JP2008504012A5 - - Google Patents
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- Publication number
- JP2008504012A5 JP2008504012A5 JP2006551550A JP2006551550A JP2008504012A5 JP 2008504012 A5 JP2008504012 A5 JP 2008504012A5 JP 2006551550 A JP2006551550 A JP 2006551550A JP 2006551550 A JP2006551550 A JP 2006551550A JP 2008504012 A5 JP2008504012 A5 JP 2008504012A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- fsh
- αfsh
- βfsh
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020001507 fusion proteins Proteins 0.000 claims 22
- 102000037865 fusion proteins Human genes 0.000 claims 22
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 8
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 6
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 108010000732 alpha Subunit Glycoprotein Hormones Proteins 0.000 claims 2
- 102000002287 alpha Subunit Glycoprotein Hormones Human genes 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 230000035558 fertility Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 102100040796 Glycoprotein hormones alpha chain Human genes 0.000 claims 1
- 101001038874 Homo sapiens Glycoprotein hormones alpha chain Proteins 0.000 claims 1
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 claims 1
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 claims 1
- 102000035824 beta Subunit Follicle Stimulating Hormone Human genes 0.000 claims 1
- 108010081485 beta Subunit Follicle Stimulating Hormone Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54023604P | 2004-01-28 | 2004-01-28 | |
| PCT/US2005/003034 WO2005073383A2 (en) | 2004-01-28 | 2005-01-27 | HETERODIMERIC FOLLICLE STIMULATING HORMONE-Fc (FSH-Fc) FUSION PROTEINS FOR THE TREATMENT OF INFERTILITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504012A JP2008504012A (ja) | 2008-02-14 |
| JP2008504012A5 true JP2008504012A5 (enExample) | 2008-03-27 |
Family
ID=34826205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551550A Pending JP2008504012A (ja) | 2004-01-28 | 2005-01-27 | 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Ｆｃ（ＦＳＨ−Ｆｃ）融合タンパク質 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7601516B2 (enExample) |
| EP (1) | EP1711610A2 (enExample) |
| JP (1) | JP2008504012A (enExample) |
| CN (1) | CN1926237A (enExample) |
| AU (1) | AU2005207960A1 (enExample) |
| BR (1) | BRPI0507174A (enExample) |
| CA (1) | CA2553187A1 (enExample) |
| IL (2) | IL177049A (enExample) |
| NO (1) | NO20063807L (enExample) |
| WO (1) | WO2005073383A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8007805B2 (en) | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
| BRPI0406605B8 (pt) | 2003-11-13 | 2021-05-25 | Hanmi Holdings Co Ltd | conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| WO2005072097A2 (en) * | 2003-12-16 | 2005-08-11 | University Of Massachusetts | Toll-like receptor 9 modulators |
| CA2553187A1 (en) * | 2004-01-28 | 2005-08-11 | Syntonix Pharmaceuticals, Inc. | Heterodimeric follicle stimulating hormone-fc (fsh-fc) fusion proteins for the treatment of infertility |
| GB0510627D0 (en) | 2005-05-25 | 2005-06-29 | Avidex Ltd | Polypeptides |
| EP1948802A4 (en) * | 2005-10-13 | 2009-01-14 | Virexx Medical Corp | CHIMERIC ANTIGEN WITH HEPATITIS C VIRUS POLYPEPTIDE AND FC FRAGMENT FOR CALLING UP AN IMMUNE RESPONSE |
| EP1948271B1 (en) | 2005-11-17 | 2013-10-02 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| EP1801121A1 (en) * | 2005-12-23 | 2007-06-27 | CONARIS research institute AG | Soluble gp130 molecule variants useful as a medicament |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| CN101909642B (zh) * | 2007-11-30 | 2013-04-17 | 阿斯彭生物制药有限公司 | 重组型马科动物促卵泡激素的活性 |
| WO2009080764A2 (en) * | 2007-12-20 | 2009-07-02 | Abylnx N.V. | Oral or nasal administration of compounds comprising amino acid sequences |
| AR081755A1 (es) * | 2010-04-02 | 2012-10-17 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo |
| FR2958936A1 (fr) * | 2010-04-14 | 2011-10-21 | Sanofi Aventis | Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs |
| EP4086338A1 (en) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| EP2707021B1 (en) * | 2011-05-09 | 2024-02-21 | Minerva Biotechnologies Corporation | Genetically engineered growth factor variants |
| AU2012286048A1 (en) * | 2011-07-18 | 2014-02-20 | Arts Biologics A/S | Long acting luteinizing hormone (LH) compound |
| KR101967345B1 (ko) * | 2012-10-18 | 2019-04-09 | 삼성전자주식회사 | 안지오포이에틴-2와 인테그린 간의 결합을 저해하는 펩타이드 및 그 용도 |
