JP2007530622A5 - - Google Patents
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- Publication number
- JP2007530622A5 JP2007530622A5 JP2007505480A JP2007505480A JP2007530622A5 JP 2007530622 A5 JP2007530622 A5 JP 2007530622A5 JP 2007505480 A JP2007505480 A JP 2007505480A JP 2007505480 A JP2007505480 A JP 2007505480A JP 2007530622 A5 JP2007530622 A5 JP 2007530622A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- tinnitus
- drug
- preventing
- tinnitus according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000009205 Tinnitus Diseases 0.000 claims 21
- 231100000886 tinnitus Toxicity 0.000 claims 21
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 210000003027 ear inner Anatomy 0.000 claims 8
- 206010029350 Neurotoxicity Diseases 0.000 claims 5
- 206010044221 Toxic encephalopathy Diseases 0.000 claims 5
- 231100000228 neurotoxicity Toxicity 0.000 claims 5
- 230000007135 neurotoxicity Effects 0.000 claims 5
- 210000003477 cochlea Anatomy 0.000 claims 4
- 230000002964 excitative effect Effects 0.000 claims 3
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 210000000860 cochlear nerve Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 1
- 206010002660 Anoxia Diseases 0.000 claims 1
- 241000976983 Anoxia Species 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical group C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 1
- 206010036626 Presbyacusis Diseases 0.000 claims 1
- 230000007953 anoxia Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 230000003492 excitotoxic effect Effects 0.000 claims 1
- 231100000063 excitotoxicity Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 229960003299 ketamine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 231100000189 neurotoxic Toxicity 0.000 claims 1
- 230000002887 neurotoxic effect Effects 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 230000008736 traumatic injury Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/812,298 US8268866B2 (en) | 2004-03-29 | 2004-03-29 | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US10/812,298 | 2004-03-29 | ||
| PCT/EP2005/003254 WO2005094799A2 (en) | 2004-03-29 | 2005-03-29 | Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011013018A Division JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007530622A JP2007530622A (ja) | 2007-11-01 |
| JP2007530622A5 true JP2007530622A5 (https=) | 2008-01-24 |
| JP4927706B2 JP4927706B2 (ja) | 2012-05-09 |
Family
ID=34966520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505480A Expired - Fee Related JP4927706B2 (ja) | 2004-03-29 | 2005-03-29 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
| JP2011013018A Pending JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011013018A Pending JP2011105740A (ja) | 2004-03-29 | 2011-01-25 | 蝸牛の興奮性内耳神経毒性によって引き起こされる耳鳴りの処置の方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8268866B2 (https=) |
| EP (2) | EP1729753B1 (https=) |
| JP (2) | JP4927706B2 (https=) |
| KR (2) | KR101429735B1 (https=) |
| CN (2) | CN104906079B (https=) |
| AU (1) | AU2005229543B2 (https=) |
| BR (1) | BRPI0508251A (https=) |
| CA (1) | CA2558896C (https=) |
| CY (1) | CY1110495T1 (https=) |
| DE (1) | DE602005015562D1 (https=) |
| DK (1) | DK1729753T3 (https=) |
| ES (1) | ES2330350T3 (https=) |
| IL (1) | IL177490A (https=) |
| MX (1) | MXPA06011078A (https=) |
| NZ (1) | NZ549399A (https=) |
| PL (1) | PL1729753T3 (https=) |
| PT (1) | PT1729753E (https=) |
| RU (1) | RU2380094C2 (https=) |
| SI (1) | SI1729753T1 (https=) |
| WO (1) | WO2005094799A2 (https=) |
| ZA (1) | ZA200607161B (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| CN101163481A (zh) * | 2005-03-04 | 2008-04-16 | 纽罗赛斯特克公司 | 改进的加环利定制剂 |
| ES2524994T3 (es) | 2005-09-28 | 2014-12-16 | Auris Medical Ag | Composiciones farmacéuticas para el tratamiento de trastornos del oído interno. |
