JP2007529544A - ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩 - Google Patents
３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩 Download PDFInfo
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- JP2007529544A JP2007529544A JP2007504115A JP2007504115A JP2007529544A JP 2007529544 A JP2007529544 A JP 2007529544A JP 2007504115 A JP2007504115 A JP 2007504115A JP 2007504115 A JP2007504115 A JP 2007504115A JP 2007529544 A JP2007529544 A JP 2007529544A
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55355404P | 2004-03-17 | 2004-03-17 | |
| US58467404P | 2004-07-02 | 2004-07-02 | |
| PCT/US2005/008935 WO2005090380A1 (en) | 2004-03-17 | 2005-03-17 | Pharmaceuticals salts of 3-o-(3',3'-dimethylsuccinyl) betulinic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007529544A true JP2007529544A (ja) | 2007-10-25 |
| JP2007529544A5 JP2007529544A5 (https=) | 2008-05-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007504115A Pending JP2007529544A (ja) | 2004-03-17 | 2005-03-17 | ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20050239748A1 (https=) |
| EP (1) | EP1730163A4 (https=) |
| JP (1) | JP2007529544A (https=) |
| AU (1) | AU2005224260A1 (https=) |
| BR (1) | BRPI0508854A (https=) |
| CA (1) | CA2560266A1 (https=) |
| IL (1) | IL178128A0 (https=) |
| MX (1) | MXPA06010592A (https=) |
| NO (1) | NO20064676L (https=) |
| RU (1) | RU2387665C2 (https=) |
| WO (1) | WO2005090380A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009120516A (ja) * | 2007-11-13 | 2009-06-04 | Tokyo Medical Univ | 抗ウィルス剤 |
| JP2013527242A (ja) * | 2010-06-04 | 2013-06-27 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｉｖ成熟阻害剤としての修飾ｃ−３ベツリン酸誘導体 |
| JP2019524724A (ja) * | 2016-07-15 | 2019-09-05 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | テコビリマットの経口用医薬組成物及びその調製法 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1868613B1 (en) * | 2005-04-12 | 2012-03-07 | Myrexis, Inc. | Polymorphs of 3-o-(3',3'-dimethylsuccinyl) betulinic acid di-n-methyl-d-glucamine |
| BRPI0619936A2 (pt) * | 2005-12-16 | 2011-10-25 | Panacos Pharmaceuticals Inc | preparação de sais farmacêuticos de ácido 3-o-(3',3'- dimetilsuccinil) betulìnico |
| US20080039428A1 (en) * | 2006-06-29 | 2008-02-14 | Panacos Pharmaceuticals, Inc. | Antiretroviral combination therapy |
| CZ300722B6 (cs) * | 2006-09-27 | 2009-07-22 | Univerzita Karlova v Praze, Prírodovedecká fakulta | Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující |
| AR063546A1 (es) | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
| WO2008091532A1 (en) * | 2007-01-19 | 2008-07-31 | Panacos Pharmaceuticals, Inc. | Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof |
| WO2009042166A1 (en) * | 2007-09-25 | 2009-04-02 | Panacos Pharmaceuticals, Inc. | Liquid bevirimat dosage forms for oral administration |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| US8802727B2 (en) * | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
| US8802661B2 (en) | 2010-06-04 | 2014-08-12 | Bristol-Myers Squibb Company | C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors |
| WO2012095705A1 (en) * | 2011-01-10 | 2012-07-19 | Hetero Research Foundation | Pharmaceutically acceptable salts of novel betulinic acid derivatives |
| KR101886467B1 (ko) | 2011-01-31 | 2018-08-07 | 비브 헬스케어 유케이 (넘버4) 리미티드 | Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드 |
| PL2670764T3 (pl) | 2011-01-31 | 2016-02-29 | Bristol Myers Squibb Co | C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV |
| RU2489147C2 (ru) * | 2011-08-31 | 2013-08-10 | Людмила Петровна Лазурина | Фармацевтическая антибактериальная композиция для местного применения на основе активных биометаллокомплексов |
| WO2013043778A1 (en) | 2011-09-21 | 2013-03-28 | Bristol-Myers Squibb Company | Novel betulinic acid derivatives with antiviral activity |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| SG11201505639SA (en) | 2013-02-06 | 2015-08-28 | Bristol Myers Squibb Co | C-19 modified triterpenoids with hiv maturation inhibitory activity |
| SG11201506445PA (en) | 2013-02-25 | 2015-09-29 | Bristol Myers Squibb Co | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv |
| SI3129392T1 (sl) | 2014-04-11 | 2020-11-30 | VIIV Healthcare UK(No.4) Limited | Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent |
| WO2015195776A1 (en) | 2014-06-19 | 2015-12-23 | Bristol-Myers Squibb Company | Betulinic acid derivatives with hiv maturation inhibitory activity |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
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- 2005-03-17 RU RU2006136409/04A patent/RU2387665C2/ru not_active IP Right Cessation
- 2005-03-17 BR BRPI0508854-2A patent/BRPI0508854A/pt not_active IP Right Cessation
- 2005-03-17 WO PCT/US2005/008935 patent/WO2005090380A1/en not_active Ceased
- 2005-03-17 MX MXPA06010592A patent/MXPA06010592A/es not_active Application Discontinuation
- 2005-03-17 US US11/081,802 patent/US20050239748A1/en not_active Abandoned
- 2005-03-17 AU AU2005224260A patent/AU2005224260A1/en not_active Abandoned
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2006
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| JP2009120516A (ja) * | 2007-11-13 | 2009-06-04 | Tokyo Medical Univ | 抗ウィルス剤 |
| JP2013527242A (ja) * | 2010-06-04 | 2013-06-27 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｉｖ成熟阻害剤としての修飾ｃ−３ベツリン酸誘導体 |
| JP2019524724A (ja) * | 2016-07-15 | 2019-09-05 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ | テコビリマットの経口用医薬組成物及びその調製法 |
| US11318115B2 (en) | 2016-07-15 | 2022-05-03 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Oral pharmaceutical composition of Tecovirimat and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005224260A1 (en) | 2005-09-29 |
| RU2387665C2 (ru) | 2010-04-27 |
| NO20064676L (no) | 2006-12-01 |
| CA2560266A1 (en) | 2005-09-29 |
| US20050239748A1 (en) | 2005-10-27 |
| BRPI0508854A (pt) | 2007-08-28 |
| WO2005090380A1 (en) | 2005-09-29 |
| EP1730163A1 (en) | 2006-12-13 |
| RU2006136409A (ru) | 2008-04-27 |
| MXPA06010592A (es) | 2007-06-12 |
| EP1730163A4 (en) | 2009-12-30 |
| US20120214775A1 (en) | 2012-08-23 |
| IL178128A0 (en) | 2006-12-31 |
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