| CN103509121B (zh) | 2012-11-22 | 2015-01-28 | 苏州康宁杰瑞生物科技有限公司 | 一种fsh融合蛋白及其制备方法和用途 |
| EA201591700A1 (ru) * | 2013-03-14 | 2015-12-30 | Ридженерон Фармасьютикалз, Инк. | Гибридные белки апелина и их применение |
| CN103539862B (zh) * | 2013-11-01 | 2015-04-01 | 广州联康生物科技有限公司 | 一种长效重组促卵泡激素及其应用 |
| CN103539860B (zh) * | 2013-11-01 | 2014-12-03 | 广州优联康医药科技有限公司 | 一种长效重组人促卵泡激素融合蛋白 |
| CA2931299C (en) | 2013-11-20 | 2024-03-05 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
| CN104524553B (zh) * | 2014-12-12 | 2015-07-29 | 薛传校 | 一种长效促排卵注射液 |
| WO2016133372A2 (ko) * | 2015-02-17 | 2016-08-25 | 한미약품 주식회사 | 지속형 인슐린 또는 이의 아날로그 결합체 |
| CN107969127B (zh) * | 2015-09-08 | 2022-09-06 | 赛瑞品股份有限公司 | Apoa-1融合多肽及相关组合物和方法 |
| CN105567733B (zh) * | 2016-01-11 | 2019-04-23 | 佛山安普泽生物医药股份有限公司 | CHO细胞表达凝血酶-Fc融合蛋白的方法 |
| CN106046176B (zh) * | 2016-08-16 | 2019-09-10 | 中国药科大学 | 一种高活性长效降糖融合蛋白及其制备方法与医药用途 |
| CN107082815A (zh) * | 2017-06-28 | 2017-08-22 | 杭州皓阳生物技术有限公司 | 一种fsh‑hsa融合蛋白及其制备方法 |
| CN107540748B (zh) * | 2017-09-15 | 2020-07-14 | 北京伟杰信生物科技有限公司 | 长效重组猪fsh融合蛋白及其制备方法与应用 |
| CN110305903B (zh) * | 2019-07-31 | 2021-10-01 | 江苏璟泽生物医药有限公司 | 重组人促卵泡激素及其制备方法 |
| CN113599503A (zh) * | 2021-07-28 | 2021-11-05 | 安徽中起生物科技有限公司 | 一种调节卵巢功能的生物制剂及其制备方法和应用 |
| CN118562018B (zh) * | 2021-09-30 | 2024-12-13 | 宁波三生生物科技股份有限公司 | 重组促卵泡激素融合蛋白 |
| CN116768979B (zh) * | 2022-07-06 | 2025-04-29 | 华兰基因工程有限公司 | 一种重组人促卵泡生成素CTP-Fc融合蛋白及制备方法 |
| CN115947860B (zh) * | 2022-07-06 | 2025-04-25 | 华兰基因工程有限公司 | 一种重组人促卵泡生成素Fc融合蛋白及制备方法 |
| CN120569412A (zh) * | 2023-12-28 | 2025-08-29 | 江苏众红生物工程创药研究院有限公司 | 新型长效人fsh与lh融合蛋白及其制备方法与应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713339A (en) * | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4840896A (en) * | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| ES2092468T3 (es) * | 1988-01-22 | 1996-12-01 | Zymogenetics Inc | Metodos para producir analogos de receptores secretados. |
| US5338835A (en) * | 1989-02-21 | 1994-08-16 | Washington University | CTP-extended form of FSH |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| DE59010908D1 (de) * | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| EP0533006A1 (en) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| ATE311895T1 (de) * | 1992-05-26 | 2005-12-15 | Immunex Corp | Neue zytokine die cd30 binden |
| US6485726B1 (en) * | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6030613A (en) * | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6086875A (en) * | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| AU706504B2 (en) * | 1996-02-20 | 1999-06-17 | Merck Serono Sa | Hybrid proteins which form heterodimers |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| WO2000008015A2 (en) * | 1998-08-07 | 2000-02-17 | Applied Research Systems Ars Holding N.V. | Fsh mimetics for the treatment of infertility |
| US7081446B2 (en) * | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
| CA2479212A1 (en) * | 2002-03-15 | 2003-09-25 | Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| CA2491129A1 (en) * | 2002-07-03 | 2004-01-15 | Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US6936574B2 (en) * | 2002-08-30 | 2005-08-30 | Halliburton Energy Services, Inc. | Process for controlling gas migration during well cementing |
| CA2553187A1 (en) | 2004-01-28 | 2005-08-11 | Syntonix Pharmaceuticals, Inc. | Heterodimeric follicle stimulating hormone-fc (fsh-fc) fusion proteins for the treatment of infertility |
-
2005
- 2005-01-27 CA CA002553187A patent/CA2553187A1/en not_active Abandoned
- 2005-01-27 WO PCT/US2005/003034 patent/WO2005073383A2/en not_active Ceased
- 2005-01-27 EP EP05712467A patent/EP1711610A2/en not_active Withdrawn
- 2005-01-27 AU AU2005207960A patent/AU2005207960A1/en not_active Abandoned
- 2005-01-27 BR BRPI0507174-7A patent/BRPI0507174A/pt not_active IP Right Cessation
- 2005-01-27 JP JP2006551550A patent/JP2008504012A/ja active Pending
- 2005-01-27 US US11/045,022 patent/US7601516B2/en not_active Expired - Fee Related
- 2005-01-27 CN CNA2005800062581A patent/CN1926237A/zh active Pending
-
2006
- 2006-07-24 IL IL177049A patent/IL177049A/en not_active IP Right Cessation
- 2006-08-25 NO NO20063807A patent/NO20063807L/no not_active Application Discontinuation
-
2009
- 2009-04-21 US US12/427,640 patent/US8293707B2/en not_active Expired - Fee Related
-
2010
- 2010-06-21 IL IL206518A patent/IL206518A0/en unknown
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