| US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
| US8175712B2 (en) * | 2006-09-05 | 2012-05-08 | The Penn State Research Foundation | Homotopic conditioning of the brain stem baroreflex of a subject |
| KR20130097813A (ko) * | 2008-04-21 | 2013-09-03 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| KR101534422B1 (ko) * | 2008-05-14 | 2015-07-09 | 오토노미, 인코포레이티드 | 귀 질환 치료를 위한 제어 방출형 코르티코스테로이드 조성물 및 방법 |
| US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| US8349353B2 (en) * | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| US20100016218A1 (en) * | 2008-07-14 | 2010-01-21 | Otonomy, Inc. | Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
| US8496957B2 (en) * | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| JP5421366B2 (ja) * | 2008-07-21 | 2014-02-19 | オトノミ―，インク． | 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法 |
| US8399018B2 (en) * | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| CA2751761A1 (en) | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| JP6013736B2 (ja) * | 2008-12-22 | 2016-10-25 | オトノミ—，インク． | 耳の障害の処置のための耳感覚細胞モジュレータ組成物の制御放出及びその方法 |
| WO2012098000A1 (en) * | 2011-01-20 | 2012-07-26 | Merz Pharma Gmbh & Co. Kgaa | Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss |
| EP2790686B1 (en) | 2011-12-12 | 2021-03-10 | Zilentin Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
| US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
| US9486405B2 (en) | 2013-08-27 | 2016-11-08 | Otonomy, Inc. | Methods for the treatment of pediatric otic disorders |
| JP2017513870A (ja) * | 2014-04-23 | 2017-06-01 | オーリス メディカル エージーＡｕｒｉｓ Ｍｅｄｉｃａｌ Ａｇ | 耳鳴りの治療と予防のための方法及び組成物 |
| US11207316B2 (en) | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| US11040004B2 (en) | 2016-09-16 | 2021-06-22 | Otonomy, Inc. | Otic gel formulations for treating otitis externa |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254124A (en) | 1962-06-29 | 1966-05-31 | Parke Davis & Co | Aminoketones and methods for their production |
| CH535201A (de) | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
| AU5171293A (en) | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
| US5421818A (en) | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
| JP4097285B2 (ja) | 1994-09-22 | 2008-06-11 | リチャード・アラン・スミス | 種々の頑固な疾患の治療のための医薬の製造に有用な組成物 |
| US5945409A (en) | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
| US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| DE19528388A1 (de) | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| TW450807B (en) | 1995-09-15 | 2001-08-21 | Pfizer | Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents |
| US5746961A (en) * | 1995-12-04 | 1998-05-05 | Michael J. Stevenson | Method for enhancement of the surfaces of molded plastic products |
| WO1997038698A1 (en) | 1996-04-18 | 1997-10-23 | University Technology Corporation | Methods for treating middle and inner ear disorders |
| WO1998010757A2 (en) | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | The use of functional n-methyl-d-aspartate antagonists to ameliorate or prevent aminoglycoside-induced ototoxicity |
| US6045528A (en) | 1997-06-13 | 2000-04-04 | Intraear, Inc. | Inner ear fluid transfer and diagnostic system |
| US6309410B1 (en) | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
| DE19853299C2 (de) | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
| US6120484A (en) | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
| US6017961A (en) | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
| DE19936719A1 (de) | 1999-08-06 | 2001-02-15 | Gruenenthal Gmbh | Substituierte 1,5-Dihydropyrrol-2-on-Derivate |
| US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
