PL1729753T3 - Zastosowanie agonisty receptora NMDA do leczenia szumów usznych powodowanych ekscytotoksycznością ślimaka - Google Patents

Zastosowanie agonisty receptora NMDA do leczenia szumów usznych powodowanych ekscytotoksycznością ślimaka

Info

Publication number
PL1729753T3
PL1729753T3 PL05736619T PL05736619T PL1729753T3 PL 1729753 T3 PL1729753 T3 PL 1729753T3 PL 05736619 T PL05736619 T PL 05736619T PL 05736619 T PL05736619 T PL 05736619T PL 1729753 T3 PL1729753 T3 PL 1729753T3
Authority
PL
Poland
Prior art keywords
treatment
receptor antagonist
nmda receptor
cochlear excitotoxicity
tinnitus induced
Prior art date
Application number
PL05736619T
Other languages
English (en)
Inventor
Matthieu Guitton
Jean-Luc Puel
Remy Pujol
Original Assignee
Auris Medical Ag
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1729753(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Auris Medical Ag, Inst Nat Sante Rech Med filed Critical Auris Medical Ag
Publication of PL1729753T3 publication Critical patent/PL1729753T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • A61K31/015Hydrocarbons carbocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/02Halogenated hydrocarbons
    • A61K31/025Halogenated hydrocarbons carbocyclic
    • A61K31/03Halogenated hydrocarbons carbocyclic aromatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL05736619T 2004-03-29 2005-03-29 Zastosowanie agonisty receptora NMDA do leczenia szumów usznych powodowanych ekscytotoksycznością ślimaka PL1729753T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/812,298 US8268866B2 (en) 2004-03-29 2004-03-29 Methods for the treatment of tinnitus induced by cochlear excitotoxicity
EP05736619A EP1729753B1 (en) 2004-03-29 2005-03-29 Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity
PCT/EP2005/003254 WO2005094799A2 (en) 2004-03-29 2005-03-29 Use of an nmda receptor antagonist for the treatment of tinnitus induced by cochlear excitotoxicity

Publications (1)

Publication Number Publication Date
PL1729753T3 true PL1729753T3 (pl) 2010-01-29

Family

ID=34966520

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05736619T PL1729753T3 (pl) 2004-03-29 2005-03-29 Zastosowanie agonisty receptora NMDA do leczenia szumów usznych powodowanych ekscytotoksycznością ślimaka

Country Status (21)

Country Link
US (1) US8268866B2 (pl)
EP (2) EP2077108A1 (pl)
JP (2) JP4927706B2 (pl)
KR (2) KR101451414B1 (pl)
CN (2) CN104906079B (pl)
AU (1) AU2005229543B2 (pl)
BR (1) BRPI0508251A (pl)
CA (1) CA2558896C (pl)
CY (1) CY1110495T1 (pl)
DE (1) DE602005015562D1 (pl)
DK (1) DK1729753T3 (pl)
ES (1) ES2330350T3 (pl)
IL (1) IL177490A (pl)
MX (1) MXPA06011078A (pl)
NZ (1) NZ549399A (pl)
PL (1) PL1729753T3 (pl)
PT (1) PT1729753E (pl)
RU (1) RU2380094C2 (pl)
SI (1) SI1729753T1 (pl)
WO (1) WO2005094799A2 (pl)
ZA (1) ZA200607161B (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063802A1 (en) * 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) * 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
EP1861104A4 (en) * 2005-03-04 2011-12-14 Neurosystec Corp IMPROVED GACYCLIDINE FORMULATIONS
CN101309667A (zh) * 2005-09-28 2008-11-19 奥里斯医学股份有限公司 治疗内耳疾病的药用合成物
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US8175712B2 (en) * 2006-09-05 2012-05-08 The Penn State Research Foundation Homotopic conditioning of the brain stem baroreflex of a subject
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
KR101449785B1 (ko) 2008-04-21 2014-10-14 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
WO2009139924A2 (en) 2008-05-14 2009-11-19 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders
US8648119B2 (en) * 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
US8846770B2 (en) 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
US8349353B2 (en) * 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
WO2010011466A2 (en) * 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
WO2010008995A2 (en) * 2008-07-14 2010-01-21 Otonomy, Inc. Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders
US20100016450A1 (en) * 2008-07-21 2010-01-21 Otonomy, Inc. Controlled release delivery devices for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
EP2306975A4 (en) * 2008-07-21 2012-10-31 Otonomy Inc COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US8399018B2 (en) * 2008-07-21 2013-03-19 Otonomy, Inc. Controlled release ion channel modulator compositions and methods for the treatment of otic disorders
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US9173864B2 (en) 2008-10-22 2015-11-03 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
CA2732686C (en) * 2008-12-22 2017-10-03 Otonomy, Inc. Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
EP2665474A1 (en) * 2011-01-20 2013-11-27 Merz Pharma GmbH & Co. KGaA Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss
ES2862673T3 (es) 2011-12-12 2021-10-07 Zilentin AG Tratamiento del tinnitus mediante la modulación del cotransportador de cloruro NKCC1 en el sistema auditivo
US8920855B1 (en) 2012-10-30 2014-12-30 Setem Hemth, Inc Methods of topically treating tinnitus and related disorders
JP2016534121A (ja) 2013-08-27 2016-11-04 オトノミ—,インク. 小児の耳の病気の処置
JP2017513870A (ja) * 2014-04-23 2017-06-01 オーリス メディカル エージーAuris Medical Ag 耳鳴りの治療と予防のための方法及び組成物
US11207316B2 (en) 2014-05-30 2021-12-28 West Virginia University Ketamine or dextromethorphan formulations and methods of use
JP7033789B2 (ja) 2016-06-29 2022-03-11 オトノミー,インク. トリグリセリド耳用製剤とその使用
WO2018053173A1 (en) 2016-09-16 2018-03-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
US10561736B1 (en) 2019-01-09 2020-02-18 Spiral Therapeutics, Inc. Apoptosis inhibitor formulations for prevention of hearing loss

