JP2007532479A - Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター - Google Patents

Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター Download PDF

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Publication number
JP2007532479A
JP2007532479A JP2006541606A JP2006541606A JP2007532479A JP 2007532479 A JP2007532479 A JP 2007532479A JP 2006541606 A JP2006541606 A JP 2006541606A JP 2006541606 A JP2006541606 A JP 2006541606A JP 2007532479 A JP2007532479 A JP 2007532479A
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Japan
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pharmaceutical composition
alkyl
group
compound according
cycloalkyl
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JP2006541606A
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Japanese (ja)
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JP2007532479A5 (https=
Inventor
スリカンス ベンカトラマン，
ビョー エム． ギリジャバラバン，
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2007532479A publication Critical patent/JP2007532479A/ja
Publication of JP2007532479A5 publication Critical patent/JP2007532479A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2006541606A 2003-11-20 2004-11-19 Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター Pending JP2007532479A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52371503P 2003-11-20 2003-11-20
PCT/US2004/039131 WO2005051980A1 (en) 2003-11-20 2004-11-19 Depeptidized inhibitors of hepatitis c virus ns3 protease

Publications (2)

Publication Number Publication Date
JP2007532479A true JP2007532479A (ja) 2007-11-15
JP2007532479A5 JP2007532479A5 (https=) 2007-12-27

Family

ID=34632818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006541606A Pending JP2007532479A (ja) 2003-11-20 2004-11-19 Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター

Country Status (7)

Country Link
US (2) US7253160B2 (https=)
EP (1) EP1689770A1 (https=)
JP (1) JP2007532479A (https=)
CN (1) CN1902216A (https=)
CA (1) CA2546290A1 (https=)
MX (1) MXPA06005683A (https=)
WO (1) WO2005051980A1 (https=)

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US7176208B2 (en) 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
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US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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Also Published As

Publication number Publication date
US20070258947A1 (en) 2007-11-08
US20050164921A1 (en) 2005-07-28
MXPA06005683A (es) 2006-12-14
US7253160B2 (en) 2007-08-07
US7442695B2 (en) 2008-10-28
WO2005051980A8 (en) 2006-09-08
EP1689770A1 (en) 2006-08-16
WO2005051980A1 (en) 2005-06-09
CA2546290A1 (en) 2005-06-09
CN1902216A (zh) 2007-01-24

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