JP2008506659A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008506659A5 JP2008506659A5 JP2007520779A JP2007520779A JP2008506659A5 JP 2008506659 A5 JP2008506659 A5 JP 2008506659A5 JP 2007520779 A JP2007520779 A JP 2007520779A JP 2007520779 A JP2007520779 A JP 2007520779A JP 2008506659 A5 JP2008506659 A5 JP 2008506659A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cys2
- cys1
- gly
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04016890.8 | 2004-07-16 | ||
| EP04016890 | 2004-07-16 | ||
| PCT/EP2005/007748 WO2006008096A1 (en) | 2004-07-16 | 2005-07-15 | Expression-enhanced polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012057380A Division JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008506659A JP2008506659A (ja) | 2008-03-06 |
| JP2008506659A5 true JP2008506659A5 (https=) | 2011-10-20 |
| JP5014988B2 JP5014988B2 (ja) | 2012-08-29 |
Family
ID=35229693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520779A Expired - Lifetime JP5014988B2 (ja) | 2004-07-16 | 2005-07-15 | 発現増強ポリペプチド |
| JP2012057380A Pending JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012057380A Pending JP2012144552A (ja) | 2004-07-16 | 2012-03-14 | 発現増強ポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8518403B2 (https=) |
| EP (1) | EP1769000B1 (https=) |
| JP (2) | JP5014988B2 (https=) |
| KR (1) | KR20070042967A (https=) |
| CN (1) | CN101018809B (https=) |
| AU (1) | AU2005263555B2 (https=) |
| CA (1) | CA2570990C (https=) |
| EA (1) | EA010374B1 (https=) |
| MX (1) | MX2007000387A (https=) |
| NZ (1) | NZ552745A (https=) |
| WO (1) | WO2006008096A1 (https=) |
| ZA (1) | ZA200610478B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| CN101245110B (zh) * | 2007-02-16 | 2010-09-15 | 鲁南制药集团股份有限公司 | 重组中性粒细胞抑制因子和水蛭原嵌合蛋白及其药物组合物 |
| WO2009032949A2 (en) | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| CA2700410C (en) * | 2007-10-03 | 2020-10-06 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
| AU2009270405B2 (en) * | 2008-06-30 | 2014-06-05 | Esbatech, An Alcon Biomedical Research Unit Llc | Functionalized polypeptides |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| US20110293619A1 (en) | 2008-10-01 | 2011-12-01 | Micromet Ag | CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY |
| EP2370467B1 (en) * | 2008-10-01 | 2016-09-07 | Amgen Research (Munich) GmbH | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| ES2712732T3 (es) * | 2009-02-17 | 2019-05-14 | Cornell Res Foundation Inc | Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico |
| JP2011026294A (ja) * | 2009-06-26 | 2011-02-10 | Canon Inc | 化合物 |
| US9290577B2 (en) | 2009-07-03 | 2016-03-22 | Avipep Pty Limited | Immuno-conjugates and methods for producing them |
| US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| AU2010325969B2 (en) | 2009-12-02 | 2016-10-20 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen |
| JP2013514788A (ja) * | 2009-12-23 | 2013-05-02 | アビペップ ピーティーワイ リミテッド | イムノコンジュゲート及びその作製方法２ |
| EP2699596A4 (en) | 2011-04-22 | 2015-01-14 | Emergent Product Dev Seattle | PROSTATE-SPECIFIC MEMBRANE-BINDING PROTEINS AND COMPOSITIONS AND METHOD THEREFOR |
| EP2825553B1 (en) * | 2012-03-14 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Multispecific antigen-binding molecules and uses thereof |
| JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| US10738118B2 (en) | 2015-05-29 | 2020-08-11 | Amphivena Therapeutics, Inc. | Methods of using bispecific CD33 and CD3 binding proteins |
| US11254744B2 (en) | 2015-08-07 | 2022-02-22 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
| EP3448891A1 (en) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| AU2018219887B2 (en) | 2017-02-08 | 2024-08-15 | Dragonfly Therapeutics, LLC | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