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
CH535201A (de) 1969-12-19 1973-03-31 Bristol Myers Co Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren
WO1994008599A1 (en) 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
US5421818A (en) * 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
AU8071894A (en) * 1994-09-22 1996-04-09 Jonathan M Licht Compositions useful for the preparation of medicines for treating a variety of intractable disorders
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
US5654337A (en) * 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
DE19528388A1 (de) * 1995-08-02 1997-02-06 Hans Peter Prof Dr Med Zenner Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs
TW450807B (en) 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents
US5746961A (en) * 1995-12-04 1998-05-05 Michael J. Stevenson Method for enhancement of the surfaces of molded plastic products
WO1997038698A1 (en) 1996-04-18 1997-10-23 University Technology Corporation Methods for treating middle and inner ear disorders
AU4424697A (en) 1996-09-11 1998-04-02 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The The use of functional n-methyl-d-aspartate antagonists to ameliorate or prevent aminoglycoside-induced ototoxicity
US6045528A (en) * 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
US6309410B1 (en) * 1998-08-26 2001-10-30 Advanced Bionics Corporation Cochlear electrode with drug delivery channel and method of making same
DE19853299C2 (de) * 1998-11-19 2003-04-03 Thomas Lenarz Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs
US6120484A (en) * 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
US6017961A (en) * 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
DE19936719A1 (de) * 1999-08-06 2001-02-15 Gruenenthal Gmbh Substituierte 1,5-Dihydropyrrol-2-on-Derivate
US6265379B1 (en) * 1999-10-13 2001-07-24 Allergan Sales, Inc. Method for treating otic disorders
JP2001187737A (ja) 1999-10-18 2001-07-10 Toyama Chem Co Ltd 聴力改善剤
DE10025238A1 (de) 2000-05-22 2001-11-29 Gruenenthal Gmbh Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel
BRPI0002693B8 (pt) 2000-06-19 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis
DE10048969A1 (de) 2000-08-23 2002-03-14 Mueller Schwefe Gerhard Verwendung von Flupirtin zur Tinnitusbehandlung
DE10044649A1 (de) 2000-09-08 2002-07-04 Gruenenthal Gmbh Substituierte 4-Phenyl-1-(1-phenyl-cyclohexyl)-1,2,3,6-tetrahydropyridine
US6924273B2 (en) * 2000-10-03 2005-08-02 Scott W. Pierce Chondroprotective/restorative compositions and methods of use thereof
DE10124953A1 (de) 2001-05-21 2002-12-12 Marlies Knipper Substanz für die therapeutische Behandlung von Tinnitus
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US20030143195A1 (en) * 2002-01-30 2003-07-31 Pinsker Judy Senior Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery
US6638081B2 (en) * 2002-03-22 2003-10-28 Hon Hai Precision Ind. Co., Ltd. Electrical connector
JP2006502158A (ja) 2002-09-06 2006-01-19 デュレクト コーポレーション グルタメート媒介神経伝達のモジュレーターの内耳への送達
US6656172B1 (en) * 2002-09-27 2003-12-02 Medtronic, Inc. Method for treating severe tinnitus
US6969383B2 (en) * 2002-09-27 2005-11-29 Medtronic, Inc. Method for treating severe tinnitus
EP1560807B1 (de) 2002-11-12 2010-02-10 Grünenthal GmbH 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
EP1438942A1 (en) 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
WO2004101072A1 (en) 2003-05-16 2004-11-25 Universite Laval Cns chloride modulation and uses thereof
ES2552936T3 (es) 2003-12-12 2015-12-03 Otic Pharma Ltd. Composiciones para el tratamiento del desordenes en el oído y métodos para el uso de los mismos
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity

Also Published As

Publication number Publication date
CY1110495T1 (el) 2015-04-29
EP1729753B1 (en) 2009-07-22
JP2007530622A (ja) 2007-11-01
CN1972677A (zh) 2007-05-30
SI1729753T1 (sl) 2009-12-31
KR101429735B1 (ko) 2014-08-12
BRPI0508251A (pt) 2007-07-31
NZ549399A (en) 2009-12-24
JP2011105740A (ja) 2011-06-02
DE602005015562D1 (de) 2009-09-03
ES2330350T3 (es) 2009-12-09
EP1729753A2 (en) 2006-12-13
US8268866B2 (en) 2012-09-18
CN104906079B (zh) 2018-01-19
CN1972677B (zh) 2015-03-11
PT1729753E (pt) 2009-09-21
MXPA06011078A (es) 2007-11-20
WO2005094799A3 (en) 2006-03-02
KR101451414B1 (ko) 2014-10-22
JP4927706B2 (ja) 2012-05-09
CN104906079A (zh) 2015-09-16
IL177490A (en) 2013-10-31
RU2380094C2 (ru) 2010-01-27
IL177490A0 (en) 2006-12-10
KR20120049364A (ko) 2012-05-16
KR20130103615A (ko) 2013-09-23
WO2005094799A2 (en) 2005-10-13
CA2558896A1 (en) 2005-10-13
DK1729753T3 (da) 2009-11-23
ZA200607161B (en) 2007-11-28
AU2005229543B2 (en) 2009-12-03
RU2006138153A (ru) 2008-05-10
AU2005229543A1 (en) 2005-10-13
US20050214338A1 (en) 2005-09-29
CA2558896C (en) 2012-11-20
EP2077108A1 (en) 2009-07-08

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