JP2008110993A - 抗菌性組成物及び皮膚外用剤 - Google Patents
抗菌性組成物及び皮膚外用剤 Download PDFInfo
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- JP2008110993A JP2008110993A JP2008017600A JP2008017600A JP2008110993A JP 2008110993 A JP2008110993 A JP 2008110993A JP 2008017600 A JP2008017600 A JP 2008017600A JP 2008017600 A JP2008017600 A JP 2008017600A JP 2008110993 A JP2008110993 A JP 2008110993A
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- Prior art keywords
- acid
- skin
- triclosan
- antibacterial composition
- acne
- Prior art date
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Landscapes
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Abstract
【解決手段】トリクロサンと、レゾルシン及び/又はサリチル酸とを含有してなる、抗腋臭原因菌用、抗ニキビ菌用、抗フケ菌用などの抗菌性組成物、並びに該組成物を含有してなる皮膚外用剤とする。
【選択図】なし
Description
〔1〕トリクロサンと、レゾルシン及び/又はサリチル酸とを含有することを特徴とする抗菌性組成物、並びに
〔2〕前記〔1〕に記載の抗菌性組成物を含有してなる皮膚外用剤
に関する。
腋臭原因菌として、スタフィロコッカス エピデルミディス(Staphylococcus epidermidis IAM1296)及びコリネバクテリウム ミヌティシマム(Corynebacterium minutissimum ATCC23348)を用いた。ニキビ原因菌として、プロピオニバクテリウム アクネス(Propionibacterium acnes ATCC6919)を用いた。フケ原因菌として、マラセチア フルフル(Malassezia furfur NBRC0656)を用いた。
接種用菌液としてスタフィロコッカス エピデルミディス、コリネバクテリウム ミヌティシマム及びプロピオニバクテリウム アクネスについては、寒天培地で35℃で培養後、更にブイヨン培地に移植して35℃で培養した。得られた培養液をブイヨン培地で約107個/mLに希釈したものを接種用菌液とした。尚、プロピオニバクテリウム アクネスは嫌気培養した。
トリクロサン(比較例1)、レゾルシン(比較例2)、及びサリチル酸(比較例3)は、70%エタノールを希釈溶媒として3000μg/mLに調製し、11段階に倍倍希釈して希釈系列を調製した。
上記の各被験物質を含む希釈系列1mLに対して各寒天培地9mLをシャーレに入れ、それぞれについて、上記各接種用菌液を約1cmの長さに画線した。培養は、スタフィロコッカス エピデルミディス、コリネバクテリウム ミヌティシマム、及びプロピオニバクテリウム アクネスについては、35℃で行い、5日後の菌の生育の有無を判定した。また、マラセチア フルフルについては、30℃で培養を行い、5日後の菌の生育の有無を判定した。尚、プロピオニバクテリウム アクネスは嫌気培養した。
皮脂成分の影響による殺菌効果を検討するために、皮脂成分としてトレオレインを添加して下記試験を実施した。即ち、上記各被験物質を含む希釈系列1mLに対して、0.1重量%のトリオレインと寒天培地8.9mLをシャーレに入れ、それぞれについて、上記と同様に接種用菌液を約1cmの長さに画線し、培養した。
(試料の調製)
表9に記した組成に従い、実施例3〜4および比較例4〜6の各デオドラント剤を常法により調製し下記評価に供した。尚、表中の配合量は重量%を表す。
