JP2008056680A5 - - Google Patents
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- Publication number
- JP2008056680A5 JP2008056680A5 JP2007239523A JP2007239523A JP2008056680A5 JP 2008056680 A5 JP2008056680 A5 JP 2008056680A5 JP 2007239523 A JP2007239523 A JP 2007239523A JP 2007239523 A JP2007239523 A JP 2007239523A JP 2008056680 A5 JP2008056680 A5 JP 2008056680A5
- Authority
- JP
- Japan
- Prior art keywords
- asthma
- bronchitis
- group
- bronchiectasis
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000006673 asthma Diseases 0.000 claims 19
- 206010006451 bronchitis Diseases 0.000 claims 15
- 201000009267 bronchiectasis Diseases 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 4
- 206010014561 Emphysema Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 201000010659 intrinsic asthma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000023504 respiratory system disease Diseases 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 229940122086 Adenosine A2a receptor agonist Drugs 0.000 claims 2
- 208000000884 Airway Obstruction Diseases 0.000 claims 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 claims 2
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 claims 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims 2
- 229940122694 Muscarinic M3 receptor antagonist Drugs 0.000 claims 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 102000000551 Syk Kinase Human genes 0.000 claims 2
- 108010016672 Syk Kinase Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000002465 adenosine A2a receptor agonist Substances 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000007451 chronic bronchitis Diseases 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 230000010250 cytokine signaling pathway Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000024711 extrinsic asthma Diseases 0.000 claims 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 239000003681 muscarinic M3 receptor antagonist Substances 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 2
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 2
- 230000008506 pathogenesis Effects 0.000 claims 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 102000004023 5-Lipoxygenase-Activating Proteins Human genes 0.000 claims 1
- 108090000411 5-Lipoxygenase-Activating Proteins Proteins 0.000 claims 1
- 206010003557 Asthma exercise induced Diseases 0.000 claims 1
- 206010003645 Atopy Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010006448 Bronchiolitis Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- 206010011416 Croup infectious Diseases 0.000 claims 1
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 claims 1
- 101100135868 Dictyostelium discoideum pde3 gene Proteins 0.000 claims 1
- 102000015554 Dopamine receptor Human genes 0.000 claims 1
- 108050004812 Dopamine receptor Proteins 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 229940122858 Elastase inhibitor Drugs 0.000 claims 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 229940122236 Histamine receptor antagonist Drugs 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 239000003458 I kappa b kinase inhibitor Substances 0.000 claims 1
- 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 229940123263 Phosphodiesterase 3 inhibitor Drugs 0.000 claims 1
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 claims 1
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 claims 1
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 claims 1
- 208000010362 Protozoan Infections Diseases 0.000 claims 1
- 239000000150 Sympathomimetic Substances 0.000 claims 1
- 102000003141 Tachykinin Human genes 0.000 claims 1
- 206010054094 Tumour necrosis Diseases 0.000 claims 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 239000000533 adrenergic alpha-1 receptor agonist Substances 0.000 claims 1
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000000954 anitussive effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000009323 chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- 201000010549 croup Diseases 0.000 claims 1
- 239000003260 cyclooxygenase 1 inhibitor Substances 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003602 elastase inhibitor Substances 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000003395 histamine H3 receptor antagonist Substances 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 230000002427 irreversible effect Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000002483 medication Methods 0.000 claims 1
- 230000000510 mucolytic effect Effects 0.000 claims 1
- 229940066491 mucolytics Drugs 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 208000007892 occupational asthma Diseases 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000001991 pathophysiological effect Effects 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 1
- 239000002570 phosphodiesterase III inhibitor Substances 0.000 claims 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229940127230 sympathomimetic drug Drugs 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 108060008037 tachykinin Proteins 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229960005356 urokinase Drugs 0.000 claims 1
- 239000005526 vasoconstrictor agent Substances 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 *c1c(CC(C2)N(*)N)c2c(*)c(*)c1* Chemical compound *c1c(CC(C2)N(*)N)c2c(*)c(*)c1* 0.000 description 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N NN1CCCCC1 Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04290767 | 2004-03-23 | ||
| EP04290767.5 | 2004-03-23 | ||
| GB0425054A GB0425054D0 (en) | 2004-03-23 | 2004-11-12 | Formamide derivatives for the treatment of diseases |
