JP2008512484A5 - - Google Patents
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- JP2008512484A5 JP2008512484A5 JP2007531364A JP2007531364A JP2008512484A5 JP 2008512484 A5 JP2008512484 A5 JP 2008512484A5 JP 2007531364 A JP2007531364 A JP 2007531364A JP 2007531364 A JP2007531364 A JP 2007531364A JP 2008512484 A5 JP2008512484 A5 JP 2008512484A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- heart
- phosphatase inhibitor
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 38
- 239000002245 particle Substances 0.000 claims 9
- 229940122907 Phosphatase inhibitor Drugs 0.000 claims 7
- 210000004351 coronary vessel Anatomy 0.000 claims 7
- 108091006086 inhibitor proteins Proteins 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 230000003612 virological effect Effects 0.000 claims 7
- 230000017531 blood circulation Effects 0.000 claims 6
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 5
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 5
- 102000004097 Protein phosphatase inhibitor 1 Human genes 0.000 claims 5
- 108090000506 Protein phosphatase inhibitor 1 Proteins 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 230000000747 cardiac effect Effects 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 241000702421 Dependoparvovirus Species 0.000 claims 3
- 206010019280 Heart failures Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 210000003462 vein Anatomy 0.000 claims 3
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 102220540010 Protein phosphatase 1 regulatory subunit 1A_T35D_mutation Human genes 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000004217 heart function Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 108091006112 ATPases Proteins 0.000 claims 1
- 241000972680 Adeno-associated virus - 6 Species 0.000 claims 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 102000005604 Myosin Heavy Chains Human genes 0.000 claims 1
- 108010084498 Myosin Heavy Chains Proteins 0.000 claims 1
- 102000016349 Myosin Light Chains Human genes 0.000 claims 1
- 108010067385 Myosin Light Chains Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 102000004987 Troponin T Human genes 0.000 claims 1
- 108090001108 Troponin T Proteins 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 230000003913 calcium metabolism Effects 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 230000008602 contraction Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000010247 heart contraction Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000002530 ischemic preconditioning effect Effects 0.000 claims 1
- 230000006371 metabolic abnormality Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 102000005681 phospholamban Human genes 0.000 claims 1
- 108010059929 phospholamban Proteins 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 210000001908 sarcoplasmic reticulum Anatomy 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60821404P | 2004-09-09 | 2004-09-09 | |
| PCT/US2005/032162 WO2006029319A2 (en) | 2004-09-09 | 2005-09-08 | Modulating phosphatase activity in cardiac cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008512484A JP2008512484A (ja) | 2008-04-24 |
| JP2008512484A5 true JP2008512484A5 (OSRAM) | 2008-10-23 |
Family
ID=36037020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531364A Pending JP2008512484A (ja) | 2004-09-09 | 2005-09-08 | 心臓細胞におけるホスファターゼ活性の調節 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9114148B2 (OSRAM) |
