JP2008509132A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008509132A5 JP2008509132A5 JP2007524466A JP2007524466A JP2008509132A5 JP 2008509132 A5 JP2008509132 A5 JP 2008509132A5 JP 2007524466 A JP2007524466 A JP 2007524466A JP 2007524466 A JP2007524466 A JP 2007524466A JP 2008509132 A5 JP2008509132 A5 JP 2008509132A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- day
- pharmaceutical composition
- treatment
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims 4
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 4
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 4
- 229960001109 policosanol Drugs 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 239000006014 omega-3 oil Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- QOEHNLSDMADWEF-UHFFFAOYSA-N I-Dotriacontanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO QOEHNLSDMADWEF-UHFFFAOYSA-N 0.000 claims 2
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 230000002402 anti-lipaemic effect Effects 0.000 claims 2
- 210000000748 cardiovascular system Anatomy 0.000 claims 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 2
- 229940110767 coenzyme Q10 Drugs 0.000 claims 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229930014626 natural product Natural products 0.000 claims 2
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 claims 2
- 229960000903 pantethine Drugs 0.000 claims 2
- 235000008975 pantethine Nutrition 0.000 claims 2
- 239000011581 pantethine Substances 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 239000011669 selenium Substances 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- 229960002855 simvastatin Drugs 0.000 claims 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 2
- UZSAQAWEIQNGJT-UHFFFAOYSA-N tetracontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO UZSAQAWEIQNGJT-UHFFFAOYSA-N 0.000 claims 2
- TYWMIZZBOVGFOV-UHFFFAOYSA-N tetracosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCO TYWMIZZBOVGFOV-UHFFFAOYSA-N 0.000 claims 2
- REZQBEBOWJAQKS-UHFFFAOYSA-N triacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO REZQBEBOWJAQKS-UHFFFAOYSA-N 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 1
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 1
- 240000000111 Saccharum officinarum Species 0.000 claims 1
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 229960005110 cerivastatin Drugs 0.000 claims 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 ecocontanol Chemical compound 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- DDJYKWPDLSFXPT-UHFFFAOYSA-N hexacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO DDJYKWPDLSFXPT-UHFFFAOYSA-N 0.000 claims 1
- 229960004844 lovastatin Drugs 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 229960000672 rosuvastatin Drugs 0.000 claims 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 1
- 229940091258 selenium supplement Drugs 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM2004A000395 | 2004-08-03 | ||
| IT000395A ITRM20040395A1 (it) | 2004-08-03 | 2004-08-03 | Composizione comprendente statine e acidi grassi omega 3. |
| PCT/IT2005/000414 WO2006013602A1 (en) | 2004-08-03 | 2005-07-19 | Composition containing statins and omega-3 fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509132A JP2008509132A (ja) | 2008-03-27 |
| JP2008509132A5 true JP2008509132A5 (https=) | 2008-09-04 |
| JP5103179B2 JP5103179B2 (ja) | 2012-12-19 |
Family
ID=35124288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524466A Expired - Fee Related JP5103179B2 (ja) | 2004-08-03 | 2005-07-19 | スタチンおよびオメガ−３脂肪酸を含む組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8853229B2 (https=) |
