2 (en) | 2009-08-06 | 2014-09-09 | Koninklijke Philips N.V. | Oncology therapies employing radioactive seeds |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| KR101718534B1 (ko) | 2009-12-09 | 2017-03-22 | 닛토덴코 가부시키가이샤 | Ｈｓｐ４７ 발현의 조절 |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| CN103492572A (zh) | 2011-03-03 | 2014-01-01 | 夸克医药公司 | 用于治疗肺疾病和损伤的组合物和方法 |
| RU2639459C2 (ru) | 2011-06-21 | 2017-12-21 | Нитто Денко Корпорейшн | Апоптоз-индуцирующее средство |
| CN103509183A (zh) * | 2012-06-21 | 2014-01-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | 基于聚乙烯亚胺可降解的基因载体及其制备方法 |
| CN103509182A (zh) * | 2012-06-21 | 2014-01-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | 具有高缓冲能力基于聚乙烯亚胺的基因载体及其制备方法 |
| US9109087B2 (en) * | 2012-09-13 | 2015-08-18 | International Business Machines Corporation | Low molecular weight branched polyamines for delivery of biologically active materials |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| CN104109241B (zh) * | 2013-04-17 | 2019-01-11 | 复旦大学附属肿瘤医院 | 共价疏水修饰的聚乙烯亚胺及其制备方法和应用 |
| JP6727765B2 (ja) | 2014-06-17 | 2020-07-22 | 日東電工株式会社 | アポトーシス誘導剤 |
| US10086083B2 (en) | 2014-10-30 | 2018-10-02 | Seoul National University R&Db Foundation | Polyol-based osmotic polydixylitol polymer gene transporter and use thereof |
| CN105732981A (zh) * | 2014-12-10 | 2016-07-06 | 深圳先进技术研究院 | 改性聚乙烯亚胺、基因载体复合物及其制备方法和应用 |
| EP3225246A1 (en) * | 2016-03-31 | 2017-10-04 | Klinikum der Universität München | Synthetic compound for improving efficiency of transfection |
| CA3020754C (en) | 2016-04-14 | 2023-07-25 | Benitec Biopharma Limited | Reagents for treatment of oculopharyngeal muscular dystrophy (opmd) and use thereof |
| WO2020118110A1 (en) * | 2018-12-05 | 2020-06-11 | Fred Hutchinson Cancer Research Center | Reduced and minimal manipulation manufacturing of genetically-modified cells |
| CN109776347B (zh) * | 2019-02-18 | 2021-03-26 | 华南农业大学 | 一种热固性植物油基丙烯酸酯衍生物及其制备方法和应用 |
| BR112022002143A2 (pt) | 2019-08-05 | 2022-04-19 | Polyplus Transfection | Composição adequada para transfectar uma molécula de ácido nucleico em uma célula, métodos para transfecção in vitro ou ex vivo de células vivas e para a produção e usos in vitro ou ex vivo da composição |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| CN114874422B (zh) * | 2022-06-16 | 2023-05-12 | 上海云沂生物医药科技有限公司 | 一种聚烷基胺、其合成方法、颗粒及用途 |
| WO2025072615A1 (en) | 2023-09-29 | 2025-04-03 | Orbital Therapeutics, Inc. | Improved methods of making rna by splinted ligation and compositions thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2229711A (en) * | 1938-06-29 | 1941-01-28 | Ansul Chemical Co | Method of preventing formation of ice crystals in refrigerants |
| GB2092164B (en) * | 1980-12-17 | 1984-12-05 | Hitachi Ltd | Loght or radiation-sensitive polymer composition |
| US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US6509032B1 (en) * | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
| DE4142130A1 (de) * | 1991-12-20 | 1993-06-24 | Basf Ag | Verwendung von polyacetalen auf basis von vinylethern und dihydroxyverbindungen in wasch- und reinigungsmitteln und polyacetale |
| JPH0789909A (ja) * | 1993-09-22 | 1995-04-04 | Nippon Soda Co Ltd | 新規アニリニウム塩化合物および重合開始剤 |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| JP4285766B2 (ja) | 1994-03-23 | 2009-06-24 | オハイオ ユニバーシティ | 緻密にした核酸および細胞へのデリバリ |
| AU2946295A (en) * | 1994-06-27 | 1996-01-19 | Johns Hopkins University, The | Targeted gene delivery system |
| US5767168A (en) * | 1995-03-30 | 1998-06-16 | The Proctor & Gamble Company | Biodegradable and/or compostable polymers made from conjugated dienes such as isoprene and 2,3-dimethyl-1, 3-butadiene |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| US6169074B1 (en) | 1996-03-18 | 2001-01-02 | The Regents Of The University Of California | Peptide inhibitors of neurotransmitter secretion by neuronal cells |
| CA2256900A1 (en) | 1996-05-29 | 1997-12-04 | Xiao-Ying Meng | Cationic polymer/lipid nucleic acid delivery vehicles |
| US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
| US20020006664A1 (en) * | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
| AU2001265252A1 (en) * | 2000-05-31 | 2001-12-11 | The Johns-Hopkins University | Biologically useful polyphosphates |
| EP1315777B1 (en) * | 2000-09-06 | 2007-10-31 | AP Pharma, Inc. | Degradable polyacetal polymers |
| US20040142474A1 (en) | 2000-09-14 | 2004-07-22 | Expression Genetics, Inc. | Novel cationic lipopolymer as a biocompatible gene delivery agent |
