JP2008514643A5 - - Google Patents
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- Publication number
- JP2008514643A5 JP2008514643A5 JP2007533765A JP2007533765A JP2008514643A5 JP 2008514643 A5 JP2008514643 A5 JP 2008514643A5 JP 2007533765 A JP2007533765 A JP 2007533765A JP 2007533765 A JP2007533765 A JP 2007533765A JP 2008514643 A5 JP2008514643 A5 JP 2008514643A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pyrimidin
- piperidin
- amine
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)CCC*N(C)c1nc(*)nc2c1c(*)c(C)[s]2 Chemical compound CC(*)CCC*N(C)c1nc(*)nc2c1c(*)c(C)[s]2 0.000 description 6
- TVSMLBGFGKLKOO-UHFFFAOYSA-N CC1CCN(C)CC1 Chemical compound CC1CCN(C)CC1 TVSMLBGFGKLKOO-UHFFFAOYSA-N 0.000 description 1
- IGNGFGXAWDQJGP-UHFFFAOYSA-N CC1CN(C)CC1 Chemical compound CC1CN(C)CC1 IGNGFGXAWDQJGP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/947,995 US20050222175A1 (en) | 2004-03-31 | 2004-09-23 | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US11/075,565 US7612078B2 (en) | 2003-03-31 | 2005-03-08 | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| PCT/US2005/034862 WO2006034511A1 (en) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thieno[2,3-d] pyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514643A JP2008514643A (ja) | 2008-05-08 |
| JP2008514643A5 true JP2008514643A5 (OSRAM) | 2008-11-13 |
Family
ID=35528225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533765A Pending JP2008514643A (ja) | 2004-09-23 | 2005-09-23 | 新規ピペリジニルアミノ−チエノ［２，３−ｄ］ピリミジン化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7612078B2 (OSRAM) |
| EP (1) | EP1797099B1 (OSRAM) |
| JP (1) | JP2008514643A (OSRAM) |
| KR (1) | KR20070057970A (OSRAM) |
| CN (1) | CN101048412A (OSRAM) |
| AR (1) | AR054982A1 (OSRAM) |
| AT (1) | ATE477257T1 (OSRAM) |
| AU (1) | AU2005287898A1 (OSRAM) |
| BR (1) | BRPI0515530A (OSRAM) |
| CA (1) | CA2581175A1 (OSRAM) |
| DE (1) | DE602005022897D1 (OSRAM) |
| DK (1) | DK1797099T3 (OSRAM) |
| HR (1) | HRP20100607T1 (OSRAM) |
| IL (1) | IL182099A0 (OSRAM) |
| MX (1) | MX2007003026A (OSRAM) |
| NO (1) | NO20072037L (OSRAM) |
| NZ (1) | NZ553886A (OSRAM) |
| PL (1) | PL1797099T3 (OSRAM) |
| PT (1) | PT1797099E (OSRAM) |
| TW (1) | TW200628472A (OSRAM) |
| WO (1) | WO2006034511A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| JP5186219B2 (ja) | 2005-01-25 | 2013-04-17 | エピックス デラウェア， インコーポレイテッド | 置換アリールアミン化合物および５−ｈｔ６調節因子としてのその使用 |
| WO2007056208A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc. | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| WO2007056215A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc. | N-aryl-thienopyrimidin-4-amines and the use thereof |
| US20070213305A1 (en) * | 2005-11-02 | 2007-09-13 | Cytovia, Inc. | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US7939661B2 (en) * | 2006-09-11 | 2011-05-10 | Hoffman-La Roche Inc. | Pyridine, quinoline and pyrimidine derivatives |
| WO2008061966A2 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim International Gmbh | New use of flibanserin |
| WO2008061968A1 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivates in the treatment of pulmonary arterial hypertension |
| EP2194988A2 (en) * | 2007-09-04 | 2010-06-16 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-d] pyrimidine compounds for treating fibrosis |
| EP2445877B1 (en) * | 2008-12-03 | 2014-07-23 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| US8618116B2 (en) * | 2009-08-03 | 2013-12-31 | Daljit Singh Dhanoa | Deuterium-enriched pyrimidine compounds and derivatives |
| WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| KR101401496B1 (ko) * | 2011-05-12 | 2014-06-11 | 한국화학연구원 | 티에노피리미딘 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CA2861464C (en) | 2012-01-25 | 2018-03-06 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating tricyclic compounds |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| MX2015011576A (es) * | 2013-03-13 | 2016-05-16 | Univ Michigan | Composiciones que comprenden compuestos de tienopirimidina y tienopiridina y metodos para usar los mismos. |