| EP (1) | EP1773312B1 (https=) |
| JP (1) | JP5103179B2 (https=) |
| KR (1) | KR101355122B1 (https=) |
| CN (1) | CN1993119B (https=) |
| AU (1) | AU2005268402B2 (https=) |
| BR (1) | BRPI0514026A (https=) |
| CA (1) | CA2573000C (https=) |
| CY (1) | CY1115416T1 (https=) |
| DK (1) | DK1773312T3 (https=) |
| EA (1) | EA014444B1 (https=) |
| ES (1) | ES2481169T3 (https=) |
| IL (1) | IL180602A (https=) |
| IT (1) | ITRM20040395A1 (https=) |
| MX (1) | MX2007001009A (https=) |
| NZ (1) | NZ552396A (https=) |
| PL (1) | PL1773312T3 (https=) |
| PT (1) | PT1773312E (https=) |
| SI (1) | SI1773312T1 (https=) |
| WO (1) | WO2006013602A1 (https=) |
| ZA (1) | ZA200701816B (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008509154A (ja) | 2004-08-06 | 2008-03-27 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なスタチン薬剤組成物および関連治療方法 |
| DE102004063638A1 (de) * | 2004-12-31 | 2006-07-13 | Biosyn Arzneimittel Gmbh | Selen-haltige Medikamente zur Prophylaxe oder Therapie von endothelialen Gefäßerkrankungen |
| WO2006096806A2 (en) * | 2005-03-08 | 2006-09-14 | Reliant Pharmaceutiacals, Inc. | Treatment with statin and omega-3 fatty acids and a combination product thereof |
| KR20080068850A (ko) * | 2005-10-14 | 2008-07-24 | 디에스엠 아이피 어셋츠 비.브이. | 레스베라트롤을 포함하는 기능성식품 조성물의 신규한 용도 |
| US8784886B2 (en) | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
| US20080085911A1 (en) | 2006-10-10 | 2008-04-10 | Reliant Pharmaceuticals, Inc. | Statin and omega-3 fatty acids for reduction of apo-b levels |
| EP2334295B1 (en) | 2008-09-02 | 2017-06-28 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| ITFI20080243A1 (it) * | 2008-12-15 | 2010-06-16 | Valpharma Sa | Formulazioni per la somministrazione orale di acidi grassi omega polienoici in combinazione con statine di origine naturale o semi-sintetica. |
| SI2395991T1 (sl) | 2009-02-10 | 2013-12-31 | Amarin Pharmaceuticals Ireland Limited | Uporaba etil estra eikozapentaenojske kisline za zdravljenje hipertrigliceridemije |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| SG10201605794PA (en) | 2009-04-29 | 2016-09-29 | Amarin Pharmaceuticals Ie Ltd | Stable Pharmaceutical Composition And Methods Of Using Same |
| DK2440065T3 (en) * | 2009-06-12 | 2018-12-10 | Calanus As | COPYPOD OIL COMPOSITION, FORMULATIONS CONTAINING THE OIL COMPOSITION, AND ITS APPLICATION FOR REDUCING VISCAL FAT COLLECTION, IMPROVEMENT OF GLUCOSET TOLERANCE AND PREVENTION OR TREATMENT OF PATIENTS |
| EP3318255B1 (en) | 2009-06-15 | 2021-03-10 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating stroke in a subject on concomitant statin therapy |
| AU2010298222B2 (en) * | 2009-09-23 | 2017-01-05 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| KR20120104270A (ko) | 2009-12-23 | 2012-09-20 | 데피안떼 파마슈띠까 에스.에이. | 심혈관계 질환 치료에 유용한 복합 조성물 |
| US8557236B2 (en) * | 2010-02-09 | 2013-10-15 | Vascure Natural LLC | Cardiovascular support supplement and compositions and methods thereof |
| NZ744990A (en) | 2010-11-29 | 2019-10-25 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US9861116B2 (en) | 2010-12-20 | 2018-01-09 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| AU2015201811B2 (en) * | 2010-12-20 | 2016-09-29 | Hill's Pet Nutrition, Inc. | Pet food compositions for inducing a satiety response |
| KR101310710B1 (ko) * | 2011-03-23 | 2013-09-27 | 한미약품 주식회사 | 오메가-3 지방산 에스테르 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 경구용 복합 조성물 |
