JP2008504257A5 - - Google Patents
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- Publication number
- JP2008504257A5 JP2008504257A5 JP2007518098A JP2007518098A JP2008504257A5 JP 2008504257 A5 JP2008504257 A5 JP 2008504257A5 JP 2007518098 A JP2007518098 A JP 2007518098A JP 2007518098 A JP2007518098 A JP 2007518098A JP 2008504257 A5 JP2008504257 A5 JP 2008504257A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- pharmaceutically acceptable
- related macular
- macular degeneration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 208000011325 dry age related macular degeneration Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- RYCNUMLMNKHWPZ-SNVBAGLBSA-N 1-acetyl-sn-glycero-3-phosphocholine Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C RYCNUMLMNKHWPZ-SNVBAGLBSA-N 0.000 claims 1
- 241000208140 Acer Species 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- -1 elixir Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58229304P | 2004-06-23 | 2004-06-23 | |
| US60/582,293 | 2004-06-23 | ||
| US62969504P | 2004-11-19 | 2004-11-19 | |
| US60/629,695 | 2004-11-19 | ||
| US66090405P | 2005-03-11 | 2005-03-11 | |
| US60/660,904 | 2005-03-11 | ||
| US67240505P | 2005-04-18 | 2005-04-18 | |
| US60/672,405 | 2005-04-18 | ||
| PCT/US2005/020080 WO2006007314A1 (en) | 2004-06-23 | 2005-06-06 | Methods and compositions for treating ophthalmic conditions with retinyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504257A JP2008504257A (ja) | 2008-02-14 |
| JP2008504257A5 true JP2008504257A5 (enExample) | 2008-07-10 |
| JP4855396B2 JP4855396B2 (ja) | 2012-01-18 |
Family
ID=34981643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518098A Expired - Fee Related JP4855396B2 (ja) | 2004-06-23 | 2005-06-06 | レチナール誘導体で眼科的な状態を処置するための方法および組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8314152B2 (enExample) |
| EP (3) | EP2277516A1 (enExample) |
| JP (1) | JP4855396B2 (enExample) |
| KR (1) | KR100862930B1 (enExample) |
| AR (1) | AR049929A1 (enExample) |
| AT (1) | ATE404188T1 (enExample) |
| AU (1) | AU2005262558B8 (enExample) |
| BR (1) | BRPI0512569A (enExample) |
| CA (1) | CA2569691C (enExample) |
| CY (1) | CY1110435T1 (enExample) |
| DE (1) | DE602005008970D1 (enExample) |
| DK (1) | DK1768657T3 (enExample) |
| EA (1) | EA011864B1 (enExample) |
| ES (1) | ES2313368T3 (enExample) |
| GE (1) | GEP20084520B (enExample) |
| IL (1) | IL179872A (enExample) |
| LV (1) | LV13564B (enExample) |
| MX (1) | MXPA06014978A (enExample) |
| NO (1) | NO20070408L (enExample) |
| NZ (1) | NZ551955A (enExample) |
| PL (1) | PL1768657T3 (enExample) |
| PT (1) | PT1768657E (enExample) |
| SG (1) | SG140607A1 (enExample) |
| SI (1) | SI1768657T1 (enExample) |
| TW (1) | TWI396532B (enExample) |
| WO (1) | WO2006007314A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2327401A3 (en) | 2003-03-14 | 2011-10-19 | University of Washington | Retinoid Replacements and Opsin Agonists and Methods for the Use Thereof |
| AU2005215778B2 (en) | 2004-02-17 | 2009-03-12 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| JP2007525496A (ja) * | 2004-02-17 | 2007-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 黄班変性症を含む眼科疾患の管理 |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| JP5166026B2 (ja) | 2004-06-18 | 2013-03-21 | ユニバーシティ オブ ワシントン | 視力障害の治療のためのレチナール誘導体およびその使用方法 |
| DK1768657T3 (da) | 2004-06-23 | 2008-12-01 | Sirion Therapeutics Inc | Fremgangsmåder og sammensætninger til at behandle ophthalmiske tilstande med retinylderivater |
| US20060089411A1 (en) * | 2004-08-07 | 2006-04-27 | Gierhart Dennis L | Treatment of Stargardt's disease and other lipofuscin disorders with combined retinaldehyde inhibitor and zeaxanthin |
| WO2006033734A2 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| EP1804771A2 (en) * | 2004-10-28 | 2007-07-11 | Idexx Laboratories, Inc. | Compositions for controlled delivery of pharmaceutically active compounds |
| WO2006052860A2 (en) * | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
| SG144145A1 (en) * | 2004-12-08 | 2008-07-29 | Sirion Therapeutics Inc | Methods, assays and compositions for treating retinol-related diseases |
| UA81382C2 (en) * | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding | |
| US7754679B2 (en) * | 2005-11-16 | 2010-07-13 | Idexx Laboratories, Inc. | Pharmaceutical compositions for the administration of aptamers |