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| AU2017235462B2 (en) | 2016-03-16 | 2021-07-01 | Kura Oncology, Inc. | Bridged bicyclic inhibitors of menin-MLL and methods of use |
| RS64261B1 (sr) | 2016-03-16 | 2023-07-31 | Kura Oncology Inc | Supstituisani derivati tieno[2,3-d]pirimidina kao inhibitori menin-mll i načini upotrebe |
| US10611778B2 (en) * | 2016-09-14 | 2020-04-07 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| LT3512857T (lt) | 2016-09-14 | 2021-04-12 | Janssen Pharmaceutica Nv | Menin-mll sąveikos spirobicikliniai inhibitoriai |
| MX391405B (es) | 2016-12-15 | 2025-03-21 | Janssen Pharmaceutica Nv | Inhibidores de azepano de la interacción menina-mll. |
| EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| CN110075109B (zh) * | 2019-03-28 | 2021-07-27 | 中国人民解放军军事科学院军事医学研究院 | 一种促进干细胞因子合成和分泌的化合物及其用途 |
| UA129208C2 (uk) | 2019-12-19 | 2025-02-05 | Янссен Фармацевтика Нв | Заміщені спіропохідні з прямим ланцюгом |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| CN114560843B (zh) * | 2022-04-02 | 2023-04-18 | 河南维诺生物科技有限公司 | 一种作为荧光探针的化合物及其合成方法和应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3069412A (en) | 1958-08-15 | 1962-12-18 | Fmc Corp | N-aminoazetidine and preparation thereof |
| CA933923A (en) | 1969-12-19 | 1973-09-18 | Eichenberger Kurt | Process for the manufacture of new thiopyranes |
| GB1570494A (en) | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| DE2925175A1 (de) | 1979-06-22 | 1981-01-08 | Basf Ag | Verfahren zur herstellung von isatosaeureanhydriden |
| IT1203323B (it) | 1987-02-02 | 1989-02-15 | Hoechst Italia Spa | Additivo fotoattivatore per composizioni polimeriche costituito dal sale metallico di una cera ossidata |
| US5236917A (en) | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| DE4008726A1 (de) | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| US5219864A (en) | 1991-03-12 | 1993-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Thienopyridine derivatives |
| US5155115A (en) | 1991-03-12 | 1992-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Thienopyridine derivatives |
| US5227387A (en) | 1991-09-03 | 1993-07-13 | Dowelanco | Quinoline nematicidal method |
| DE4138820A1 (de) | 1991-11-26 | 1993-05-27 | Basf Ag | Chinolin-3-carbonsaeureamide, deren herstellung und verwendung |
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| DE4227747A1 (de) | 1992-08-21 | 1994-02-24 | Basf Ag | Heteroaromatisch kondensierte Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung |
| US5409948A (en) | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| JPH06239858A (ja) | 1993-02-16 | 1994-08-30 | Otsuka Pharmaceut Co Ltd | 末梢血管拡張剤 |
| GB9306460D0 (en) | 1993-03-29 | 1993-05-19 | Smithkline Beecham Plc | Novel compounds |
| TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| JP3829879B2 (ja) | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| DE19636769A1 (de) | 1996-09-10 | 1998-03-12 | Basf Ag | 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| DE19724980A1 (de) | 1997-06-13 | 1998-12-17 | Basf Ag | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| JPH11130777A (ja) | 1997-08-13 | 1999-05-18 | Takeda Chem Ind Ltd | チエノピリジン誘導体、その中間体およびそれらの製造法 |
| EP1020445B1 (en) | 1997-10-02 | 2008-08-13 | Eisai R&D Management Co., Ltd. | Fused pyridine derivatives |
| AU2879799A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands |
| DE19815026A1 (de) | 1998-04-03 | 1999-10-07 | Hoechst Schering Agrevo Gmbh | Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| EP1173168A2 (en) | 1999-04-28 | 2002-01-23 | Respiratorius AB | Compound for use as a medicament for treatment of disorders involving bronchocontraction |
| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| WO2001025218A1 (en) | 1999-10-01 | 2001-04-12 | Japan Energy Corporation | Novel quinazoline derivatives |
| EP1270568A1 (en) | 2001-06-19 | 2003-01-02 | Biofrontera Pharmaceuticals AG | 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist |
| WO2003020728A1 (en) | 2001-08-30 | 2003-03-13 | Pharmacia & Upjohn Company | 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS |
| MXPA03000145A (es) | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
| AU2003298514A1 (en) | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
| WO2004017950A2 (en) | 2002-08-22 | 2004-03-04 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
| AU2003277215A1 (en) | 2002-10-01 | 2004-04-23 | Predix Pharmaceuticals Holdings, Inc. | Novel neurokinin antagonists and methods of use thereof |
| US7153858B2 (en) | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US20050222175A1 (en) | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| WO2004089312A2 (en) | 2003-03-31 | 2004-10-21 | Predix Pharmaceuticals Holdings, Inc. | New piperidinylamino-thieno[2,3-d] pyrimidine compounds |
| US7119205B2 (en) | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| SI1651234T1 (sl) | 2003-07-25 | 2008-02-29 | Hoffmann La Roche | Kombinacija antagonista mglur2 in inhibitorja ache za zdravljenje akutnih in/ali kronicnih nevroloskih motenj |
| GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| JP2007509898A (ja) | 2003-11-03 | 2007-04-19 | プロビオドルグ エージー | 神経障害治療に有用な組合せ |
| US7488736B2 (en) | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US20060084806A1 (en) | 2004-07-21 | 2006-04-20 | Ramasubramanian Sridharan | Processes for the preparation of imidazo[1,2-a] pyridine derivatives |
| US7598265B2 (en) | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7407966B2 (en) | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| JP5186219B2 (ja) | 2005-01-25 | 2013-04-17 | エピックス デラウェア， インコーポレイテッド | 置換アリールアミン化合物および５−ｈｔ６調節因子としてのその使用 |
| JP2009520688A (ja) | 2005-11-23 | 2009-05-28 | エピックス デラウェア， インコーポレイテッド | Ｓ１ｐ受容体調節化合物およびそれらの使用 |
-
2005
- 2005-03-08 US US11/075,565 patent/US7612078B2/en not_active Expired - Fee Related
- 2005-09-23 AU AU2005287898A patent/AU2005287898A1/en not_active Abandoned
- 2005-09-23 MX MX2007003026A patent/MX2007003026A/es unknown
- 2005-09-23 JP JP2007533765A patent/JP2008514643A/ja active Pending
- 2005-09-23 PL PL05800014T patent/PL1797099T3/pl unknown
- 2005-09-23 KR KR1020077009078A patent/KR20070057970A/ko not_active Ceased
- 2005-09-23 TW TW094133175A patent/TW200628472A/zh unknown
- 2005-09-23 WO PCT/US2005/034862 patent/WO2006034511A1/en not_active Ceased
- 2005-09-23 NZ NZ553886A patent/NZ553886A/en unknown
- 2005-09-23 CA CA002581175A patent/CA2581175A1/en not_active Abandoned
- 2005-09-23 AT AT05800014T patent/ATE477257T1/de active
- 2005-09-23 DK DK05800014.2T patent/DK1797099T3/da active
- 2005-09-23 CN CNA2005800360646A patent/CN101048412A/zh active Pending
- 2005-09-23 HR HR20100607T patent/HRP20100607T1/hr unknown
- 2005-09-23 EP EP05800014A patent/EP1797099B1/en not_active Expired - Lifetime
- 2005-09-23 BR BRPI0515530-4A patent/BRPI0515530A/pt not_active IP Right Cessation
- 2005-09-23 PT PT05800014T patent/PT1797099E/pt unknown
- 2005-09-23 DE DE602005022897T patent/DE602005022897D1/de not_active Expired - Lifetime
- 2005-09-26 AR ARP050103996A patent/AR054982A1/es unknown
-
2007
- 2007-03-21 IL IL182099A patent/IL182099A0/en unknown
- 2007-04-20 NO NO20072037A patent/NO20072037L/no not_active Application Discontinuation
-
2009
- 2009-10-30 US US12/609,470 patent/US20100113485A1/en not_active Abandoned
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