JP2008201787A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008201787A5 JP2008201787A5 JP2008069369A JP2008069369A JP2008201787A5 JP 2008201787 A5 JP2008201787 A5 JP 2008201787A5 JP 2008069369 A JP2008069369 A JP 2008069369A JP 2008069369 A JP2008069369 A JP 2008069369A JP 2008201787 A5 JP2008201787 A5 JP 2008201787A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- bond
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- -1 acenaphthyl Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 239000001301 oxygen Substances 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 4
- 239000005977 Ethylene Substances 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000005059 halophenyl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66655605P | 2005-03-31 | 2005-03-31 | |
| US75085305P | 2005-12-16 | 2005-12-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503525A Division JP2008534558A (ja) | 2005-03-31 | 2006-03-30 | ピペリジン置換体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008201787A JP2008201787A (ja) | 2008-09-04 |
| JP2008201787A5 true JP2008201787A5 (enExample) | 2009-05-14 |
Family
ID=36586065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503525A Pending JP2008534558A (ja) | 2005-03-31 | 2006-03-30 | ピペリジン置換体 |
| JP2008069369A Pending JP2008201787A (ja) | 2005-03-31 | 2008-03-18 | ピペリジン置換体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503525A Pending JP2008534558A (ja) | 2005-03-31 | 2006-03-30 | ピペリジン置換体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20100029628A1 (enExample) |
| EP (1) | EP1863803B1 (enExample) |
| JP (2) | JP2008534558A (enExample) |
| AR (2) | AR055756A1 (enExample) |
| AT (1) | ATE479681T1 (enExample) |
| BR (2) | BRPI0621969A2 (enExample) |
| CA (1) | CA2601702A1 (enExample) |
| DE (1) | DE602006016573D1 (enExample) |
| IL (2) | IL186130A0 (enExample) |
| PL (1) | PL1863803T3 (enExample) |
| PT (1) | PT1863803E (enExample) |
| TW (2) | TW200716622A (enExample) |
| WO (1) | WO2006103277A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005020314D1 (de) | 2004-08-25 | 2010-05-12 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
| TW200716622A (en) * | 2005-03-31 | 2007-05-01 | Speedel Experimenta Ag | Substituted piperidines |
| MX2007014722A (es) | 2005-05-27 | 2008-02-15 | Actelion Pharmaceuticals Ltd | Nuevos derivados de amida de acido piperidin carboxilico. |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| CN102516241B (zh) | 2006-05-19 | 2015-07-29 | 艾伯维巴哈马有限公司 | Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物 |
| CN101448824A (zh) * | 2006-06-08 | 2009-06-03 | 斯皮德尔实验股份公司 | 2,5-双基取代的哌啶 |
| TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
| EP1958634A3 (en) * | 2007-02-14 | 2008-09-24 | Speedel Experimenta AG | Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease |
| TW200922596A (en) * | 2007-10-25 | 2009-06-01 | Speedel Experimenta Ag | 4,4-disubstituted piperidines |
| AR069145A1 (es) * | 2007-11-02 | 2009-12-30 | Speedel Experimenta Ag | Piperidinas 4,4- disusutituidas, uso del compuesto en la produccion de un medicamento, un producto farmaceutico en base al compuesto y un metodo de prevencion de enfermedades |
| KR20100095605A (ko) | 2007-12-19 | 2010-08-31 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 바이시클릭 헤테로시클릭 유도체 |
| CA2714347A1 (en) | 2008-02-08 | 2009-08-13 | Novartis Ag | Substituted piperidines as renin inhibitors |
| WO2009098276A1 (en) * | 2008-02-08 | 2009-08-13 | Novartis Ag | Substituted piperidines as renin inhibitors |
| EA020853B1 (ru) | 2008-05-05 | 2015-02-27 | Мерк Кэнэда Инк. | 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина |
| EP2163245A1 (en) | 2008-09-10 | 2010-03-17 | Novartis Ag | Renin inhibitors for the treatment of psoriasis |
| US8389731B2 (en) * | 2009-05-15 | 2013-03-05 | Northwestern University | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase |
| KR20120109292A (ko) | 2009-06-24 | 2012-10-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Ｎ-치환-시클릭 아미노 유도체 |