| WO2013070735A1 (en) | 2011-11-07 | 2013-05-16 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| ES2891473T3 (es) | 2012-01-06 | 2022-01-28 | Amarin Pharmaceuticals Ie Ltd | Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto |
| EP3072510B1 (en) * | 2012-03-30 | 2019-05-08 | Micelle BioPharma, Inc. | Omega-3 fatty acid ester compositions |
| EP2875359A4 (en) | 2012-03-30 | 2015-08-19 | Charles R Drew University Of Medicine And Science | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES |
| NZ727849A (en) | 2012-06-29 | 2018-06-29 | Amarin Pharmaceuticals Ie Ltd | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| WO2015003246A1 (en) * | 2013-07-09 | 2015-01-15 | Mcmaster University | Combination of a statin with an inflammasome inhibitor |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| RU2554806C1 (ru) * | 2014-07-29 | 2015-06-27 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | Способ коррекции повышенного уровня тревоги и депрессии у пациентов с артериальной гипертонией на фоне сахарного диабета 2 типа |
| CN104922160A (zh) * | 2015-05-22 | 2015-09-23 | 舟山三合生物科技有限公司 | 他汀与Omega-3脂肪酸和辅酶Q10复配的组合物及其应用 |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| ITUA20162575A1 (it) | 2016-04-13 | 2017-10-13 | S&R Farm S P A | Composizione farmaceutica o nutraceutica per l’uso nel trattamento della sindrome dell’ovaio policistico o di malattie o disturbi correlati ad essa |
| TW201900160A (zh) | 2017-05-19 | 2019-01-01 | 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 | 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法 |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| CN111989093A (zh) | 2018-04-16 | 2020-11-24 | S&R制药股份有限公司 | 一种用于治疗女性生育的负载在金属氢氧化物上的白藜芦醇与非负载纯白藜芦醇的混合物 |
| LT3750536T (lt) | 2018-09-24 | 2026-03-25 | Amarin Pharmaceuticals Ireland Limited | Širdies ir kraujagyslių sistemos reiškinių rizikos subjekto organizme sumažinimo būdai |
| BR112022009189A2 (pt) | 2019-11-12 | 2022-07-26 | Amarin Pharmaceuticals Ie Ltd | Métodos para reduzir o risco de eventos cardiovasculares em um sujeito com fibrilação atrial e/ou palpitação atrial |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055638C (zh) * | 1995-07-14 | 2000-08-23 | 李江 | 富硒虫草口服液及其制备方法 |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US20030228393A1 (en) * | 2002-05-31 | 2003-12-11 | Zhao Iris Ginron | Multi-phase food & beverage |
| CN1061259C (zh) | 1998-11-24 | 2001-01-31 | 彭素萍 | 藜蒿中生物活性物质的富集物及用途 |
| WO2002043659A2 (en) * | 2000-11-29 | 2002-06-06 | Smithkline Beecham Corporation | Composition containing statins and calcium for improved cardiovascular health |
| US20050002992A1 (en) * | 2003-06-17 | 2005-01-06 | Mccleary Edward Larry | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
| US20020182585A1 (en) * | 2001-01-10 | 2002-12-05 | George Kindness | Combination and method using EDTA, cystine, zinc and selenium for anti-thrombin effect and for anti-platelet aggregation and measurement of efficacy |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| US20040018248A1 (en) * | 2001-11-29 | 2004-01-29 | Adrianne Bendich | Composition containing statins and calcium for improved cardiovascular health |
| US6855353B2 (en) * | 2002-03-08 | 2005-02-15 | Yaguang Liu | Method for producing antioxidant and prevention of cancer |
| US20050256178A1 (en) * | 2002-08-23 | 2005-11-17 | Eggersdorfer Manfred L | Novel nutraceutical compositions comprising boitin |
| EP2384750A1 (en) * | 2002-09-27 | 2011-11-09 | Martek Biosciences Corporation | Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid |
| JP2006508096A (ja) * | 2002-11-07 | 2006-03-09 | ディーエスエム アイピー アセッツ ビー．ブイ． | 没食子酸エピガロカテキンを含む新規な栄養補助組成物 |