| US6696038B1 (en) * | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| US7427394B2 (en) * | 2000-10-10 | 2008-09-23 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US6998115B2 (en) * | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US6652886B2 (en) * | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| US20030120355A1 (en) * | 2001-06-08 | 2003-06-26 | Urs Hafeli | Biocompatible and biodegradable polymers for diagnostic and therapeutic radioisotope delivery |
| KR100448170B1 (ko) * | 2001-06-23 | 2004-09-10 | 주식회사 태평양 | 폴리에틸렌이민을 친수성 블록으로 갖고 폴리에스테르계고분자를 소수성 블록으로 갖는 양친성 생분해성 블록공중합체 및 이를 이용한 수용액 상에서의 고분자자기조합 회합체 |
| US6586524B2 (en) * | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| US20030186915A1 (en) | 2002-02-11 | 2003-10-02 | Yang Pan | Regulatory polynucleotides and uses thereof |
| AU2003220161A1 (en) * | 2002-03-12 | 2003-09-29 | Nitto Denko Corporation | Vector for transfection of eukaryotic cells |
| US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| CN1166831C (zh) * | 2002-08-23 | 2004-09-15 | 清华大学 | 表面高接枝率高分子抗菌纤维的制备方法 |
| US20040048260A1 (en) * | 2002-09-10 | 2004-03-11 | Fu-Hsiung Chang | Transfection of nucleic acid |
| US20070269891A9 (en) * | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
| US6878374B2 (en) * | 2003-02-25 | 2005-04-12 | Nitto Denko Corporation | Biodegradable polyacetals |
| US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
| US7048925B2 (en) * | 2003-08-28 | 2006-05-23 | Nitto Denko Corporation | Acid-sensitive polyacetals and methods |
| WO2005032597A1 (en) * | 2003-09-29 | 2005-04-14 | Nitto Denko Corporation | Biodegradable polyacetals for in vivo polynucleotide delivery |
| US7163677B2 (en) * | 2003-10-24 | 2007-01-16 | Nitto Denko Corporation | Cationic polymers having degradable crosslinks |
| US7125709B2 (en) * | 2004-02-10 | 2006-10-24 | Nitto Denko Corporation | Culture device and method for eukaryotic cell transfection |
| US7358223B2 (en) | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| EP1836293A2 (en) | 2004-12-17 | 2007-09-26 | Nitto Denko Corporation | Immobilized degradable cationic polymer for transfecting eukaryotic cells |
| JP2009221164A (ja) * | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| ES2900801T3 (es) * | 2004-12-22 | 2022-03-18 | Nitto Denko Corp | Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis |
| US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
| US20060278751A1 (en) * | 2005-06-13 | 2006-12-14 | Chen Hsiu-Man Y | Membrane reel fixing device for a membrane strapping dispenser |
| RU2375081C1 (ru) * | 2005-10-05 | 2009-12-10 | Ска Хайджин Продактс Аб | Адсорбирующее изделие, включающее гидрофильные и гидрофобные участки |
| JP5342834B2 (ja) * | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
| CN101351515A (zh) | 2006-01-04 | 2009-01-21 | 陶氏环球技术公司 | 反应性(甲基)丙烯酸酯单体组合物及其制备和应用 |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| TWI407971B (zh) * | 2007-03-30 | 2013-09-11 | 日東電工股份有限公司 | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| KR20100065190A (ko) * | 2007-09-14 | 2010-06-15 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| AU2008359989A1 (en) * | 2008-07-30 | 2010-02-04 | Nitto Denko Corporation | Drug carriers |
| JP5744723B2 (ja) | 2008-09-12 | 2015-07-08 | 日東電工株式会社 | 線維性疾患のイメージング剤 |
-
2005
- 2005-08-31 US US11/216,986 patent/US7358223B2/en not_active Expired - Fee Related
- 2005-09-16 MX MX2007003822A patent/MX2007003822A/es active IP Right Grant
- 2005-09-16 RU RU2007110736/04A patent/RU2440380C2/ru not_active IP Right Cessation
- 2005-09-16 DE DE602005019439T patent/DE602005019439D1/de not_active Expired - Lifetime
- 2005-09-16 JP JP2007534633A patent/JP5191233B2/ja not_active Expired - Fee Related
- 2005-09-16 CA CA2581632A patent/CA2581632C/en not_active Expired - Fee Related
- 2005-09-16 EP EP05812055A patent/EP1799748B1/en not_active Expired - Lifetime
- 2005-09-16 DK DK05812055.1T patent/DK1799748T3/da active
- 2005-09-16 AT AT05812055T patent/ATE458021T1/de not_active IP Right Cessation
- 2005-09-16 CN CN2005800337847A patent/CN101035835B/zh not_active Expired - Fee Related
- 2005-09-16 WO PCT/US2005/033274 patent/WO2006041617A1/en not_active Ceased
- 2005-09-16 CN CN2011100831389A patent/CN102250346A/zh active Pending
- 2005-09-16 KR KR1020077009203A patent/KR20070059171A/ko not_active Abandoned
- 2005-09-16 AU AU2005294699A patent/AU2005294699B2/en not_active Ceased
-
2008
- 2008-01-15 US US12/014,446 patent/US7700542B2/en not_active Expired - Fee Related
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2010
- 2010-02-18 US US12/707,959 patent/US8258235B2/en not_active Expired - Fee Related
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