JP2008500275A5 - - Google Patents

Info

Publication number

JP2008500275A5

JP2008500275A5 JP2006547297A JP2006547297A JP2008500275A5 JP 2008500275 A5 JP2008500275 A5 JP 2008500275A5 JP 2006547297 A JP2006547297 A JP 2006547297A JP 2006547297 A JP2006547297 A JP 2006547297A JP 2008500275 A5 JP2008500275 A5 JP 2008500275A5

Authority

JP

Japan

Prior art keywords

erythropoietin

conjugate

moiety

amino acid

seq

Prior art date

2004-12-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 28
• 102000003951 Erythropoietin Human genes 0.000 claims 21
• 108090000394 Erythropoietin Proteins 0.000 claims 21
• 229940105423 erythropoietin Drugs 0.000 claims 19
• 150000001413 amino acids Chemical class 0.000 claims 10
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 7
• 235000001014 amino acid Nutrition 0.000 claims 7
• 229920001477 hydrophilic polymer Polymers 0.000 claims 7
• 235000018102 proteins Nutrition 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 230000004071 biological effect Effects 0.000 claims 5
• 235000018417 cysteine Nutrition 0.000 claims 5
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 5
• 229920000233 poly(alkylene oxides) Polymers 0.000 claims 5
• 229920001223 polyethylene glycol Polymers 0.000 claims 5
• 150000003573 thiols Chemical class 0.000 claims 5
• 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 4
• 102100031939 Erythropoietin Human genes 0.000 claims 4
• 239000002202 Polyethylene glycol Substances 0.000 claims 4
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
• 125000003827 glycol group Chemical group 0.000 claims 4
• 230000001225 therapeutic effect Effects 0.000 claims 4
• 210000002798 bone marrow cell Anatomy 0.000 claims 3
• 235000014113 dietary fatty acids Nutrition 0.000 claims 3
• 239000000194 fatty acid Substances 0.000 claims 3
• 229930195729 fatty acid Natural products 0.000 claims 3
• 125000005313 fatty acid group Chemical group 0.000 claims 3
• 229920001519 homopolymer Polymers 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 150000003904 phospholipids Chemical class 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108020004705 Codon Proteins 0.000 claims 2
• 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims 2
• 102000002265 Human Growth Hormone Human genes 0.000 claims 2
• 108010000521 Human Growth Hormone Proteins 0.000 claims 2
• 239000000854 Human Growth Hormone Substances 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 210000003743 erythrocyte Anatomy 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 102000044890 human EPO Human genes 0.000 claims 2
• 125000003473 lipid group Chemical group 0.000 claims 2
• 150000007523 nucleic acids Chemical group 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
• 101000999370 Homo sapiens Interferon omega-1 Proteins 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 229960002685 biotin Drugs 0.000 claims 1
• 235000020958 biotin Nutrition 0.000 claims 1
• 239000011616 biotin Substances 0.000 claims 1
• 229920001400 block copolymer Polymers 0.000 claims 1
• 125000000837 carbohydrate group Chemical group 0.000 claims 1
• 230000001268 conjugating effect Effects 0.000 claims 1
• 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 claims 1
• 108700041286 delta Proteins 0.000 claims 1
• 230000002255 enzymatic effect Effects 0.000 claims 1
• 230000010437 erythropoiesis Effects 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
• 229920001451 polypropylene glycol Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Chemical group 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Chemical group 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 230000012846 protein folding Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 230000001568 sexual effect Effects 0.000 claims 1
• 238000002741 site-directed mutagenesis Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1