JP2008508289A - 大環状βセクレターゼ阻害剤 - Google Patents
大環状βセクレターゼ阻害剤 Download PDFInfo
- Publication number
- JP2008508289A JP2008508289A JP2007523724A JP2007523724A JP2008508289A JP 2008508289 A JP2008508289 A JP 2008508289A JP 2007523724 A JP2007523724 A JP 2007523724A JP 2007523724 A JP2007523724 A JP 2007523724A JP 2008508289 A JP2008508289 A JP 2008508289A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- effective amount
- compound according
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C[C@](C[C@](Cc1cc(OCC=C)cc(F)c1)NC(C(C1)CN(CC=C)C1=O)=O)N(CC*Cc1ccccc1)C(OC(C)(C)C)=O Chemical compound C[C@](C[C@](Cc1cc(OCC=C)cc(F)c1)NC(C(C1)CN(CC=C)C1=O)=O)N(CC*Cc1ccccc1)C(OC(C)(C)C)=O 0.000 description 5
- MTUYSHOIUGFHHY-UNMCSNQZSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(F)cc(O)c2)N)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(F)cc(O)c2)N)C1=O)=O MTUYSHOIUGFHHY-UNMCSNQZSA-N 0.000 description 2
- KDYFFPSAFZGSMT-FCVAVIOVSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OCC=C)cc(F)c2)NC(C(C2)CN(CC=C)C2=O)=O)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OCC=C)cc(F)c2)NC(C(C2)CN(CC=C)C2=O)=O)C1=O)=O KDYFFPSAFZGSMT-FCVAVIOVSA-N 0.000 description 2
- DURRSEGFTCZKMK-UHFFFAOYSA-N C=CCN(CCC1)C1=O Chemical compound C=CCN(CCC1)C1=O DURRSEGFTCZKMK-UHFFFAOYSA-N 0.000 description 1
- NQPNARIZMOTIPS-LURJTMIESA-N C=CCN(C[C@H](C1)C(O)=O)C1=O Chemical compound C=CCN(C[C@H](C1)C(O)=O)C1=O NQPNARIZMOTIPS-LURJTMIESA-N 0.000 description 1
- VUBRXPCCSDAKSF-FLJXZVEISA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](CC(CC(O)=C2)C=C2F)NCO)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](CC(CC(O)=C2)C=C2F)NCO)C1=O)=O VUBRXPCCSDAKSF-FLJXZVEISA-N 0.000 description 1
- WLAIPYWRPVVJBN-GIWKVKTRSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(O)cc(F)c2)N(Cc2ccccc2)Cc2ccccc2)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(O)cc(F)c2)N(Cc2ccccc2)Cc2ccccc2)C1=O)=O WLAIPYWRPVVJBN-GIWKVKTRSA-N 0.000 description 1
- LPZZXOCVHACGJC-YBHZACMCSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OC/C=C\CN(CC3C4)C4=O)cc(F)c2)NC3=O)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OC/C=C\CN(CC3C4)C4=O)cc(F)c2)NC3=O)C1=O)=O LPZZXOCVHACGJC-YBHZACMCSA-N 0.000 description 1
- DTKDCAPUYTYMNM-NJZVCLLNSA-N CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OCCCCN(CC3C4)C4=O)cc(F)c2)NC3=O)C1=O)=O Chemical compound CC(C)(C)OC(N(CCN1Cc2ccccc2)[C@@H](C[C@H](Cc2cc(OCCCCN(CC3C4)C4=O)cc(F)c2)NC3=O)C1=O)=O DTKDCAPUYTYMNM-NJZVCLLNSA-N 0.000 description 1
- GWCKXQKMIPLNBH-JDWSMFLASA-N CC(C)(C)OC(N1[C@@H](C[C@H](Cc2cc(OCC=C)cc(F)c2)NC(C(C2)CN(CC=C)C2=O)=O)CN(Cc2ccccc2)CC1)=O Chemical compound CC(C)(C)OC(N1[C@@H](C[C@H](Cc2cc(OCC=C)cc(F)c2)NC(C(C2)CN(CC=C)C2=O)=O)CN(Cc2ccccc2)CC1)=O GWCKXQKMIPLNBH-JDWSMFLASA-N 0.000 description 1
- MJEVGEOCNIDHIY-PXVVLKLASA-N CC1C=CC(CN(CCN([C@H]2C[C@H](Cc3cc(O)cc(F)c3)N(Cc3ccccc3)Cc3ccccc3)C(OC(C)(C)C)=O)C2O)=CC1 Chemical compound CC1C=CC(CN(CCN([C@H]2C[C@H](Cc3cc(O)cc(F)c3)N(Cc3ccccc3)Cc3ccccc3)C(OC(C)(C)C)=O)C2O)=CC1 MJEVGEOCNIDHIY-PXVVLKLASA-N 0.000 description 1
- RZFOQDRVCZVOPK-UHFFFAOYSA-N CCCN(CC=C)C(c1cccc(C(OC)=O)c1)=O Chemical compound CCCN(CC=C)C(c1cccc(C(OC)=O)c1)=O RZFOQDRVCZVOPK-UHFFFAOYSA-N 0.000 description 1
- XFJGIOBRXXUOJE-SPSLYSOASA-N CN(CCN1Cc2ccccc2)[C@@H](C[C@H](CC(C2)=CC(OCCCCN(CC3C4)C4=O)=CC2F)NC3=O)C1=O Chemical compound CN(CCN1Cc2ccccc2)[C@@H](C[C@H](CC(C2)=CC(OCCCCN(CC3C4)C4=O)=CC2F)NC3=O)C1=O XFJGIOBRXXUOJE-SPSLYSOASA-N 0.000 description 1
- WMZNGTSLFSJHMZ-UHFFFAOYSA-N COC(c1cc(C(O)=O)ccc1)=O Chemical compound COC(c1cc(C(O)=O)ccc1)=O WMZNGTSLFSJHMZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59189904P | 2004-07-28 | 2004-07-28 | |
| PCT/US2005/026468 WO2006014944A1 (en) | 2004-07-28 | 2005-07-26 | Macrocyclic beta-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008508289A true JP2008508289A (ja) | 2008-03-21 |
| JP2008508289A5 JP2008508289A5 (https=) | 2008-09-04 |
Family
ID=35106859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007523724A Pending JP2008508289A (ja) | 2004-07-28 | 2005-07-26 | 大環状βセクレターゼ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7652003B2 (https=) |
