GEP20084520B - Use of retinyl derivatives and compositions thereof for treating ophthalmic diseases - Google Patents
Use of retinyl derivatives and compositions thereof for treating ophthalmic diseasesInfo
- Publication number
- GEP20084520B GEP20084520B GEAP20059816A GEAP2005009816A GEP20084520B GE P20084520 B GEP20084520 B GE P20084520B GE AP20059816 A GEAP20059816 A GE AP20059816A GE AP2005009816 A GEAP2005009816 A GE AP2005009816A GE P20084520 B GEP20084520 B GE P20084520B
- Authority
- GE
- Georgia
- Prior art keywords
- compositions
- ophthalmic diseases
- treating ophthalmic
- retinyl derivatives
- retinyl
- Prior art date
Links
- 125000000946 retinyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/16—Ophthalmology
- G01N2800/164—Retinal disorders, e.g. retinopathy
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58229304P | 2004-06-23 | 2004-06-23 | |
| US62969504P | 2004-11-19 | 2004-11-19 | |
| US66090405P | 2005-03-11 | 2005-03-11 | |
| US67240505P | 2005-04-18 | 2005-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP20084520B true GEP20084520B (en) | 2008-10-27 |
Family
ID=34981643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP20059816A GEP20084520B (en) | 2004-06-23 | 2005-06-06 | Use of retinyl derivatives and compositions thereof for treating ophthalmic diseases |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8314152B2 (enExample) |
| EP (3) | EP1768657B1 (enExample) |
| JP (1) | JP4855396B2 (enExample) |
| KR (1) | KR100862930B1 (enExample) |
| AR (1) | AR049929A1 (enExample) |
| AT (1) | ATE404188T1 (enExample) |
| AU (1) | AU2005262558B8 (enExample) |
| BR (1) | BRPI0512569A (enExample) |
| CA (1) | CA2569691C (enExample) |
| CY (1) | CY1110435T1 (enExample) |
| DE (1) | DE602005008970D1 (enExample) |
| DK (1) | DK1768657T3 (enExample) |
| EA (1) | EA011864B1 (enExample) |
| ES (1) | ES2313368T3 (enExample) |
| GE (1) | GEP20084520B (enExample) |
| IL (1) | IL179872A (enExample) |
| LV (1) | LV13564B (enExample) |
| MX (1) | MXPA06014978A (enExample) |
| NO (1) | NO20070408L (enExample) |
| NZ (1) | NZ551955A (enExample) |
| PL (1) | PL1768657T3 (enExample) |
| PT (1) | PT1768657E (enExample) |
| SG (1) | SG140607A1 (enExample) |
| SI (1) | SI1768657T1 (enExample) |
| TW (1) | TWI396532B (enExample) |
| WO (1) | WO2006007314A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2327401A3 (en) | 2003-03-14 | 2011-10-19 | University of Washington | Retinoid Replacements and Opsin Agonists and Methods for the Use Thereof |
| PL380611A1 (pl) | 2004-02-17 | 2007-02-19 | President And Fellows Of Harvard College | Postępowanie z zaburzeniami oftalmologicznymi, włącznie ze zwyrodnieniem plamki |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| JP2007525496A (ja) * | 2004-02-17 | 2007-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 黄班変性症を含む眼科疾患の管理 |
| PL2397133T3 (pl) | 2004-06-18 | 2018-01-31 | Univ Washington | Pochodne retinalu i sposoby ich zastosowania do leczenia zaburzeń wzroku |
| PL1768657T3 (pl) | 2004-06-23 | 2009-01-30 | Revision Therapeutics Inc | Sposoby i kompozycje do leczenia stanów ocznych za pomocą pochodnych retinylowych |
| US20060089411A1 (en) * | 2004-08-07 | 2006-04-27 | Gierhart Dennis L | Treatment of Stargardt's disease and other lipofuscin disorders with combined retinaldehyde inhibitor and zeaxanthin |
| WO2006033734A2 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders |
| EP1804771A2 (en) * | 2004-10-28 | 2007-07-11 | Idexx Laboratories, Inc. | Compositions for controlled delivery of pharmaceutically active compounds |
