ATE404188T1 - Verfahren und zusammensetzungen zur behandlung von augenerkrankungen mit retinyl-derivaten - Google Patents
Verfahren und zusammensetzungen zur behandlung von augenerkrankungen mit retinyl-derivatenInfo
- Publication number
- ATE404188T1 ATE404188T1 AT05758777T AT05758777T ATE404188T1 AT E404188 T1 ATE404188 T1 AT E404188T1 AT 05758777 T AT05758777 T AT 05758777T AT 05758777 T AT05758777 T AT 05758777T AT E404188 T1 ATE404188 T1 AT E404188T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- eye diseases
- treating eye
- retinyl derivatives
- Prior art date
Links
- 208000030533 eye disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/16—Ophthalmology
- G01N2800/164—Retinal disorders, e.g. retinopathy
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58229304P | 2004-06-23 | 2004-06-23 | |
| US62969504P | 2004-11-19 | 2004-11-19 | |
| US66090405P | 2005-03-11 | 2005-03-11 | |
| US67240505P | 2005-04-18 | 2005-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404188T1 true ATE404188T1 (de) | 2008-08-15 |
Family
ID=34981643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05758777T ATE404188T1 (de) | 2004-06-23 | 2005-06-06 | Verfahren und zusammensetzungen zur behandlung von augenerkrankungen mit retinyl-derivaten |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8314152B2 (enExample) |
| EP (3) | EP2277516A1 (enExample) |
| JP (1) | JP4855396B2 (enExample) |
| KR (1) | KR100862930B1 (enExample) |
| AR (1) | AR049929A1 (enExample) |
| AT (1) | ATE404188T1 (enExample) |
| AU (1) | AU2005262558B8 (enExample) |
| BR (1) | BRPI0512569A (enExample) |
| CA (1) | CA2569691C (enExample) |
| CY (1) | CY1110435T1 (enExample) |
| DE (1) | DE602005008970D1 (enExample) |
| DK (1) | DK1768657T3 (enExample) |
| EA (1) | EA011864B1 (enExample) |
| ES (1) | ES2313368T3 (enExample) |
| GE (1) | GEP20084520B (enExample) |
| IL (1) | IL179872A (enExample) |
| LV (1) | LV13564B (enExample) |
| MX (1) | MXPA06014978A (enExample) |
| NO (1) | NO20070408L (enExample) |
| NZ (1) | NZ551955A (enExample) |
| PL (1) | PL1768657T3 (enExample) |
| PT (1) | PT1768657E (enExample) |
| SG (1) | SG140607A1 (enExample) |
| SI (1) | SI1768657T1 (enExample) |
| TW (1) | TWI396532B (enExample) |
| WO (1) | WO2006007314A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2327401A3 (en) | 2003-03-14 | 2011-10-19 | University of Washington | Retinoid Replacements and Opsin Agonists and Methods for the Use Thereof |
| AU2005215778B2 (en) | 2004-02-17 | 2009-03-12 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| JP2007525496A (ja) * | 2004-02-17 | 2007-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 黄班変性症を含む眼科疾患の管理 |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| JP5166026B2 (ja) | 2004-06-18 | 2013-03-21 | ユニバーシティ オブ ワシントン | 視力障害の治療のためのレチナール誘導体およびその使用方法 |
| DK1768657T3 (da) | 2004-06-23 | 2008-12-01 | Sirion Therapeutics Inc | Fremgangsmåder og sammensætninger til at behandle ophthalmiske tilstande med retinylderivater |
| US20060089411A1 (en) * | 2004-08-07 | 2006-04-27 | Gierhart Dennis L | Treatment of Stargardt's disease and other lipofuscin disorders with combined retinaldehyde inhibitor and zeaxanthin |
| WO2006033734A2 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| EP1804771A2 (en) * | 2004-10-28 | 2007-07-11 | Idexx Laboratories, Inc. | Compositions for controlled delivery of pharmaceutically active compounds |
| WO2006052860A2 (en) * | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
| SG144145A1 (en) * | 2004-12-08 | 2008-07-29 | Sirion Therapeutics Inc | Methods, assays and compositions for treating retinol-related diseases |
| UA81382C2 (en) * | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding | |
| US7754679B2 (en) * | 2005-11-16 | 2010-07-13 | Idexx Laboratories, Inc. | Pharmaceutical compositions for the administration of aptamers |
| US8114440B2 (en) * | 2005-11-16 | 2012-02-14 | Idexx Laboratories Inc. | Pharmaceutical compositions for the administration of aptamers |
| WO2007150046A2 (en) * | 2006-06-22 | 2007-12-27 | Sirion Therapeutics, Inc | Methods and compositions for treating ophthalmic conditions via modulation of megalin activity |
| EP2069391A4 (en) * | 2006-07-27 | 2009-12-30 | Univ Florida | COMPOSITIONS AND METHODS FOR TREATING AND / OR PREVENTING OPHTHALMOLOGICAL DISEASES |