| EP (1) | EP1781644B1 (https=) |
| JP (1) | JP2008508289A (https=) |
| CN (1) | CN101027297B (https=) |
| AR (1) | AR050184A1 (https=) |
| AT (1) | ATE396990T1 (https=) |
| CA (1) | CA2575340A1 (https=) |
| DE (1) | DE602005007245D1 (https=) |
| ES (1) | ES2306200T3 (https=) |
| MX (1) | MX2007001102A (https=) |
| TW (1) | TWI297337B (https=) |
| WO (1) | WO2006014944A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| GB0500683D0 (en) * | 2005-01-13 | 2005-02-23 | Novartis Ag | Organic compounds |
| PE20070135A1 (es) | 2005-06-14 | 2007-03-09 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil proteasas |
| AU2006259675A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| PE20080155A1 (es) | 2006-06-12 | 2008-03-10 | Schering Corp | Compuestos heterociclicos como inhibidores de aspartil-proteasa |
| BRPI0715437A2 (pt) * | 2006-07-20 | 2013-04-16 | Novartis Ag | lactamas macrocÍclicas |
| ATE549923T1 (de) | 2006-10-06 | 2012-04-15 | Merck Sharp & Dohme | Makrozyklische spiropiperidin-beta-sekretase- hemmer zur behandlung von morbus alzheimer |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| JP2010512389A (ja) | 2006-12-12 | 2010-04-22 | シェーリング コーポレイション | アスパルチルプロテアーゼ阻害剤 |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| US8518975B2 (en) | 2007-09-06 | 2013-08-27 | Merck Sharp + Dohme Corp. | Gamma secretase modulators |
| MX2010005028A (es) | 2007-11-05 | 2010-05-27 | Schering Corp | Moduladores de gamma secretasa. |
| EP2227471A1 (en) | 2007-12-11 | 2010-09-15 | Schering Corporation | Gamma secretase modulators |
| CA2723222C (en) | 2008-04-22 | 2013-04-02 | Schering Corporation | Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1 inhibitors, compositions, and their use |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| WO2010075204A2 (en) | 2008-12-22 | 2010-07-01 | Schering Corporation | Gamma secretase modulators |
| EP2379563B1 (en) | 2008-12-22 | 2014-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
| WO2010147973A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147975A1 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| WO2010147969A2 (en) | 2009-06-16 | 2010-12-23 | Schering Corporation | Gamma secretase modulators |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| WO2011044187A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| EP2485590B1 (en) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| EP2485920B1 (en) | 2009-10-08 | 2016-04-27 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| CN103874496A (zh) | 2011-08-22 | 2014-06-18 | 默沙东公司 | 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 |
| CN104270945B (zh) | 2012-03-19 | 2017-03-29 | 巴克老龄化研究所 | App特异性bace抑制剂(asbi)及其用途 |
| WO2014056816A1 (en) | 2012-10-10 | 2014-04-17 | F. Hoffmann-La Roche Ag | COMBINATION OF AN Aβ ANTIBODY AND A BACE INHIBITOR |
| EP2908824B1 (en) | 2012-10-17 | 2018-05-02 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
| US9422277B2 (en) | 2012-10-17 | 2016-08-23 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
| CA2899938C (en) | 2013-02-12 | 2021-10-19 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
| CN105175488A (zh) * | 2015-09-07 | 2015-12-23 | 西北农林科技大学 | 一种具有抗老年痴呆症活性的化合物及其制备方法 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| WO2002100856A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| WO2004043916A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2004062625A2 (en) * | 2003-01-07 | 2004-07-29 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03500772A (ja) | 1987-10-21 | 1991-02-21 | ジ・アップジョン・カンパニー | （１‐アミノ‐２‐ヒドロキシ‐２‐ヘテロサイクリック）エチル基を含有するレニン抑制物質類 |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| JP2004502664A (ja) | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病処置用化合物 |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| US20040171614A1 (en) * | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| RU2006144075A (ru) * | 2004-06-16 | 2008-07-27 | Вайет (Us) | ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ |
