JP2008534558A - ピペリジン置換体 - Google Patents

ピペリジン置換体 Download PDF

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Publication number
JP2008534558A
JP2008534558A JP2008503525A JP2008503525A JP2008534558A JP 2008534558 A JP2008534558 A JP 2008534558A JP 2008503525 A JP2008503525 A JP 2008503525A JP 2008503525 A JP2008503525 A JP 2008503525A JP 2008534558 A JP2008534558 A JP 2008534558A
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
methoxy
propyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008503525A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008534558A5 (enExample
Inventor
ヘーロルト，ペーター
マー，ロベルト
チンケ，ヴィンチェンツォ
マルツィ，クリスティアーネ
シュトゥッツ，シュテファン
イェラコビッチ，スティエパン
ホリンガー，フランク
コンテアティス，ゼノン・ディー
ラジントン，ジェニファー・エル
クィルムバッハ，ミヒャエル
ストヤノビッチ，アレクサンダー
ベーンケ，ディルク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Speedel Experimenta AG
Original Assignee
Speedel Experimenta AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Experimenta AG filed Critical Speedel Experimenta AG
Publication of JP2008534558A publication Critical patent/JP2008534558A/ja
Publication of JP2008534558A5 publication Critical patent/JP2008534558A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP2008503525A 2005-03-31 2006-03-30 ピペリジン置換体 Pending JP2008534558A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66655605P 2005-03-31 2005-03-31
US75085305P 2005-12-16 2005-12-16
PCT/EP2006/061197 WO2006103277A2 (en) 2005-03-31 2006-03-30 2 , 4 , 5-substituted piperidines as renin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008069369A Division JP2008201787A (ja) 2005-03-31 2008-03-18 ピペリジン置換体

Publications (2)

Publication Number Publication Date
JP2008534558A true JP2008534558A (ja) 2008-08-28
JP2008534558A5 JP2008534558A5 (enExample) 2009-05-14

Family

ID=36586065

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008503525A Pending JP2008534558A (ja) 2005-03-31 2006-03-30 ピペリジン置換体
JP2008069369A Pending JP2008201787A (ja) 2005-03-31 2008-03-18 ピペリジン置換体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008069369A Pending JP2008201787A (ja) 2005-03-31 2008-03-18 ピペリジン置換体

Country Status (13)

Country Link
US (2) US20100029628A1 (enExample)
EP (1) EP1863803B1 (enExample)
JP (2) JP2008534558A (enExample)
AR (2) AR055756A1 (enExample)
AT (1) ATE479681T1 (enExample)
BR (2) BRPI0608758A2 (enExample)
CA (1) CA2601702A1 (enExample)
DE (1) DE602006016573D1 (enExample)
IL (2) IL186130A0 (enExample)
PL (1) PL1863803T3 (enExample)
PT (1) PT1863803E (enExample)
TW (2) TW200833687A (enExample)
WO (1) WO2006103277A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2577084A1 (en) 2004-08-25 2006-03-02 Olivier Bezencon Bicyclononene derivatives as renin inhibitors
TW200833687A (en) * 2005-03-31 2008-08-16 Speedel Experimenta Ag Substituted piperidines
AU2006253805A1 (en) 2005-05-27 2006-12-07 Actelion Pharmaceuticals Ltd. Novel piperidine carboxylic acid amide derivatives
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
NZ573735A (en) 2006-05-19 2011-10-28 Abbott Lab Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives
TW200815425A (en) * 2006-06-08 2008-04-01 Speedel Experimenta Ag 2,5-disubstituted piperidines
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
EP1958634A3 (en) * 2007-02-14 2008-09-24 Speedel Experimenta AG Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease
TW200922596A (en) * 2007-10-25 2009-06-01 Speedel Experimenta Ag 4,4-disubstituted piperidines
TW200934499A (en) * 2007-11-02 2009-08-16 Speedel Experimenta Ag 4,4-disubstituted piperidines
CA2708866A1 (en) 2007-12-19 2009-06-25 Hiroyuki Nakahira Bicyclic heterocyclic derivative
KR20100131427A (ko) * 2008-02-08 2010-12-15 노파르티스 아게 레닌 억제제로서의 치환된 피페리딘
CA2714347A1 (en) 2008-02-08 2009-08-13 Novartis Ag Substituted piperidines as renin inhibitors
US8889714B2 (en) 2008-05-05 2014-11-18 Actelion Pharmaceuticals Ltd. 3,4-substituted piperidine derivatives as renin inhibitors
EP2163245A1 (en) 2008-09-10 2010-03-17 Novartis Ag Renin inhibitors for the treatment of psoriasis
US8389731B2 (en) * 2009-05-15 2013-03-05 Northwestern University Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
KR20120109292A (ko) 2009-06-24 2012-10-08 다이닛본 스미토모 세이야꾸 가부시끼가이샤 Ｎ-치환-시클릭 아미노 유도체
HK1246743A1 (zh) * 2015-01-09 2018-09-14 J.W. Speaker Corporation 用於车辆的跟踪和照明系统及方法
DE102015013191A1 (de) * 2015-10-10 2017-04-13 Daimler Ag Verfahren zum Betrieb einer Leuchteinheit und Leuchteinheit

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543072A (ja) * 1999-04-27 2002-12-17 エフ．ホフマン−ラ ロシュ アーゲー レニン阻害剤
JP2002543063A (ja) * 1999-04-27 2002-12-17 エフ．ホフマン−ラ ロシュ アーゲー レニンインヒビター
WO2004089903A1 (en) * 2003-04-10 2004-10-21 Warner-Lambert Company Llc Piperidine derivatives as renin inhibitors for the treatment of hypertension
JP2008201787A (ja) * 2005-03-31 2008-09-04 Speedel Experimenta Ag ピペリジン置換体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL193686B1 (pl) * 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543072A (ja) * 1999-04-27 2002-12-17 エフ．ホフマン−ラ ロシュ アーゲー レニン阻害剤
JP2002543063A (ja) * 1999-04-27 2002-12-17 エフ．ホフマン−ラ ロシュ アーゲー レニンインヒビター
WO2004089903A1 (en) * 2003-04-10 2004-10-21 Warner-Lambert Company Llc Piperidine derivatives as renin inhibitors for the treatment of hypertension
JP2008201787A (ja) * 2005-03-31 2008-09-04 Speedel Experimenta Ag ピペリジン置換体

Also Published As

Publication number Publication date
EP1863803A2 (en) 2007-12-12
JP2008201787A (ja) 2008-09-04
DE602006016573D1 (de) 2010-10-14
TW200716622A (en) 2007-05-01
PL1863803T3 (pl) 2011-02-28
US20100029628A1 (en) 2010-02-04
AR065188A2 (es) 2009-05-20
PT1863803E (pt) 2010-11-18
EP1863803B1 (en) 2010-09-01
BRPI0621969A2 (pt) 2011-07-19
WO2006103277A3 (en) 2006-12-28
AR055756A1 (es) 2007-09-05
ATE479681T1 (de) 2010-09-15
WO2006103277A2 (en) 2006-10-05
TW200833687A (en) 2008-08-16
BRPI0608758A2 (pt) 2009-07-07
IL189429A0 (en) 2008-06-05
CA2601702A1 (en) 2006-10-05
US20080171748A1 (en) 2008-07-17
IL186130A0 (en) 2008-01-20
US7687495B2 (en) 2010-03-30

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