| EP2069390A4 (en) * | 2006-07-27 | 2009-12-30 | Univ Florida | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE |
| CA2657164A1 (en) * | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating or preventing ophthalmic light toxicity |
| US8828960B2 (en) * | 2007-07-17 | 2014-09-09 | Idexx Laboratories, Inc. | Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds |
| JP6022746B2 (ja) | 2008-02-11 | 2016-11-09 | ユニヴァーシティ オブ ワシントン | 加齢関連性網膜機能不全の治療及び予防方法 |
| WO2009114136A2 (en) * | 2008-03-12 | 2009-09-17 | Albert Einstein College Of Medicine Of Yeshiva University | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents |
| MX2011000545A (es) * | 2008-07-14 | 2011-02-24 | Otonomy Inc | Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos. |
| EP2427052B1 (en) * | 2009-05-04 | 2015-08-26 | Acucela, Inc. | Compositions for use in the treatment of glaucoma or ocular hypertension |
| IN2012DN00352A (enExample) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| JP5663025B2 (ja) | 2009-09-15 | 2015-02-04 | キューエルティー インコーポレイテッド | 9−cis−レチニルエステルを脂質ビヒクル中に含む医薬製剤 |
| CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
| CA2796991A1 (en) * | 2010-04-19 | 2011-10-27 | Qlt Inc. | Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency |
| EP2944628B1 (en) | 2011-11-30 | 2017-01-04 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| WO2013119988A1 (en) * | 2012-02-10 | 2013-08-15 | Taiwan Liposome Company, Ltd | Pharmaceutical compositions to reduce complications of ocular steroid |
| MX370928B (es) | 2012-03-01 | 2020-01-08 | Retinagenix LLC | El uso de 9-cis-retinil acetato para mejorar la función visual de un sujeto que padece de pérdida de la función visual originada por una deficiencia retinoide endógena de 11-cis retinal. |
| WO2014003850A2 (en) | 2012-06-26 | 2014-01-03 | Timothy Paul Foster | Methods for treatment of ocular diseases |
| US9011845B2 (en) | 2012-06-26 | 2015-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Methods for treatment of inflammatory and infectious viral diseases |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| ES2848999T3 (es) | 2014-10-24 | 2021-08-13 | Takeda Pharmaceuticals Co | Compuestos heteroarilo para el tratamiento de enfermedades oftálmicas |
| EP3233174B1 (en) * | 2014-12-19 | 2021-03-31 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| RU2718065C2 (ru) * | 2016-02-15 | 2020-03-30 | Кемин Индастриз, Инк. | Положительно заряженные липосомы в качестве липофильных молекул-носителей |
| US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
| US11369695B2 (en) | 2016-12-05 | 2022-06-28 | The Jackson Laboratory | Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans |
| EP3650045B1 (en) * | 2017-07-04 | 2024-11-13 | Daiichi Sankyo Company, Limited | Drug for retinal degenerative disease associated with photoreceptor degeneration |
| US20220211654A1 (en) * | 2019-05-06 | 2022-07-07 | The Regents Of The University Of California | Materials and methods for treating age-related macular degeneration |
| FR3105790B1 (fr) * | 2019-12-26 | 2022-01-14 | Biophytis | Composés chimiques ciblant l’œil et leur utilisation dans le traitement de maladies oculaires |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4190594A (en) | 1975-11-03 | 1980-02-26 | Johnson & Johnson | Retinoic acid derivatives |
| US4323581A (en) | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
| US4665098A (en) | 1985-03-28 | 1987-05-12 | Mcneilab, Inc. | Pharmaceutical composition of N-(4-hydroxyphenyl) retinamide having increased bioavailability |
| US4874795A (en) | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
| US4673044A (en) * | 1985-08-02 | 1987-06-16 | Eastman Christensen Co. | Earth boring bit for soft to hard formations |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4682663A (en) * | 1986-02-18 | 1987-07-28 | Reed Tool Company | Mounting means for cutting elements in drag type rotary drill bit |
| US4743400A (en) | 1986-09-22 | 1988-05-10 | Mcneilab, Inc. | Process for preparing retinoyl chlorides |
| WO1991001745A1 (en) | 1989-07-28 | 1991-02-21 | Sloan-Kettering Institute For Cancer Research | Growth factors containing vitamin a or other retinoids and uses thereof |
