BRPI0508251A - métodos para o tratamento de tinido auditivo induzido por excitotoxicidade coclear - Google Patents
métodos para o tratamento de tinido auditivo induzido por excitotoxicidade coclearInfo
- Publication number
- BRPI0508251A BRPI0508251A BRPI0508251-0A BRPI0508251A BRPI0508251A BR PI0508251 A BRPI0508251 A BR PI0508251A BR PI0508251 A BRPI0508251 A BR PI0508251A BR PI0508251 A BRPI0508251 A BR PI0508251A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- methods
- tinnitus
- excitotoxicity
- cochlear excitotoxicity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A61K31/025—Halogenated hydrocarbons carbocyclic
- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
MéTODOS PARA O TRATAMENTO DE TINDO AUDITIVO INDUZIDO POR EXCITOTOXICIDADE COCLEAR. Apresente invenção refere-se a métodos para a prevenção e/ou tratamento de tinido induzido por excitotoxicidade coclear. Nestes métodos, uma composiçãop farmacêutica que compreende um antaginista de receptor de NMDA é administrada a um individuo que necessita de tal tratamento, por dispositivo e/ou formulações apropriadas para administração local ao ouvido interno. O tinido a ser prevenido e/ou tratado pode ser provocado por traumatismo acústico, presbiacusia, isquemia. anóxia, tratamento com uma ou mais medições atotóxicas, surdez súbita, ou outra ocorrência indutora de excitotoxicidade coclear.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/812,298 US8268866B2 (en) | 2004-03-29 | 2004-03-29 | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
PCT/EP2005/003254 WO2005094799A2 (en) | 2004-03-29 | 2005-03-29 | Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0508251A true BRPI0508251A (pt) | 2007-07-31 |
Family
ID=34966520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508251-0A BRPI0508251A (pt) | 2004-03-29 | 2005-03-29 | métodos para o tratamento de tinido auditivo induzido por excitotoxicidade coclear |
Country Status (21)
Country | Link |
---|---|
US (1) | US8268866B2 (pt) |
EP (2) | EP2077108A1 (pt) |
JP (2) | JP4927706B2 (pt) |
KR (2) | KR101451414B1 (pt) |
CN (2) | CN104906079B (pt) |
AU (1) | AU2005229543B2 (pt) |
BR (1) | BRPI0508251A (pt) |
CA (1) | CA2558896C (pt) |
CY (1) | CY1110495T1 (pt) |
DE (1) | DE602005015562D1 (pt) |
DK (1) | DK1729753T3 (pt) |
ES (1) | ES2330350T3 (pt) |
IL (1) | IL177490A (pt) |
MX (1) | MXPA06011078A (pt) |
NZ (1) | NZ549399A (pt) |
PL (1) | PL1729753T3 (pt) |
PT (1) | PT1729753E (pt) |
RU (1) | RU2380094C2 (pt) |
SI (1) | SI1729753T1 (pt) |
WO (1) | WO2005094799A2 (pt) |
ZA (1) | ZA200607161B (pt) |
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US8268866B2 (en) * | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
US20060063802A1 (en) * | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
US9072662B2 (en) | 2004-03-29 | 2015-07-07 | Auris Medical Ag | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
EP2932971A1 (en) * | 2005-03-04 | 2015-10-21 | Otonomy, Inc. | Ketamine formulations |
KR101271263B1 (ko) | 2005-09-28 | 2013-06-07 | 아우리스 메디칼 아게 | 내이 장애 치료용 약학 조성물 |
US7803148B2 (en) | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
US8175712B2 (en) * | 2006-09-05 | 2012-05-08 | The Penn State Research Foundation | Homotopic conditioning of the brain stem baroreflex of a subject |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
WO2009132050A2 (en) | 2008-04-21 | 2009-10-29 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
CN103417472B (zh) * | 2008-05-14 | 2018-01-02 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放皮质类固醇组合物和方法 |
US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
US8846770B2 (en) * | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
US8349353B2 (en) * | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
WO2010008995A2 (en) * | 2008-07-14 | 2010-01-21 | Otonomy, Inc. | Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders |
US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