| US8114440B2 (en) * | 2005-11-16 | 2012-02-14 | Idexx Laboratories Inc. | Pharmaceutical compositions for the administration of aptamers |
| WO2007150046A2 (en) * | 2006-06-22 | 2007-12-27 | Sirion Therapeutics, Inc | Methods and compositions for treating ophthalmic conditions via modulation of megalin activity |
| EP2069391A4 (en) * | 2006-07-27 | 2009-12-30 | Univ Florida | COMPOSITIONS AND METHODS FOR TREATING AND / OR PREVENTING OPHTHALMOLOGICAL DISEASES |
| EP2069390A4 (en) * | 2006-07-27 | 2009-12-30 | Univ Florida | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE |
| CA2657164A1 (en) * | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating or preventing ophthalmic light toxicity |
| US8828960B2 (en) * | 2007-07-17 | 2014-09-09 | Idexx Laboratories, Inc. | Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds |
| JP6022746B2 (ja) | 2008-02-11 | 2016-11-09 | ユニヴァーシティ オブ ワシントン | 加齢関連性網膜機能不全の治療及び予防方法 |
| WO2009114136A2 (en) * | 2008-03-12 | 2009-09-17 | Albert Einstein College Of Medicine Of Yeshiva University | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents |
| MX2011000545A (es) * | 2008-07-14 | 2011-02-24 | Otonomy Inc | Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos. |
| EP2427052B1 (en) * | 2009-05-04 | 2015-08-26 | Acucela, Inc. | Compositions for use in the treatment of glaucoma or ocular hypertension |
| IN2012DN00352A (enExample) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| JP5663025B2 (ja) | 2009-09-15 | 2015-02-04 | キューエルティー インコーポレイテッド | ９−ｃｉｓ−レチニルエステルを脂質ビヒクル中に含む医薬製剤 |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| CA2796991A1 (en) * | 2010-04-19 | 2011-10-27 | Qlt Inc. | Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency |
| EP2944628B1 (en) | 2011-11-30 | 2017-01-04 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| WO2013119988A1 (en) * | 2012-02-10 | 2013-08-15 | Taiwan Liposome Company, Ltd | Pharmaceutical compositions to reduce complications of ocular steroid |
| MX370928B (es) | 2012-03-01 | 2020-01-08 | Retinagenix LLC | El uso de 9-cis-retinil acetato para mejorar la función visual de un sujeto que padece de pérdida de la función visual originada por una deficiencia retinoide endógena de 11-cis retinal. |
| WO2014003850A2 (en) | 2012-06-26 | 2014-01-03 | Timothy Paul Foster | Methods for treatment of ocular diseases |
| US9011845B2 (en) | 2012-06-26 | 2015-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods for treatment of inflammatory and infectious viral diseases |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| ES2848999T3 (es) | 2014-10-24 | 2021-08-13 | Takeda Pharmaceuticals Co | Compuestos heteroarilo para el tratamiento de enfermedades oftálmicas |
| EP3233174B1 (en) * | 2014-12-19 | 2021-03-31 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| RU2718065C2 (ru) * | 2016-02-15 | 2020-03-30 | Кемин Индастриз, Инк. | Положительно заряженные липосомы в качестве липофильных молекул-носителей |
| US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
| US11369695B2 (en) | 2016-12-05 | 2022-06-28 | The Jackson Laboratory | Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans |
| EP3650045B1 (en) * | 2017-07-04 | 2024-11-13 | Daiichi Sankyo Company, Limited | Drug for retinal degenerative disease associated with photoreceptor degeneration |
| US20220211654A1 (en) * | 2019-05-06 | 2022-07-07 | The Regents Of The University Of California | Materials and methods for treating age-related macular degeneration |
| FR3105790B1 (fr) * | 2019-12-26 | 2022-01-14 | Biophytis | Composés chimiques ciblant l’œil et leur utilisation dans le traitement de maladies oculaires |
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| US4190594A (en) | 1975-11-03 | 1980-02-26 | Johnson & Johnson | Retinoic acid derivatives |
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| US4673044A (en) * | 1985-08-02 | 1987-06-16 | Eastman Christensen Co. | Earth boring bit for soft to hard formations |
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| US6506917B1 (en) | 1991-12-18 | 2003-01-14 | The Salk Institute For Biological Studies | Compounds and compositions useful for modulation of processes mediated by RXR |
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| US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
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| US20030032078A1 (en) | 2001-01-23 | 2003-02-13 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of macular and retinal degenerations |