| US5814612A (en) | 1991-04-09 | 1998-09-29 | Sloan-Kettering Institute For Cancer Research | Retinol derivatives and uses thereof |
| US6506917B1 (en) | 1991-12-18 | 2003-01-14 | The Salk Institute For Biological Studies | Compounds and compositions useful for modulation of processes mediated by RXR |
| US6050354A (en) * | 1992-01-31 | 2000-04-18 | Baker Hughes Incorporated | Rolling cutter bit with shear cutting gage |
| US5314909A (en) | 1993-03-17 | 1994-05-24 | Merck & Co., Inc. | Use of non-steroidal antiiflammatory agents in macular degeneration |
| US5399757A (en) | 1993-07-20 | 1995-03-21 | Ortho Pharmaceutical Corporation | Process for the preparation of N-(4-hydroxyphenyl)-retinamide |
| US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
| US5596011A (en) | 1995-04-06 | 1997-01-21 | Repine; Karen M. | Method for the treatment of macular degeneration |
| US5702357A (en) * | 1995-06-07 | 1997-12-30 | Cobe Laboratories, Inc. | Extracorporeal blood processing methods and apparatus |
| US5706906A (en) * | 1996-02-15 | 1998-01-13 | Baker Hughes Incorporated | Superabrasive cutting element with enhanced durability and increased wear life, and apparatus so equipped |
| US5758733A (en) * | 1996-04-17 | 1998-06-02 | Baker Hughes Incorporated | Earth-boring bit with super-hard cutting elements |
| US5846220A (en) | 1996-04-30 | 1998-12-08 | Medtronic, Inc. | Therapeutic method for treatment of Alzheimer's disease |
| US6034211A (en) | 1996-06-03 | 2000-03-07 | Kelly; Jeffery W. | β-sheet nucleating peptidomimetics |
| GB9621217D0 (en) * | 1996-10-11 | 1996-11-27 | Camco Drilling Group Ltd | Improvements in or relating to preform cutting elements for rotary drill bits |
| AU5727798A (en) | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
| US5955305A (en) | 1997-04-28 | 1999-09-21 | Incyte Pharmaceuticals, Inc. | Human retinoid binding protein |
| US5776915A (en) | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
| ATE411016T1 (de) | 1997-08-15 | 2008-10-15 | Univ Duke | Verfahren zur prophylaxis oder behandlung von östrogen-abhängigen krankheiten |
| CA2331620A1 (en) | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| EP1216221A2 (en) | 1999-09-14 | 2002-06-26 | Ligand Pharmaceuticals Incorporated | Rxr modulators with improved pharmacologic profile |
| AU3082901A (en) | 1999-11-23 | 2001-06-04 | Gerhart Graupner | Modulation of signal transduction |
| US20020031539A1 (en) | 2000-08-30 | 2002-03-14 | The Brigham And Women's Hospital, Inc. | Oxidized forms of retinoic acid as ligands for peroxisome proliferator activated receptor gamma |
| EP1328262A2 (en) | 2000-10-17 | 2003-07-23 | Board of Regents, The University of Texas System | A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes |
| US6408958B1 (en) * | 2000-10-23 | 2002-06-25 | Baker Hughes Incorporated | Superabrasive cutting assemblies including cutters of varying orientations and drill bits so equipped |
| WO2002058689A1 (en) | 2000-12-05 | 2002-08-01 | Childrens Hospital Los Angeles | Pharmaceutical compositions of fenretinide having increased bioavailability and methods of using the same |
| US20030032078A1 (en) | 2001-01-23 | 2003-02-13 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of macular and retinal degenerations |
| EP1390343B1 (en) | 2001-05-29 | 2009-10-14 | Chebigen Co., Ltd. | Novel retinoid derivatives and an anti-cancer pharmaceutical composition comprising said compounds |
| CA2450562A1 (en) | 2001-06-22 | 2003-01-03 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU2002316593A1 (en) | 2001-07-06 | 2003-01-21 | The Ohio State University Research Foundation | Solid phase synthesis of arylretinamides |
| US6599891B2 (en) | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
| US20030229062A1 (en) | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
| US20040014131A1 (en) | 2002-07-09 | 2004-01-22 | Pfizer Inc. | Assay methods |
| US7595430B2 (en) | 2002-10-30 | 2009-09-29 | University Of Kentucky Research Foundation | Methods and animal model for analyzing age-related macular degeneration |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| WO2004050101A2 (en) | 2002-11-29 | 2004-06-17 | Gpc Biotech Ag | Formulations useful against hepatitis c virus infections |
