JP2008507531A5 - - Google Patents
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- Publication number
- JP2008507531A5 JP2008507531A5 JP2007522672A JP2007522672A JP2008507531A5 JP 2008507531 A5 JP2008507531 A5 JP 2008507531A5 JP 2007522672 A JP2007522672 A JP 2007522672A JP 2007522672 A JP2007522672 A JP 2007522672A JP 2008507531 A5 JP2008507531 A5 JP 2008507531A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- angptl4
- hepatocytes
- subject
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100025674 Angiopoietin-related protein 4 Human genes 0.000 claims 30
- 210000003494 hepatocyte Anatomy 0.000 claims 16
- 239000005557 antagonist Substances 0.000 claims 13
- 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 102000055659 human ANGPTL4 Human genes 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 210000000229 preadipocyte Anatomy 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 3
- 230000004936 stimulating effect Effects 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 230000021164 cell adhesion Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 101150054149 ANGPTL4 gene Proteins 0.000 claims 1
- 108700042530 Angiopoietin-Like Protein 4 Proteins 0.000 claims 1
- 102000045205 Angiopoietin-Like Protein 4 Human genes 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58987504P | 2004-07-20 | 2004-07-20 | |
| US60/589,875 | 2004-07-20 | ||
| PCT/US2005/025650 WO2006014678A2 (en) | 2004-07-20 | 2005-07-19 | Compositions and methods of using angiopoietin-like 4 protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011184642A Division JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様４タンパク質を使用する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008507531A JP2008507531A (ja) | 2008-03-13 |
| JP2008507531A5 true JP2008507531A5 (enExample) | 2008-08-07 |
| JP5318412B2 JP5318412B2 (ja) | 2013-10-16 |
Family
ID=35787695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522672A Expired - Fee Related JP5318412B2 (ja) | 2004-07-20 | 2005-07-19 | アンジオポエチン様４タンパク質を使用する組成物および方法 |
| JP2011184642A Withdrawn JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様４タンパク質を使用する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011184642A Withdrawn JP2011235179A (ja) | 2004-07-20 | 2011-08-26 | アンジオポエチン様４タンパク質を使用する組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7371384B2 (enExample) |
| EP (1) | EP1781698B1 (enExample) |
| JP (2) | JP5318412B2 (enExample) |
| KR (1) | KR20070061524A (enExample) |
| CN (1) | CN101080419B (enExample) |
| AU (1) | AU2005269758B2 (enExample) |
| BR (1) | BRPI0513477A (enExample) |
| CA (1) | CA2574791A1 (enExample) |
| DK (1) | DK1781698T3 (enExample) |
| HU (1) | HUE029170T2 (enExample) |
| IL (4) | IL180752A0 (enExample) |
| LT (1) | LT1781698T (enExample) |
| MX (1) | MX2007000783A (enExample) |
| NO (1) | NO342525B1 (enExample) |
| NZ (2) | NZ552957A (enExample) |
| RU (2) | RU2380411C2 (enExample) |
| WO (1) | WO2006014678A2 (enExample) |
| ZA (1) | ZA200701184B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| MX2007000783A (es) | 2004-07-20 | 2007-04-09 | Genentech Inc | Inhibidores de proteina angiopoietina tipo 4, combinaciones y su uso. |
| US8604185B2 (en) | 2004-07-20 | 2013-12-10 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| AU2005269716B2 (en) * | 2004-07-20 | 2011-01-27 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| MX2007008256A (es) * | 2005-01-07 | 2007-12-06 | Lexicon Pharmaceuticals Inc | Anticuerpos monoclonales contra proteina 4 similar a angiopoyetina (angptl4). |