| JP2001187737A (ja) | 1999-10-18 | 2001-07-10 | Toyama Chem Co Ltd | 聴力改善剤 |
| DE10025238A1 (de) | 2000-05-22 | 2001-11-29 | Gruenenthal Gmbh | Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel |
| BRPI0002693B8 (pt) | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
| DE10048969A1 (de) | 2000-08-23 | 2002-03-14 | Mueller Schwefe Gerhard | Verwendung von Flupirtin zur Tinnitusbehandlung |
| DE10044649A1 (de) | 2000-09-08 | 2002-07-04 | Gruenenthal Gmbh | Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine |
| US6924273B2 (en) | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
| DE10124953A1 (de) | 2001-05-21 | 2002-12-12 | Marlies Knipper | Substanz für die therapeutische Behandlung von Tinnitus |
| US6638981B2 (en) | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| US20030143195A1 (en) | 2002-01-30 | 2003-07-31 | Pinsker Judy Senior | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
| US6638081B2 (en) | 2002-03-22 | 2003-10-28 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector |
| JP2006502158A (ja) | 2002-09-06 | 2006-01-19 | デュレクト コーポレーション | グルタメート媒介神経伝達のモジュレーターの内耳への送達 |
| US6969383B2 (en) | 2002-09-27 | 2005-11-29 | Medtronic, Inc. | Method for treating severe tinnitus |
| US6656172B1 (en) | 2002-09-27 | 2003-12-02 | Medtronic, Inc. | Method for treating severe tinnitus |
| EP1560807B1 (de) | 2002-11-12 | 2010-02-10 | Grünenthal GmbH | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| EP1438942A1 (en) | 2003-01-17 | 2004-07-21 | Schering Oy | An otorhinological drug delivery device |
| EP1624936B1 (en) | 2003-05-16 | 2009-10-28 | Universite Laval | Cns chloride modulation and uses thereof |
| WO2005055921A2 (en) | 2003-12-12 | 2005-06-23 | Eran Eilat | Compositions for treatment of ear disorders and methods of use thereof |
| GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
-
2004
- 2004-03-29 US US10/812,298 patent/US8268866B2/en not_active Expired - Fee Related
-
2005
- 2005-03-29 NZ NZ549399A patent/NZ549399A/en not_active IP Right Cessation
- 2005-03-29 CA CA2558896A patent/CA2558896C/en not_active Expired - Lifetime
- 2005-03-29 PL PL05736619T patent/PL1729753T3/pl unknown
- 2005-03-29 CN CN201510076933.3A patent/CN104906079B/zh not_active Expired - Fee Related
- 2005-03-29 DE DE602005015562T patent/DE602005015562D1/de not_active Expired - Lifetime
- 2005-03-29 AU AU2005229543A patent/AU2005229543B2/en not_active Ceased
- 2005-03-29 BR BRPI0508251-0A patent/BRPI0508251A/pt not_active Application Discontinuation
- 2005-03-29 WO PCT/EP2005/003254 patent/WO2005094799A2/en not_active Ceased
- 2005-03-29 PT PT05736619T patent/PT1729753E/pt unknown
- 2005-03-29 EP EP05736619A patent/EP1729753B1/en not_active Expired - Lifetime
- 2005-03-29 KR KR1020127007363A patent/KR101429735B1/ko not_active Expired - Fee Related
- 2005-03-29 CN CN200580009886.5A patent/CN1972677B/zh not_active Expired - Fee Related
- 2005-03-29 ES ES05736619T patent/ES2330350T3/es not_active Expired - Lifetime
- 2005-03-29 KR KR1020137020276A patent/KR101451414B1/ko not_active Expired - Fee Related
- 2005-03-29 EP EP09005167A patent/EP2077108A1/en not_active Withdrawn
- 2005-03-29 RU RU2006138153/14A patent/RU2380094C2/ru active
- 2005-03-29 DK DK05736619T patent/DK1729753T3/da active
- 2005-03-29 ZA ZA200607161A patent/ZA200607161B/en unknown
- 2005-03-29 SI SI200530751T patent/SI1729753T1/sl unknown
- 2005-03-29 MX MXPA06011078A patent/MXPA06011078A/es active IP Right Grant
- 2005-03-29 JP JP2007505480A patent/JP4927706B2/ja not_active Expired - Fee Related
-
2006
- 2006-08-15 IL IL177490A patent/IL177490A/en active IP Right Grant
-
2009
- 2009-09-10 CY CY20091100944T patent/CY1110495T1/el unknown
-
2011
- 2011-01-25 JP JP2011013018A patent/JP2011105740A/ja active Pending
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