| SI21392A (sl) | 2002-12-24 | 2004-06-30 | Vinko Kunc | Postopek za avtomatsko nastavitev ojačenja izpraševalnikovega sprejemnika v brezkontaktnem identifikacijskem sistemu |
| WO2004069203A2 (en) | 2003-01-31 | 2004-08-19 | Childrens Hospital Los Angeles Research Institute | Oral compositions of fenretinide having increased bioavailability and methods of using the same |
| FI20030426A7 (fi) | 2003-03-24 | 2004-09-25 | Jaervinen Tomi | Syklodekstriinikompleksit |
| US7178609B2 (en) * | 2003-08-19 | 2007-02-20 | Baker Hughes Incorporated | Window mill and drill bit |
| JP4869942B2 (ja) | 2003-12-11 | 2012-02-08 | ベス・イスラエル・ディーコネス・メディカル・センター,インコーポレイテッド | インスリン感受性/抵抗性、糖尿病および肥満におけるrbp4 |
| WO2005077176A1 (en) | 2004-02-11 | 2005-08-25 | The Trustees Of Columbia University In The City Of New York | Anthocyanin compounds and methods of use thereof |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| AU2005215778B2 (en) * | 2004-02-17 | 2009-03-12 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| CA2601278C (en) | 2004-03-17 | 2014-06-10 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
| JP5166026B2 (ja) | 2004-06-18 | 2013-03-21 | ユニバーシティ オブ ワシントン | 視力障害の治療のためのレチナール誘導体およびその使用方法 |
| DK1768657T3 (da) | 2004-06-23 | 2008-12-01 | Sirion Therapeutics Inc | Fremgangsmåder og sammensætninger til at behandle ophthalmiske tilstande med retinylderivater |
| US7286860B2 (en) | 2004-07-23 | 2007-10-23 | Dyna Llc | Systems and methods for a comfortable wireless communication device |
| WO2006033734A2 (en) | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| WO2006052860A2 (en) | 2004-11-04 | 2006-05-18 | Sirion Therapeutics, Inc. | Modulators of retinol-retinol binding protein (rbp)-transthyretin (ttr) complex formation |
| SG144145A1 (en) | 2004-12-08 | 2008-07-29 | Sirion Therapeutics Inc | Methods, assays and compositions for treating retinol-related diseases |
| UA81382C2 (en) | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding |
-
2005
- 2005-06-06 DK DK05758777T patent/DK1768657T3/da active
- 2005-06-06 NZ NZ551955A patent/NZ551955A/en not_active IP Right Cessation
- 2005-06-06 KR KR1020077001270A patent/KR100862930B1/ko not_active Expired - Fee Related
- 2005-06-06 SG SG200801546-3A patent/SG140607A1/en unknown
- 2005-06-06 EP EP10181656A patent/EP2277516A1/en not_active Withdrawn
- 2005-06-06 EP EP05758777A patent/EP1768657B1/en not_active Expired - Lifetime
- 2005-06-06 AU AU2005262558A patent/AU2005262558B8/en not_active Ceased
- 2005-06-06 PL PL05758777T patent/PL1768657T3/pl unknown
- 2005-06-06 GE GEAP20059816A patent/GEP20084520B/en unknown
- 2005-06-06 EA EA200700109A patent/EA011864B1/ru not_active IP Right Cessation
- 2005-06-06 PT PT05758777T patent/PT1768657E/pt unknown
- 2005-06-06 CA CA2569691A patent/CA2569691C/en not_active Expired - Fee Related
- 2005-06-06 MX MXPA06014978A patent/MXPA06014978A/es active IP Right Grant
- 2005-06-06 SI SI200530415T patent/SI1768657T1/sl unknown
- 2005-06-06 AT AT05758777T patent/ATE404188T1/de active
- 2005-06-06 JP JP2007518098A patent/JP4855396B2/ja not_active Expired - Fee Related
- 2005-06-06 DE DE602005008970T patent/DE602005008970D1/de not_active Expired - Lifetime
- 2005-06-06 ES ES05758777T patent/ES2313368T3/es not_active Expired - Lifetime
- 2005-06-06 BR BRPI0512569-3A patent/BRPI0512569A/pt not_active IP Right Cessation
- 2005-06-06 WO PCT/US2005/020080 patent/WO2006007314A1/en not_active Ceased
- 2005-06-06 EP EP08014275A patent/EP2025336A1/en not_active Withdrawn
- 2005-06-10 US US11/150,641 patent/US8314152B2/en not_active Expired - Fee Related
- 2005-06-21 AR ARP050102545A patent/AR049929A1/es not_active Application Discontinuation
- 2005-06-22 TW TW094120880A patent/TWI396532B/zh not_active IP Right Cessation
-
2006
- 2006-12-06 IL IL179872A patent/IL179872A/en not_active IP Right Cessation
-
2007
- 2007-01-19 LV LVP-07-05A patent/LV13564B/lv unknown
- 2007-01-22 NO NO20070408A patent/NO20070408L/no not_active Application Discontinuation
-
2008
- 2008-11-12 CY CY20081101287T patent/CY1110435T1/el unknown
-
2010
- 2010-04-21 US US12/764,764 patent/US8410168B2/en not_active Expired - Fee Related
-
2011
- 2011-05-27 US US13/118,330 patent/US20110294891A1/en not_active Abandoned
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