| JP2008519054A (ja) * | 2004-11-04 | 2008-06-05 | シリオン セラピューティクス, インコーポレイテッド | レチノール−レチノール結合タンパク質(rbp)−トランスチレチン(ttr)複合体の形成のモジュレーター |
| BRPI0520207A2 (pt) * | 2004-12-08 | 2012-09-25 | Revision Therapeutics Inc | uso de uma quantidade eficaz de um primeiro composto, e, medicamento sistemicamente formulado |
| UA81382C2 (en) * | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding | |
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| EP2037951A2 (en) * | 2006-06-22 | 2009-03-25 | Sirion Therapeutics, Inc. | Methods and compositions for treating ophthalmic conditions via modulation of megalin activity |
| AU2007277032A1 (en) * | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Opsin stabilizing compounds and methods of use |
| CA2657164A1 (en) * | 2006-07-27 | 2008-01-31 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating or preventing ophthalmic light toxicity |
| EP2069391A4 (en) * | 2006-07-27 | 2009-12-30 | Univ Florida | COMPOSITIONS AND METHODS FOR TREATING AND / OR PREVENTING OPHTHALMOLOGICAL DISEASES |
| US8828960B2 (en) * | 2007-07-17 | 2014-09-09 | Idexx Laboratories, Inc. | Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds |
| MX337656B (es) | 2008-02-11 | 2016-03-14 | Univ Washington | Metodos para el tratamiento y prevencion de disfuncion retinal relacionada con la edad. |
| WO2009114136A2 (en) * | 2008-03-12 | 2009-09-17 | Albert Einstein College Of Medicine Of Yeshiva University | Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents |
| MX2011000545A (es) * | 2008-07-14 | 2011-02-24 | Otonomy Inc | Composiciones de liberacion controlada para la modulacion de apoptosis y metodos para el tratamiento de trastornos oticos. |
| EP2427052B1 (en) * | 2009-05-04 | 2015-08-26 | Acucela, Inc. | Compositions for use in the treatment of glaucoma or ocular hypertension |
| IN2012DN00352A (enExample) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| RU2546005C2 (ru) | 2009-09-15 | 2015-04-10 | Кью Эл Ти ИНК. | Фармацевтические составы, содержащие 9-цис-ретиниловые сложные эфиры в липидном наполнителе |
| ES2758554T3 (es) | 2009-12-08 | 2020-05-05 | Univ Case Western Reserve | Aminoácidos gama para tratamiento de trastornos oculares |
| US9173856B2 (en) * | 2010-04-19 | 2015-11-03 | Qlt Inc. | Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency |
| WO2013082000A1 (en) | 2011-11-30 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
| US10058616B2 (en) * | 2012-02-10 | 2018-08-28 | Tlc Biopharmaceuticals, Inc. | Pharmaceutical compositions to reduce complications of ocular steroid |
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| US8877183B2 (en) | 2012-06-26 | 2014-11-04 | National Institutes Of Health (Nih) | Methods for treatment of ocular diseases |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
| US10471118B2 (en) * | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| MY183209A (en) | 2014-10-24 | 2021-02-18 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| US10327946B2 (en) * | 2014-12-19 | 2019-06-25 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| PL3416622T3 (pl) * | 2016-02-15 | 2023-09-11 | Kemin Industries, Inc. | Dodatnio naładowane liposomy jako nośniki cząsteczek lipofilowych |
| US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
| WO2018106594A2 (en) * | 2016-12-05 | 2018-06-14 | The Jackson Laboratory | Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans |
| JP7163288B2 (ja) * | 2017-07-04 | 2022-10-31 | 第一三共株式会社 | 視細胞変性を伴う網膜変性疾患用薬 |
| BR112021022270A2 (pt) * | 2019-05-06 | 2022-01-11 | Univ California | Materiais e métodos para tratar degeneração macular relacionada à idade |
