JP2008513500A - 化学物質 - Google Patents
化学物質 Download PDFInfo
- Publication number
- JP2008513500A JP2008513500A JP2007532632A JP2007532632A JP2008513500A JP 2008513500 A JP2008513500 A JP 2008513500A JP 2007532632 A JP2007532632 A JP 2007532632A JP 2007532632 A JP2007532632 A JP 2007532632A JP 2008513500 A JP2008513500 A JP 2008513500A
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- phenyl
- indole
- sulfonyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(C(N)=O)c([n]cc2[U]C)c2c(*)c1* Chemical compound Cc1c(C(N)=O)c([n]cc2[U]C)c2c(*)c1* 0.000 description 3
- KQDJRYJQMNKFGS-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1c[s]cc1)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1c[s]cc1)=O KQDJRYJQMNKFGS-UHFFFAOYSA-N 0.000 description 1
- URKWDRCDAOQQEN-UHFFFAOYSA-N CC(C)N(CCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O)C(C)C Chemical compound CC(C)N(CCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O)C(C)C URKWDRCDAOQQEN-UHFFFAOYSA-N 0.000 description 1
- OLNBYGRBQGMJSI-UHFFFAOYSA-N CN(C)CCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2Br)(=O)=O Chemical compound CN(C)CCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2Br)(=O)=O OLNBYGRBQGMJSI-UHFFFAOYSA-N 0.000 description 1
- CBYQDSQGZQSPML-UHFFFAOYSA-N COCCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1c[s]c(C=O)c1)(=O)=O Chemical compound COCCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1c[s]c(C=O)c1)(=O)=O CBYQDSQGZQSPML-UHFFFAOYSA-N 0.000 description 1
- DLDFITGBQJJTFD-UHFFFAOYSA-N COCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2Br)(=O)=O Chemical compound COCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2Br)(=O)=O DLDFITGBQJJTFD-UHFFFAOYSA-N 0.000 description 1
- ZRMNPGXIUJCABM-UHFFFAOYSA-N CONCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O Chemical compound CONCCS(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O ZRMNPGXIUJCABM-UHFFFAOYSA-N 0.000 description 1
- BYULRLHCFBURQO-UHFFFAOYSA-N Cc([n](C)nc1C)c1S(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O Chemical compound Cc([n](C)nc1C)c1S(N(CC1)CCC1c1c[nH]c(c(C(N)=O)c2)c1cc2-c1ccccc1)(=O)=O BYULRLHCFBURQO-UHFFFAOYSA-N 0.000 description 1
- HSCDZKQGTYAMNP-UHFFFAOYSA-N NC(c1cc(-c2ccc[s]2)cc2c1[nH]cc2C(CC1)CCN1S(CCCO)(=O)=O)=O Chemical compound NC(c1cc(-c2ccc[s]2)cc2c1[nH]cc2C(CC1)CCN1S(CCCO)(=O)=O)=O HSCDZKQGTYAMNP-UHFFFAOYSA-N 0.000 description 1
- CHHUYGMDEDHQSD-UHFFFAOYSA-N NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(CCCOCCCCO)(=O)=O)=O Chemical compound NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(CCCOCCCCO)(=O)=O)=O CHHUYGMDEDHQSD-UHFFFAOYSA-N 0.000 description 1
- SBJVEKGQJZBVRM-UHFFFAOYSA-N NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(c1ccc(CNCc2ccccc2)[s]1)(=O)=O)=O Chemical compound NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(c1ccc(CNCc2ccccc2)[s]1)(=O)=O)=O SBJVEKGQJZBVRM-UHFFFAOYSA-N 0.000 description 1
- MRRDZWFAMJDCPP-UHFFFAOYSA-N NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(c1ccc[s]1)(=O)=O)=O Chemical compound NC(c1cc(-c2ccccc2)cc2c1[nH]cc2C(CC1)CCN1S(c1ccc[s]1)(=O)=O)=O MRRDZWFAMJDCPP-UHFFFAOYSA-N 0.000 description 1
- IIVMCGIWJFIGNF-UHFFFAOYSA-N NC(c1cc(Br)cc2c1[nH]cc2C(CC1)CCN1S(CCCNC1CCCC1)(=O)=O)=O Chemical compound NC(c1cc(Br)cc2c1[nH]cc2C(CC1)CCN1S(CCCNC1CCCC1)(=O)=O)=O IIVMCGIWJFIGNF-UHFFFAOYSA-N 0.000 description 1
- CSWUECOTOHLZIU-UHFFFAOYSA-N NC(c1cc(Br)cc2c1[nH]cc2C1CCNCC1)=O Chemical compound NC(c1cc(Br)cc2c1[nH]cc2C1CCNCC1)=O CSWUECOTOHLZIU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61176104P | 2004-09-21 | 2004-09-21 | |
| US69545405P | 2005-06-30 | 2005-06-30 | |
| PCT/US2005/033752 WO2006034317A2 (en) | 2004-09-21 | 2005-09-21 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513500A true JP2008513500A (ja) | 2008-05-01 |
| JP2008513500A5 JP2008513500A5 (https=) | 2008-11-06 |
Family