| CA2617984A1 (en) * | 2005-08-19 | 2007-03-01 | Washington University In St. Louis | Methods and compositions for treating gastrointestinal radiosensitivity in a subject |
| US20080311107A1 (en) * | 2006-02-17 | 2008-12-18 | Genetech, Inc. | Novel Gene Disruptions, Compositions and Methods Relating Thereto |
| CA2698812A1 (en) | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| EP2344890B1 (en) * | 2008-10-20 | 2021-08-11 | Liposcience, Inc. | Lipoprotein insulin resistance indexes and related methods |
| SG10201406420XA (en) | 2009-10-14 | 2014-11-27 | Univ Nanyang Tech | Antiproliferative agent |
| CN106146591B (zh) | 2010-01-08 | 2020-07-31 | Ionis制药公司 | 血管生成素样3表达的调节 |
| WO2011089152A1 (en) * | 2010-01-20 | 2011-07-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity |
| NO2575858T3 (enExample) * | 2010-06-05 | 2018-05-19 | ||
| US9139629B2 (en) | 2010-06-05 | 2015-09-22 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| US9475850B2 (en) * | 2010-06-05 | 2016-10-25 | The Uab Research Foundation | Methods for treatment of nephrotic syndrome and related conditions |
| CA2824434A1 (en) * | 2011-01-08 | 2012-07-12 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN102692500B (zh) * | 2011-03-21 | 2015-06-10 | 上海市肿瘤研究所 | Angptl4作为血清学检测肝癌转移的标志物及其应用 |
| CN102692496B (zh) * | 2011-03-21 | 2015-10-28 | 上海市肿瘤研究所 | Angptl4作为缺氧检测的标志物及其应用 |
| CN102242198A (zh) * | 2011-05-25 | 2011-11-16 | 信阳师范学院 | 通过angptl4基因多态性进行牛育种方法 |
| AU2012272970A1 (en) * | 2011-06-21 | 2014-02-06 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof |
| EP2726493B1 (en) * | 2011-07-01 | 2020-10-14 | Monsanto Technology LLC | Methods and compositions for selective regulation of protein expression |
| CN107536847A (zh) * | 2011-08-08 | 2018-01-05 | 南洋理工大学 | 血管生成素样4及其在调节细胞渗漏中的用途 |
| WO2013082667A1 (en) | 2011-12-09 | 2013-06-13 | Metabolic Pharmaceuticals Pty Ltd | Use of growth hormone fragments |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| SG11201500186VA (en) | 2012-07-19 | 2015-02-27 | Univ Nanyang Tech | Angiopoietin-like 4 and a method of its use in wound healing |
| JP2016516726A (ja) * | 2013-03-15 | 2016-06-09 | ザ・ユー・エイ・ビー・リサーチ・フアンデーシヨン | ネフローゼ症候群及び関連状態の治療方法 |
| KR102482890B1 (ko) | 2013-05-01 | 2022-12-30 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법 |
| EP3021942A4 (en) * | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| MX383753B (es) | 2013-12-24 | 2025-03-14 | Ionis Pharmaceuticals Inc | Modulación de la expresión similar a la angiopoyetina tipo 3. |
| US20170042870A1 (en) * | 2014-02-17 | 2017-02-16 | The Brigham And Women's Hospital, Inc. | Targeted nanoparticle compositions and methods of their use to treat obesity |
| SI3137605T1 (sl) | 2014-05-01 | 2021-02-26 | Ionis Pharmaceuticals, Inc. | Sestavki in metode za modulacijo ekspresije angiopoetin 3-podobnega |
| SG10201805646WA (en) | 2014-08-07 | 2018-08-30 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| CN105021827B (zh) * | 2015-07-17 | 2016-09-28 | 北京大学第一医院 | 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用 |
| RS63980B1 (sr) | 2015-07-22 | 2023-03-31 | Monsanto Technology Llc | Metode i sastavi za selektivnu regulaciju ekspresije proteina |
| CA2999341A1 (en) | 2015-11-06 | 2017-05-11 | Ionis Pharmaceuticals, Inc. | Modulating apolipoprotein (a) expression |
| EP3478840A1 (en) * | 2016-06-29 | 2019-05-08 | Crispr Therapeutics AG | Compositions and methods for gene editing |