腋臭が強いと判定された男子被験者10名に、各試料を被験者の一方の腋下に塗布し、もう一方の腋下は比較対照として塗布しなかった。塗布前とその直後及び3時間後のそれぞれについて下記評価基準に従って臭いの判定をし、その平均値を採用した。結果を表9に示す。
臭わない・・・・・・・・0点
かすかに臭う・・・・・・1点
やや臭うが弱い・・・・・2点
はっきりと臭う・・・・・3点
非常に強く臭う・・・・・4点
(試料の調製)
表10に記した組成に従い、実施例5〜6および比較例7〜9の各ニキビ用皮膚外用剤を常法により調製し下記評価に供した。尚、表中の配合量は重量%を表す。
ニキビ症の被験者10名に、各試料を被験者の一方の頬に、1日2回づつ4週間塗布し、下記評価基準に従って改善の程度の人数を判定した。結果を表10に示す。
有効:ニキビの改善が認められる。
やや有効:ニキビの改善がやや認められる。
無効:ニキビの改善が認められない。
(試料の調製)
表11に記した組成に従い、実施例7〜8および比較例10〜12の各ヘアトニックを常法により調製し下記評価に供した。尚、表中の配合量は重量%を表す。
フケ症と自覚する被験者10名に、各試料を被験者に1日2回づつ4週間使用させ、下記評価基準に従って改善の程度の人数を判定した。結果を表11に示す。
有効:フケの改善が認められる。
やや有効:フケの改善がやや認められる。
無効:フケの改善が認められない。
パラフェノールスルホン酸亜鉛 2.0
エタノール 30.0
1,3−ブチレングリコール 3.0
レゾルシン 0.1
トリクロサン 0.1
ポリオキシエチレン(50)硬化ヒマシ油 0.5
香料 適量
精製水 残分
合 計 100.0
精製水 30.0
エタノール 20.0
サリチル酸 0.2
トリクロサン 0.1
ジメチルエーテル 49.7
合 計 100.0
クロロヒドロキシアルミニウム 3.0
無水ケイ酸 1.5
シリコーン処理タルク 1.5
酸化亜鉛 0.5
トリクロサン 0.01
レゾルシン 0.01
イソプロピルミリスチン酸エステル 2.18
ジメチルポリシロキサン 1.0
ソルビタン脂肪酸エステル 0.3
液化石油ガス 90.0
合 計 100.0
ステアリルアルコール 25.0
ポリエチレングリコール 10.0
クロロヒドロキシアルミニウム 20.0
環状ジメチルポリシロキサン 44.6
トリクロサン 0.15
サリチル酸 0.15
香料 0.1
合 計 100.0
エタノール 30.0
ポリオキシエチレン(40)硬化ヒマシ油 1.0
クロロヒドロキシアルミニウム 10.0
ヒドロキシプロピルメチルセルロース 0.5
トリクロサン 0.2
レゾルシン 0.1
香料 適量
精製水 残分
合 計 100.0
エタノール 45.0
ポリオキシエチレン(50)硬化ヒマシ油 0.5
パラフェノールスルホン酸亜鉛 0.3
架橋ポリスチレン 5.0
サリチル酸 0.1
トリクロサン 0.2
香料 適量
精製水 残分
合計 100.0
エタノール 60.0
カルボキシビニルポリマー 0.4
環状シリコーン 1.0
ポリエーテル変性シリコーン 0.5
サリチル酸 0.2
トリクロサン 0.2
トリエタノールアミン 0.4
シリコーンパウダー 1.0
香料 適量
精製水 残分
合計 100.0
ステアリルアルコール 8.0
ステアリン酸 3.0
精製ラノリン 6.0
レゾルシン 0.1
トリクロサン 0.2
グリセリン 3.0
モノステアリン酸グリセリル 2.0
ポリオキシエチレンセチルエーテル 3.0
香料 適量
精製水 残分
合計 100.0
1,3−ブチレングリコール 4.0
グリセリン 3.0
エタノール 10.0
ポリオキシエチレン(20)オレイルエーテル 1.0
サリチル酸 0.05
トリクロサン 0.05
クエン酸 0.01
クエン酸ナトリウム 0.1
香料 適量
精製水 残分
合計 100.0
セチルアルコール 1.0
ミツロウ 0.5
ワセリン 2.0
スクワラン 6.0
ジメチルポリシロキサン 2.0
エタノール 3.0
1,3−ブチレングリコール 4.0
グリセリン 4.0
ポリオキシエチレン(60)硬化ヒマシ油 0.3
グリセロールモノステアリン酸エステル 1.0
レゾルシン 0.15
トリクロサン 0.2
香料 適量
精製水 残分
合計 100.0
ジプロピレングリコール 7.0
カルボキシビニルポリマー 0.4
メチルセルロース 0.2
エタノール 5.0