| FR3105790B1 (fr) * | 2019-12-26 | 2022-01-14 | Biophytis | Composés chimiques ciblant l’œil et leur utilisation dans le traitement de maladies oculaires |
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| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| PL380611A1 (pl) * | 2004-02-17 | 2007-02-19 | President And Fellows Of Harvard College | Postępowanie z zaburzeniami oftalmologicznymi, włącznie ze zwyrodnieniem plamki |
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| PL2397133T3 (pl) | 2004-06-18 | 2018-01-31 | Univ Washington | Pochodne retinalu i sposoby ich zastosowania do leczenia zaburzeń wzroku |
| PL1768657T3 (pl) | 2004-06-23 | 2009-01-30 | Revision Therapeutics Inc | Sposoby i kompozycje do leczenia stanów ocznych za pomocą pochodnych retinylowych |
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| JP2008519054A (ja) | 2004-11-04 | 2008-06-05 | シリオン セラピューティクス, インコーポレイテッド | レチノール−レチノール結合タンパク質(rbp)−トランスチレチン(ttr)複合体の形成のモジュレーター |
| BRPI0520207A2 (pt) | 2004-12-08 | 2012-09-25 | Revision Therapeutics Inc | uso de uma quantidade eficaz de um primeiro composto, e, medicamento sistemicamente formulado |
| UA81382C2 (en) | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding |
-
2005
- 2005-06-06 PL PL05758777T patent/PL1768657T3/pl unknown
- 2005-06-06 KR KR1020077001270A patent/KR100862930B1/ko not_active Expired - Fee Related
- 2005-06-06 EA EA200700109A patent/EA011864B1/ru not_active IP Right Cessation
- 2005-06-06 DK DK05758777T patent/DK1768657T3/da active
- 2005-06-06 BR BRPI0512569-3A patent/BRPI0512569A/pt not_active IP Right Cessation
- 2005-06-06 DE DE602005008970T patent/DE602005008970D1/de not_active Expired - Lifetime
- 2005-06-06 EP EP05758777A patent/EP1768657B1/en not_active Expired - Lifetime
- 2005-06-06 MX MXPA06014978A patent/MXPA06014978A/es active IP Right Grant
- 2005-06-06 GE GEAP20059816A patent/GEP20084520B/en unknown
- 2005-06-06 SI SI200530415T patent/SI1768657T1/sl unknown
- 2005-06-06 EP EP08014275A patent/EP2025336A1/en not_active Withdrawn
- 2005-06-06 ES ES05758777T patent/ES2313368T3/es not_active Expired - Lifetime
- 2005-06-06 JP JP2007518098A patent/JP4855396B2/ja not_active Expired - Fee Related
- 2005-06-06 NZ NZ551955A patent/NZ551955A/en not_active IP Right Cessation
- 2005-06-06 PT PT05758777T patent/PT1768657E/pt unknown
- 2005-06-06 EP EP10181656A patent/EP2277516A1/en not_active Withdrawn
- 2005-06-06 AU AU2005262558A patent/AU2005262558B8/en not_active Ceased
- 2005-06-06 AT AT05758777T patent/ATE404188T1/de active
- 2005-06-06 SG SG200801546-3A patent/SG140607A1/en unknown
- 2005-06-06 WO PCT/US2005/020080 patent/WO2006007314A1/en not_active Ceased
- 2005-06-06 CA CA2569691A patent/CA2569691C/en not_active Expired - Fee Related
- 2005-06-10 US US11/150,641 patent/US8314152B2/en not_active Expired - Fee Related
- 2005-06-21 AR ARP050102545A patent/AR049929A1/es not_active Application Discontinuation
- 2005-06-22 TW TW094120880A patent/TWI396532B/zh not_active IP Right Cessation
-
2006
- 2006-12-06 IL IL179872A patent/IL179872A/en not_active IP Right Cessation
-
2007
- 2007-01-19 LV LVP-07-05A patent/LV13564B/lv unknown
- 2007-01-22 NO NO20070408A patent/NO20070408L/no not_active Application Discontinuation
-
2008
- 2008-11-12 CY CY20081101287T patent/CY1110435T1/el unknown
-
2010
- 2010-04-21 US US12/764,764 patent/US8410168B2/en not_active Expired - Fee Related
-
2011
- 2011-05-27 US US13/118,330 patent/US20110294891A1/en not_active Abandoned
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