| US12024708B2 (en) | 2018-11-13 | 2024-07-02 | Lipigon Pharmaceuticals Ab | ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism |
| US20220372169A1 (en) * | 2019-11-06 | 2022-11-24 | Northwestern University | Inhibition of the ve-ptp phosphatase protects the kidney from ischemia-reperfusion injury |
| CN115175685B (zh) * | 2019-12-09 | 2024-12-13 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| CN120254294B (zh) * | 2025-06-05 | 2025-09-09 | 南昌大学第一附属医院 | Angptl3在乙肝相关慢加急性肝衰竭预后中的应用 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227158A (en) | 1991-06-10 | 1993-07-13 | Genentech, Inc. | Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon |
| WO1999066041A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | 94 human secreted proteins |
| US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6348350B1 (en) | 1997-09-19 | 2002-02-19 | Genentech, Inc. | Ligand homologues |
| US20030207375A1 (en) | 1997-10-24 | 2003-11-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU1931599A (en) | 1997-12-19 | 1999-07-12 | Zymogenetics Inc. | Angiopoietin homolog, dna encoding it, and method of making it |
| CA2322425A1 (en) | 1998-03-02 | 1999-09-10 | Millennium Pharmaceuticals, Inc. | Novel fdrg protein and nucleic acid molecules and uses therefor |
| US20030099994A1 (en) | 1998-03-02 | 2003-05-29 | Millennium Pharamceuticals, Inc. | Novel FDRG protein and nucleic acid molecules and uses therefor |
| JP2000026767A (ja) | 1998-05-01 | 2000-01-25 | Daikin Ind Ltd | 熱硬化性粉体塗料組成物 |
| AU4643699A (en) | 1998-06-24 | 2000-01-10 | Compugen Ltd. | Angiopoietin-like growth factor sequences |
| WO2001057188A2 (en) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| WO2001053455A2 (en) | 1999-12-23 | 2001-07-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| JP2000308488A (ja) | 1999-02-23 | 2000-11-07 | Herikkusu Kenkyusho:Kk | 血管新生に関連するタンパク質および該タンパク質をコードする遺伝子 |
| WO2000052165A2 (en) | 1999-03-04 | 2000-09-08 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| DK1607402T3 (da) | 1999-03-08 | 2007-04-16 | Genentech Inc | Sammensætninger og fremgangsmåder til tumorbehandling |
| CA2370489A1 (en) | 1999-04-09 | 2000-10-19 | Human Genome Sciences, Inc. | 49 human secreted proteins |
| EP1171594B1 (en) | 1999-04-16 | 2006-06-07 | Genentech, Inc. | Vascular endothelial cell growth factor variants and uses thereof |
| AU5979300A (en) | 1999-07-02 | 2001-01-22 | Bayer Aktiengesellschaft | Angiopoietin-6 and uses thereof |
| WO2001005825A2 (en) | 1999-07-16 | 2001-01-25 | Hyseq, Inc. | Nucleic acid sequences encoding putative angiopoietin proteins |
| WO2001005971A2 (en) | 1999-07-20 | 2001-01-25 | Curagen Corporation | Secreted polypeptides and corresponding polynucleotides |
| US20030207348A1 (en) | 1999-07-20 | 2003-11-06 | Shimkets Richard A. | Polypeptides and polynucleotides encoding same |
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| CN1315451A (zh) | 2000-03-29 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人血管形成素类似因子45和编码这种多肽的多核苷酸 |
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| US6673545B2 (en) | 2000-07-28 | 2004-01-06 | Incyte Corporation | Prostate cancer markers |
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| WO2003010205A1 (en) | 2001-07-26 | 2003-02-06 | Duke University Medical Center | Genes induced by hypoxia |