| JP2018502778A (ja) * | 2015-01-09 | 2018-02-01 | ジェイ．ダブリュ． スピーカー コーポレイション | 車両用の追跡及び照明システム及び方法 |
| DE102015013191A1 (de) * | 2015-10-10 | 2017-04-13 | Daimler Ag | Verfahren zum Betrieb einer Leuchteinheit und Leuchteinheit |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009311A1 (de) * | 1995-09-07 | 1997-03-13 | F. Hoffmann-La Roche Ag | Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz |
| US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| US6197959B1 (en) * | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US20040204455A1 (en) * | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| TW200716622A (en) * | 2005-03-31 | 2007-05-01 | Speedel Experimenta Ag | Substituted piperidines |
-
2006
- 2006-03-29 TW TW095110894A patent/TW200716622A/zh unknown
- 2006-03-29 AR ARP060101217A patent/AR055756A1/es unknown
- 2006-03-29 TW TW097113173A patent/TW200833687A/zh unknown
- 2006-03-30 JP JP2008503525A patent/JP2008534558A/ja active Pending
- 2006-03-30 DE DE602006016573T patent/DE602006016573D1/de active Active
- 2006-03-30 CA CA002601702A patent/CA2601702A1/en not_active Abandoned
- 2006-03-30 PL PL06725445T patent/PL1863803T3/pl unknown
- 2006-03-30 US US11/887,227 patent/US20100029628A1/en not_active Abandoned
- 2006-03-30 BR BRPI0621969-1A patent/BRPI0621969A2/pt not_active IP Right Cessation
- 2006-03-30 BR BRPI0608758-2A patent/BRPI0608758A2/pt not_active IP Right Cessation
- 2006-03-30 AT AT06725445T patent/ATE479681T1/de active
- 2006-03-30 PT PT06725445T patent/PT1863803E/pt unknown
- 2006-03-30 WO PCT/EP2006/061197 patent/WO2006103277A2/en not_active Ceased
- 2006-03-30 EP EP06725445A patent/EP1863803B1/en not_active Not-in-force
-
2007
- 2007-09-20 IL IL186130A patent/IL186130A0/en unknown
-
2008
- 2008-02-05 AR ARP080100485A patent/AR065188A2/es not_active Application Discontinuation
- 2008-02-11 IL IL189429A patent/IL189429A0/en unknown
- 2008-03-14 US US12/076,221 patent/US7687495B2/en not_active Expired - Fee Related
- 2008-03-18 JP JP2008069369A patent/JP2008201787A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008201787A5 (enExample) | ||
| JP2008534558A5 (enExample) | ||
| RU2012123372A (ru) | Гетероциклические модуляторы транспортеров атф-связывающей кассеты | |
| MX2010004501A (es) | Inhibidor de la proteina de activacion de 5-lipoxigenasa (plap). | |
| JP2011527334A5 (enExample) | ||
| WO2007087066A3 (en) | 1-(benzo [d] [1,3] di0x0l-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis | |
| US20010031757A1 (en) | Method for treating inflammatory diseases by administering a thrombin inhibitor | |
| CY1115533T1 (el) | Παραγωγα χολικου οξεος ως προσδετες fxr για την προληψη ή τη θεραπευτικη αγωγη νοσηματων ή καταστασεων οι οποιες προκαλουνται με τη μεσολαβηση fxr | |
| JP2012533546A5 (enExample) | ||
| AU2018277523B2 (en) | 5-5 fused rings as C5a inhibitors | |
| EA201300342A1 (ru) | Производные изоксазола и их применение в качестве потенциирующих средств для метаботропных глутаматных рецепторов | |
| JP2018518537A5 (enExample) | ||
| EA200870448A1 (ru) | Тризамещенные 1,2,4-триазолы | |
| NO20076319L (no) | Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav | |
| EA200900613A1 (ru) | Спирокетоновые ингибиторы ацетил-коа-карбоксилаз | |
| NO20072978L (no) | Nye betuinderivater, preparat derav og anvendelse derav | |
| EA201071094A1 (ru) | Тризамещенные 1,2,4-триазолы в качестве модуляторов никотиновых ацетилхолиновых рецепторов | |
| JP2010511631A5 (enExample) | ||
| NO20085060L (no) | Triazolpyrazinderivater anvendelige som anti-cancermidler | |
| EA200901423A1 (ru) | Бензимидазолы и содержащие их фармацевтические композиции | |
| EA200870302A1 (ru) | 1,3-диоксанкарбоновые кислоты | |
| WO2007090882A3 (en) | Pharmaceutical extended release compositions comprising pramipexole | |
| NO20083708L (no) | 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer | |
| ECSP10010052A (es) | Formulaciones galenicas de alisquireno y valsartan | |
| CN117157049A (zh) | Atp合酶抑制剂-化妆品和治疗用途 |