-
2004
- 2004-08-03 IT IT000395A patent/ITRM20040395A1/it unknown
-
2005
- 2005-07-19 ES ES05769486.1T patent/ES2481169T3/es not_active Expired - Lifetime
- 2005-07-19 CN CN2005800258385A patent/CN1993119B/zh not_active Expired - Fee Related
- 2005-07-19 EP EP05769486.1A patent/EP1773312B1/en not_active Expired - Lifetime
- 2005-07-19 AU AU2005268402A patent/AU2005268402B2/en not_active Ceased
- 2005-07-19 PL PL05769486T patent/PL1773312T3/pl unknown
- 2005-07-19 CA CA2573000A patent/CA2573000C/en not_active Expired - Fee Related
- 2005-07-19 MX MX2007001009A patent/MX2007001009A/es active IP Right Grant
- 2005-07-19 SI SI200531865T patent/SI1773312T1/sl unknown
- 2005-07-19 EA EA200700240A patent/EA014444B1/ru not_active IP Right Cessation
- 2005-07-19 WO PCT/IT2005/000414 patent/WO2006013602A1/en not_active Ceased
- 2005-07-19 BR BRPI0514026-9A patent/BRPI0514026A/pt not_active Application Discontinuation
- 2005-07-19 JP JP2007524466A patent/JP5103179B2/ja not_active Expired - Fee Related
- 2005-07-19 NZ NZ552396A patent/NZ552396A/en not_active IP Right Cessation
- 2005-07-19 DK DK05769486.1T patent/DK1773312T3/da active
- 2005-07-19 PT PT57694861T patent/PT1773312E/pt unknown
- 2005-07-19 US US11/632,953 patent/US8853229B2/en not_active Expired - Fee Related
- 2005-07-19 KR KR1020077004538A patent/KR101355122B1/ko not_active Expired - Fee Related
-
2007
- 2007-01-08 IL IL180602A patent/IL180602A/en not_active IP Right Cessation
- 2007-03-01 ZA ZA200701816A patent/ZA200701816B/en unknown
-
2014
- 2014-07-16 CY CY20141100583T patent/CY1115416T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008509132A5 (https=) | ||
| KR101355122B1 (ko) | 스타틴 및 오메가 3 지방산 함유 조성물 | |
| RU2022100434A (ru) | Фармацевтические композиции, содержащие epa и сердечно-сосудистое средство, и способы их применения | |
| US20120219619A1 (en) | Substances for reducing occurrence of major cardiac events in humans | |
| ES2542412T3 (es) | Composición útil para el tratamiento de trastornos del metabolismo de los lípidos | |
| HRP20180423T1 (hr) | Pripravci i postupci za smanjivanje triglicerida bez povećavanja razina ldl-c kod subjekta koji je na istovremenoj terapiji sa statinom | |
| HK1222551A1 (zh) | ω-3脂肪酸的自乳化组合物 | |
| JP2008542300A (ja) | 炎症と関連した状態を予防及び治療するための組成物及び方法 | |
| JP2003048831A5 (https=) | ||
| DE60005152D1 (de) | Arzneimittel, nahrungszusätze und kosmetische zubereitung enthaltend eine fettsäure und ingwer | |
| JP2012516842A5 (https=) | ||
| JP2008050367A5 (https=) | ||
| CN103002889B (zh) | Sn‑2‑单酰基甘油和脂质吸收不良 | |
| CN102791266A (zh) | 用于减少主要心脏事件发生的包括红曲米提取物和ω-3多不饱和脂肪酸或其衍生物的物质 | |
| McCarty | Policosanol safely down-regulates HMG-CoA reductase–potential as a component of the Esselstyn regimen | |
| WO2008146016A3 (en) | Cyclodextrins for administering fatty acids in tablets | |
| WO2009059717A3 (en) | Pharmaceutical compositions containing statins and omega-3 fatty acids derivatives and their solid formulations for oral use | |
| JP6083942B2 (ja) | 長命草及び魚介油を含む組成物 | |
| CA2617805A1 (en) | Novel formulations comprising fenofibrate and a statin, and related methods of treatment | |
| JP4005104B2 (ja) | 脳卒中再発予防用組成物 | |
| JP2006176498A5 (https=) | ||
| NZ807894B2 (en) | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same | |
| CA2676583C (en) | Composition comprising red yeast rice and an omega-3 polyunsaturated fatty acid | |
| HK40040979A (en) | SELF-EMULSIFYING COMPOSITION OF ω-3 FATTY ACID | |
| HK1105871B (en) | Composition containing statins and omega-3 fatty acids |