| EP (1) | EP1791432A4 (OSRAM) |
| JP (1) | JP2008512484A (OSRAM) |
| CN (1) | CN101056539B (OSRAM) |
| AU (1) | AU2005282352B2 (OSRAM) |
| CA (1) | CA2579519A1 (OSRAM) |
| WO (1) | WO2006029319A2 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964196B2 (en) * | 2004-05-25 | 2011-06-21 | Chimeros, Inc. | Self-assembling nanoparticle drug delivery system |
| EP2441770A1 (en) * | 2006-02-10 | 2012-04-18 | The University of Cincinnati | Phosphatase inhibitor protein-1 as a regulator of cardiac function |
| EP2018156B1 (en) * | 2006-04-07 | 2010-03-17 | Chimeros, Inc. | Compositions and methods for treating b- cell malignancies |
| PL2044199T3 (pl) * | 2006-07-25 | 2013-04-30 | Celladon Corp | Przedłużony, podawany z prądem krwi, nasierdziowy, wieńcowy wlew wektorów wirusowych na bazie wirusów towarzyszących adenowirusom, zawierający SERCA2a do terapii genowej |
| US20090226525A1 (en) * | 2007-04-09 | 2009-09-10 | Chimeros Inc. | Self-assembling nanoparticle drug delivery system |
| WO2008137681A2 (en) * | 2007-05-02 | 2008-11-13 | Intrexon Corporation | Pp1 ligands |
| WO2010093784A2 (en) | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| JP5370969B2 (ja) * | 2010-02-23 | 2013-12-18 | 国立大学法人金沢大学 | 心筋障害の検査方法 |
| JP6042825B2 (ja) | 2011-02-10 | 2016-12-14 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 改変された形質導入プロファイルを有するウイルスベクターならびにその製造および使用の方法 |
| EP2747774A4 (en) | 2011-09-09 | 2015-02-11 | Biomed Realty L P | METHOD AND COMPOSITIONS FOR CONTROLLING VIRUS PROTECTION |
| IL293294B2 (en) | 2013-03-15 | 2023-04-01 | Univ North Carolina Chapel Hill | Methods and compounds for ligation of paired aav glycan vectors |
| US10907176B2 (en) | 2015-01-14 | 2021-02-02 | The University Of North Carolina At Chapel Hill | Methods and compositions for targeted gene transfer |
| JP6854766B2 (ja) | 2015-01-26 | 2021-04-07 | イエール ユニバーシティ | チロシンキナーゼ阻害剤を用いる組成物および方法 |
| MX2017010698A (es) | 2015-02-20 | 2018-04-30 | Univ Texas | Metodos y composiciones para chlamydia atenuada como vacuna y vector. |
| PT3356390T (pt) | 2015-09-28 | 2021-04-21 | Univ Florida | Métodos e composições para vetores virais que se evadem a anticorpos |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
| CN110770346B (zh) | 2017-03-15 | 2024-01-12 | 北卡罗来纳-查佩尔山大学 | 多倍体腺相关病毒载体及其制备和使用方法 |
| EP3759218A4 (en) | 2018-02-28 | 2021-12-08 | The University of North Carolina at Chapel Hill | PROCEDURES AND COMPOSITIONS FOR ANTIBODY ELIMINATING VIRUS VECTORS |
| JP7425738B2 (ja) | 2018-04-03 | 2024-01-31 | ギンコ バイオワークス インコーポレイテッド | 眼組織を標的とするウイルスベクター |
| SG11202009452WA (en) | 2018-04-03 | 2020-10-29 | Stridebio Inc | Antibody-evading virus vectors |
| JP2021519581A (ja) | 2018-04-03 | 2021-08-12 | ストライドバイオ，インコーポレイテッド | 抗体を回避するウイルスベクター |
| AU2020241888A1 (en) | 2019-03-21 | 2021-09-30 | Ginkgo Bioworks, Inc. | Recombinant adeno-associated virus vectors |
| CN110367188A (zh) * | 2019-04-04 | 2019-10-25 | 上海大学 | 心肌层转染慢病毒的小鼠模型的构建方法 |
| JP2022529662A (ja) | 2019-04-26 | 2022-06-23 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 二重グリカン結合ａａｖ２．５ベクターのための方法および組成物 |
| KR20220083714A (ko) | 2019-10-17 | 2022-06-20 | 스트라이드바이오 인코포레이티드 | 니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터 |
| CN116096394A (zh) | 2020-02-13 | 2023-05-09 | 特纳亚治疗股份有限公司 | 用于治疗心脏病的基因疗法载体 |