レゾルシン 0.1
トリクロサン 0.1
ポリオキシエチレン(15)オレイルエーテル 1.0
水酸化カリウム 0.1
香料 適量
精製水 残分
合計 100.0
ポリビニルアルコール 12.0
カルボキシメチルセルロース 5.0
エタノール 7.0
1,3−ブチレングリコール 5.0
ポリオキシエチレン(20)硬化ヒマシ油 0.5
サリチル酸 0.1
トリクロサン 0.15
香料 適量
精製水 残分
合計 100.0
セリサイト 15.0
カオリン 10.0
二酸化チタン 5.0
ミリスチン酸亜鉛 5.0
炭酸マグネシウム 5.0
スクワラン 3.0
トリイソオクタン酸グリセリン 2.0
サリチル酸 0.2
トリクロサン 0.1
着色顔料 適量
香料 適量
タルク 残分
合計 100.0
パントテニルエチルエーテル 0.2
ポリオキシエチレン(20)ポリオキシプロピレン(6)
テトラデシルエーテル 0.5
レゾルシン 0.05
トリクロサン 0.1
エタノール 40.0
香料 適量
精製水 残分
合計 100.0
サリチル酸 0.2
トリクロサン 0.2
L−メントール 0.25
ポリオキシエチレン(50)硬化ヒマシ油 0.3
アラントイン 0.01
エタノール 50.0
香料 適量
精製水 残分
合計 100.0
オリーブ油 5.0
セタノール 7.0
塩化セチルトリメチルアンモニウム 1.0
塩化ステアリルトリメチルアンモニウム 0.5
1,3−ブチレングリコール 3.0
レゾルシン 0.1
トリクロサン 0.1
エタノール 5.0
香料 適量
精製水 残分
合計 100.0
〔中身液1〕
エタノール 60.0
酢酸トコフェロール 0.1
サリチル酸 0.2
トリクロサン 0.15
d−カンフル 0.2
ポリオキシエチレン硬化油 0.5
セタノール 0.3
ポリオキシエチレンソルビタンモノステアレート0.1
1,3−ブチレングリコール 2.0
プロピレングリコール 2.0
香料 適量
精製水 残分
合計 100.0
LPG 10.0
窒素ガス 0.4
合計 100.0
Claims (8)
- トリクロサンと、レゾルシン及び/又はサリチル酸とを含有することを特徴とする抗菌性組成物。
- 抗腋臭原因菌用である請求項1に記載の抗菌性組成物。
- 抗ニキビ菌用である請求項1に記載の抗菌性組成物。
- 抗フケ菌用である請求項1に記載の抗菌性組成物。
- 請求項1〜4の何れかに記載の抗菌性組成物を含有してなる皮膚外用剤。
- 請求項2に記載の抗菌性組成物を含有してなるデオドラント剤。
- 請求項3に記載の抗菌性組成物を含有してなるニキビ用皮膚外用剤。
- 請求項4に記載の抗菌性組成物を含有してなる抗フケ用頭髪化粧料。
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JP2013043857A (ja) * | 2011-08-24 | 2013-03-04 | Lion Corp | 外用剤組成物 |
JP5881879B1 (ja) * | 2015-03-31 | 2016-03-09 | 小林製薬株式会社 | 尋常性ざ瘡改善用外用組成物 |
JP6311049B1 (ja) * | 2016-11-25 | 2018-04-11 | ロート製薬株式会社 | 背中用にきび予防及び/又は治療薬 |
CN114533809A (zh) * | 2022-03-02 | 2022-05-27 | 北京鲁齐生物科技有限公司 | 一种维生素e抑菌膏及其制备方法 |
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JP6311049B1 (ja) * | 2016-11-25 | 2018-04-11 | ロート製薬株式会社 | 背中用にきび予防及び/又は治療薬 |
CN114533809A (zh) * | 2022-03-02 | 2022-05-27 | 北京鲁齐生物科技有限公司 | 一种维生素e抑菌膏及其制备方法 |
CN114533809B (zh) * | 2022-03-02 | 2023-03-31 | 北京鲁齐生物科技有限公司 | 一种维生素e抑菌膏及其制备方法 |
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