| EP1434881A4 (en) | 2001-09-17 | 2005-10-26 | Protein Design Labs Inc | METHOD FOR DIAGNOSIS OF CANCER COMPOSITIONS AND METHOD FOR SCREENING ON CANCER MODULATORS |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| CA2460653A1 (en) | 2001-11-05 | 2003-05-15 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| US20040038230A1 (en) | 2001-11-05 | 2004-02-26 | Alsobrook John P. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| ES2429034T3 (es) | 2001-11-16 | 2013-11-12 | Genentech, Inc. | Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas |
| AU2002359464A1 (en) | 2001-11-30 | 2003-06-17 | Genvec, Inc. | Angiopioetin related factors |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| WO2003103581A2 (en) | 2002-06-05 | 2003-12-18 | Genentech, Inc. | Compositions and methods for liver growth and liver protection |
| US20050239706A1 (en) | 2003-10-31 | 2005-10-27 | Washington University In St. Louis | Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject |
| CA2499791A1 (en) | 2004-03-30 | 2005-09-30 | F. Hoffmann-La Roche Ag | Angptl4/fiaf as marker for ppardelta modulation |
| MX2007000783A (es) * | 2004-07-20 | 2007-04-09 | Genentech Inc | Inhibidores de proteina angiopoietina tipo 4, combinaciones y su uso. |
| AU2005269716B2 (en) * | 2004-07-20 | 2011-01-27 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| MX2007008256A (es) * | 2005-01-07 | 2007-12-06 | Lexicon Pharmaceuticals Inc | Anticuerpos monoclonales contra proteina 4 similar a angiopoyetina (angptl4). |
-
2005
- 2005-07-19 MX MX2007000783A patent/MX2007000783A/es active IP Right Grant
- 2005-07-19 DK DK05790823.8T patent/DK1781698T3/en active
- 2005-07-19 WO PCT/US2005/025650 patent/WO2006014678A2/en not_active Ceased
- 2005-07-19 RU RU2007106075/13A patent/RU2380411C2/ru active
- 2005-07-19 BR BRPI0513477-3A patent/BRPI0513477A/pt not_active Application Discontinuation
- 2005-07-19 CA CA002574791A patent/CA2574791A1/en not_active Abandoned
- 2005-07-19 HU HUE05790823A patent/HUE029170T2/en unknown
- 2005-07-19 US US11/185,204 patent/US7371384B2/en active Active
- 2005-07-19 CN CN200580031686.XA patent/CN101080419B/zh not_active Expired - Fee Related
- 2005-07-19 EP EP05790823.8A patent/EP1781698B1/en not_active Expired - Lifetime
- 2005-07-19 NZ NZ552957A patent/NZ552957A/en not_active IP Right Cessation
- 2005-07-19 KR KR1020077003874A patent/KR20070061524A/ko not_active Ceased
- 2005-07-19 JP JP2007522672A patent/JP5318412B2/ja not_active Expired - Fee Related
- 2005-07-19 AU AU2005269758A patent/AU2005269758B2/en not_active Expired
- 2005-07-19 ZA ZA200701184A patent/ZA200701184B/en unknown
- 2005-07-19 LT LTEP05790823.8T patent/LT1781698T/lt unknown
-
2006
- 2006-09-28 US US11/540,430 patent/US20070054856A1/en not_active Abandoned
-
2007
- 2007-01-17 IL IL180752A patent/IL180752A0/en active IP Right Grant
- 2007-02-19 NO NO20070950A patent/NO342525B1/no not_active IP Right Cessation
-
2009
- 2009-10-05 US US12/573,832 patent/US8633155B2/en not_active Expired - Fee Related
- 2009-10-06 RU RU2009137017/10A patent/RU2009137017A/ru not_active Application Discontinuation
-
2010
- 2010-06-20 IL IL206483A patent/IL206483A/en active IP Right Grant
- 2010-12-07 IL IL209823A patent/IL209823A0/en unknown
-
2011
- 2011-05-20 NZ NZ592973A patent/NZ592973A/xx not_active IP Right Cessation
- 2011-08-26 JP JP2011184642A patent/JP2011235179A/ja not_active Withdrawn
-
2012
- 2012-02-28 IL IL218357A patent/IL218357A/en active IP Right Grant
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