| CN116406297A (zh) * | 2020-08-05 | 2023-07-07 | 阿斯克肋匹奥生物制药公司 | 治疗心脏疾患和充血性心力衰竭以及施用aav载体的方法 |
| AR123288A1 (es) | 2020-08-19 | 2022-11-16 | Stridebio Inc | Vectores de virus adenoasociados para el tratamiento del síndrome de rett |
| ES3001131T3 (es) | 2020-10-28 | 2025-03-04 | Univ North Carolina Chapel Hill | Métodos y composiciones para la unión dual de glicanos al vector de AAV2.5 |
| WO2022093769A1 (en) | 2020-10-28 | 2022-05-05 | The University Of North Carolina At Chapel Hill | Methods and compositions for dual glycan binding aav2.5 vector |
| TW202242124A (zh) | 2021-01-14 | 2022-11-01 | 美商史崔德生物公司 | 靶向ｔ細胞之ａａｖ載體 |
| CA3216491A1 (en) | 2021-04-16 | 2022-10-20 | Asklepios Biopharmaceutical, Inc. | Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response |
| TW202342759A (zh) | 2022-02-04 | 2023-11-01 | 美商史崔德生物公司 | 重組腺相關病毒載體及其使用方法 |
| WO2024124019A2 (en) | 2022-12-07 | 2024-06-13 | Ginkgo Bioworks, Inc. | Aav vectors targeting hematopoietic stem cells |
| KR20240173703A (ko) * | 2023-06-05 | 2024-12-13 | (주)벳바젠 | 포스포람반의 단백질 포스파타아제 1-매개 탈인산화 억제용 데코이 펩타이드를 암호화하는 뉴클레오타이드 및 ccn5 단백질 또는 이의 단편을 암호화하는 뉴클레오타이드를 포함하는 유전자 컨스트럭트 및 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5589375A (en) * | 1992-10-06 | 1996-12-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. | PTP 1D: a novel protein tyrosine phosphatase |
| US7745416B2 (en) * | 1995-04-11 | 2010-06-29 | The Regents Of The University Of California | Method for in vivo regulation of cardiac muscle contractility |
| US20020040010A1 (en) * | 1997-07-22 | 2002-04-04 | Anthony Rosenzweig | Use of agents to treat heart disorders |
| US20050095227A1 (en) * | 1997-07-22 | 2005-05-05 | The General Hospital Corporation | Treating heart failure |
| US6416992B1 (en) * | 1998-10-13 | 2002-07-09 | Avigen, Inc. | Compositions and methods for producing recombinant adeno-associated virus |
| WO2002055710A2 (en) * | 2001-01-11 | 2002-07-18 | Bayer Ag | Regulation of human purple acid phosphatase |
| WO2002056837A2 (en) | 2001-01-15 | 2002-07-25 | Henry Ford Health System | Inhibition of protein-phosphatases for the treatment of heart failure |
| US20020159978A1 (en) * | 2001-02-06 | 2002-10-31 | James Allen | Muscle-directed gene transfer by use of recombinant AAV-1 and AAV-6 virions |
| US7655467B2 (en) * | 2003-11-14 | 2010-02-02 | The University Of Washington | Compositions and methods for systemic nucleic acid sequence delivery |
| EP2441770A1 (en) | 2006-02-10 | 2012-04-18 | The University of Cincinnati | Phosphatase inhibitor protein-1 as a regulator of cardiac function |
-
2005
- 2005-09-08 CN CN2005800383370A patent/CN101056539B/zh not_active Expired - Fee Related
- 2005-09-08 CA CA002579519A patent/CA2579519A1/en not_active Abandoned
- 2005-09-08 US US11/662,439 patent/US9114148B2/en active Active
- 2005-09-08 EP EP05804009A patent/EP1791432A4/en not_active Withdrawn
- 2005-09-08 WO PCT/US2005/032162 patent/WO2006029319A2/en not_active Ceased
- 2005-09-08 JP JP2007531364A patent/JP2008512484A/ja active Pending
- 2005-09-08 AU AU2005282352A patent/AU2005282352B2/en not_active Ceased
-
2016
- 2016-03-09 US US15/065,507 patent/US11213534B2/en not_active Expired - Lifetime
-
2019
- 2019-04-11 US US16/381,781 patent/US12343353B2/en not_active Expired - Lifetime
- 2019-12-31 US US16/731,585 patent/US20200171059A1/en not_active Abandoned
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