| GB0425054.4 | 2004-11-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504493A Division JP4033892B2 (ja) | 2004-03-23 | 2005-03-10 | アドレナリン受容体として有用なホルムアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008056680A JP2008056680A (ja) | 2008-03-13 |
| JP2008056680A5 true JP2008056680A5 (https=) | 2008-04-24 |
| JP4819770B2 JP4819770B2 (ja) | 2011-11-24 |
Family
ID=35432183
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504493A Expired - Fee Related JP4033892B2 (ja) | 2004-03-23 | 2005-03-10 | アドレナリン受容体として有用なホルムアミド誘導体 |
| JP2007239523A Expired - Fee Related JP4819770B2 (ja) | 2004-03-23 | 2007-09-14 | アドレナリン受容体として有用なホルムアミド誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504493A Expired - Fee Related JP4033892B2 (ja) | 2004-03-23 | 2005-03-10 | アドレナリン受容体として有用なホルムアミド誘導体 |
Country Status (30)
| Country | Link |
|---|---|
| JP (2) | JP4033892B2 (https=) |
| KR (1) | KR100806478B1 (https=) |
| AR (1) | AR050236A1 (https=) |
| AT (1) | ATE469121T1 (https=) |
| CA (1) | CA2560547C (https=) |
| CY (1) | CY1112549T1 (https=) |
| DE (1) | DE602005021472D1 (https=) |
| DK (1) | DK1730103T3 (https=) |
| DO (1) | DOP2005000045A (https=) |
| EA (1) | EA010133B1 (https=) |
| ES (1) | ES2343808T3 (https=) |
| GB (1) | GB0425054D0 (https=) |
| GE (1) | GEP20084455B (https=) |
| HN (1) | HN2005000118A (https=) |
| HR (1) | HRP20100402T1 (https=) |
| IL (1) | IL178102A (https=) |
| IS (1) | IS8552A (https=) |
| MA (1) | MA28480B1 (https=) |
| MX (1) | MXPA06011019A (https=) |
| MY (1) | MY144103A (https=) |
| NL (1) | NL1028597C2 (https=) |
| NO (1) | NO20064806L (https=) |
| NZ (1) | NZ549839A (https=) |
| PE (1) | PE20060264A1 (https=) |
| PT (1) | PT1730103E (https=) |
| RS (1) | RS51438B (https=) |
| SI (1) | SI1730103T1 (https=) |
| SV (1) | SV2005002056A (https=) |
| TW (1) | TWI335312B (https=) |
| UY (1) | UY28819A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2005492A6 (es) * | 1987-12-23 | 1989-03-01 | Lasa Lab | Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i). |
| CH686869A5 (de) * | 1991-04-05 | 1996-07-31 | Sepracor Inc | Beta (2) -bronchienerweiternde Arzneistoffe in Form ihrer Bronchienerweiternden Enantiomeren zur Verwendung fuer die Herstellung eines Mittels zur verbesserten Therapie. |
| UA73965C2 (en) * | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| OA11558A (en) * | 1999-12-08 | 2004-06-03 | Advanced Medicine Inc | Beta 2-adrenergic receptor agonists. |
| US6653323B2 (en) * | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI249515B (en) * | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| WO2003099764A1 (en) * | 2002-05-28 | 2003-12-04 | Theravance, Inc. | ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS |
| JP4767842B2 (ja) * | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| US7268147B2 (en) * | 2003-05-15 | 2007-09-11 | Pfizer Inc | Compounds useful for the treatment of diseases |
| PL1708991T3 (pl) * | 2004-01-22 | 2008-02-29 | Pfizer | Pochodne sulfonoamidu do leczenia chorób |
| WO2005092861A1 (en) * | 2004-03-11 | 2005-10-06 | Pfizer Limited | Quinolinone derivatives pharmaceutical compositions containing them and their use |
| BRPI0508927A (pt) * | 2004-03-17 | 2007-08-14 | Pfizer | compostos úteis para o tratamento de doenças |
| WO2005092887A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds for the treatment of diseases |
| WO2005092841A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds having beta-agonist activity |
-
2004
- 2004-11-12 GB GB0425054A patent/GB0425054D0/en not_active Ceased
-
2005
- 2005-03-10 RS RSP-2010/0339A patent/RS51438B/sr unknown
- 2005-03-10 EA EA200601544A patent/EA010133B1/ru not_active IP Right Cessation
- 2005-03-10 JP JP2007504493A patent/JP4033892B2/ja not_active Expired - Fee Related
- 2005-03-10 CA CA2560547A patent/CA2560547C/en not_active Expired - Fee Related
- 2005-03-10 DE DE602005021472T patent/DE602005021472D1/de not_active Expired - Lifetime
- 2005-03-10 MX MXPA06011019A patent/MXPA06011019A/es active IP Right Grant
- 2005-03-10 DK DK05708714.0T patent/DK1730103T3/da active
- 2005-03-10 AT AT05708714T patent/ATE469121T1/de active
- 2005-03-10 HR HR20100402T patent/HRP20100402T1/hr unknown
- 2005-03-10 SI SI200531057T patent/SI1730103T1/sl unknown
- 2005-03-10 ES ES05708714T patent/ES2343808T3/es not_active Expired - Lifetime
- 2005-03-10 PT PT05708714T patent/PT1730103E/pt unknown
- 2005-03-10 GE GEAP20059631A patent/GEP20084455B/en unknown
- 2005-03-10 KR KR1020067019640A patent/KR100806478B1/ko not_active Expired - Fee Related
- 2005-03-10 NZ NZ549839A patent/NZ549839A/en not_active IP Right Cessation
- 2005-03-16 MY MYPI20051118A patent/MY144103A/en unknown
- 2005-03-18 SV SV2005002056A patent/SV2005002056A/es unknown
- 2005-03-18 HN HN2005000118A patent/HN2005000118A/es unknown
- 2005-03-21 PE PE2005000321A patent/PE20060264A1/es not_active Application Discontinuation
- 2005-03-22 NL NL1028597A patent/NL1028597C2/nl not_active IP Right Cessation
- 2005-03-22 TW TW094108791A patent/TWI335312B/zh not_active IP Right Cessation
- 2005-03-22 AR ARP050101118A patent/AR050236A1/es not_active Application Discontinuation
- 2005-03-23 UY UY28819A patent/UY28819A1/es unknown
- 2005-03-23 DO DO2005000045A patent/DOP2005000045A/es unknown
-
2006
- 2006-09-14 IL IL178102A patent/IL178102A/en not_active IP Right Cessation
- 2006-09-22 MA MA29335A patent/MA28480B1/fr unknown
- 2006-10-10 IS IS8552A patent/IS8552A/is unknown
- 2006-10-23 NO NO20064806A patent/NO20064806L/no not_active Application Discontinuation
-
2007
- 2007-09-14 JP JP2007239523A patent/JP4819770B2/ja not_active Expired - Fee Related
-
2010
- 2010-07-05 CY CY20101100620T patent/CY1112549T1/el unknown
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