JP2007534697A5 - - Google Patents
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- Publication number
- JP2007534697A5 JP2007534697A5 JP2007509732A JP2007509732A JP2007534697A5 JP 2007534697 A5 JP2007534697 A5 JP 2007534697A5 JP 2007509732 A JP2007509732 A JP 2007509732A JP 2007509732 A JP2007509732 A JP 2007509732A JP 2007534697 A5 JP2007534697 A5 JP 2007534697A5
- Authority
- JP
- Japan
- Prior art keywords
- chloride
- tin
- catalyst
- iron
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims 4
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 235000011150 stannous chloride Nutrition 0.000 claims 2
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 claims 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 2
- 229960001763 zinc sulfate Drugs 0.000 claims 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims 1
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56605604P | 2004-04-27 | 2004-04-27 | |
| US57298504P | 2004-05-20 | 2004-05-20 | |
| US58940004P | 2004-07-19 | 2004-07-19 | |
| US63915104P | 2004-12-22 | 2004-12-22 | |
| US63847804P | 2004-12-23 | 2004-12-23 | |
| US64286705P | 2005-01-10 | 2005-01-10 | |
| US66148505P | 2005-03-15 | 2005-03-15 | |
| PCT/US2005/014238 WO2005105771A1 (en) | 2004-04-27 | 2005-04-26 | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007534697A JP2007534697A (ja) | 2007-11-29 |
| JP2007534697A5 true JP2007534697A5 (enExample) | 2008-10-09 |
Family
ID=34981904
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549718A Pending JP2007522117A (ja) | 2004-04-27 | 2005-04-26 | ミコフェノール酸モフェチル不純物 |
| JP2007509732A Pending JP2007534697A (ja) | 2004-04-27 | 2005-04-26 | ミコフェノール酸モフェチルおよび他のミコフェノール酸エステルの調製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549718A Pending JP2007522117A (ja) | 2004-04-27 | 2005-04-26 | ミコフェノール酸モフェチル不純物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7358247B2 (enExample) |
| EP (2) | EP1675841A1 (enExample) |
| JP (2) | JP2007522117A (enExample) |
| CA (2) | CA2555454C (enExample) |
| IL (2) | IL175516A0 (enExample) |
| MX (2) | MXPA06005660A (enExample) |
| TW (2) | TWI338006B (enExample) |
| WO (2) | WO2005105771A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007532585A (ja) | 2004-04-26 | 2007-11-15 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ミコフェノール酸及びそのエステル誘導体の調製方法 |
| MXPA06005660A (es) * | 2004-04-27 | 2007-04-10 | Teva Gyogyszergyar Zartkoruen | Impureza de micofenolato mofetil. |
| US20080300404A1 (en) * | 2005-01-20 | 2008-12-04 | Apotex Fermentation Inc. | Process for the Preparation of Mycophenolate Mofetil |
| EP2194047A1 (en) * | 2005-06-14 | 2010-06-09 | Schering Corporation | Preparation and use of aspartyl protease inhibitors |
| US20080009050A1 (en) * | 2006-06-29 | 2008-01-10 | Zdenek Pokluda | Regulation of acid metabolite production |
| CN1974564B (zh) * | 2006-12-15 | 2010-05-12 | 丽珠集团新北江制药股份有限公司 | 一种霉酚酸莫啡酯的制备方法 |
| US20080188653A1 (en) * | 2007-02-04 | 2008-08-07 | Formosa Laboratories, Inc. | Process for Preparation of Mycophenolate Mofetil |
| TW200904982A (en) * | 2007-04-11 | 2009-02-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Method for reducing impurity level in mycophenolic acid fermentation |
| WO2008125616A2 (en) * | 2007-04-12 | 2008-10-23 | Dsm Ip Assets B.V. | Method for the purification of bio-molecules |
| WO2009010503A1 (en) * | 2007-07-18 | 2009-01-22 | Dsm Ip Assets B.V. | Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil |
| CN105510496B (zh) * | 2015-11-25 | 2017-06-16 | 宜昌东阳光长江药业股份有限公司 | 一种富马酸卢帕他定原料药合成工艺中dmf残留的测定方法 |
| CN107727605A (zh) * | 2016-08-11 | 2018-02-23 | 立邦涂料（中国）有限公司 | 一种分析矿物油类消泡剂的新方法 |
| CN113549040B (zh) * | 2020-04-23 | 2024-08-06 | 鲁南制药集团股份有限公司 | 一种吗替麦考酚酯杂质d的制备方法 |