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| AU2002316593A1 (en) | 2001-07-06 | 2003-01-21 | The Ohio State University Research Foundation | Solid phase synthesis of arylretinamides |
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| US20030229062A1 (en) | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
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| WO2004050101A2 (en) | 2002-11-29 | 2004-06-17 | Gpc Biotech Ag | Formulations useful against hepatitis c virus infections |
| SI21392A (sl) | 2002-12-24 | 2004-06-30 | Vinko Kunc | Postopek za avtomatsko nastavitev ojačenja izpraševalnikovega sprejemnika v brezkontaktnem identifikacijskem sistemu |
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| JP4869942B2 (ja) | 2003-12-11 | 2012-02-08 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | インスリン感受性／抵抗性、糖尿病および肥満におけるｒｂｐ４ |
| WO2005077176A1 (en) | 2004-02-11 | 2005-08-25 | The Trustees Of Columbia University In The City Of New York | Anthocyanin compounds and methods of use thereof |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| AU2005215778B2 (en) * | 2004-02-17 | 2009-03-12 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| CA2601278C (en) | 2004-03-17 | 2014-06-10 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
| JP5166026B2 (ja) | 2004-06-18 | 2013-03-21 | ユニバーシティ オブ ワシントン | 視力障害の治療のためのレチナール誘導体およびその使用方法 |
| DK1768657T3 (da) | 2004-06-23 | 2008-12-01 | Sirion Therapeutics Inc | Fremgangsmåder og sammensætninger til at behandle ophthalmiske tilstande med retinylderivater |
| US7286860B2 (en) | 2004-07-23 | 2007-10-23 | Dyna Llc | Systems and methods for a comfortable wireless communication device |
| WO2006033734A2 (en) | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| WO2006052860A2 (en) | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
| SG144145A1 (en) | 2004-12-08 | 2008-07-29 | Sirion Therapeutics Inc | Methods, assays and compositions for treating retinol-related diseases |
| UA81382C2 (en) | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding |
-
2005
- 2005-06-06 DK DK05758777T patent/DK1768657T3/da active
- 2005-06-06 NZ NZ551955A patent/NZ551955A/en not_active IP Right Cessation
- 2005-06-06 KR KR1020077001270A patent/KR100862930B1/ko not_active Expired - Fee Related
- 2005-06-06 SG SG200801546-3A patent/SG140607A1/en unknown
- 2005-06-06 EP EP10181656A patent/EP2277516A1/en not_active Withdrawn
- 2005-06-06 EP EP05758777A patent/EP1768657B1/en not_active Expired - Lifetime
- 2005-06-06 AU AU2005262558A patent/AU2005262558B8/en not_active Ceased
- 2005-06-06 PL PL05758777T patent/PL1768657T3/pl unknown
- 2005-06-06 GE GEAP20059816A patent/GEP20084520B/en unknown
- 2005-06-06 EA EA200700109A patent/EA011864B1/ru not_active IP Right Cessation
- 2005-06-06 PT PT05758777T patent/PT1768657E/pt unknown
- 2005-06-06 CA CA2569691A patent/CA2569691C/en not_active Expired - Fee Related
- 2005-06-06 MX MXPA06014978A patent/MXPA06014978A/es active IP Right Grant
- 2005-06-06 SI SI200530415T patent/SI1768657T1/sl unknown
- 2005-06-06 AT AT05758777T patent/ATE404188T1/de active
- 2005-06-06 JP JP2007518098A patent/JP4855396B2/ja not_active Expired - Fee Related
- 2005-06-06 DE DE602005008970T patent/DE602005008970D1/de not_active Expired - Lifetime
- 2005-06-06 ES ES05758777T patent/ES2313368T3/es not_active Expired - Lifetime
- 2005-06-06 BR BRPI0512569-3A patent/BRPI0512569A/pt not_active IP Right Cessation
- 2005-06-06 WO PCT/US2005/020080 patent/WO2006007314A1/en not_active Ceased
- 2005-06-06 EP EP08014275A patent/EP2025336A1/en not_active Withdrawn
- 2005-06-10 US US11/150,641 patent/US8314152B2/en not_active Expired - Fee Related
- 2005-06-21 AR ARP050102545A patent/AR049929A1/es not_active Application Discontinuation
- 2005-06-22 TW TW094120880A patent/TWI396532B/zh not_active IP Right Cessation
-
2006
- 2006-12-06 IL IL179872A patent/IL179872A/en not_active IP Right Cessation
-
2007
- 2007-01-19 LV LVP-07-05A patent/LV13564B/lv unknown
- 2007-01-22 NO NO20070408A patent/NO20070408L/no not_active Application Discontinuation
-
2008
- 2008-11-12 CY CY20081101287T patent/CY1110435T1/el unknown
-
2010
- 2010-04-21 US US12/764,764 patent/US8410168B2/en not_active Expired - Fee Related
-
2011
- 2011-05-27 US US13/118,330 patent/US20110294891A1/en not_active Abandoned
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