CN1902216A - 丙肝病毒ns3蛋白酶的去肽化抑制剂 - Google Patents

丙肝病毒ns3蛋白酶的去肽化抑制剂 Download PDF

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Publication number
CN1902216A
CN1902216A CNA2004800399478A CN200480039947A CN1902216A CN 1902216 A CN1902216 A CN 1902216A CN A2004800399478 A CNA2004800399478 A CN A2004800399478A CN 200480039947 A CN200480039947 A CN 200480039947A CN 1902216 A CN1902216 A CN 1902216A
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CN
China
Prior art keywords
compound
alkyl
pharmaceutical composition
cycloalkyl
aryl
Prior art date
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Pending
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CNA2004800399478A
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English (en)
Chinese (zh)
Inventor
S·文卡特拉曼
V·M·吉里加瓦拉布汉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Schering Corp
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Publication of CN1902216A publication Critical patent/CN1902216A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2004800399478A 2003-11-20 2004-11-19 丙肝病毒ns3蛋白酶的去肽化抑制剂 Pending CN1902216A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52371503P 2003-11-20 2003-11-20
US60/523,715 2003-11-20

Publications (1)

Publication Number Publication Date
CN1902216A true CN1902216A (zh) 2007-01-24

Family

ID=34632818

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800399478A Pending CN1902216A (zh) 2003-11-20 2004-11-19 丙肝病毒ns3蛋白酶的去肽化抑制剂

Country Status (7)

Country Link
US (2) US7253160B2 (https=)
EP (1) EP1689770A1 (https=)
JP (1) JP2007532479A (https=)
CN (1) CN1902216A (https=)
CA (1) CA2546290A1 (https=)
MX (1) MXPA06005683A (https=)
WO (1) WO2005051980A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951769A (zh) * 2007-12-21 2011-01-19 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN101951769A (zh) * 2007-12-21 2011-01-19 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
CN101951769B (zh) * 2007-12-21 2014-12-31 阿维拉制药公司 Hcv蛋白酶抑制剂和其用途
US9676785B2 (en) 2007-12-21 2017-06-13 Celgene Car Llc HCV protease inhibitors and uses thereof

Also Published As

Publication number Publication date
US7442695B2 (en) 2008-10-28
WO2005051980A8 (en) 2006-09-08
JP2007532479A (ja) 2007-11-15
CA2546290A1 (en) 2005-06-09
US7253160B2 (en) 2007-08-07
EP1689770A1 (en) 2006-08-16
MXPA06005683A (es) 2006-12-14
US20070258947A1 (en) 2007-11-08
WO2005051980A1 (en) 2005-06-09
US20050164921A1 (en) 2005-07-28

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