| BRPI0512213A (pt) * | 2004-06-16 | 2008-02-19 | Wyeth Corp | método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto |
| TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| AU2006266167A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation |
| TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| JP2009509957A (ja) * | 2005-09-26 | 2009-03-12 | ワイス | β−セクレターゼ阻害剤としてのアミノ−５−［４−（ジフルオロメトキシ）フェニル］−５−フェニルイミダゾロン化合物 |
| CN101460480A (zh) | 2006-04-05 | 2009-06-17 | 阿斯利康(瑞典)有限公司 | 2-氨基嘧啶-4-酮类化合物及其用于治疗或预防Aβ相关病理的用途 |
| TW200815443A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
| TW200815449A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
| TW200815447A (en) | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
| TW200808796A (en) | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
-
2005
- 2005-07-26 CA CA002575340A patent/CA2575340A1/en not_active Abandoned
- 2005-07-26 DE DE602005007245T patent/DE602005007245D1/de not_active Expired - Lifetime
- 2005-07-26 AR ARP050103099A patent/AR050184A1/es not_active Application Discontinuation
- 2005-07-26 MX MX2007001102A patent/MX2007001102A/es active IP Right Grant
- 2005-07-26 WO PCT/US2005/026468 patent/WO2006014944A1/en not_active Ceased
- 2005-07-26 CN CN2005800323948A patent/CN101027297B/zh not_active Expired - Fee Related
- 2005-07-26 JP JP2007523724A patent/JP2008508289A/ja active Pending
- 2005-07-26 EP EP05776414A patent/EP1781644B1/en not_active Expired - Lifetime
- 2005-07-26 ES ES05776414T patent/ES2306200T3/es not_active Expired - Lifetime
- 2005-07-26 US US11/189,346 patent/US7652003B2/en not_active Expired - Lifetime
- 2005-07-26 AT AT05776414T patent/ATE396990T1/de not_active IP Right Cessation
- 2005-07-27 TW TW094125432A patent/TWI297337B/zh not_active IP Right Cessation
-
2009
- 2009-10-01 US US12/571,840 patent/US8012953B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| WO2002100856A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| WO2004043916A1 (en) * | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2004062625A2 (en) * | 2003-01-07 | 2004-07-29 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AR050184A1 (es) | 2006-10-04 |
| CN101027297B (zh) | 2010-09-08 |
| US7652003B2 (en) | 2010-01-26 |
| US20060040948A1 (en) | 2006-02-23 |
| US20100178294A1 (en) | 2010-07-15 |
| EP1781644A1 (en) | 2007-05-09 |
| US8012953B2 (en) | 2011-09-06 |
| ATE396990T1 (de) | 2008-06-15 |
| CN101027297A (zh) | 2007-08-29 |
| DE602005007245D1 (https=) | 2008-07-10 |
| TWI297337B (en) | 2008-06-01 |
| EP1781644B1 (en) | 2008-05-28 |
| WO2006014944A1 (en) | 2006-02-09 |
| TW200607807A (en) | 2006-03-01 |
| CA2575340A1 (en) | 2006-02-09 |
| HK1102328A1 (en) | 2007-11-16 |
| ES2306200T3 (es) | 2008-11-01 |
| MX2007001102A (es) | 2007-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008508289A (ja) | 大環状βセクレターゼ阻害剤 | |
| JP2008507538A (ja) | 置換アミドβセクレターゼインヒビター | |
| JP4448134B2 (ja) | ベンズアミド置換基を有する環状アミンｂａｓｅ−１阻害剤 | |
| JP4472700B2 (ja) | 複素環置換基を有する環状アミンｂａｓｅ−１阻害剤 | |
| JP5020638B2 (ja) | 複素環式アスパルチルプロテアーゼインヒビター | |
| JP7264810B2 (ja) | アルファｖインテグリン阻害剤としてのシクロブタン－およびアゼチジン－含有の単環およびスピロ環式化合物 | |
| TW200948364A (en) | Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use | |
| JP2007513973A5 (https=) | ||
| CN104870000A (zh) | 作为bace抑制剂的c5,c6氧杂环稠合的亚胺基噻嗪二氧化物化合物,组合物及其用途 | |
| US20230303552A1 (en) | Arylsulfonyl derivatives and their use as muscarinic acetylcholine receptor m5 inhibitors | |
| US20240182445A1 (en) | Modulators of trek (twik related k+ channels) channel function | |
| HK1102328B (en) | Macrocyclic beta-secretase inhibitors | |
| WO2023150526A1 (en) | Competitive and noncompetitive octahydrocyclopenta[c]pyrrole inhibitors of the muscarinic acetylcholine receptor m5 | |
| WO2023150525A1 (en) | Competitive and noncompetitive piperidine sulfonyl inhibitors of the muscarinic acetylcholine receptor m5 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080718 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080718 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110921 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120307 |