| CN112710752A (zh) * | 2020-12-18 | 2021-04-27 | 卓和药业集团有限公司 | 麦考酚钠残留溶剂的检测方法 |
| CN116500172B (zh) * | 2023-06-29 | 2023-09-05 | 成都普康唯新生物科技有限公司 | 一种酸性底物中胺类溶剂的检测方法 |
| CN118330068A (zh) * | 2024-04-16 | 2024-07-12 | 中国热带农业科学院分析测试中心 | 一种检测农产品复杂基质中盐酸吗啉胍的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1157099A (en) | 1966-09-27 | 1969-07-02 | Ici Ltd | Fermentation Process |
| GB1158387A (en) | 1967-06-13 | 1969-07-16 | Ici Ltd | Procedure for Isolation of Mycophenolic Acid |
| ZA684959B (en) | 1967-11-22 | 1969-05-22 | Lilly Co Eli | Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals |
| US4452891A (en) | 1980-09-08 | 1984-06-05 | Ajinomoto Company Incorporated | Method for production of mycophenolic acid by fermentation |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4861776A (en) | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
| US5455045A (en) | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| DK0724581T3 (da) | 1993-09-15 | 1999-08-02 | Syntex Inc | Krystallinsk vandfri mycophenolatmofetil og intravenøs formulering deraf |
| WO1995009626A1 (en) * | 1993-10-01 | 1995-04-13 | Syntex (U.S.A.) Inc. | Mycophenolate mofetil high dose oral suspensions |
| ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| IN188985B (enExample) | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
| HUP9903226A2 (en) | 1999-09-23 | 2002-08-28 | Gyogyszerki | Process for producing mycophenolic acid and derivatives thereof |
| WO2001064931A1 (en) | 2000-02-29 | 2001-09-07 | Biocon India Limited | Manufacture and purification of mycophenolic acid |
| CZ292123B6 (cs) | 2001-06-08 | 2003-08-13 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy mykofenolátu mofetilu |
| US6706846B2 (en) * | 2001-10-10 | 2004-03-16 | General Electric Company | Method for end-capping polycarbonate resins and composition for use in same |
| US7122687B2 (en) | 2002-08-29 | 2006-10-17 | Sunesis Pharmaceuticals, Inc. | Process for the production of an immunosuppressant |
| GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
| TWI221414B (en) * | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
| GB0307553D0 (en) | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
| MXPA06005660A (es) * | 2004-04-27 | 2007-04-10 | Teva Gyogyszergyar Zartkoruen | Impureza de micofenolato mofetil. |
| US20080280977A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
-
2005
- 2005-04-26 MX MXPA06005660A patent/MXPA06005660A/es active IP Right Grant
- 2005-04-26 JP JP2006549718A patent/JP2007522117A/ja active Pending
- 2005-04-26 CA CA002555454A patent/CA2555454C/en not_active Expired - Fee Related
- 2005-04-26 MX MXPA06005658A patent/MXPA06005658A/es unknown
- 2005-04-26 JP JP2007509732A patent/JP2007534697A/ja active Pending
- 2005-04-26 EP EP05744402A patent/EP1675841A1/en not_active Withdrawn
- 2005-04-26 US US11/115,593 patent/US7358247B2/en not_active Expired - Fee Related
- 2005-04-26 WO PCT/US2005/014238 patent/WO2005105771A1/en not_active Ceased
- 2005-04-26 EP EP05739984A patent/EP1740563A2/en not_active Withdrawn
- 2005-04-26 US US11/115,820 patent/US20050250773A1/en not_active Abandoned
- 2005-04-26 WO PCT/US2005/014354 patent/WO2005105769A2/en not_active Ceased
- 2005-04-26 CA CA002555461A patent/CA2555461A1/en not_active Abandoned
- 2005-04-27 TW TW094113530A patent/TWI338006B/zh not_active IP Right Cessation
- 2005-04-27 TW TW094113507A patent/TW200606160A/zh unknown
-
2006
- 2006-05-09 IL IL175516A patent/IL175516A0/en unknown
- 2006-05-09 IL IL175517A patent/IL175517A0/en unknown
-
2008
- 2008-03-31 US US12/012,343 patent/US20080241948A1/en not_active Abandoned
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