EP2306975A4 (en) * | 2008-07-21 | 2012-10-31 | Otonomy Inc | CONTROLLED RELEASE COMPOSITIONS MODULATING THE OTIC STRUCTURE AND MODULATING THE NATURAL IMMUNE SYSTEM AND METHODS OF TREATING OTIC DISORDERS |
US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
US8399018B2 (en) * | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
US8496957B2 (en) * | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
WO2010048095A2 (en) | 2008-10-22 | 2010-04-29 | House Ear Institute | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
CN106344495A (zh) * | 2008-12-22 | 2017-01-25 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放耳感觉细胞调节剂组合物 |
JP6084931B2 (ja) * | 2011-01-20 | 2017-02-22 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | ストレス又は急性聴力損失に関連する耳鳴の治療又は予防のためのネラメキサン |
CA2849085C (en) | 2011-12-12 | 2019-10-01 | Auris Medical Ag | Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system |
US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
JP2016534121A (ja) | 2013-08-27 | 2016-11-04 | オトノミ—,インク. | 小児の耳の病気の処置 |
JP2017513870A (ja) * | 2014-04-23 | 2017-06-01 | オーリス メディカル エージーAuris Medical Ag | 耳鳴りの治療と予防のための方法及び組成物 |
US11207316B2 (en) | 2014-05-30 | 2021-12-28 | West Virginia University | Ketamine or dextromethorphan formulations and methods of use |
KR20190024983A (ko) | 2016-06-29 | 2019-03-08 | 오토노미, 인코포레이티드 | 트리글리세라이드 귀 제제 및 이의 용도 |
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EP1438942A1 (en) | 2003-01-17 | 2004-07-21 | Schering Oy | An otorhinological drug delivery device |
DE602004023832D1 (de) | 2003-05-16 | 2009-12-10 | Univ Laval | Cns chlorid-modulierung und verwendung derselben |
EP1699431B1 (en) | 2003-12-12 | 2015-08-19 | Otic Pharma Ltd. | Compositions for treatment of ear disorders and methods of use thereof |
GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
US8268866B2 (en) * | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
-
2004
- 2004-03-29 US US10/812,298 patent/US8268866B2/en active Active
-
2005
- 2005-03-29 KR KR1020137020276A patent/KR101451414B1/ko active IP Right Grant
- 2005-03-29 AU AU2005229543A patent/AU2005229543B2/en not_active Ceased
- 2005-03-29 EP EP09005167A patent/EP2077108A1/en not_active Withdrawn
- 2005-03-29 PL PL05736619T patent/PL1729753T3/pl unknown
- 2005-03-29 JP JP2007505480A patent/JP4927706B2/ja not_active Expired - Fee Related
- 2005-03-29 DE DE602005015562T patent/DE602005015562D1/de active Active
- 2005-03-29 ES ES05736619T patent/ES2330350T3/es active Active
- 2005-03-29 SI SI200530751T patent/SI1729753T1/sl unknown
- 2005-03-29 WO PCT/EP2005/003254 patent/WO2005094799A2/en active Application Filing
- 2005-03-29 BR BRPI0508251-0A patent/BRPI0508251A/pt not_active Application Discontinuation
- 2005-03-29 RU RU2006138153/14A patent/RU2380094C2/ru active
- 2005-03-29 NZ NZ549399A patent/NZ549399A/en not_active IP Right Cessation
- 2005-03-29 KR KR1020127007363A patent/KR101429735B1/ko active IP Right Grant
- 2005-03-29 DK DK05736619T patent/DK1729753T3/da active
- 2005-03-29 ZA ZA200607161A patent/ZA200607161B/en unknown
- 2005-03-29 EP EP05736619A patent/EP1729753B1/en active Active
- 2005-03-29 MX MXPA06011078A patent/MXPA06011078A/es active IP Right Grant
- 2005-03-29 CN CN201510076933.3A patent/CN104906079B/zh not_active Expired - Fee Related
- 2005-03-29 CN CN200580009886.5A patent/CN1972677B/zh not_active Expired - Fee Related
- 2005-03-29 CA CA2558896A patent/CA2558896C/en active Active
- 2005-03-29 PT PT05736619T patent/PT1729753E/pt unknown
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2006
- 2006-08-15 IL IL177490A patent/IL177490A/en active IP Right Grant
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2009
- 2009-09-10 CY CY20091100944T patent/CY1110495T1/el unknown
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2011
- 2011-01-25 JP JP2011013018A patent/JP2011105740A/ja active Pending
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