JP2008508298A5 - - Google Patents
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- JP2008508298A5 JP2008508298A5 JP2007523776A JP2007523776A JP2008508298A5 JP 2008508298 A5 JP2008508298 A5 JP 2008508298A5 JP 2007523776 A JP2007523776 A JP 2007523776A JP 2007523776 A JP2007523776 A JP 2007523776A JP 2008508298 A5 JP2008508298 A5 JP 2008508298A5
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- Prior art keywords
- inhibitor
- cancer
- disease
- pharmaceutical composition
- sarcoma
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| CN1713905A (zh) * | 2002-10-15 | 2005-12-28 | 细胞基因公司 | 用于治疗骨髓增生异常综合征的选择性细胞因子抑制药 |
| MXPA05004777A (es) * | 2002-11-06 | 2005-07-22 | Celgene Corp | Metodos de uso y composiciones que comprenden farmacos inhibidores selectivos de citocina para el tratamiento y el manejo de padecimientos mieloproliferativos. |
| US20080213213A1 (en) * | 2004-04-14 | 2008-09-04 | Zeldis Jerome B | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione |
| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
| EP1896007B1 (en) * | 2005-05-04 | 2014-03-19 | Medigene AG | Method of administering a cationic liposomal preparation comprising paclitexel |
| MX2007016290A (es) | 2005-06-30 | 2008-03-10 | Celgene Corp | Procesos para la preparacion de compuestos de 4-amino-2(2,6-dioxopiperidin-3-il)isoindolin-1,3-diona. |
| BRPI0709075A2 (pt) | 2006-03-20 | 2011-10-11 | Medigene Ag | tratamento de cáncer de mama triplo receptor negativo |
| US20080064876A1 (en) * | 2006-05-16 | 2008-03-13 | Muller George W | Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| TW200806625A (en) * | 2006-05-26 | 2008-02-01 | Astrazeneca Ab | Therapeutic compounds |
| WO2009039635A1 (en) * | 2007-09-24 | 2009-04-02 | Painceptor Pharma Corporation | Methods of modulating neurotrophin-mediated activity |
| EP2395995A1 (en) | 2009-02-10 | 2011-12-21 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
| BRPI1007620A2 (pt) * | 2009-05-12 | 2016-02-23 | Koninkl Philips Electronics Nv | fosfodoestera 9a,composição metodo,metodo de aquisição de dados e imunoesnsaio para diagnostico, detecção, monitoramento ou prognostico do cancer de proposta, ou para diagnostico,detecção monitoramento ou prognostico da progressao do cancer de prostata. |
| CN101580501B (zh) * | 2009-06-01 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体 |
| EP2493872A1 (en) * | 2009-09-03 | 2012-09-05 | Ranbaxy Laboratories Limited | Process for the preparation of lenalidomide |
| GB2474120B (en) * | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| CN101747255B (zh) * | 2009-12-22 | 2011-11-23 | 上海大学 | 含烯炔结构的异吲哚酮类化合物及其合成方法 |
| PL3202460T3 (pl) | 2010-02-11 | 2019-12-31 | Celgene Corporation | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| EP2583098B1 (en) | 2010-06-15 | 2018-08-08 | Celgene Corporation | Biomarkers for the treatment of psoriasis |
| CN104045594B (zh) * | 2012-02-21 | 2016-08-17 | 四川大学 | 一类1,3-二氢-1-氧-2h-异吲哚类化合物及其用途 |
| CN102603610B (zh) * | 2012-02-21 | 2014-07-09 | 四川大学 | 1,3-二氢-1-氧-2h-异吲哚类化合物、其制备方法和用途 |
| KR101441096B1 (ko) * | 2012-11-27 | 2014-09-25 | 가톨릭대학교 산학협력단 | 제피티닙을 포함하는 톡소포자충 감염증의 예방 및 치료용 조성물 |
| NZ629456A (en) | 2013-04-17 | 2017-06-30 | Signal Pharm Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| CN104721820A (zh) * | 2013-12-24 | 2015-06-24 | 信达生物制药(苏州)有限公司 | 双特异性单克隆抗体在治疗葡萄膜炎中的用途 |
| WO2015175956A1 (en) | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
| TR201807217T4 (tr) * | 2014-07-08 | 2018-06-21 | Viiv Healthcare Uk Ltd | Bir viral enfeksiyon sahasının tedavisinde kullanım için izoindolin türevleri. |
| EP3324962A4 (en) | 2015-07-23 | 2018-12-19 | Temple University Of The Commonwealth System Of Higher Education | Novel aminothiazole compounds and methods using same |
| WO2017070291A1 (en) | 2015-10-21 | 2017-04-27 | Celgene Corporation | Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris) |
| WO2018136766A1 (en) * | 2017-01-19 | 2018-07-26 | Temple University-Of The Commonwealth System Of Higher Education | Novel bridged bicycloalkyl-substituted aminothizoles and their methods of use |
| US10717703B2 (en) | 2017-08-21 | 2020-07-21 | Celgene Corporation | Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate |
| JP7086272B2 (ja) * | 2018-08-16 | 2022-06-17 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | イソインドリン－１－オン誘導体、同じものを調製する方法、およびがんを予防するまたは処置するための有効な構成要素として同じものを含む医薬組成物 |
| AU2020412805A1 (en) * | 2019-12-26 | 2022-07-14 | Hendrix College | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-CD38 therapeutic agent |
| CN114644586A (zh) * | 2022-04-12 | 2022-06-21 | 江苏豪森药业集团有限公司 | 一种来那度胺有关物质的制备方法 |
| WO2025118133A1 (zh) * | 2023-12-05 | 2025-06-12 | 浙江普洛家园药业有限公司 | 一种(s)-来那度胺-5-位衍生物及其合成方法和应用 |
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| HUP0003761A3 (en) | 1997-07-31 | 2001-04-28 | Celgene Corp Warren | Substituted alkanohydroxamic acids and pharmaceutical compositions containing them |
| CN1342146A (zh) * | 1999-03-18 | 2002-03-27 | 塞尔基因公司 | 取代的1－氧代－和1,3－二氧代异吲哚啉及其在用于减少炎性细胞因子含量的药物组合物中的用途 |
| US6326388B1 (en) * | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| NZ531294A (en) | 2001-08-06 | 2005-11-25 | Childrens Medical Center | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
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