JP5318412B2 - アンジオポエチン様4タンパク質を使用する組成物および方法 - Google Patents

アンジオポエチン様4タンパク質を使用する組成物および方法 Download PDF

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JP5318412B2
JP5318412B2 JP2007522672A JP2007522672A JP5318412B2 JP 5318412 B2 JP5318412 B2 JP 5318412B2 JP 2007522672 A JP2007522672 A JP 2007522672A JP 2007522672 A JP2007522672 A JP 2007522672A JP 5318412 B2 JP5318412 B2 JP 5318412B2
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angptl4
antibody
composition
human
cells
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JP2008507531A5 (enExample
JP2008507531A (ja
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スチュアート バンティング,
ハンス−ピーター ゲルバー,
ファン リャン シャオ,
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Genentech Inc
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JP2007522672A 2004-07-20 2005-07-19 アンジオポエチン様4タンパク質を使用する組成物および方法 Expired - Fee Related JP5318412B2 (ja)

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US58987504P 2004-07-20 2004-07-20
US60/589,875 2004-07-20
PCT/US2005/025650 WO2006014678A2 (en) 2004-07-20 2005-07-19 Compositions and methods of using angiopoietin-like 4 protein

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JP2011184642A Withdrawn JP2011235179A (ja) 2004-07-20 2011-08-26 アンジオポエチン様4タンパク質を使用する組成物および方法