ID=36090636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532632A Pending JP2008513500A (ja) | 2004-09-21 | 2005-09-21 | 化学物質 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7858796B2 (https=) |
| EP (1) | EP1793826A4 (https=) |
| JP (1) | JP2008513500A (https=) |
| KR (1) | KR20070057969A (https=) |
| AR (1) | AR054084A1 (https=) |
| AU (1) | AU2005286795A1 (https=) |
| BR (1) | BRPI0515524A (https=) |
| CA (1) | CA2581180A1 (https=) |
| IL (1) | IL181877A0 (https=) |
| MA (1) | MA28912B1 (https=) |
| MX (1) | MX2007003283A (https=) |
| NO (1) | NO20071988L (https=) |
| PE (1) | PE20060748A1 (https=) |
| SG (1) | SG155932A1 (https=) |
| TW (1) | TW200626142A (https=) |
| WO (1) | WO2006034317A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008504296A (ja) * | 2004-06-24 | 2008-02-14 | スミスクライン・ビーチャム・コーポレイション | 新規なインダゾールカルボキサミドおよびその使用 |
| JP2012512888A (ja) * | 2008-12-19 | 2012-06-07 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物 |
| JP2016531893A (ja) * | 2013-09-30 | 2016-10-13 | ベイジン・シナーケアー・ファーマ・テク・カンパニー、リミテッドＢｅｉｊｉｎｇ Ｓｙｎｅｒｃａｒｅ Ｐｈａｒｍａ Ｔｅｃｈ Ｃｏ．， Ｌｔｄ． | Ｂｔｋの置換ニコチンイミド阻害剤およびそれらの調製、ならびにがん、炎症および自己免疫疾患の治療における使用 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
| NZ563687A (en) * | 2005-06-30 | 2011-07-29 | Smithkline Beecham Corp | 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[2-(1-methylethyl)-2,3-dihydro-1H-isoindol-5-yl]-1H-indole-7-carboxamide for inhibiting IKK2 (aka IKKbeta) |
| US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| JP2009516702A (ja) * | 2005-11-18 | 2009-04-23 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
| US20080293802A1 (en) * | 2005-12-16 | 2008-11-27 | Smithline Beecham Corporation | Chemical Compounds |
| TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法 |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| US8815840B2 (en) | 2008-12-19 | 2014-08-26 | Bristol-Myers Squibb Company | Carbazole and carboline kinase inhibitors |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| UA110112C2 (uk) | 2010-05-07 | 2015-11-25 | Глаксосмітклайн Ллс | Індоли |
| US8685969B2 (en) | 2010-06-16 | 2014-04-01 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
| JP6509838B2 (ja) * | 2013-06-26 | 2019-05-08 | アッヴィ・インコーポレイテッド | Ｂｔｋ阻害薬としての一級カルボキサミド類 |
| EA034931B1 (ru) | 2014-10-24 | 2020-04-08 | Бристол-Майерс Сквибб Компани | Индолкарбоксамидные соединения |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008504296A (ja) * | 2004-06-24 | 2008-02-14 | スミスクライン・ビーチャム・コーポレイション | 新規なインダゾールカルボキサミドおよびその使用 |
| JP2012512888A (ja) * | 2008-12-19 | 2012-06-07 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物 |
| JP2016531893A (ja) * | 2013-09-30 | 2016-10-13 | ベイジン・シナーケアー・ファーマ・テク・カンパニー、リミテッドＢｅｉｊｉｎｇ Ｓｙｎｅｒｃａｒｅ Ｐｈａｒｍａ Ｔｅｃｈ Ｃｏ．， Ｌｔｄ． | Ｂｔｋの置換ニコチンイミド阻害剤およびそれらの調製、ならびにがん、炎症および自己免疫疾患の治療における使用 |
| US10301297B2 (en) | 2013-09-30 | 2019-05-28 | Guangzhou Innocare Pharma Tech Co., Ltd. | Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
| US11345695B2 (en) | 2013-09-30 | 2022-05-31 | Guangzhou Innocare Pharma Tech Co., Ltd. | Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease |
| US11840513B2 (en) | 2013-09-30 | 2023-12-12 | Guangzhou Innocare Pharma Tech Co., Ltd | Substituted nicotinimide inhibitors of BTK for treating cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0515524A (pt) | 2008-07-29 |
| US7858796B2 (en) | 2010-12-28 |
| IL181877A0 (en) | 2007-07-04 |
| CA2581180A1 (en) | 2006-03-30 |
| WO2006034317A2 (en) | 2006-03-30 |
| WO2006034317A3 (en) | 2007-04-19 |
| US20070254873A1 (en) | 2007-11-01 |
| AR054084A1 (es) | 2007-06-06 |
| EP1793826A2 (en) | 2007-06-13 |
| MX2007003283A (es) | 2007-05-18 |
| MA28912B1 (fr) | 2007-10-01 |
| EP1793826A4 (en) | 2010-04-21 |
| NO20071988L (no) | 2007-04-18 |
| PE20060748A1 (es) | 2006-10-01 |
| KR20070057969A (ko) | 2007-06-07 |
| TW200626142A (en) | 2006-08-01 |
| AU2005286795A1 (en) | 2006-03-30 |
| SG155932A1 (en) | 2009-10-29 |
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