JP2008506659A5 - - Google Patents
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- Publication number
- JP2008506659A5 JP2008506659A5 JP2007520779A JP2007520779A JP2008506659A5 JP 2008506659 A5 JP2008506659 A5 JP 2008506659A5 JP 2007520779 A JP2007520779 A JP 2007520779A JP 2007520779 A JP2007520779 A JP 2007520779A JP 2008506659 A5 JP2008506659 A5 JP 2008506659A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cys2
- cys1
- gly
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016890.8 | 2004-07-16 | ||
| EP04016890 | 2004-07-16 | ||
| PCT/EP2005/007748 WO2006008096A1 (en) | 2004-07-16 | 2005-07-15 | Expression-enhanced polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012057380A Division JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008506659A JP2008506659A (ja) | 2008-03-06 |
| JP2008506659A5 true JP2008506659A5 (https=) | 2011-10-20 |
| JP5014988B2 JP5014988B2 (ja) | 2012-08-29 |
Family
ID=35229693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520779A Expired - Lifetime JP5014988B2 (ja) | 2004-07-16 | 2005-07-15 | 発現増強ポリペプチド |
| JP2012057380A Pending JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012057380A Pending JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8518403B2 (https=) |
| EP (1) | EP1769000B1 (https=) |
| JP (2) | JP5014988B2 (https=) |
| KR (1) | KR20070042967A (https=) |
| CN (1) | CN101018809B (https=) |
| AU (1) | AU2005263555B2 (https=) |
| CA (1) | CA2570990C (https=) |
| EA (1) | EA010374B1 (https=) |
| MX (1) | MX2007000387A (https=) |
| NZ (1) | NZ552745A (https=) |
| WO (1) | WO2006008096A1 (https=) |
| ZA (1) | ZA200610478B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| CN101245110B (zh) * | 2007-02-16 | 2010-09-15 | 鲁南制药集团股份有限公司 | 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物 |
| US8940298B2 (en) * | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| WO2009046294A2 (en) * | 2007-10-03 | 2009-04-09 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
| WO2010006454A2 (en) * | 2008-06-30 | 2010-01-21 | Esbatech, An Alcon Biomedical Research Unit Llc | Functionalized polypeptides |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| JP6126782B2 (ja) * | 2008-10-01 | 2017-05-10 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハー | 異種間特異的ｐｓｍａ×ｃｄ３二重特異性単鎖抗体 |
| NZ591087A (en) * | 2008-10-01 | 2012-08-31 | Micromet Ag | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| EP2398504B1 (en) * | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| JP2011026294A (ja) * | 2009-06-26 | 2011-02-10 | Canon Inc | 化合物 |
| JP2012531212A (ja) * | 2009-07-03 | 2012-12-10 | アビペップ ピーティーワイ リミテッド | イムノコンジュゲート及びその作製方法 |
| US8993715B2 (en) | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| CA2782333C (en) | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| SG181814A1 (en) | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
| UA118950C2 (uk) | 2011-04-22 | 2019-04-10 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептид, який зв'язує специфічний мембранний антиген простати та комплекс т-клітинного рецептора |
| MX361875B (es) * | 2012-03-14 | 2018-12-18 | Regeneron Pharma | Moléculas de unión de antígeno multiespecifícas y usos de las mismas. |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| MX2017015380A (es) | 2015-05-29 | 2018-03-28 | Amphivena Therapeutics Inc | Metodos para utilizar proteinas de enlace biespecificas cd3 y cd33. |
| WO2017027325A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| EP3352760B1 (en) | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3 binding polypeptides |
| WO2017190079A1 (en) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| IL268755B2 (en) | 2017-02-20 | 2025-12-01 | Dragonfly Therapeutics Inc | Proteins that bind her2, nkg2d, and cd16 |
| DK3749346T3 (da) | 2018-02-08 | 2024-09-09 | Dragonfly Therapeutics Inc | Antistof variable domænekombinationer rettet mod nkg2d-receptoren |
| EA202091887A1 (ru) | 2018-02-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Комбинированная терапия рака с применением мультиспецифических связывающих белков, которые активируют естественные клетки-киллеры |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| US12378318B2 (en) | 2018-08-08 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| WO2020033630A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| CN110668984B (zh) * | 2019-12-03 | 2020-04-10 | 凯莱英医药集团（天津）股份有限公司 | 一种依特卡肽中间体及依特卡肽的合成方法 |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| EP4247850A1 (en) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| CN117285647A (zh) * | 2022-06-17 | 2023-12-26 | 南京北恒生物科技有限公司 | 靶向ccr8的嵌合抗原受体及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| WO2001004135A2 (en) | 1999-07-13 | 2001-01-18 | The Regents Of The University Of Michigan | Crosslinked dna condensate compositions and gene delivery methods |
| IL152804A0 (en) * | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| DE60105647T2 (de) * | 2000-06-09 | 2005-09-22 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Pegylation von linker verbessert die antitumor-aktivität und verringert die toxizität von immunkonjugaten |
| AU6845201A (en) * | 2000-06-15 | 2001-12-24 | Us Gov Health & Human Serv | A recombinant non-replicating virus expressing GM-CSF and uses thereof to enhance immune responses |
| AU2002248571B2 (en) * | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| CN1195779C (zh) * | 2001-05-24 | 2005-04-06 | 中国科学院遗传与发育生物学研究所 | 抗人卵巢癌抗人cd3双特异性抗体 |
| HRP20040242A2 (en) * | 2001-11-08 | 2005-02-28 | Yongna Xing William | Protein knobs |
| BRPI0819765A2 (pt) * | 2007-11-30 | 2015-05-05 | Bristol Myers Squibb Co | Conjugados de anticorpos anti-rg-1 |
-
2005
- 2005-07-15 AU AU2005263555A patent/AU2005263555B2/en not_active Expired
- 2005-07-15 MX MX2007000387A patent/MX2007000387A/es not_active Application Discontinuation
- 2005-07-15 CA CA2570990A patent/CA2570990C/en not_active Expired - Lifetime
- 2005-07-15 CN CN2005800240023A patent/CN101018809B/zh not_active Expired - Lifetime
- 2005-07-15 EP EP05774883.2A patent/EP1769000B1/en not_active Expired - Lifetime
- 2005-07-15 EA EA200700292A patent/EA010374B1/ru not_active IP Right Cessation
- 2005-07-15 KR KR1020077001061A patent/KR20070042967A/ko not_active Withdrawn
- 2005-07-15 US US11/572,116 patent/US8518403B2/en active Active
- 2005-07-15 WO PCT/EP2005/007748 patent/WO2006008096A1/en not_active Ceased
- 2005-07-15 NZ NZ552745A patent/NZ552745A/en unknown
- 2005-07-15 JP JP2007520779A patent/JP5014988B2/ja not_active Expired - Lifetime
-
2006
- 2006-12-14 ZA ZA200610478A patent/ZA200610478B/en unknown
-
2012
- 2012-03-14 JP JP2012057380A patent/JP2012144552A/ja active Pending
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