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EP (1) EP1781698B1 (enExample)
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KR (1) KR20070061524A (enExample)
CN (1) CN101080419B (enExample)
AU (1) AU2005269758B2 (enExample)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
MX2007000783A (es) 2004-07-20 2007-04-09 Genentech Inc Inhibidores de proteina angiopoietina tipo 4, combinaciones y su uso.
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
AU2005269716B2 (en) * 2004-07-20 2011-01-27 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
MX2007008256A (es) * 2005-01-07 2007-12-06 Lexicon Pharmaceuticals Inc Anticuerpos monoclonales contra proteina 4 similar a angiopoyetina (angptl4).
CA2617984A1 (en) * 2005-08-19 2007-03-01 Washington University In St. Louis Methods and compositions for treating gastrointestinal radiosensitivity in a subject
US20080311107A1 (en) * 2006-02-17 2008-12-18 Genetech, Inc. Novel Gene Disruptions, Compositions and Methods Relating Thereto
CA2698812A1 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
EP2344890B1 (en) * 2008-10-20 2021-08-11 Liposcience, Inc. Lipoprotein insulin resistance indexes and related methods
SG10201406420XA (en) 2009-10-14 2014-11-27 Univ Nanyang Tech Antiproliferative agent
CN106146591B (zh) 2010-01-08 2020-07-31 Ionis制药公司 血管生成素样3表达的调节
WO2011089152A1 (en) * 2010-01-20 2011-07-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity
NO2575858T3 (enExample) * 2010-06-05 2018-05-19
US9139629B2 (en) 2010-06-05 2015-09-22 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
US9475850B2 (en) * 2010-06-05 2016-10-25 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
CA2824434A1 (en) * 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102692500B (zh) * 2011-03-21 2015-06-10 上海市肿瘤研究所 Angptl4作为血清学检测肝癌转移的标志物及其应用
CN102692496B (zh) * 2011-03-21 2015-10-28 上海市肿瘤研究所 Angptl4作为缺氧检测的标志物及其应用
CN102242198A (zh) * 2011-05-25 2011-11-16 信阳师范学院 通过angptl4基因多态性进行牛育种方法
AU2012272970A1 (en) * 2011-06-21 2014-02-06 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
EP2726493B1 (en) * 2011-07-01 2020-10-14 Monsanto Technology LLC Methods and compositions for selective regulation of protein expression
CN107536847A (zh) * 2011-08-08 2018-01-05 南洋理工大学 血管生成素样4及其在调节细胞渗漏中的用途
WO2013082667A1 (en) 2011-12-09 2013-06-13 Metabolic Pharmaceuticals Pty Ltd Use of growth hormone fragments
TW201823460A (zh) 2012-05-29 2018-07-01 美商再生元醫藥公司 生產細胞株增強子
SG11201500186VA (en) 2012-07-19 2015-02-27 Univ Nanyang Tech Angiopoietin-like 4 and a method of its use in wound healing
JP2016516726A (ja) * 2013-03-15 2016-06-09 ザ・ユー・エイ・ビー・リサーチ・フアンデーシヨン ネフローゼ症候群及び関連状態の治療方法
KR102482890B1 (ko) 2013-05-01 2022-12-30 아이오니스 파마수티컬즈, 인코포레이티드 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법
EP3021942A4 (en) * 2013-07-19 2017-04-19 The Regents of The University of California Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
MX383753B (es) 2013-12-24 2025-03-14 Ionis Pharmaceuticals Inc Modulación de la expresión similar a la angiopoyetina tipo 3.
US20170042870A1 (en) * 2014-02-17 2017-02-16 The Brigham And Women's Hospital, Inc. Targeted nanoparticle compositions and methods of their use to treat obesity
SI3137605T1 (sl) 2014-05-01 2021-02-26 Ionis Pharmaceuticals, Inc. Sestavki in metode za modulacijo ekspresije angiopoetin 3-podobnega
SG10201805646WA (en) 2014-08-07 2018-08-30 Novartis Ag Angiopoietin-like 4 antibodies and methods of use
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
CN105021827B (zh) * 2015-07-17 2016-09-28 北京大学第一医院 检测血清血管生成素样蛋白2含量的物质在制备检测肝脏炎症和纤维化程度产品中的应用
RS63980B1 (sr) 2015-07-22 2023-03-31 Monsanto Technology Llc Metode i sastavi za selektivnu regulaciju ekspresije proteina
CA2999341A1 (en) 2015-11-06 2017-05-11 Ionis Pharmaceuticals, Inc. Modulating apolipoprotein (a) expression
EP3478840A1 (en) * 2016-06-29 2019-05-08 Crispr Therapeutics AG Compositions and methods for gene editing
US12024708B2 (en) 2018-11-13 2024-07-02 Lipigon Pharmaceuticals Ab ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism
US20220372169A1 (en) * 2019-11-06 2022-11-24 Northwestern University Inhibition of the ve-ptp phosphatase protects the kidney from ischemia-reperfusion injury
CN115175685B (zh) * 2019-12-09 2024-12-13 艾姆皮瑞克公司 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸
CN120254294B (zh) * 2025-06-05 2025-09-09 南昌大学第一附属医院 Angptl3在乙肝相关慢加急性肝衰竭预后中的应用