| CA3237846A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| CN110668984B (zh) * | 2019-12-03 | 2020-04-10 | 凯莱英医药集团（天津）股份有限公司 | 一种依特卡肽中间体及依特卡肽的合成方法 |
| JP7512394B2 (ja) | 2020-05-06 | 2024-07-08 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質 |
| JP2023550148A (ja) | 2020-11-20 | 2023-11-30 | シンシア・イノベーション・インコーポレイテッド | がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法 |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| CN117285647A (zh) * | 2022-06-17 | 2023-12-26 | 南京北恒生物科技有限公司 | 靶向ccr8的嵌合抗原受体及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| WO2001004135A2 (en) | 1999-07-13 | 2001-01-18 | The Regents Of The University Of Michigan | Crosslinked dna condensate compositions and gene delivery methods |
| IL152804A0 (en) | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| JP2004503512A (ja) * | 2000-06-09 | 2004-02-05 | アメリカ合衆国 | 免疫複合体の抗腫瘍活性を改善し、かつ、毒性を低減するリンカーのｐｅｇ化 |
| JP2004507231A (ja) * | 2000-06-15 | 2004-03-11 | アメリカ合衆国 | 免疫応答を向上させるための、ｇｍ−ｃｓｆを発現する組換え非−複製性ウィルスおよびその使用 |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| CN1195779C (zh) * | 2001-05-24 | 2005-04-06 | 中国科学院遗传与发育生物学研究所 | 抗人卵巢癌抗人cd3双特异性抗体 |
| KR20040063928A (ko) * | 2001-11-08 | 2004-07-14 | 윌리암 알. 모일 | 단백질 노브 |
| US20110020329A1 (en) * | 2007-11-30 | 2011-01-27 | Bristol-Myers Squibb Company | Conjugates of anti-rg-1 antibodies |
-
2005
- 2005-07-15 AU AU2005263555A patent/AU2005263555B2/en not_active Expired
- 2005-07-15 EP EP05774883.2A patent/EP1769000B1/en not_active Expired - Lifetime
- 2005-07-15 CA CA2570990A patent/CA2570990C/en not_active Expired - Lifetime
- 2005-07-15 EA EA200700292A patent/EA010374B1/ru not_active IP Right Cessation
- 2005-07-15 CN CN2005800240023A patent/CN101018809B/zh not_active Expired - Lifetime
- 2005-07-15 KR KR1020077001061A patent/KR20070042967A/ko not_active Withdrawn
- 2005-07-15 US US11/572,116 patent/US8518403B2/en active Active
- 2005-07-15 WO PCT/EP2005/007748 patent/WO2006008096A1/en not_active Ceased
- 2005-07-15 MX MX2007000387A patent/MX2007000387A/es not_active Application Discontinuation
- 2005-07-15 JP JP2007520779A patent/JP5014988B2/ja not_active Expired - Lifetime
- 2005-07-15 NZ NZ552745A patent/NZ552745A/en unknown
-
2006
- 2006-12-14 ZA ZA200610478A patent/ZA200610478B/en unknown
-
2012
- 2012-03-14 JP JP2012057380A patent/JP2012144552A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5014988B2 (ja) | 発現増強ポリペプチド | |
| JP2008506659A5 (https=) | ||
| JP7076152B2 (ja) | ＩｇＧ結合ペプチドによる抗体の特異的修飾 | |
| JP7481852B2 (ja) | 免疫リガンド／ペイロード複合体の生産方法 | |
| Kipriyanov et al. | High level production of soluble single chain antibodies in small-scale Escherichia coli cultures | |
| JP3280376B2 (ja) | 多価抗原結合性蛋白質 | |
| EP0938571B1 (en) | Method for the oligomerisation of peptides | |
| US20070274985A1 (en) | Antibody | |
| JP2021166521A (ja) | Ｓｉｒｐ−アルファ変異体構築物及びその使用 | |
| WO2007044887A2 (en) | Method for producing a population of homogenous tetravalent bispecific antibodies | |
| CZ289641B6 (cs) | Imunokonjugát, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje | |
| Albrecht et al. | Monospecific bivalent scFv-SH: effects of linker length and location of an engineered cysteine on production, antigen binding activity and free SH accessibility | |
| CN100357314C (zh) | 一种分子物质连接的方法 | |
| WO2001094547A2 (en) | Molecular delivery vehicle for delivery of selected compounds to targets | |
| WO2017143839A1 (zh) | 基于内含肽的药用重组蛋白的合成方法 | |
| Power et al. | Synthesis of high avidity antibody fragments (scFv multimers) for cancer imaging | |
| JP7440516B2 (ja) | 切断多価多量体 | |
| JP2561113B2 (ja) | 細胞接着活性ポリペプチド | |
| CN119998326A (zh) | 具有新型二硫键的超稳定抗体片段 | |
| Farshdari et al. | Enhanced Solubility of Anti-HER2 scFv Using Bacterial Pelb Leader Sequence: Influence of leader sequence on anti-HRR2 scFv expression | |
| KR20200098831A (ko) | 신규한 부위-특이적 항체 절편 플랫폼 | |
| HK1245803A1 (en) | Specific modification of antibody by igg-binding peptide |