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227158A (en) 1991-06-10 1993-07-13 Genentech, Inc. Method of stimulating hepatocyte proliferation by administration of hepatocyte growth factor and gamma-interferon
WO1999066041A1 (en) 1998-06-16 1999-12-23 Human Genome Sciences, Inc. 94 human secreted proteins
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6348350B1 (en) 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
US20030207375A1 (en) 1997-10-24 2003-11-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU1931599A (en) 1997-12-19 1999-07-12 Zymogenetics Inc. Angiopoietin homolog, dna encoding it, and method of making it
CA2322425A1 (en) 1998-03-02 1999-09-10 Millennium Pharmaceuticals, Inc. Novel fdrg protein and nucleic acid molecules and uses therefor
US20030099994A1 (en) 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
JP2000026767A (ja) 1998-05-01 2000-01-25 Daikin Ind Ltd 熱硬化性粉体塗料組成物
AU4643699A (en) 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
WO2001057188A2 (en) 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001053455A2 (en) 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
JP2000308488A (ja) 1999-02-23 2000-11-07 Herikkusu Kenkyusho:Kk 血管新生に関連するタンパク質および該タンパク質をコードする遺伝子
WO2000052165A2 (en) 1999-03-04 2000-09-08 Corixa Corporation Compositions and methods for breast cancer therapy and diagnosis
DK1607402T3 (da) 1999-03-08 2007-04-16 Genentech Inc Sammensætninger og fremgangsmåder til tumorbehandling
CA2370489A1 (en) 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 49 human secreted proteins
EP1171594B1 (en) 1999-04-16 2006-06-07 Genentech, Inc. Vascular endothelial cell growth factor variants and uses thereof
AU5979300A (en) 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
WO2001005825A2 (en) 1999-07-16 2001-01-25 Hyseq, Inc. Nucleic acid sequences encoding putative angiopoietin proteins
WO2001005971A2 (en) 1999-07-20 2001-01-25 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
US20030207348A1 (en) 1999-07-20 2003-11-06 Shimkets Richard A. Polypeptides and polynucleotides encoding same
AU2001233041A1 (en) 2000-01-25 2001-08-07 Hyseq, Inc. Novel nucleic acids and polypeptides
CN1315451A (zh) 2000-03-29 2001-10-03 上海博德基因开发有限公司 一种新的多肽——人血管形成素类似因子45和编码这种多肽的多核苷酸
AU2001249929A1 (en) 2000-04-07 2001-10-23 Dana-Farber Cancer Institute Inc. Fdrg proteins and nucleic acid molecules and uses therefor
PL359653A1 (en) * 2000-06-23 2004-08-23 Schering Aktiengesellschaft Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii)
US6673545B2 (en) 2000-07-28 2004-01-06 Incyte Corporation Prostate cancer markers
CN1170850C (zh) 2000-09-19 2004-10-13 上海市肿瘤研究所 人血管生成素样蛋白和编码序列及其用途
US20030120056A1 (en) 2000-10-16 2003-06-26 Audrey Goddard TIE ligand homologues
WO2002099085A2 (en) 2001-03-27 2002-12-12 Human Genome Sciences, Inc. Human secreted proteins
EP1403367A4 (en) 2001-06-08 2005-08-17 Sankyo Co A MEDICAMENT TEST METHOD FOR TREATING OR PREVENTING DISEASES SUCH AS HYPERLIPEMIA
WO2003010205A1 (en) 2001-07-26 2003-02-06 Duke University Medical Center Genes induced by hypoxia
EP1434881A4 (en) 2001-09-17 2005-10-26 Protein Design Labs Inc METHOD FOR DIAGNOSIS OF CANCER COMPOSITIONS AND METHOD FOR SCREENING ON CANCER MODULATORS
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
CA2460653A1 (en) 2001-11-05 2003-05-15 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20040038230A1 (en) 2001-11-05 2004-02-26 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
ES2429034T3 (es) 2001-11-16 2013-11-12 Genentech, Inc. Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas
AU2002359464A1 (en) 2001-11-30 2003-06-17 Genvec, Inc. Angiopioetin related factors
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
WO2003103581A2 (en) 2002-06-05 2003-12-18 Genentech, Inc. Compositions and methods for liver growth and liver protection
US20050239706A1 (en) 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
CA2499791A1 (en) 2004-03-30 2005-09-30 F. Hoffmann-La Roche Ag Angptl4/fiaf as marker for ppardelta modulation
MX2007000783A (es) * 2004-07-20 2007-04-09 Genentech Inc Inhibidores de proteina angiopoietina tipo 4, combinaciones y su uso.
AU2005269716B2 (en) * 2004-07-20 2011-01-27 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
MX2007008256A (es) * 2005-01-07 2007-12-06 Lexicon Pharmaceuticals Inc Anticuerpos monoclonales contra proteina 4 similar a angiopoyetina (angptl4).

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WO2006014678A3 (en) 2006-06-22
KR20070061524A (ko) 2007-06-13
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IL180752A0 (en) 2007-06-03
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US7371384B2 (en) 2008-05-13
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